Heikki Nieminen

Publications

Research output per year 2012 2015 2016 2017 2019 2024

• 22 Article
• 8 Conference contribution
• 4 Abstract
• 4 Patent
• 2 More
  • 2 Conference article

Research output per year

Research output per year

Search results

• 2024

  Development of Focused Ultrasound-Assisted Nanoplexes for RNA Delivery

  Ranjan, S., Bosch, S., Lukkari, H., Schirmer, J., Aaltonen, N., Nieminen, H. J., Lehto, V-P., Urtti, A., Lajunen, T. & Rilla, K., Jul 2024, In: Nanomaterials. 14, 13, 1089.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Ultrasound-Enhanced Fine-Needle Biopsy Improves Yield in Human Epithelial and Lymphoid Tissue

  Le Bourlout, Y., Rehell, M., Kelppe, J., Rautava, J., Perra, E., Rantanen, J., Ehnholm, G., Hayward, N., Nyman, K., Pritzker, K. P. H., Tarkkanen, J., Atula, T., Aro, K. & Nieminen, H. J., 2024, In: Ultrasound in Medicine and Biology. 50, 8, p. 1247-1254 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2023

  Evaluation of bone growth around bioactive glass S53P4 by scanning acoustic microscopy co-registered with optical interferometry and elemental analysis

  Holmström, A., Meriläinen, A., Hyvönen, J. T. J., Nolvi, A., Ylitalo, T., Steffen, K., Björkenheim, R., Strömberg, G. G., Nieminen, H., Kassamakov, I., Pajarinen, J., Hupa, L., Salmi, A., Haeggström, E. & Lindfors, N., 24 Apr 2023, In: Scientific Reports. 13, 1, 11 p., 6646.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2022

  Flow correlations from a hydrodynamics model with dynamical freeze-out and initial conditions based on perturbative QCD and saturation

  Hirvonen, H., Eskola, K. J. & Niemi, H., 27 Oct 2022, In: Physical Review C. 106, 4, 20 p., 044913.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2020

  Deep-Learning for Tidemark Segmentation in Human Osteochondral Tissues Imaged with Micro-computed Tomography

  Tiulpin, A., Finnilä, M., Lehenkari, P., Nieminen, H. J. & Saarakkala, S., 2020, Advanced Concepts for Intelligent Vision Systems : 20th International Conference, ACIVS 2020, Auckland, New Zealand, February 10–14, 2020, Proceedings. Blanc-Talon, J., Delmas, P., Philips, W., Popescu, D. & Scheunders, P. (eds.). Cham: Springer Nature Switzerland AG, p. 131-138 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 12002 LNCS).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

• Non-contact determination of intra-ocular pressure in an ex vivo porcine model

  Salmi, A., Nieminen, H., Veira Canle, D., Haeggström, E. & Kontiola, A., 3 Feb 2020, In: PLoS One. 15, 2, 13 p., 0227488.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2019

  3D morphometric analysis of calcified cartilage properties using micro-computed tomography

  Kauppinen, S., Karhula, S. S., Thevenot, J., Ylitalo, T., Rieppo, L., Kestilä, I., Haapea, M., Hadjab, I., Finnilä, M. A., Quenneville, E., Garon, M., Gahunia, H. K., Pritzker, K. P. H., Buschmann, M. D., Saarakkala, S. & Nieminen, H. J., Jan 2019, In: Osteoarthritis and Cartilage. 27, 1, p. 172-180 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems

  Hakkarainen, E., Korkjas, A., Laidmae, I., Lust, A., Semjonov, K., Kogermann, K., Nieminen, H. J., Salmi, A., Korhonen, O., Haeggström, E. & Heinämäki, J., Oct 2019, In: Pharmaceutics. 11, 10, 10 p., 495.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• FEM Modelling of Ultrasound Enhanced Electrospinning (USES)

  Mäkinen, J., Helander, P., Puranen, T., Hunnakko, J., Kogermann, K., Laidmäe, I., Nieminen, H. J., Salmi, A., Heinämäki, J. & Haeggström, E., 2019, 2019 IEEE International Ultrasonics Symposium (IUS). IEEE, p. 2511-2514 4 p. (IEEE International Ultrasonics Symposium).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

  Open Access

  File

• Localized delivery of compounds into articular cartilage by using high-intensity focused ultrasound

  Nieminen, H. J., Lampsijarvi, E., Barreto, G., Finnilä, M. A. J., Salmi, A., Airaksinen, A. J., Eklund, K. K., Saarakkala, S., Pritzker, K. P. H. & Haeggström, E., 4 Nov 2019, In: Scientific Reports. 9, 9 p., 15937.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Practical realization of a sub-λ/2 acoustic jet

  Canle, D. V., Kekkonen, T., Mäkinen, J., Puranen, T., Nieminen, H. J., Kuronen, A., Franssila, S., Kotiaho, T., Salmi, A. & Haeggstrom, E., 26 Mar 2019, In: Scientific Reports. 9, 6 p., 5189.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses

  Ylitalo, T., Finnilä, M. A. J., Gahunia, H. K., Karhula, S. S., Suhonen, H., Valkealahti, M., Lehenkari, P., Haeggström, E., Pritzker, K. P. H., Saarakkala, S. & Nieminen, H. J., Apr 2019, In: Journal of Orthopaedic Research. 37, 4, p. 855-866 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Towards Chronic Wound Pads: Gradient Nanofiber Structure Generated by Ultrasound Enhanced Electrospinning (USES)

  Hunnakko, J., Laidmäe, I., Puranen, T., Mäkinen, J., Helander, P., Nieminen, H. J., Nolvi, A., Kogermann, K., Heinämäki, J., Salmi, A. & Haeggström, E., 2019, 2019 IEEE International Ultrasonics Symposium (IUS). IEEE, p. 2447-2449 3 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

  Open Access

  File
• 2018

  Delivery of Agents Into Articular Cartilage With Electric Spark-Induced Sound Waves

  Pérez, A. G., Nieminen, H. J., Finnilä, M., Salmi, A., Pritzker, K. P. H., Lampsijärvi, E., Paulin, T., Airaksinen, A. J., Saarakkala, S. & Haeggström, E., 16 Oct 2018, In: Frontiers in Physics. 6, 7 p., 116.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• In vitro method for 3D morphometry of human articular cartilage chondrons based on micro-computed tomography

  Kestilä, I., Thevenot, J., Finnilä, M. A., Karhula, S. S., Hadjab, I., Kauppinen, S., Garon, M., Quenneville, E., Haapea, M., Rieppo, L., Pritzker, K. P., Buschmann, M. D., Nieminen, H. J. & Saarakkala, S., Aug 2018, In: Osteoarthritis and Cartilage. 26, 8, p. 1118-1126 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Ultrasound-enhanced electrospinning

  Nieminen, H. J., Laidmae, I., Salmi, A., Rauhala, T., Paulin, T., Heinämäki, J. & Haeggström, E., 13 Mar 2018, In: Scientific Reports. 8, 6 p., 4437.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2017

  3D histopathological grading of osteochondral tissue using contrast-enhanced micro-computed tomography

  Nieminen, H. J., Gahunia, H. K., Pritzker, K. P. H., Ylitalo, T., Rieppo, L., Karhula, S. S., Lehenkari, P., Haeggstörm, E. & Saarakkala, S., Oct 2017, In: Osteoarthritis and Cartilage. 25, 10, p. 1680-1689 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Apparatus for delivery of substances into bone

  Salmi, A. H., Haeggström, E. O., Garcia Pérez, A., Moilanen, P. L. I. & Nieminen, H. J., 16 Mar 2017, IPC No. A61M37/00, Patent No. WO2017042422A1, 16 Mar 2017, Priority date 9 Sept 2015, Priority No. WO2015FI50589 20150909

  Research output: Patent

• Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography

  Karhula, S. S., Finnilä, M. A., Lammi, M. J., Ylärinne, J. H., Kauppinen, S., Rieppo, L., Pritzker, K. P. H., Nieminen, H. J. & Saarakkala, S., 30 Jan 2017, In: PLoS One. 12, 1, 12 p., 0171075.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Laser-ultrasonic delivery of agents into articular cartilage

  Nieminen, H. J., Correia Pinto de Almeida, G. E., Finnilä, M. A., Garcia Pérez, A., Salmi, A. H., Ranjan, S., Eklund, K. K., Pritzker, K. P. H., Saarakkala, S. & Haeggström, E. O., 2017, In: Scientific Reports. 7, 12 p., 3991.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Method and arrangement for eye measurements

  Salmi, A. H., Haeggström, E. O., Kassamakov, I. V., Nieminen, H. J., Hanhijärvi, K. J., Rauhala, T. J. J. & Kontiola, A., 9 Mar 2017, IPC No. A61B3/16, Patent No. WO 2017037330 A1, 9 Mar 2017, Priority No. WO2015FI50579 20150903

  Research output: Patent

• Micro-Scale Distribution of CA4+ in Ex vivo Human Articular Cartilage Detected with Contrast-Enhanced Micro-Computed Tomography Imaging

  Karhula, S., Finnilä, M. A., Freedman, J. H., Kauppinen, S., Valkealahti, M., Lehenkari, P., Pritzker, K. P. H., Nieminen, H. J., Snyder, B., Grinstaff, M. & Saarakkala, S., 31 Aug 2017, In: Frontiers in Physics. 5, 8 p., 38.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2016

  3D-HISTOPATHOLOGICAL GRADING OF ARTICULAR CARTILAGE USING CONTRAST-ENHANCED HIGH-RESOLUTION MICRO-CT

  Gahunia, H., Karhula, S., Ylitalo, T., Haeggstrom, E., Pritzker, K. P., Saarakkala, S. & Nieminen, H. J., Apr 2016, p. S277-S278. 2 p.

  Research output: Conference materials › Abstract › peer-review

• Characterizing shockwave propagation in waveguides by Schlieren imaging

  Lampsijärvi, E., Hanhijärvi, K., Nieminen, H. J., Salmi, A., Kassamakov, I. & Haeggström, E., 2016, IEEE International Ultrasonic Symposium Proceedings. New York: IEEE, 4 p. (IEEE International Ultrasonics Symposium).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

• DELIVERY OF AGENTS INTO ARTICULAR CARTILAGE BY LASER-ULTRASOUND

  Nieminen, H. J., Garcia-Perez, A., Finnila, M. A., Salmi, A., Ranjan, S., Saarakkala, S., Pritzker, K. P. & Haeggstrom, E., Apr 2016, p. S523-S524. 2 p.

  Research output: Conference materials › Abstract › peer-review

• Device and method to produce nanofibers and constructs thereof

  Salmi, A. H., Haeggström, E. O., Nieminen, H. J., Paulin, T. A., Rauhala, T. J. J., Yliruusi, J. K., Heinämäki, J. T., Laidmäe, I., Falk, K. & Veski, P., 29 Sept 2016, Patent No. WO 2016151191 A1, Priority date 24 Mar 2015

  Research output: Patent

• HIGH-INTENSITY PULSED ULTRASOUND AND ELECTRIC FIELD PERMIT LOCALIZED PHARMACOTHERAPY TARGETING ARTICULAR CARTILAGE

  Perez, A. G., Nieminen, H. J., Finnila, M., Salmi, A., Lampsijarvi, E., Paulin, T., Pritzker, K. P., Saarakkala, S. & Haeggstrom, E., Apr 2016, p. S522-S522. 1 p.

  Research output: Conference materials › Abstract › peer-review

• MICROLOCALIZED TRANSPORT OF AGENTS INTO ARTICULAR CARTILAGE USING HIGH INTENSITY ULTRASOUND

  Nieminen, H. J., Lampsijarvi, E., Salmi, A., Airaksinen, A., Saarakkala, S., Pritzker, K. P. & Haeggstrom, E., Apr 2016, p. S522-S523. 2 p.

  Research output: Conference materials › Abstract › peer-review

• 2015

  Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound

  Nieminen, H. J., Ylitalo, T., Suuronen, J-P., Rahunen, K., Salmi, A., Saarakkala, S., Serimaa, R. & Haeggstrom, E., Aug 2015, In: Ultrasound in Medicine & Biology. 41, 8, p. 2259-2265 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Determining collagen distribution in articular cartilage using contrast-enhanced micro-computed tomography

  Nieminen, H. J., Ylitalo, T., Karhula, S., Suuronen, J. -P., Kauppinen, S., Serimaa, R., Haeggstrom, E., Pritzker, K. P. H., Valkealahti, M., Lehenkari, P., Finnila, M. & Saarakkala, S., Sept 2015, In: Osteoarthritis and Cartilage. 23, 9, p. 1613-1621 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Effects of acoustic levitation on the development of zebrafish, Danio rerio, embryos

  Sundvik, M., Nieminen, H. J., Salmi, A., Panula, P. & Haeggstrom, E., 4 Sept 2015, In: Scientific Reports. 5, 11 p., 13596.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Method and arrangement for eye pressure measurements

  Salmi, A. H., Haeggström, E. O., Nieminen, H. J. & Kontiola, A., 11 Sept 2015, IPC No. A61B3/16, Patent No. WO 2015132467 A1, 11 Sept 2015, Priority date 4 Mar 2014, Priority No. FI20140005205 20140304

  Research output: Patent

• SURFACE CHARACTERIZATION OF DEGENERATED ARTICULAR CARTILAGE SURFACE BY CONTRAST-ENHANCED MICRO-COMPUTED TOMOGRAPHY

  Ylitalo, T. J., Finnila, M., Karhula, S., Haeggstrom, E., Pritzker, K. P., Saarakkala, S. & Nieminen, H. J., Apr 2015, In: Osteoarthritis and Cartilage. 23, Supplement 2, p. A249-A250 2 p., A384.

  Research output: Contribution to journal › Conference article › Scientific › peer-review
• 2014

  Automatic segmentation for detecting uterine fibroid regions treated with MR-guided high intensity focused ultrasound (MR-HIFU)

  Antila, K., Nieminen, H. J., Sequeiros, R. B. & Ehnholm, G., Jul 2014, In: Medical Physics. 41, 7, 8 p., 073502.

  Research output: Contribution to journal › Article › Scientific › peer-review

• DETERMINING SPATIAL DISTRIBUTION OF COLLAGEN IN ARTICULAR CARTILAGE BY CONTRAST-ENHANCED mu CT

  Nieminen, H. J., Ylitalo, T., Kauppinen, S., Haeggstrom, E., Finnila, M. & Saarakkala, S., Apr 2014, In: Osteoarthritis and Cartilage. 22, p. S271-S272 2 p.

  Research output: Contribution to journal › Conference article › Scientific › peer-review

• The potential utility of high-intensity ultrasound to treat osteoarthritis

  Nieminen, H. J., Salmi, A., Karppinen, P., Haeggstrom, E. & Hacking, S. A., 2014, In: Osteoarthritis and Cartilage. 22, 11, p. 1784-1799 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2013

  Detecting defects in adhesion between a metal hemisphere and a polymer base

  Salmi, A., Heino, O., Nieminen, H. J., Salmi, T., Karppinen, P., Patola, T., Haeggstrom, E. & Hacking, S. A., 2013, 2013 IEEE International Ultrasonics Symposium (IUS). IEEE, p. 1692-1695 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

• MHz Ultrasonic Drive-In: Localized Drug Delivery for Osteoarthritis Therapy

  Nieminen, H. J., Salmi, A., Rinta-aho, J., Hubbel, G., Wjuga, K., Suuronen, J-P., Serimaa, R. & Haeggstrom, E., 2013, 2013 IEEE International Ultrasonics Symposium (IUS). IEEE, p. 615-618 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

• Ultrasonic Damage Assessment of Articular Cartilage for Ultrasonic Drug Delivery

  Fridlund, C., Kananen, V., Nieminen, H. J. & Haeggstrom, E., 2013, 2013 IEEE International Ultrasonics Symposium (IUS). IEEE, p. 2114-2117 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review
• 2012

  Ultrasonic transport of particles into articular cartilage and subchondral bone

  Nieminen, H. J., Herranen, T., Kananen, V., Hacking, S. A., Salmi, A., Karppinen, P. & Haeggström, E., 2012, Ultrasonics Symposium (IUS), 2012 IEEE International. IEEE, p. 1869-1872 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific