Research output per year
Research output per year
Personal profile
Description of research and teaching
The research group lead by Professor Ilkka Tikkanen, Unit of Cardiovascular Research, Minerva Institute for Medical Research, Biomedicum 2U Helsinki, and Department of Medicine, Helsinki University Central Hospital, studies mechanisms and repair of end-organ damage in cardiovascular and renal diseases. The local expression of components of the renin-angiotensin-aldosterone system, other vasoactive factors and apoptosis in hypertension, heart failure, and in progression of renal damage has been studied. In addition, the cardiovascular and renal protective properties of new cardiovascular drugs have been evaluated. Recently, the research has focused on exploring the regenerative and reparative mechanisms of cardiac injury after myocardial infarction.
Fields of Science
- 311 Basic medicine
- Hypertension
- Cardiovascular diseases
- Nephrology
- 312 Clinical medicine
- Hypertension
- Cardiovascular diseases
- Nephrology
- 3121 General medicine, internal medicine and other clinical medicine
International and National Collaboration
Publications and projects within past five years.
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Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function
Wang, H., Siren, J., Perttunen, S., Immonen, K., Chen, Y-C., Narumanchi, S., Kosonen, R., Paavola, J., Laine, M., Tikkanen, I. & Lakkisto, P., Apr 2024, In: Journal of Cellular and Molecular Medicine. 28, 7, 16 p., e18243.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Sham-Controlled Randomized Pilot Trial on Baroreflex Activation Therapy in Resistant Hypertension
Simonsen, J. R., Vikatmaa, L., Vikatmaa, P., Laine, M., Granroth-Wilding, H., Groop, P-H., Tikkanen, I. & Gordin, D., 1 Aug 2024, In: Hypertension. 81, 8, p. e91-e93 3 p.Research output: Contribution to journal › Letter › Scientific
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Moderate hyperuricaemia ameliorated kidney damage in a low-renin model of experimental renal insufficiency
Kurra, V., Eräranta, A., Paavonen, T., Honkanen, T., Myllymäki, J., Riutta, A., Tikkanen, I., Lakkisto, P., Mustonen, J. & Pörsti, I., Jan 2023, In: Basic & Clinical Pharmacology & Toxicology. 132, 1, p. 21-32 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Alterations of Cardiac Protein Kinases in Cyclic Nucleotide-Dependent Signaling Pathways in Human Ischemic Heart Failure
Wang, C., Taskinen, J. H., Segersvärd, H., Immonen, K., Kosonen, R., Tolva, J. M., Mäyränpää, M. I., Kovanen, P. T., Olkkonen, V. M., Sinisalo, J., Laine, M., Tikkanen, I. & Lakkisto, P., 2022, In: Frontiers in cardiovascular medicine. 9, 18 p., 919355.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
MiR-185-5p regulates the development of myocardial fibrosis
Lin, R., Rahtu-Korpela, L., Szabo, Z., Kemppi, A., Skarp, S., Kiviniemi, A. M., Lepojärvi, E. S., Halmetoja, E., Kilpiö, T., Porvari, K., Pakanen, L., Tolva, J., Paakkanen, R., Segersvärd, H., Tikkanen, I., Laine, M., Sinisalo, J., Lakkisto, P., Huikuri, H., Magga, J., & 2 others, Apr 2022, In: Journal of Molecular and Cellular Cardiology. 165, p. 130-140 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
Activities
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Taking the Kidney to Heart in Diabetes: from pathophysiology to treatment
Ilkka Tikkanen (Speaker: Presenter)
11 Sept 2016Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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26th European Meeting on Hypertension and Cardiovascular Protection
Ilkka Tikkanen (Speaker: Presenter)
13 Jun 2016Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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KDIGO Controversies Conference on the Management of Patients with Diabetes and Chronic Kidney Disease
Ilkka Tikkanen (Scientific Committee Member)
5 Feb 2015 → 8 Feb 2015Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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25th European Meeting on Hypertension and Cardiovascular Protection
Ilkka Tikkanen (Speaker: Presenter)
13 Jun 2015Activity: Participating in or organising an event types › Public Talks
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Reviewer for doctoral dissertation (Heikki Tokola 2015)
Ilkka Tikkanen (Pre-examiner)
2015 → …Activity: Examination types › Pre-examiner of doctoral thesis