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  • PL 56 (Viikinkaari 5)

    00014

    Finland

20032019
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Publications 2003 2019

2019

Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells

Qi, S., Zhang, P., Ma, M., Yao, M., Wu, J., Mäkilä, E., Salonen, J., Ruskoaho, H., Xu, Y., Santos, H. A. & Zhang, H., 4 Jan 2019, In : Small. 15, 1, 13 p., 1804332.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish

Narumanchi, S., Kalervo, K., Perttunen, S., Wang, H., Immonen, K., Kosonen, R., Laine, M., Ruskoaho, H., Tikkanen, I., Lakkisto, P. & Paavola, J., Jun 2019, In : Journal of Cardiovascular Development and Disease. 6, 2, 12 p., 16.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lääketieteellinen farmakologia ja toksikologia

Ruskoaho, H. (ed.), Hakkola, J. (ed.), Huupponen, R. (ed.), Kantele, A. (ed.), Korpi, E. (ed.), Moilanen, E. (ed.), Piepponen, P. (ed.), Savontaus, E., Tenhunen, O. (ed.), Vähäkangas, K. & Anttila, V-J., 2019, 5. uud. p. ed. Helsinki: Duodecim. 1288 p.

Research output: Book/ReportBookProfessional

Targeting GATA4 for cardiac repair

Välimäki, M. J. & Ruskoaho, H. J., 16 Aug 2019, In : IUBMB Life. 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2018

Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction

Kinnunen, S. M., Tölli, M. A., Välimäki, M. J., Gao, E., Szabo, Z., Rysä, J., Almeida Ferreira, M. P., J. Ohukainen, P., Serpi, R., Correia, A., Makila, E., Salonen, J., Hirvonen, J. T., Almeida Santos, H. & Ruskoaho, H. J., 15 Mar 2018, In : Scientific Reports. 8, 14 p., 4611 .

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Cellular Mechanisms of Valvular Thickening in Early and Intermediate Calcific Aortic Valve Disease

Ohukainen, P., Ruskoaho, H. & Rysä, J., 2018, In : Current Cardiology Reviews. 14, 4, p. 264-271 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Combined transcriptomics, proteomics and metabolomics analysis identifies metabolic pathways associated with the loss of cardiac regeneration

Talman, V., Teppo, J., Poho, P., Movahedi, P., Vaikkinen, A., Pahikkala, T., Kotiaho, T., Kostiainen, R., Varjosalo, M. & Ruskoaho, H., Apr 2018, In : Cardiovascular Research. 114, p. S22-S23 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access
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Dual‐drug delivery using dextran‐functionalized nanoparticles targeting cardiac fibroblasts for cellular reprogramming

Ferreira, M. P. A., Talman, V., Torrieri, G., Liu, D., Marques, G., Moslova, K., Liu, Z., Pinto, J. F., Hirvonen, J., Ruskoaho, H. & Santos, H. A., 11 Apr 2018, In : Advanced Functional Materials. 28, 15, 12 p., 1705134.

Research output: Contribution to journalArticleScientificpeer-review

Identification of cardiomyocyte-specific lncRNAs as potential regulators of cardiac regeneration

Pohjolainen, L., Kinnunen, S., Ruskoaho, H. & Talman, V., Apr 2018, In : Cardiovascular Research. 114, p. S1-S1 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access

Isoxazole-amides for treating cardiac diseases

Kinnunen, S. M., Tölli, M., Välimäki, M. J., Jumppanen, A. M., Boije af Gennäs, P. G., Yli-Kauhaluoma, J. T. & Ruskoaho, H. J., 29 Mar 2018, IPC No. C07D 261/18 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), C07D 413/04 (2006.01), C07D 413/14 (2006.01), A61K 31/42 (2006.01), A61P 9/00 (2006.01), World Intellectual Property Organization (WIPO), Patent No. WO 2018/055235 A1, 20 Sep 2017, Priority date 21 Sep 2016, Priority No. 20165712

Research output: PatentScientific

Mechanical stretch induced transcriptomic profiles in cardiac myocytes

Rysä, J., Tokola, H. & Ruskoaho, H. J., Jan 2018, In : Scientific Reports. 8, 1, 14 p., 4733.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Molecular Atlas of Postnatal Mouse Heart Development

Talman, V., Teppo, J. S., Pöhö, P. A., Movahedi, P., Vaikkinen, A., Karhu, S. T., Trošt, K., Suvitaival, T., Heikkonen, J., Pahikkala, T., Kotiaho, A. A. T., Kostiainen, R. K., Varjosalo, M. T. & Ruskoaho, H. J., 16 Oct 2018, In : Journal of the American Heart Association. 7, 20, 46 p., 010378.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality

Fernandez, C., Rysä, J., Almgren, P., Nilsson, J., Engström, G., Orho-Melander, M., Ruskoaho, H. & Melander, O., Oct 2018, In : Journal of Internal Medicine. 284, 4, p. 377-387 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart

Renko, O., Tolonen, A-M., Rysä, J., Magga, J., Mustonen, E., Ruskoaho, H. & Serpi, R., 18 Jan 2018, In : Scientific Reports. 8, 11 p., 1160.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Ambulatory pulse pressure predicts the development of left ventricular diastolic dysfunction in over 20 years of follow-up

Pääkkö, T., Renko, RJ., Perkiömäki, J., Kesäniemi, A., Ylitalo, A., Lumme, J., Huikuri, H., Ruskoaho, H. J., Vuolteenaho, O. & Ukkola, O., 1 Oct 2017, In : American Journal of Hypertension. 30, 10, p. 985-992 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

Välimäki, M. J., Tölli, M. A., Kinnunen, S. M., Aro, J., Serpi, R., Pohjolainen, L., Talman, V., Poso, A. & Ruskoaho, H. J., 28 Sep 2017, In : Journal of Medicinal Chemistry. 60, 18, p. 7781-7798 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Drug-loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

Ferreira, M. P. A., Ranjan, S., Kinnunen, S., Correia, A., Talman, V., Mäkilä, E., Barrios-Lopez, B., Kemell, M., Balasubramanian, V., Salonen, J., Hirvonen, J., Ruskoaho, H., Airaksinen, A. J. & Santos, H. A., 6 Sep 2017, In : Small. 13, 33, 14 p., 1701276.

Research output: Contribution to journalArticleScientificpeer-review

Targeting vasoactive peptides for managing calcific aortic valve disease

Peltonen, T., Ohukainen, P., Ruskoaho, H. J. & Rysä, J., Feb 2017, In : Annals of Medicine. 49, 1, p. 63-74 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression

Acosta, A. J., Rysä, J., Szabo, Z., Moilanen, A-M., Komati, H., Nemer, M. & Ruskoaho, H., Feb 2017, In : Cell and Tissue Research. 367, 2, p. 369-385 17 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Cardiac fibrosis in myocardial infarction - from repair and remodeling to regeneration

Talman, V. & Ruskoaho, H. J., 1 Sep 2016, In : Cell and Tissue Research. 365, 3, p. 563-581 19 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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CYP2D6-metabolia ja sydänlääkkeet

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., H. H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 87 1 p. kar01736 (006.075)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Effect of vasoactive peptides in Tetrahymena: chemotactic activities of adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP) and calcitonin gene-related peptide (CGRP)

Kohidai, L., Toth, K., Samotik, P., Ranganathan, K., Lang, O., Toth, M. & Ruskoaho, H., Jan 2016, In : Molecular and Cellular Biochemistry. 411, 1-2, p. 271-280 10 p.

Research output: Contribution to journalArticleScientificpeer-review

In Vitro and In Vivo Assessment of Heart-Homing Porous Silicon Nanoparticles

Almeida Ferreira, M. P., Ranjan, S., Correia, A., Mäkilä, E., Kinnunen, S. M., Zhang, H., Shahbazi, M-A., Vingadas Almeida, P., Salonen, J., Ruskoaho, H. J., Airaksinen, A., Hirvonen, J. T. & Almeida Santos, H., Jul 2016, In : Biomaterials. 94, p. 93–104 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Klopidogreelin vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 88-89 2 p. kar01739 (006.090)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Mitogen-activated protein kinase p38 target regenerating islet-derived 3gamma expression is upregulated in cardiac inflammatory response in the rat heart.

Säkkinen, H., Aro, J., Kaikkonen, L., Ohukainen, P., Näpänkangas, J., Tokola, H., Ruskoaho, H. J. & Rysä, J., 20 Oct 2016, In : Physiological Reports. 4, 20, e12996.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Natriureettiset peptidit

Ruskoaho, H. J. & Magga, J., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3., uudistettu painos ed. Helsinki: Duodecim, Vol. 2016. p. 64-68 kar01037 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Natriureettisten peptidien kliininen käyttö

Ruskoaho, H. J. & Magga, J., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3., uudistettu painos 2016, 1296 sivua, sidottu ed. Helsinki: Duodecim, Vol. 2016. p. 69 kar01038

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Neoplastic extracellular matrix environment promotes cancer invasion in vitro

Sundquist, E., Renko, O., Salo, S., Magga, J., Cervigne, N. K., Nyberg, P., Risteli, J., Sormunen, R., Vuolteenaho, O., Zandonadi, F., Leme, A. F. P., Coletta, R. D., Ruskoaho, H. & Salo, T., 10 Jun 2016, In : Experimental Cell Research. 344, 2, p. 229-240 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Statiinien vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 87 1 p. kar01737 (006.080)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Sydämessä muodostuvat paikallisesti vaikuttavat vasoaktiiviset tekijät

Ruskoaho, H. J. & Magga, J., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3., uudistettu painos ed. Helsinki: Duodecim, Vol. 2016. p. 70-74 kar01039 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Sydän endokriinisenä elimenä

Ruskoaho, H. J. & Magga, J., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3., uudistettu painos ed. Helsinki: Duodecim, Vol. 2016. p. 64 kar01206 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Sydänlääkkeiden vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 86-87 2 p. kar01735 (006.070)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Takrolimuusin vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H. J., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 89 1 p. kar01740 (006.095)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Varfariinin ja muiden oraalisten antikoagulanttien vasteen farmakogeneettinen vaihtelu

Backman, J., Niemi, M. & Ruskoaho, H., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 88 1 p. kar01738 (006.085)

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

2015

Advanced Nanomedicines for the Treatment and Diagnosis of Myocardial Infarction and Heart Failure

Almeida Ferreira, M., Balasubramanian, V., Hirvonen, J., Ruskoaho, H. & Santos, H. A., 2015, In : Current Drug Targets. 16, 14, p. 1682-1697 16 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Bone morphogenetic protein-2-A potential autocrine/paracrine factor in mediating the stretch activated B-type and atrial natriuretic peptide expression in cardiac myocytes

Tokola, H., Rysa, J., Pikkarainen, S., Hautala, N., Leskinen, H., Kerkela, R., Ilves, M., Aro, J., Vuolteenaho, O., Ritvos, O. & Ruskoaho, H., 5 Jan 2015, In : Molecular and Cellular Endocrinology. 399, C, p. 9-21 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency

Kurra, V., Vehmas, T., Eräranta, A., Jokihaara, J., Pirttiniemi, P., Ruskoaho, H., Tokola, H., Niemelä, O., Mustonen, J. & Pörsti, I., 27 Mar 2015, In : BMC Nephrology. 16, 10 p., 35.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Expression and Localization of Granzymes and Perforin in Human Calcific Aortic Valve Disease

Ohukainen, P., Napankangas, J., Ohtonen, P., Ruskoaho, H., Taskinen, P., Peltonen, T. & Rysa, J., Sep 2015, In : Journal of Heart Valve Disease. 24, 5, p. 612-620 9 p.

Research output: Contribution to journalArticleScientificpeer-review

MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease

Ohukainen, P., Syvaranta, S., Napankangas, J., Rajamaki, K., Taskinen, P., Peltonen, T., Helske-Suihko, S., Kovanen, P. T., Ruskoaho, H. & Rysa, J., 2015, In : Annals of Medicine. 47, 5, p. 423-429 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5

Kinnunen, S., Välimäki, M., Tölli, M., Wohlfahrt, G., Darwich, R., Komati, H., Nemer, M. & Ruskoaho, H., 7 Dec 2015, In : PLoS One. 10, 12, 21 p., 0144145.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Reaktívoxigén-származékok szerepe a szívműködés szabályozásában

Translated title of the contribution: Role of reactive oxygen species in the regulation of cardiac functionHorvath, I., Kittka, B., Perjes, A., Ruskoaho, H. & Szokodi, I., Nov 2015, In : Orvosi hetilap: honi és külföldi gyógyászat és kórbulvárlat közlönye . 156, 47, p. 1912-1915 4 p.

Research output: Contribution to journalArticleScientificpeer-review

The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression

Kelloniemi, A., Szabo, Z., Serpi, R., Napankangas, J., Ohukainen, P., Tenhunen, O., Kaikkonen, L., Koivisto, E., Bagyura, Z., Kerkela, R., Leosdottir, M., Hedner, T., Melander, O., Ruskoaho, H. & Rysa, J., 22 Jun 2015, In : PLoS One. 10, 6, 27 p., 0130502.

Research output: Contribution to journalArticleScientificpeer-review

TSC-22 up-regulates collagen 3a1 gene expression in the rat heart

Kelloniemi, A., Aro, J., Näpänkangas, J., Koivisto, E., Mustonen, E., Ruskoaho, H. & Rysä, J., 13 Oct 2015, In : BMC Cardiovascular Disorders. 15, 13 p., 122.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Vasopeptidase Inhibition Corrects the Structure and Function of the Small Arteries in Experimental Renal Insufficiency

Haltia, O., Törmänen, S., Eraranta, A., Jokihaara, J., Nordhausen, K., Rysä, J., Ruskoaho, H., Tikkanen, I., Mustonen, J. & Pörsti, I., 2015, In : Journal of vascular research : official journal of the European Society of Microcirculation. 52, 2, p. 94-102 9 p.

Research output: Contribution to journalArticleScientificpeer-review

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function

Moilanen, A-M., Rysa, J., Kaikkonen, L., Karvonen, T., Mustonen, E., Serpi, R., Szabo, Z., Tenhunen, O., Bagyura, Z., Napankangas, J., Ohukainen, P., Tavi, P., Kerkela, R., Leosdottir, M., Wahlstrand, B., Hedner, T., Melander, O. & Ruskoaho, H., 27 Apr 2015, In : PLoS One. 10, 4, 32 p., 0124907.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Apelin Increases Cardiac Contractility via Protein Kinase C epsilon- and Extracellular Signal-Regulated Kinase-Dependent Mechanisms

Perjes, A., Skoumal, R., Tenhunen, O., Konyi, A., Simon, M., Horvath, I. G., Kerkelä, R., Ruskoaho, H. & Szokodi, I., 2 Apr 2014, In : PLoS One. 9, 4, 10 p., 93473.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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