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  • PL 56 (Viikinkaari 5)

    00014

    Finland

20032019
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Publications 2003 2019

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2019

Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells

Qi, S., Zhang, P., Ma, M., Yao, M., Wu, J., Mäkilä, E., Salonen, J., Ruskoaho, H., Xu, Y., Santos, H. A. & Zhang, H., 4 Jan 2019, In : Small. 15, 1, 13 p., 1804332.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish

Narumanchi, S., Kalervo, K., Perttunen, S., Wang, H., Immonen, K., Kosonen, R., Laine, M., Ruskoaho, H. J., Tikkanen, I. T., Lakkisto, P. J. & Paavola, J., 4 Apr 2019, In : Journal of Cardiovascular Development and Disease. 6, 2

Research output: Contribution to journalArticleScientificpeer-review

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2018

Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction

Kinnunen, S. M., Tölli, M. A., Välimäki, M. J., Gao, E., Szabo, Z., Rysä, J., Almeida Ferreira, M. P., J. Ohukainen, P., Serpi, R., Correia, A., Makila, E., Salonen, J., Hirvonen, J. T., Almeida Santos, H. & Ruskoaho, H. J., 15 Mar 2018, In : Scientific Reports. 8, 14 p., 4611 .

Research output: Contribution to journalArticleScientificpeer-review

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Dual‐drug delivery using dextran‐functionalized nanoparticles targeting cardiac fibroblasts for cellular reprogramming

Ferreira, M. P. A., Talman, V., Torrieri, G., Liu, D., Marques, G., Moslova, K., Liu, Z., Pinto, J. F., Hirvonen, J., Ruskoaho, H. & Santos, H. A., 11 Apr 2018, In : Advanced Functional Materials. 28, 15, 12 p., 1705134.

Research output: Contribution to journalArticleScientificpeer-review

Mechanical stretch induced transcriptomic profiles in cardiac myocytes

Rysä, J., Tokola, H. & Ruskoaho, H. J., Jan 2018, In : Scientific Reports. 8, 1, 14 p., 4733.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Molecular Atlas of Postnatal Mouse Heart Development

Talman, V., Teppo, J. S., Pöhö, P. A., Movahedi, P., Vaikkinen, A., Karhu, S. T., Trošt, K., Suvitaival, T., Heikkonen, J., Pahikkala, T., Kotiaho, A. A. T., Kostiainen, R. K., Varjosalo, M. T. & Ruskoaho, H. J., 16 Oct 2018, In : Journal of the American Heart Association. 7, 20, 46 p., 010378.

Research output: Contribution to journalArticleScientificpeer-review

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Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality

Fernandez, C., Rysä, J., Almgren, P., Nilsson, J., Engström, G., Orho-Melander, M., Ruskoaho, H. & Melander, O., Oct 2018, In : Journal of Internal Medicine. 284, 4, p. 377-387 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart

Renko, O., Tolonen, A-M., Rysä, J., Magga, J., Mustonen, E., Ruskoaho, H. & Serpi, R., 18 Jan 2018, In : Scientific Reports. 8, 11 p., 1160.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Ambulatory pulse pressure predicts the development of left ventricular diastolic dysfunction in over 20 years of follow-up

Pääkkö, T., Renko, RJ., Perkiömäki, J., Kesäniemi, A., Ylitalo, A., Lumme, J., Huikuri, H., Ruskoaho, H. J., Vuolteenaho, O. & Ukkola, O., 1 Oct 2017, In : American Journal of Hypertension. 30, 10, p. 985-992 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

Välimäki, M. J., Tölli, M. A., Kinnunen, S. M., Aro, J., Serpi, R., Pohjolainen, L., Talman, V., Poso, A. & Ruskoaho, H. J., 28 Sep 2017, In : Journal of Medicinal Chemistry. 60, 18, p. 7781-7798 18 p.

Research output: Contribution to journalArticleScientificpeer-review

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Drug-loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

Ferreira, M. P. A., Ranjan, S., Kinnunen, S., Correia, A., Talman, V., Mäkilä, E., Barrios-Lopez, B., Kemell, M., Balasubramanian, V., Salonen, J., Hirvonen, J., Ruskoaho, H., Airaksinen, A. J. & Santos, H. A., 6 Sep 2017, In : Small. 13, 33, 14 p., 1701276.

Research output: Contribution to journalArticleScientificpeer-review

Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression

Acosta, A. J., Rysä, J., Szabo, Z., Moilanen, A-M., Komati, H., Nemer, M. & Ruskoaho, H., Feb 2017, In : Cell and Tissue Research. 367, 2, p. 369-385 17 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Effect of vasoactive peptides in Tetrahymena: chemotactic activities of adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP) and calcitonin gene-related peptide (CGRP)

Kohidai, L., Toth, K., Samotik, P., Ranganathan, K., Lang, O., Toth, M. & Ruskoaho, H., Jan 2016, In : Molecular and Cellular Biochemistry. 411, 1-2, p. 271-280 10 p.

Research output: Contribution to journalArticleScientificpeer-review

In Vitro and In Vivo Assessment of Heart-Homing Porous Silicon Nanoparticles

Almeida Ferreira, M. P., Ranjan, S., Correia, A., Mäkilä, E., Kinnunen, S. M., Zhang, H., Shahbazi, M-A., Vingadas Almeida, P., Salonen, J., Ruskoaho, H. J., Airaksinen, A., Hirvonen, J. T. & Almeida Santos, H., Jul 2016, In : Biomaterials. 94, p. 93–104 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Mitogen-activated protein kinase p38 target regenerating islet-derived 3gamma expression is upregulated in cardiac inflammatory response in the rat heart.

Säkkinen, H., Aro, J., Kaikkonen, L., Ohukainen, P., Näpänkangas, J., Tokola, H., Ruskoaho, H. J. & Rysä, J., 20 Oct 2016, In : Physiological Reports. 4, 20, e12996.

Research output: Contribution to journalArticleScientificpeer-review

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Neoplastic extracellular matrix environment promotes cancer invasion in vitro

Sundquist, E., Renko, O., Salo, S., Magga, J., Cervigne, N. K., Nyberg, P., Risteli, J., Sormunen, R., Vuolteenaho, O., Zandonadi, F., Leme, A. F. P., Coletta, R. D., Ruskoaho, H. & Salo, T., 10 Jun 2016, In : Experimental Cell Research. 344, 2, p. 229-240 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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2015

Bone morphogenetic protein-2-A potential autocrine/paracrine factor in mediating the stretch activated B-type and atrial natriuretic peptide expression in cardiac myocytes

Tokola, H., Rysa, J., Pikkarainen, S., Hautala, N., Leskinen, H., Kerkela, R., Ilves, M., Aro, J., Vuolteenaho, O., Ritvos, O. & Ruskoaho, H., 5 Jan 2015, In : Molecular and Cellular Endocrinology. 399, C, p. 9-21 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency

Kurra, V., Vehmas, T., Eräranta, A., Jokihaara, J., Pirttiniemi, P., Ruskoaho, H., Tokola, H., Niemelä, O., Mustonen, J. & Pörsti, I., 27 Mar 2015, In : BMC Nephrology. 16, 10 p., 35.

Research output: Contribution to journalArticleScientificpeer-review

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Expression and Localization of Granzymes and Perforin in Human Calcific Aortic Valve Disease

Ohukainen, P., Napankangas, J., Ohtonen, P., Ruskoaho, H., Taskinen, P., Peltonen, T. & Rysa, J., Sep 2015, In : Journal of Heart Valve Disease. 24, 5, p. 612-620 9 p.

Research output: Contribution to journalArticleScientificpeer-review

MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease

Ohukainen, P., Syvaranta, S., Napankangas, J., Rajamaki, K., Taskinen, P., Peltonen, T., Helske-Suihko, S., Kovanen, P. T., Ruskoaho, H. & Rysa, J., 2015, In : Annals of Medicine. 47, 5, p. 423-429 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5

Kinnunen, S., Välimäki, M., Tölli, M., Wohlfahrt, G., Darwich, R., Komati, H., Nemer, M. & Ruskoaho, H., 7 Dec 2015, In : PLoS One. 10, 12, 21 p., 0144145.

