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Publications 2008 2019

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2019

Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression

Zhang, H., Cui, W., Qu, X., Wu, H., Qu, L., Zhang, X., Mäkilä, E., Salonen, J., Zhu, Y., Yang, Z., Chen, D., Santos, H. A., Hai, M. & Weitz, D. A., 16 Apr 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 16, p. 7744-7749 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Cell Membrane-Based Nanoreactor To Mimic the Bio-Compartmentalization Strategy of a Cell

Balasubramanian, V., Poillucci, A., Correia, A., Zhang, H., Celia, C. & Santos, H. A., Apr 2018, In : Acs Biomaterials Science & Engineering. 4, 4, p. 1471-1478 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Gold Nanorods Conjugated Porous Silicon Nanoparticles Encapsulated in Calcium Alginate Nano Hydrogels Using Microemulsion Templates

Zhang, H., Zhu, Y., Qu, L., Wu, H., Kong, H., Yang, Z., Chen, D., Mäkilä, E., Salonen, J., Santos, H. A., Hai, M. & Weitz, D. A., Feb 2018, In : Nano Letters. 18, 2, p. 1448-1453 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions

Liu, D., Lipponen, K., Quan, P., Wan, X., Zhan, H., Makilä, E., Salonen, J., Kostiainen, R., Hirvonen, J., Kotiaho, T. & Santos, H. A., Jul 2018, In : Acs Biomaterials Science & Engineering. 4, 7, p. 2308-2313 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Manipulating Superparamagnetic Microparticles with an Electromagnetic Needle

Cenev, Z., Zhang, H., Sariola, V., Rahikkala, A. T. A., Almeida Santos, H., Liu, D. & Zhou, Q., 15 Jan 2018, In : Advanced Materials Technologies. 3, 1, 9 p., 1700177.

Research output: Contribution to journalArticleScientificpeer-review

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Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

Liu, Z., Li, Y., Li, W., Xiao, C., Liu, D., Dong, C., Zhang, M., Mäkilä, E., Kemell, M., Salonen, J., Hirvonen, J. T., Zhang, H., Zhou, D., Deng, X. & Santos, H. A., 13 Jun 2018, In : Advanced Materials. 30, 24, 10 p., 1703393 .

Research output: Contribution to journalArticleScientificpeer-review

2017

A Versatile Carbonic Anhydrase IX Targeting Ligand-Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging

Janoniene, A., Liu, Z., Baranauskiene, L., Mäkilä, E., Ma, M., Salonen, J., Hirvonen, J., Zhang, H., Petrikaite, V. & Santos, H. A., 26 Apr 2017, In : ACS Applied Materials & Interfaces. 9, 16, p. 13976-13987 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Biomimetic engineering using cancer cell membranes for designing compartmentalized nanoreactors with organelle-like functions

Balasubramanian, V., Rebelo Correia, A. M., Zhang, H., Fontana, F., Mäkilä, E., Salonen, J., Hirvonen, J. T. & Almeida Santos, H., 21 Mar 2017, In : Advanced Materials. 29, 11, 8 p., 1605375.

Research output: Contribution to journalArticleScientificpeer-review

Convection-Driven Pull-Down Assays in Nanoliter Droplets Using Scaffolded Aptamers

Qu, X., Zhang, H., Chen, H., Aldalbahi, A., Li, L., Tian, Y., Weitz, D. A. & Pei, H., 21 Mar 2017, In : Analytical Chemistry. 89, 6, p. 3468-3473 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation

Liu, D., Zhang, H., Cito, S., Fan, J., Mäkilä, E., Salonen, J., Hirvonen, J., Sikanen, T. M., Weitz, D. A. & Santos, H. A., Feb 2017, In : Nano Letters. 17, 2, p. 606-614 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration

Sun, X., Lang, Q., Zhang, H., Cheng, L., Zhang, Y., Pan, G., Zhao, X., Yang, H., Zhang, Y., Santos, H. A. & Cui, W., Jan 2017, In : Advanced Functional Materials. 27, 2, 12 p., 1604617.

Research output: Contribution to journalArticleScientificpeer-review

Fabrication of Calcium Phosphate-Based Nanocomposites Incorporating DNA Origami, Gold Nanorods, and Anticancer Drugs for Biomedical Applications

Zhang, H., Qu, X., Chen, H., Kong, H., Ding, R., Chen, D., Zhang, X., Pei, H., Santos, H. A., Hai, M. & Weitz, D. A., 25 Oct 2017, In : Advanced Healthcare Materials. 6, 20, 10 p., 1700664.

Research output: Contribution to journalArticleScientificpeer-review

Microfluidic assembly of a nano-in-micro dual drug delivery platform composed of halloysite nanotubes and a pH-responsive polymer for colon cancer therapy

Li, W., Liu, D., Zhang, H., Correia, A., Mäkilä, E., Salonen, J., Hirvonen, J. & Santos, H. A., 15 Jan 2017, In : Acta Biomaterialia. 48, p. 238-246 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy

Zhang, H., Liu, D., Wang, L., Liu, Z., Wu, R., Janoniene, A., Ma, M., Pan, G., Baranauskiene, L., Zhang, L., Cui, W., Petrikaite, V., Matulis, D., Zhao, H., Pan, J. & Santos, H. A., 7 Jun 2017, In : Advanced Healthcare Materials. 6, 11, 13 p., 1601406.

Research output: Contribution to journalArticleScientificpeer-review

Microfluidics platform for glass capillaries and its application in droplet and nanoparticle fabrication

Herranz-Blanco, B., Ginestar Nadal, E., Zhang, H., Hirvonen, J. & Santos, H. A., 10 Jan 2017, In : International Journal of Pharmaceutics. 516, 1-2, p. 100-105 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Multistaged Nanovaccines based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy

Fontana, F., Shahbazi, M-A., Liu, D., Zhang, H., Mäkilä, E., Salonen, J., Hirvonen, J. T. & Almeida Santos, H., 13 Feb 2017, In : Advanced Materials. 29, 7, 9 p., 1603239.

Research output: Contribution to journalArticleScientificpeer-review

Nutlin-3a and Cytokine Co-loaded Spermine-Modified Acetalated Dextran Nanoparticles for Cancer Chemo-Immunotherapy

Bauleth-Ramos, T., Shahbazi, M-A., Liu, D., Fontana, F., Correia, A., Figueiredo, P., Zhang, H., Martins, J. P., Hirvonen, J. T., Granja, P., Sarmento, B. & Santos, H. A., 10 Nov 2017, In : Advanced Functional Materials. 27, 42, 14 p., 1703303.

Research output: Contribution to journalArticleScientificpeer-review

Probing Cellular Molecules with PolyA-Based Engineered Aptamer Nanobeacon

Chen, L., Chao, J., Qu, X., Zhang, H., Zhu, D., Su, S., Aldalbahi, A., Wang, L. & Pei, H., 8 Mar 2017, In : ACS Applied Materials & Interfaces. 9, 9, p. 8014-8020 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Protein Coating of DNA Nanostructures for Enhanced Stability and Immunocompatibility

Auvinen, H., Zhang, H., Nonappa, Kopilow, A., Niemelä, E. H., Nummelin, S., Correia, A., Santos, H. A., Linko, V. & Kostiainen, M. A., 20 Sep 2017, In : Advanced Healthcare Materials. 6, 18, 6 p., 1700692 .

Research output: Contribution to journalArticleScientificpeer-review

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Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells

Liu, Z., Balasubramanian, V., Bhat, C., Vahermo, M., Mäkilä, E., Kemell, M., Fontana, F., Janoniene, A., Petrikaite, V., Salonen, J., Yli-Kauhaluoma, J., Hirvonen, J., Zhang, H. & A. Santos, H., 8 Feb 2017, In : Advanced Healthcare Materials. 6, 3, 11 p., 1601009.

Research output: Contribution to journalArticleScientificpeer-review

Receptor-Mediated Surface Charge Inversion Platform Based on Porous Silicon Nanoparticles for Efficient Cancer Cell Recognition and Combination Therapy

Zhang, F., Correia, A., Mäkilä, E., Li, W., Salonen, J., Hirvonen, J. J., Zhang, H. & Santos, H. A., 22 Mar 2017, In : ACS Applied Materials & Interfaces. 9, 11, p. 10034-10046 13 p.

Research output: Contribution to journalArticleScientificpeer-review

The Impact of Porous Silicon Nanoparticles on Human Cytochrome P450 Metabolism in Human Liver Microsomes In Vitro

Ollikainen, E., Liu, D., Kallio, A., Mäkilä, E., Zhang, H., Salonen, J., Almeida Santos, H. & Sikanen, T. M., 15 Jun 2017, In : European Journal of Pharmaceutical Sciences. 104, p. 124–132 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

An In Situ Gelling Drug Delivery System for Improved Recovery after Spinal Cord Injury

Liu, D., Jiang, T., Cai, W., Chen, J., Zhang, H., Hietala, S., Santos, H. A., Yin, G. & Fan, J., 22 Jun 2016, In : Advanced Healthcare Materials. 5, 12, p. 1513-1521 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine based on 3D Tumour Models

Guo, H., Liu, D., Gao, B., Zhang, X., You, M., Ren, H., Zhang, H., Almeida Santos, H. & Xu, F., 21 Jul 2016, In : Molecules. 21, 7, p. 954 13 p., 954.

