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Research output per year

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Personal profile

Description of research and teaching

The research group lead by Professor Ilkka Tikkanen, Unit of Cardiovascular Research, Minerva Institute for Medical Research, Biomedicum 2U Helsinki, and Department of Medicine, Helsinki University Central Hospital, studies mechanisms and repair of end-organ damage in cardiovascular and renal diseases. The local expression of components of the renin-angiotensin-aldosterone system, other vasoactive factors and apoptosis in hypertension, heart failure, and in progression of renal damage has been studied. In addition, the cardiovascular and renal protective properties of new cardiovascular drugs have been evaluated. Recently, the research has focused on exploring the regenerative and reparative mechanisms of cardiac injury after myocardial infarction.  

Fields of Science

  • 311 Basic medicine
  • Hypertension
  • Cardiovascular diseases
  • Nephrology
  • 312 Clinical medicine
  • Hypertension
  • Cardiovascular diseases
  • Nephrology
  • 3121 Internal medicine

International and National Collaboration Publications and projects within past five years.

Publications

Unfavorable Reduction in the Ratio of Endothelin B to A Receptors in Experimental 5/6 Nephrectomy and Adenine Models of Chronic Renal Insufficiency

Törmänen, S., Lakkisto, P., Eräranta, A., Kööbi, P., Tikkanen, I., Niemelä, O., Mustonen, J. & Pörsti, I., Feb 2020, In : International Journal of Molecular Sciences. 21, 3, 19 p., 936.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Vezf1 regulates cardiac structure and contractile function

Paavola, J., Alakoski, T., Ulvila, J., Kilpiö, T., Sirén, J., Perttunen, S., Narumanchi, S., Wang, H., Lin, R., Porvari, K., Junttila, J., Huikuri, H., Immonen, K., Lakkisto, P., Magga, J., Tikkanen, I. & Kerkelä, R., Jan 2020, In : EBioMedicine. 51, 12 p., 102608.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Circulating levels of microRNA 423-5p are associated with 90 day mortality in cardiogenic shock

Jäntti, T., Segersvärd, H., Tolppanen, H., Tarvasmäki, T., Lassus, J., Devaux, Y., Vausort, M., Pulkki, K., Sionis, A., Bayes-Genis, A., Tikkanen, I., Lakkisto, P. & Harjola, V-P., Feb 2019, In : ESC Heart Failure. 6, 1, p. 98-102 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish

Narumanchi, S., Kalervo, K., Perttunen, S., Wang, H., Immonen, K., Kosonen, R., Laine, M., Ruskoaho, H., Tikkanen, I., Lakkisto, P. & Paavola, J., Jun 2019, In : Journal of Cardiovascular Development and Disease. 6, 2, 12 p., 16.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Kohonnut verenpaine ja uudet eurooppalaiset hoitosuositukset

Tikkanen, I., 2019, In : Sydänääni : Suomen kardiologisen seuran lehti. 30, 1, p. 59-60 2 p.

Research output: Contribution to journalArticleProfessional

Activities

Taking the Kidney to Heart in Diabetes: from pathophysiology to treatment

Ilkka Tikkanen (Speaker: Presenter)
11 Sep 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

26th European Meeting on Hypertension and Cardiovascular Protection

Ilkka Tikkanen (Speaker: Presenter)
13 Jun 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Reviewer for doctoral dissertation (Heikki Tokola 2015)

Ilkka Tikkanen (Pre-examiner)
2015 → …

Activity: Examination typesPre-examiner of doctoral thesis

25th European Meeting on Hypertension and Cardiovascular Protection

Ilkka Tikkanen (Speaker: Presenter)
13 Jun 2015

Activity: Participating in or organising an event typesPublic Talks

KDIGO Controversies Conference on the Management of Patients with Diabetes and Chronic Kidney Disease

Ilkka Tikkanen (Scientific Committee Member)
5 Feb 20158 Feb 2015

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars