Research output per year
Research output per year
Personal profile
Education information
Research interests
Medicinal chemistry of
- combating bacterial biofilms and Gram-negative bacteria with novel antimicrobial compounds
- chemical induction of cellular reprogramming and differentiation
- targeting intracellular protozoan parasites (Leishmania sp., Plasmodium falciparum)
- bioactive terpenes of marine and forest sources
- novel synthesis methods of bioactive compounds
Topics of recent publications
- Design, synthesis and biological activity of compounds targeted to Pim and the C1 domain of PKC
- Terpene-derived compounds as antileishmanial agents
- Design, synthesis and biological activity of heterocycles and terpenoids against pathogenic parasites and Gram-negative bacteria
- Benzo[cd]azulenes: synthesis of azulene, heptafulvene, and tropone derivatives and activity against Pim kinases
Teaching activities
- Person-in-Charge of the organic chemistry in life sciences curriculum in the Viikki Campus
Recent administrative duties
- Vice Dean for Research, Faculty of Pharmacy, 2018-
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Head of the Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, 2014-2017
- President of the Finnish Chemical Society, 2016-2018
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Co-ordinator of the Marie Curie project PRINT-AID, 2017-
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Vice Co-ordinator of the EC-FP7 projects MAREX, 2010-14 & GLORIA, 2013-18
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Member of the CBRN Division of the Scientific Advisory Board for Defence, 2006-
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Member of the Pharmacopoeia Committee of the Finnish Medicines Agency, 2010-
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Member of the Expert Panel: FWO Research Foundation - Flanders, Belgium, 2012-2015
Fields of Science
- 317 Pharmacy
- medicinal chemistry
- pharmaceutical chemistry
- natural product chemistry
- 116 Chemical sciences
- organic chemistry
International and National Collaboration
Publications and projects within past five years.
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New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity
Manner, S., Vahermo, M., Skogman, M., Krogerus, S., Vuorela, P. M., Yli-Kauhaluoma, J., Fallarero , A. & Moreira, V. M., 21 Jul 2015, In: European Journal of Medicinal Chemistry. 102, p. 68-79 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
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A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides
Keurulainen, L., Vahermo, M., Puente-Felipe, M., Sandoval-Izquierdo, E., Crespo-Fernandez, B., Guijarro-Lopez, L., Huertas-Valentin, L., de las Heras-Duena, L., Leino, T. O., Siiskonen, A., Balla-Pages, L., Sanz, L. M., Castaneda-Casado, P., Belen Jimenez-Diaz, M., Martinez-Martinez, M. S., Viera, S., Kiuru, P., Calderon, F. & Yli-Kauhaluoma, J., 11 Jun 2015, In: Journal of Medicinal Chemistry. 58, 11, p. 4573-4580 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Pyrofosfaatti lääketieteessä
Translated title of the contribution :Pyrophosphate in Medicine Research output: Contribution to journal › Article › Scientific › peer-review
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Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo
Laavola, M., Haavikko, R., Hämäläinen, M., Leppänen, T., Nieminen, R., Alakurtti, S., Moreira, V. M., Yli-Kauhaluoma, J. & Moilanen, E., Feb 2016, In: Journal of Natural Products. 79, 2, p. 274-280 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi
Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K.-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S., Feb 2016, In: Journal of Natural Products. 79, 2, p. 362-368 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
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JAES 24-27 OAT-TB
Yli-Kauhaluoma, J. (Project manager) & Patel, J. Z. (Participant)
01/01/2024 → 31/12/2027
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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Viitala yhteistehtävä/ÅA-osuus
Yli-Kauhaluoma, J. (Project manager) & Viitala, T. (Participant)
01/09/2023 → 31/08/2028
Project: External funding
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DisRUPT: Mykobakteeribiofilmien estäminen tuberkuloosin lääkehoidon tehostamiseksi
Yli-Kauhaluoma, J. (Project manager) & Savijoki, K. (Participant)
Suomen Akatemia Projektilaskutus
01/09/2022 → 31/08/2026
Project: Research Council of Finland: Academy Project
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Generation Green
Sikanen, T. (Participant), Yli-Kauhaluoma, J. (Participant), Hirvonen, J. (Participant), Vuorela, P. (Participant), Kärkkäinen, R. (Participant), Vuorensola, K. (Participant), Teppo, J. (Participant), Salminen, O. (Participant), Sivula, S. (Participant) & Teräsalmi, E. (Participant)
01/01/2015 → …
Project: Other project
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H2020-MSCA-ITN-2016: PRINT-AID: Multidisciplinary European training network for development of personalized anti-infective medical devices combining printing technologies and antimicrobial functionality
Yli-Kauhaluoma, J. (Project manager), Vuorela, P. (Principal Investigator), Fallarero, A. (Principal Investigator) & Peltonen, K. (Project manager)
Project: Research project
Prizes
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Alfred Kordelinin yleinen edistys- ja sivistysrahasto: Tieteen palkinto 2015
Yli-Kauhaluoma, J. (Recipient), 6 Nov 2015
Prize: Prizes and awards
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Bioorganic and Medicinal Chemistry, one of the best reviewers
Yli-Kauhaluoma, J. (Recipient), 13 Jan 2016
Prize: Prizes and awards
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Medal of the Flemish Science Foundation, Fonds Wetenschappelijk Onderzoek – Vlaanderen (FWO)
Yli-Kauhaluoma, J. (Recipient), 12 Sept 2014
Prize: Prizes and awards
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Technical Research Centre of Finland (VTT) Award
Yli-Kauhaluoma, J. (Recipient), 1998
Prize: Prizes and awards
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Activities
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Visit by the Helsinki School of Natural Sciences (Finn. Helsingin luonnontiedelukio) 2024
Vorácová, M. (Speaker: Presenter), Häkkinen, H. (Speaker: Presenter) & Yli-Kauhaluoma, J. (Speaker: Chair)
13 Mar 2024Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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An Investigation into the Molecular Interactions and Biological Effect of Natural Stilbenoids at the TRPA1 and TRPV4 Ion Channels
Yli-Kauhaluoma, J. (Pre-examiner)
20 Oct 2024Activity: Examination types › Pre-examiner of doctoral thesis
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Antimicrobial Polysaccharides for Biomedical Applications
Yli-Kauhaluoma, J. (Pre-examiner)
7 Aug 2024Activity: Examination types › Pre-examiner of doctoral thesis
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Matinen tutkimusseminaari
Yli-Kauhaluoma, J. (Speaker: Chair)
19 Nov 2024Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Luonnon-, ympäristö- ja metsätieteilijöiden liitto (Loimu ry) (External organisation)
Yli-Kauhaluoma, J. (Board member)
Jul 2024 → …Activity: Membership types › Membership or other role in national/international committee, council, board
Press/Media
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-UNIVERSITY OF HELSINKI: PhD students collaborated and designed new anti-microbial compounds against Staphylococcus aureus
Legehar, A. & Yli-Kauhaluoma, J.
17/05/2021
1 item of Media coverage
Press/Media: Press / Media
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PhD students collaborated and designed new antimicrobial compounds against Staphylococcus aureus
Legehar, A. & Yli-Kauhaluoma, J.
14/05/2021
2 items of Media coverage
Press/Media: Press / Media
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University of Helsinki: PhD Students Collaborated and Designed New Antimicrobial Compounds Against Staphylococcus Aureus
Legehar, A. & Yli-Kauhaluoma, J.
14/05/2021
1 item of Media coverage
Press/Media: Press / Media
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University of Helsinki: Tree Resin Could Cure Infections Caused by MRSA Bacteria
13/02/2021
1 item of Media coverage
Press/Media: Press / Media
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Tree resin could cure infections caused by MRSA bacteria
11/02/2021 → 12/02/2021
2 items of Media coverage
Press/Media: Press / Media