Research output per year
Research output per year
Personal profile
Education/Academic qualification
Msc. Pharm.
Fields of Science
- 3121 General medicine, internal medicine and other clinical medicine
- Clinical Pharmacology
International and National Collaboration
Publications and projects within past five years.
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In vitro assessment of inhibitory effects of kinase inhibitors on CYP2C9, 3A and 1A2: Prediction of drug-drug interaction risk with warfarin and direct oral anticoagulants
Jin, S., Paludetto, M-N., Kurkela, M., Kahma, H., Neuvonen, M., Xiang, X., Cai, W. & Backman, J. T., 1 Dec 2024, In: European Journal of Pharmaceutical Sciences. 203, 17 p., 106884.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Screening of 16 major drug glucuronides for time-dependent inhibition of nine drug-metabolizing CYP enzymes – detailed studies on CYP3A inhibitors
Kahma, H., Paludetto, M-N., Neuvonen, M., Kurkela, M., Filppula, A. M., Niemi, M. & Backman, J. T., 1 Jul 2024, In: European Journal of Pharmaceutical Sciences. 198, 12 p., 106735.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Carvedilol is a time-dependent inhibitor of CYP3A
Kahma, H., Paludetto, M-N. I. A., Neuvonen, M., Kurkela, M., Filppula, A., Niemi, M. & Backman, J., 14 Jun 2023.Research output: Conference materials › Poster
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Elucidating the drug–drug interaction potential of hydroxychloroquine metabolites due to direct and time-dependent inhibition of CYP3A In: ABSTRACTS FROM SECOND NORDIC CONFERENCE ON PERSONALIZED MEDICINE 2023 IN TURKU, FINLAND
Kahma, H., Paludetto, M-N. I. A., Neuvonen, M., Kurkela, M., Filppula, A., Niemi, M. & Backman, J., 1 Jun 2023, In: Basic & Clinical Pharmacology & Toxicology.Research output: Contribution to journal › Meeting Abstract
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Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4 and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro
Paludetto, M-N. I. A., Kurkela, M., Kahma, H., Backman, J. T., Niemi, M. & Filppula, A. M., 1 Mar 2023, In: Drug Metabolism and Disposition. 51, 3, p. 293-305 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
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JUSELIUS 22-25 BACKMAN JANNE
Backman, J., Kahma, H., Kurkela, M. & Paludetto, M. I. A.
01/05/2022 → 30/04/2025
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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Academy of Finland Project Funding: Mechanism-Based Inactivation of Cytochrome P450 (Palautumaton sytokromi P450-entsyymien esto ja kliinisesti merkittävät lääkeaineyhteisvaikutukset: Yhteisvaikutuksia in vitro tiedosta ennustavien menetelmien kehittäminen)
Backman, J., Niemi, M., Tornio, A., Filppula, A. M., Neuvonen, P., Neuvonen, M., Launiainen, T., Kahma, H., Kaartinen, T. & Itkonen, M.
01/09/2014 → 31/08/2018
Project: Research project
Prizes
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Best three minute thesis presentation, FPDP-C section
Kahma, Helinä (Recipient), 20 Aug 2015
Prize: Prizes and awards
Activities
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The 50th Gordon Research Conference on Drug Metabolism
Helinä Kahma (Poster Presentation)
10 Jul 2022 → 15 Jul 2022Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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12th International ISSX meeting
Helinä Kahma (Poster Presentation)
28 Jul 2019 → 31 Jul 2019Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Joint 25th Anniversary Symposium of Teratology Information Service and Finnish Society of Clinical Pharmacology
Helinä Kahma (Poster Presentation)
4 Dec 2019Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Pharmacogenetics at the University of Helsinki
Helinä Kahma (Speaker: Presenter)
28 May 2019 → 29 May 2019Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Improving Rational Pharmacotherapy - 50 years of Clinical Pharmacology in Finland
Helinä Kahma (Member of organizing committee)
8 Nov 2018 → 9 Nov 2018Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars