Photo of Ilpo Tapio Vattulainen

Ilpo Tapio Vattulainen

  • PL 68 (Pietari Kalmin katu 5)

    00014

    Finland

20052020

Research output per year

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Publications

2020

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

Gutmann, T., Schäfer, I. B., Poojari, C., Brankatschk, B., Vattulainen, I. T., Strauss, M. & Coskun, Ü., 6 Jan 2020, In : Journal of Cell Biology. 219, 1, 16 p., 201907210.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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High-content imaging and structure-based predictions reveal functional differences between Niemann-Pick C1 variants

Vanharanta, L., Peränen, J., Pfisterer, S. G., Enkavi, G., Vattulainen, I. & Ikonen, E., May 2020, In : Traffic. 21, 5, p. 386-397 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Loechte, S., Stanly, T. A., Prieto, K. D. P., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S. & Piehler, J., 7 Feb 2020, In : Science. 367, 6478, p. 643-+ 58 p.

Research output: Contribution to journalArticleScientificpeer-review

Pulmonary Surfactant Lipid Reorganization Induced by the Adsorption of the Oligomeric Surfactant Protein B Complex

Liekkinen, J., Enkavi, G., Javanainen, M., Olmeda, B., Pérez-Gil, J. & Vattulainen, I., 1 May 2020, In : Journal of Molecular Biology. 432, 10, p. 3251-3268 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The Na,K-ATPase acts upstream of phosphoinositide PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2

Legrand, C., Saleppico, R., Sticht, J., Lolicato, F., Müller, H-M., Wegehingel, S., Dimou, E., Steringer, J. P., Ewers, H., Vattulainen, I., Freund, C. & Nickel, W., 25 Mar 2020, In : Communications Biology. 3, 1, 16 p., 141.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2019

An efficient auxin-inducible degron system with low basal degradation in human cells

Li, S., Prasanna, X., Salo, V. T., Vattulainen, I. & Ikonen, E., Sep 2019, In : Nature methods. 16, 9, p. 866-+ 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome

Paananen, R. O., Javanainen, M., Holopainen, J. M. & Vattulainen, I., 18 Jul 2019, In : Journal of Physical Chemistry Letters. 10, 14, p. 3893-3898 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

Kotila, T., Wioland, H., Enkavi, G., Kogan, K., Vattulainen, I., Jegou, A., Romet-Lemonne, G. & Lappalainen, P., 22 Nov 2019, In : Nature Communications. 10, 14 p., 5320.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance

Enkavi, G., Javanainen, M., Kulig, W., Róg, T. & Vattulainen, I., 8 May 2019, In : Chemical Reviews. 119, 9, p. 5607-5774 168 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions

Javanainen, M., Enkavi, G., Guixa-Gonzalez, R., Kulig, W., Martinez-Seara, H., Levental, I. & Vattulainen, I., May 2019, In : PLoS Computational Biology. 15, 5, 16 p., 1007033.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The Devil Is in the Details: What Do We Really Track in Single-Particle Tracking Experiments of Diffusion in Biological Membranes?

Gurtovenko, A. A., Javanainen, M., Lolicato, F. & Vattulainen, I., 7 Mar 2019, In : Journal of Physical Chemistry Letters. 10, 5, p. 1005-1011 13 p.

Research output: Contribution to journalArticleScientificpeer-review

The Role of Temperature and Lipid Charge on Intake/Uptake of Cationic Gold Nanoparticles into Lipid Bilayers

Lolicato, F., Joly, L., Martinez-Seara, H., Fragneto, G., Scoppola, E., Bombelli, F. B., Vattulainen, I., Akola, J. & Maccarini, M., Jun 2019, In : Small. 15, 23, 15 p., 1805046.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Understanding the role of lipids in signaling through atomistic and multiscale simulations of cell membranes

Manna, M., Nieminen, T. & Vattulainen, I., 2019, In : Annual Review of Biophysics. 48, p. 421-439 19 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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2018

A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction

Zhou, K., Dichlberger, A., Martinez-Seara, H., Nyholm, T. K. M., Li, S., Kim, Y. A., Vattulainen, I., Ikonen, E. & Blom, T., 23 May 2018, In : ACS central science. 4, 5, p. 548-558 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling

Pantsar, T., Rissanen, S., Dauch, D., Laitinen, T., Vattulainen, I. & Poso, A., Sep 2018, In : PLoS Computational Biology. 14, 9, 23 p., 1006458.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Atomistic model for nearly quantitative simulations of Langmuir monolayers

Javanainen, M., Lamberg, A., Cwiklik, L., Vattulainen, I. T. & Ollila, S., 20 Feb 2018, In : Langmuir. 34, 7, p. 2565–2572 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes

Kulig, W., Mikkolainen, H., Olzynska, A., Jurkiewicz, P., Cwiklik, L., Hof, M., Vattulainen, I., Jungwirth, P. & Rog, T., 1 Mar 2018, In : Journal of Physical Chemistry Letters. 9, 5, p. 1118-1123 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol Protects the Oxidized Lipid Bilayer from Water Injury: An All-Atom Molecular Dynamics Study

Owen, M. C., Kulig, W., Rog, T., Vattulainen, I. & Strodel, B., Jun 2018, In : Journal of Membrane Biology. 251, 3, p. 521-534 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico

Mobarak, E., Håversen, L., Manna, M., Rutberg, M., Levin, M., Perkins, R., Rog, T., Vattulainen, I. & Boren, J., 11 Sep 2018, In : Scientific Reports. 8, 11 p., 13600.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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How Cardiolipin Peroxidation Alters the Properties of the Inner Mitochondrial Membrane?

Vähäheikkilä, M., Peltomaa, T., Róg, T., Vazdar, M., Pöyry, S. & Vattulainen, I., Aug 2018, In : Chemistry and Physics of Lipids. 214, p. 15-23 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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How to minimize dye-induced perturbations while studying biomembrane structure and dynamics: PEG linkers as a rational alternative

Mobarak, E., Javanainen, M., Kulig, W., Honigmann, A., Sezgin, E., Aho, N., Eggeling, C., Rog, T. & Vattulainen, I., Nov 2018, In : Biochimica et Biophysica Acta. Biomembranes. 1860, 11, p. 2436-2445 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Molecular mechanism for inhibition of twinfilin by phosphoinositides

Hakala, M., Kalimeri, M., Enkavi, G., Vattulainen, I. & Lappalainen, P., 30 Mar 2018, In : Journal of Biological Chemistry. 293, 13, p. 4818-4829 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Negatively Charged Gangliosides Promote Membrane Association of Amphipathic Neurotransmitters

Juhola, H., Postila, P. A., Rissanen, S., Lolicato, F., Vattulainen, I. & Rog, T., 1 Aug 2018, In : Neuroscience. 384, p. 214-223 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Quantitative Assessment of Methods Used To Obtain Rate Constants from Molecular Dynamics Simulations-Translocation of Cholesterol across Lipid Bilayers

Filipe, H. A. L., Javanainen, M., Salvador, A., Galvao, A. M., Vattulainen, I., Loura, L. M. S. & Moreno, M. J., Jul 2018, In : Journal of Chemical Theory and Computation. 14, 7, p. 3840-3848 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Redox-coupled quinone dynamics in the respiratory complex I

Warnau, J., Sharma, V., Gamiz-Hernandez, A. P., Di Luca, A., Haapanen, O., Vattulainen, I., Wikström, M., Hummer, G. & Kaila, V. R. I., 4 Sep 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. E8413-E8420 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Structural basis of actin monomer re-charging by cyclase-associated protein

Kotila, T., Kogan, K., Enkavi, G., Guo, S., Vattulainen, I., Goode, B. L. & Lappalainen, P., 14 May 2018, In : Nature Communications. 9, 12 p., 1892.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the beta barrel in fatty acid binding proteins

Laulumaa, S., Nieminen, T., Raasakka, A., Krokengen, O. C., Safaryan, A., Hallin, E. I., Brysbaert, G., Lensink, M. F., Ruskamo, S., Vattulainen, I. & Kursula, P., 25 Jun 2018, In : BMC Structural Biology. 18, 13 p., 8.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Atomistic fingerprint of hyaluronan-CD44 binding

Vuorio, J., Vattulainen, I. & Martinez-Seara, H., Jul 2017, In : PLoS Computational Biology. 13, 7, 24 p., 1005663.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Atomistic Molecular Dynamics Simulations of Mitochondrial DNA Polymerase gamma: Novel Mechanisms of Function and Pathogenesis

Euro, L., Haapanen, O., Rog, T., Vattulainen, I., Suomalainen, A. & Sharma, V., 7 Mar 2017, In : Biochemistry. 56, 9, p. 1227-1238 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Calcium Assists Dopamine Release by Preventing Aggregation on the Inner Leaflet of Presynaptic Vesicles

Mokkila, S., Postila, P. A., Rissanen, S., Juhola, H., Vattulainen, I. & Rog, T., Jun 2017, In : ACS chemical neuroscience. 8, 6, p. 1242-1250 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Calcium Directly Regulates Phosphatidylinositol 4,5-Bisphosphate Headgroup Conformation and Recognition

Bilkova, E., Pleskot, R., Rissanen, S., Sun, S., Czogalla, A., Cwiklik, L., Rog, T., Vattulainen, I., Cremer, P. S., Jungwirth, P. & Coskun, U., 22 Mar 2017, In : Journal of the American Chemical Society. 139, 11, p. 4019-4024 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Concerted regulation of NPC2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin

Enkavi, G., Mikkolainen, H., Gungor, B., Ikonen, E. & Vattulainen, I., Oct 2017, In : PLoS Computational Biology. 13, 10, 21 p., 1005831.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Diffusion of Integral Membrane Proteins in Protein-Rich Membranes

Javanainen, M., Martinez-Seara, H., Metzler, R. & Vattulainen, I., 7 Sep 2017, In : Journal of Physical Chemistry Letters. 8, 17, p. 4308-4313 6 p.

Research output: Contribution to journalArticleScientificpeer-review

doGlycans-Tools for Preparing Carbohydrate Structures for Atomistic Simulations of Glycoproteins, Glycolipids, and Carbohydrate Polymers for GROMACS

Danne, R., Poojari, C., Martinez-Seara, H., Rissanen, S., Lolicato, F., Rog, T. & Vattulainen, I., Oct 2017, In : Journal of Chemical Information and Modeling. 57, 10, p. 2401-2406 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle

Grabon, A., Orlowski, A., Tripathi, A., Vuorio, J., Javanainen, M., Rog, T., Lönnfors, M., McDermott, M. I., Siebert, G., Somerharju, P., Vattulainen, I. & Bankaitis, V. A., 1 Sep 2017, In : Journal of Biological Chemistry. 292, 35, p. 14438-14455 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Effects of Membrane PEGylation on Entry and Location of Antifungal Drug Itraconazole and Their Pharmacological Implications

Dzieciuch-Rojek, M., Poojari, C., Bednar, J., Bunker, A., Kozik, B., Nowakowska, M., Vattulainen, I., Wydro, P., Kepczynski, M. & Rog, T., Apr 2017, In : Molecular Pharmaceutics. 14, 4, p. 1057-1070 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Excessive aggregation of membrane proteins in the Martini model

Javanainen, M., Martinez-Seara, H. & Vattulainen, I., 13 Nov 2017, In : PLoS One. 12, 11, 20 p., 0187936.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Glycosylation and Lipids Working in Concert Direct CD2 Ectodomain Orientation and Presentation

Polley, A., Orlowski, A., Danne, R., Gurtovenko, A. A., de la Serna, J. B., Eggeling, C., Davis, S. J., Rog, T. & Vattulainen, I., 2 Mar 2017, In : Journal of Physical Chemistry Letters. 8, 5, p. 1060-1066 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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How does membrane composition modulate cholesterol carrier protein NPC2?

Enkavi, G., Mikkolainen, H., Güngör, B., Ikonen, E. M. & Vattulainen, I. T., 16 Jul 2017.

Research output: Conference materialsPoster

Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

Steringer, J. P., Lange, S., Cujova, S., Sachi, R., Poojari, C., Lolicato, F., Beutel, O., Mueller, H-M., Unger, S., Coskun, U., Honigmann, A., Vattulainen, I., Hof, M., Freund, C. & Nickel, W., 19 Jul 2017, In : eLife. 6, 36 p., 28985.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lipids, Neurotransmitters and their Receptors

Juhola, H., Lolicato, F., Postila, P., Vattulainen, I. & Rog, T., 3 Feb 2017, In : Biophysical Journal. 112, 3, Supplement 1, p. 392A-392A 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Long-chain GM1 gangliosides alter transmembrane domain registration through interdigitation

Manna, M., Javanainen, M., Monne, H. M-S., Gabius, H-J., Rog, T. & Vattulainen, I., May 2017, In : Biochimica et Biophysica Acta. Biomembranes. 1859, 5, p. 870-878 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides

Senju, Y., Kalimeri, M., Koskela, E. V., Somerharju, P., Zhao, H., Vattulainen, I. & Lappalainen, P., 24 Oct 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. E8977-E8986 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Molecular Basis of GLUT4 in Glucose Transport: Atomistic Molecular Dynamics Study

Poojari, C. S., Roodhuizen, J., Lolicato, F., Rog, T. & Vattulainen, I., 3 Feb 2017, In : Biophysical Journal. 112, 3, Supplement 1, p. 139A-139A 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Molecular mechanisms of CharcotMarie-Tooth neuropathy linked to mutations in human myelin protein P2

Ruskamo, S., Nieminen, T., Kristiansen, C. K., Vatne, G. H., Baumann, A., Hallin, E. I., Raasakka, A., Joensuu, P., Bergmann, U., Vattulainen, I. & Kursula, P., 26 Jul 2017, In : Scientific Reports. 7, 13 p., 6510.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Nanoparticle builder: new software for preparing nanoparticles for molecular dynamics simulations

Lolicato, F., Akola, J., Martinez-Searaa, H. & Vattulainen, I., Jul 2017, In : European Biophysics Journal. 46, 1 Supplement, p. S222-S222 1 p.

Research output: Contribution to journalMeeting AbstractResearch

Nanoscale Membrane Domain Formation Driven by Cholesterol

Javanainen, M., Martinez-Seara, H. & Vattulainen, I., 25 Apr 2017, In : Scientific Reports. 7, 10 p., 1143.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Oxidation of Cholesterol Changes the Permeability of Lipid Membranes

Kulig, W. T., Mikkolainen, H., Olzynska, A., Jurkiewicz, P., Cwiklik, L., Rog, T., Hof, M., Vattulainen, I. & Jungwirth, P., 3 Feb 2017, In : Biophysical Journal. 112, 3, p. 377A-377A 1 p.

Research output: Contribution to journalMeeting AbstractResearch

Phase Partitioning of GM1 and Its Bodipy-Labeled Analog Determine Their Different Binding to Cholera Toxin

Rissanen, S., Grzybek, M., Orlowski, A., Rog, T., Cramariuc, O., Levental, I., Eggeling, C., Sezgin, E. & Vattulainen, I., 9 May 2017, In : Frontiers in Physiology. 8, 7 p., 252.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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PI(4,5)P2 binds to phospholipase C delta 1 in a cholesterol concentration dependent manner: Perspective on implications to PI(4,5)P2 binding proteins

Rissanen, S., Salmela, L., Vattulainen, I. T. & Rog, T. J., 2017, In : Biophysical Journal. 112, 3, p. 137a-138a 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review