Research output: Contribution to journalArticleScientificpeer-review

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Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications

Kong, F., Zhang, H., Zhang, X., Liu, D., Chen, D., Zhang, W., Zhang, L., Santos, H. A. & Hai, M., 13 Sep 2016, In : Advanced Functional Materials. 26, 34, p. 6158-6169 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Cellular delivery of enzyme-loaded DNA origami

Ora, A., Järvihaavisto, E., Zhang, H., Auvinen, H., Santos, H. A., Kostiainen, M. A. & Linko, V., 2016, In : Chemical Communications. 52, 98, p. 14161-14164 4 p.

Research output: Contribution to journalArticleScientificpeer-review

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Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle-functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy

Kong, F., Zhang, H., Qu, X., Zhang, X., Chen, D., Ding, R., Mäkilä, E., Salonen, J., Santos, H. A. & Hai, M., 14 Dec 2016, In : Advanced Materials. 28, 46, p. 10195-10203 9 p.

Research output: Contribution to journalArticleScientificpeer-review

In Vitro and In Vivo Assessment of Heart-Homing Porous Silicon Nanoparticles

Almeida Ferreira, M. P., Ranjan, S., Correia, A., Mäkilä, E., Kinnunen, S. M., Zhang, H., Shahbazi, M-A., Vingadas Almeida, P., Salonen, J., Ruskoaho, H. J., Airaksinen, A., Hirvonen, J. T. & Almeida Santos, H., Jul 2016, In : Biomaterials. 94, p. 93–104 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Spatio-Design of Multi-Dimensional Prickly Zn-Doped CuO Nanoparticle for Efficient Bacterial Killing

Wu, R., Zhang, H., Pan, J., Zhu, H., Ma, Y., Cui, W., Almeida Santos, H. & Pan, G., 20 Sep 2016, In : Advanced Materials Interfaces . 3, 18, 11 p., 1600472.

Research output: Contribution to journalArticleScientificpeer-review

Upregulating Hif-1 by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound

Chen, H., Jia, P., Kang, H., Zhang, H., Liu, Y., Yang, P., Yan, Y., Zuo, G., Guo, L., Jiang, M., Qi, J., Liu, Y., Cui, W., Santos, H. A. & Deng, L., 20 Apr 2016, In : Advanced Healthcare Materials. 5, 8, p. 907-918 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Improved stability and biocompatibility of nanostructured silicon drug carrier for intravenous administration

Näkki, S., Rytkönen, J., Nissinen, T., Florea, C., Riikonen, J., Ek, P., Zhang, H., Santos, H. A., Närvänen, A., Xu, W. & Lehto, V-P., Feb 2015, In : Acta Biomaterialia. 13, p. 207-215 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of Multidrug Resistance of Cancer Cells by Co-Delivery of DNA Nanostructures and Drugs Using Porous Silicon Nanoparticles@Giant Liposomes

Kong, F., Zhang, X., Zhang, H., Qu, X., Chen, D., Servos, M., Mäkilä, E., Salonen, J., Santos, H. A., Hai, M. & Weitz, D. A., 10 Jun 2015, In : Advanced Functional Materials. 25, 22, p. 3330-3340 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Microfluidic assisted one-step fabrication of porous silicon@acetalated dextran nanocomposites for precisely controlled combination chemotherapy

Liu, D., Zhang, H., Mäkilä, E., Fan, J., Herranz-Blanco, B., Wang, C-F., Rosa, R., Ribeiro, A. J., Salonen, J., Hirvonen, J. & Santos, H. A., Jan 2015, In : Biomaterials. 39, p. 249-259 11 p.

Research output: Contribution to journalArticleScientificpeer-review

On-Chip Self-Assembly of a Smart Hybrid Nanocomposite for Antitumoral Applications

Herranz-Blanco, B., Liu, D., Mäkilä, E., Shahbazi, M-A., Ginestar, E., Zhang, H., Aseyev, V., Balasubramanian, V., Salonen, J., Hirvonen, J. & Santos, H. A., 11 Mar 2015, In : Advanced Functional Materials. 25, 10, p. 1488-1497 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Simple microfluidic approach to fabricate monodisperse hollow microparticles for multidrug delivery

Vasiliauskas, R., Liu, D., Cito, S., Zhang, H., Shahbazi, M-A., Sikanen, T., Mazutis, L. & Santos, H. A., 15 Jul 2015, In : ACS Applied Materials & Interfaces. 7, 27, p. 14822-14832 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers

Shrestha, N., Shahbazi, M-A., Araújo, F., Zhang, H., Mäkilä, E. M., Kauppila, J., Sarmento, B., Salonen, J. J., Hirvonen, J. T. & Santos, H. A., 17 May 2014, In : Biomaterials. 35, 25, p. 7172-7179 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Fabrication of a Multifunctional Nano-in-micro Drug Delivery Platform by Microfluidic Templated Encapsulation of Porous Silicon in Polymer Matrix

Zhang, H., Liu, D., Shahbazi, M-A., Mäkilä, E., Herranz Blanco, B., Salonen, J., Hirvonen, J. & Santos, H. A., 9 Jul 2014, In : Advanced Materials. 26, 26, p. 4497–4503 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Microfluidic Assembly of Monodisperse Multistage pH-Responsive Polymer/Porous Silicon Composites for Precisely Controlled Multi-Drug Delivery

Liu, D., Zhang, H., Herranz Blanco, B., Mäkilä, E., Lehto, V-P., Salonen, J., Hirvonen, J. & Santos, H. A., 28 May 2014, In : Small. 10, 10, p. 2029-2038 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Determination of Serotonin and Dopamine Metabolites in Human Brain Microdialysis and Cerebrospinal Fluid Samples by UPLC-MS/MS: Discovery of Intact Glucuronide and Sulfate Conjugates

Suominen, T., Uutela, P., Ketola, R. A., Bergquist, J., Hillered, L., Finel, M., Zhang, H., Laakso, A. & Kostiainen, R., 27 Jun 2013, In : PLoS One. 8, 6, 9 p., e68007.

Research output: Contribution to journalArticleScientificpeer-review

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Diatom silica microparticles for sustained release and permeation enhancement following oral delivery of prednisone and mesalamine

Zhang, H., Shahbazi, M-A., Mäkilä, E. M., da Silva, T. H., Reis, R. L., Salonen, J., Hirvonen, J. T. & Santos, H. A., Dec 2013, In : Biomaterials. 34, 36, p. 9210–9219 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Nanostructured Porous Silicon-Solid Lipid Nanocomposite: Towards Enhanced Cytocompatibility and Stability, Reduced Cellular Association and Prolonged Drug Release

Liu, D., Mäkilä, E., Zhang, H., Herranz, B., Kaasalainen, M., Kinnari, P., Salonen, J., Hirvonen, J. & Santos, H. A., 19 Apr 2013, In : Advanced Functional Materials. 23, 15, p. 1893–1902 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility

Shahbazi, M-A., Hamidi, M., Mäkilä, E. M., Zhang, H., Almeida, P. V., Kaasalainen, M., Salonen, J. J., Hirvonen, J. T. & Santos, H. A., Oct 2013, In : Biomaterials. 34, 31, p. 7776–7789 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms

Zhu, L., Ge, G., Zhang, H., Liu, H., He, G., Liang, S., Zhang, Y., Fang, Z., Dong, P., Finel, M. & Yang, L., 2012, In : Drug Metabolism and Disposition. 40, 3, p. 529-538 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases

Zhang, H., Soikkeli, A., Tolonen, A., Rousu, T., Hirvonen, J. & Finel, M., 2012, In : Toxicology in Vitro. 26, 8, p. 1286-1293 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Effects of Cell Differentiation and Assay Conditions on the UDP-glucuronosyltransferases Activity in Caco-2 Cells.

Zhang, H., Tolonen, A., Rousu, T., Hirvonen, J. & Finel, M., 2011, In : Drug Metabolism and Disposition. 39, 3, p. 456-464 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

RNA packaging motor: from structure to quantum mechanical modelling and sequential-stochastic mechanism

Telenius, J., Wallin, A., Straka, M., Zhang, H., Mancini, E. J. & Tuma, R., 2008, In : Computational and mathematical methods in medicine : CMMM.. 9, 3-4, p. 351-369 19 p.

Research output: Contribution to journalArticleScientificpeer-review

The Expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells

Siissalo, S., Zhang, H., Stilgenbauer, E., Kaukonen, A. M., Hirvonen, J. & Finel, M., 2008, In : Drug Metabolism and Disposition. 36, 11, p. 2331-2336 6 p.

Research output: Contribution to journalArticleScientificpeer-review