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Publications 2008 2019

2013

Determination of Serotonin and Dopamine Metabolites in Human Brain Microdialysis and Cerebrospinal Fluid Samples by UPLC-MS/MS: Discovery of Intact Glucuronide and Sulfate Conjugates

Suominen, T., Uutela, P., Ketola, R. A., Bergquist, J., Hillered, L., Finel, M., Zhang, H., Laakso, A. & Kostiainen, R., 27 Jun 2013, In : PLoS One. 8, 6, 9 p., e68007.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Diatom silica microparticles for sustained release and permeation enhancement following oral delivery of prednisone and mesalamine

Zhang, H., Shahbazi, M-A., Mäkilä, E. M., da Silva, T. H., Reis, R. L., Salonen, J., Hirvonen, J. T. & Santos, H. A., Dec 2013, In : Biomaterials. 34, 36, p. 9210–9219 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Nanostructured Porous Silicon-Solid Lipid Nanocomposite: Towards Enhanced Cytocompatibility and Stability, Reduced Cellular Association and Prolonged Drug Release

Liu, D., Mäkilä, E., Zhang, H., Herranz, B., Kaasalainen, M., Kinnari, P., Salonen, J., Hirvonen, J. & Santos, H. A., 19 Apr 2013, In : Advanced Functional Materials. 23, 15, p. 1893–1902 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility

Shahbazi, M-A., Hamidi, M., Mäkilä, E. M., Zhang, H., Almeida, P. V., Kaasalainen, M., Salonen, J. J., Hirvonen, J. T. & Santos, H. A., Oct 2013, In : Biomaterials. 34, 31, p. 7776–7789 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms

Zhu, L., Ge, G., Zhang, H., Liu, H., He, G., Liang, S., Zhang, Y., Fang, Z., Dong, P., Finel, M. & Yang, L., 2012, In : Drug Metabolism and Disposition. 40, 3, p. 529-538 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases

Zhang, H., Soikkeli, A., Tolonen, A., Rousu, T., Hirvonen, J. & Finel, M., 2012, In : Toxicology in Vitro. 26, 8, p. 1286-1293 8 p.

Research output: Contribution to journalArticleScientificpeer-review

UGTs and glucuronidation analyses in Caco-2 cells, human microsomes and recombinant enzymes

Zhang, H., 2012, Helsinki: University of Helsinki. 74 p.

Research output: ThesisDoctoral ThesisCollection of Articles

2011

Effects of Cell Differentiation and Assay Conditions on the UDP-glucuronosyltransferases Activity in Caco-2 Cells.

Zhang, H., Tolonen, A., Rousu, T., Hirvonen, J. & Finel, M., 2011, In : Drug Metabolism and Disposition. 39, 3, p. 456-464 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

RNA packaging motor: from structure to quantum mechanical modelling and sequential-stochastic mechanism

Telenius, J., Wallin, A., Straka, M., Zhang, H., Mancini, E. J. & Tuma, R., 2008, In : Computational and mathematical methods in medicine : CMMM.. 9, 3-4, p. 351-369 19 p.

Research output: Contribution to journalArticleScientificpeer-review

The Expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells

Siissalo, S., Zhang, H., Stilgenbauer, E., Kaukonen, A. M., Hirvonen, J. & Finel, M., 2008, In : Drug Metabolism and Disposition. 36, 11, p. 2331-2336 6 p.

Research output: Contribution to journalArticleScientificpeer-review