Research output: Contribution to journalArticleScientificpeer-review

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Reaktívoxigén-származékok szerepe a szívműködés szabályozásában

Horvath, I., Kittka, B., Perjes, A., Ruskoaho, H. & Szokodi, I., Nov 2015, In : Orvosi hetilap: honi és külföldi gyógyászat és kórbulvárlat közlönye . 156, 47, p. 1912-1915 4 p.

Research output: Contribution to journalArticleScientificpeer-review

The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression

Kelloniemi, A., Szabo, Z., Serpi, R., Napankangas, J., Ohukainen, P., Tenhunen, O., Kaikkonen, L., Koivisto, E., Bagyura, Z., Kerkela, R., Leosdottir, M., Hedner, T., Melander, O., Ruskoaho, H. & Rysa, J., 22 Jun 2015, In : PLoS One. 10, 6, 27 p., 0130502.

Research output: Contribution to journalArticleScientificpeer-review

TSC-22 up-regulates collagen 3a1 gene expression in the rat heart

Kelloniemi, A., Aro, J., Näpänkangas, J., Koivisto, E., Mustonen, E., Ruskoaho, H. & Rysä, J., 13 Oct 2015, In : BMC Cardiovascular Disorders. 15, 13 p., 122.

Research output: Contribution to journalArticleScientificpeer-review

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Vasopeptidase Inhibition Corrects the Structure and Function of the Small Arteries in Experimental Renal Insufficiency

Haltia, O., Törmänen, S., Eraranta, A., Jokihaara, J., Nordhausen, K., Rysä, J., Ruskoaho, H., Tikkanen, I., Mustonen, J. & Pörsti, I., 2015, In : Journal of vascular research : official journal of the European Society of Microcirculation. 52, 2, p. 94-102 9 p.

Research output: Contribution to journalArticleScientificpeer-review

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function

Moilanen, A-M., Rysa, J., Kaikkonen, L., Karvonen, T., Mustonen, E., Serpi, R., Szabo, Z., Tenhunen, O., Bagyura, Z., Napankangas, J., Ohukainen, P., Tavi, P., Kerkela, R., Leosdottir, M., Wahlstrand, B., Hedner, T., Melander, O. & Ruskoaho, H., 27 Apr 2015, In : PLoS One. 10, 4, 32 p., 0124907.

Research output: Contribution to journalArticleScientificpeer-review

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2014

Apelin Increases Cardiac Contractility via Protein Kinase C epsilon- and Extracellular Signal-Regulated Kinase-Dependent Mechanisms

Perjes, A., Skoumal, R., Tenhunen, O., Konyi, A., Simon, M., Horvath, I. G., Kerkelä, R., Ruskoaho, H. & Szokodi, I., 2 Apr 2014, In : PLoS One. 9, 4, 10 p., 93473.

Research output: Contribution to journalArticleScientificpeer-review

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Characterization of the Regulatory Mechanisms of Activating Transcription Factor 3 by Hypertrophic Stimuli in Rat Cardiomyocytes

Koivisto, E., Acosta, A. J., Moilanen, A-M., Tokola, H., Aro, J., Pennanen, H., Sakkinen, H., Kaikkonen, L., Ruskoaho, H. & Rysa, J., 19 Aug 2014, In : PLoS One. 9, 8, 17 p., 105168.

Research output: Contribution to journalArticleScientificpeer-review

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Connective Tissue Growth Factor Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in Pressure Overload-Induced Heart Failure

Szabo, Z., Magga, J., Alakoski, T., Ulvila, J., Piuhola, J., Vainio, L., Kivirikko, K. I., Vuolteenaho, O., Ruskoaho, H., Lipson, K. E., Signore, P. & Kerkela, R., Jun 2014, In : Hypertension. 63, 6, p. 1235-1240 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice

Tolonen, A-M., Magga, J., Szabo, Z., Viitala, P., Gao, E., Moilanen, A-M., Ohukainen, P., Vainio, L., Koch, W. J., Kerkelä, R., Ruskoaho, H. J. & Serpi, R., Aug 2014, In : Pharmacology Research & Perspectives. 2014, Aug;2(4), p. e00056

Research output: Contribution to journalArticleScientificpeer-review

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In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart

Tölli, M. A., A. Ferreira, M. P., Kinnunen, S. M., Rysä, J., Mäkilä, E. M., Szabó, Z., E. Serpi, R., J. Ohukainen, P., Välimäki, M. J., M. R. Correia, A., J. Salonen, J., Hirvonen, J. T., Ruskoaho, H. J. & Santos, H. A., 28 May 2014, In : Biomaterials. 35, 29, p. 8394–8405 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Monitieteisellä tutkimuksella lääkeinnovaatioihin

Ruskoaho, H., 2014, In : Sic! Lääketietoa Fimeasta. 4, 4, p. 12-14 3 p.

Research output: Contribution to journalArticleProfessional

p38 alpha regulates SERCA2a function

Kaikkonen, L., Magga, J., Ronkainen, V-P., Koivisto, E., Perjes, A., Chuprun, J. K., Vinge, L. E., Kilpio, T., Aro, J., Ulvila, J., Alakoski, T., Bibb, J. A., Szokodi, I., Koch, W. J., Ruskoaho, H. & Kerkela, R., Feb 2014, In : Journal of Molecular and Cellular Cardiology. 67, p. 86-93 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Plasma B-type natriuretic peptide (BNP) in acute Puumala hantavirus infection

Rajaniemi, S-M., Hautala, N., Sironen, T., Vainio, O., Vapalahti, O., Vaheri, A., Vuolteenaho, O., Ruskoaho, H., Kauma, H. & Hautala, T., Feb 2014, In : Annals of Medicine. 46, 1, p. 38-43 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Prognostic value of N-terminal natriuretic peptides in systemic sclerosis: a single centre study

Koelto, G., Vuolteenaho, O., Szokodi, I., Faludi, R., Tornyos, A., Ruskoaho, H., Minier, T., Czirjak, L. & Komocsi, A., 2014, In : Clinical and Experimental Rheumatology. 32, 6, p. S75-S81 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Pregnane X Receptor Agonists Impair Postprandial Glucose Tolerance

Rysä, J., Buler, M., Savolainen, M. J., Ruskoaho, H., Hakkola, J. & Hukkanen, J., Jun 2013, In : Clinical Pharmacology and Therapeutics. 93, 6, p. 556-563 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of cardiac melusin gene expression by hypertrophic stimuli in the rat

Aro, J., Tokola, H., Ronkainen, V-P., Koivisto, E., Tenhunen, O., Ilves, M., Szokodi, I., Ruskoaho, H. & Rysa, J., Mar 2013, In : Acta Physiologica. 207, 3, p. 470-484 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

(Pro)renin Receptor Triggers Distinct Angiotensin II-Independent Extracellular Matrix Remodeling and Deterioration of Cardiac Function

Moilanen, A-M., Rysa, J., Serpi, R., Mustonen, E., Szabo, Z., Aro, J., Napankangas, J., Tenhunen, O., Sutinen, M., Salo, T. & Ruskoaho, H., 23 Jul 2012, In : PLoS One. 7, 7, 20 p., e41404.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2003

Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure

Foldes, G., Horkay, F., Szokodi, T., Vuolteenaho, O., Ilves, M., Lindstedt, A., Mayranpaa, M., Sarman, B., Seres, L., Skoumal, R., Lako-Futo, Z., deChatel, R., Ruskoaho, H. & Toth, M., 29 Aug 2003, In : Biochemical and Biophysical Research Communications. 308, 3, p. 480-485 6 p.

Research output: Contribution to journalArticleScientificpeer-review