Research output per year
Research output per year
Personal profile
Education information
Research interests
Medicinal chemistry of
- combating bacterial biofilms and Gram-negative bacteria with novel antimicrobial compounds
- chemical induction of cellular reprogramming and differentiation
- targeting intracellular protozoan parasites (Leishmania sp., Plasmodium falciparum)
- bioactive terpenes of marine and forest sources
- novel synthesis methods of bioactive compounds
Topics of recent publications
- Design, synthesis and biological activity of compounds targeted to Pim and the C1 domain of PKC
- Terpene-derived compounds as antileishmanial agents
- Design, synthesis and biological activity of heterocycles and terpenoids against pathogenic parasites and Gram-negative bacteria
- Benzo[cd]azulenes: synthesis of azulene, heptafulvene, and tropone derivatives and activity against Pim kinases
Teaching activities
- Person-in-Charge of the organic chemistry in life sciences curriculum in the Viikki Campus
Recent administrative duties
- Vice Dean for Research, Faculty of Pharmacy, 2018-
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Head of the Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, 2014-2017
- President of the Finnish Chemical Society, 2016-2018
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Co-ordinator of the Marie Curie project PRINT-AID, 2017-
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Vice Co-ordinator of the EC-FP7 projects MAREX, 2010-14 & GLORIA, 2013-18
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Member of the CBRN Division of the Scientific Advisory Board for Defence, 2006-
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Member of the Pharmacopoeia Committee of the Finnish Medicines Agency, 2010-
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Member of the Expert Panel: FWO Research Foundation - Flanders, Belgium, 2012-2015
Fields of Science
- 317 Pharmacy
- medicinal chemistry
- pharmaceutical chemistry
- natural product chemistry
- 116 Chemical sciences
- organic chemistry
International and National Collaboration
Publications and projects within past five years.
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New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity
Manner, S., Vahermo, M., Skogman, M., Krogerus, S., Vuorela, P. M., Yli-Kauhaluoma, J., Fallarero, A. & Moreira, V. M., 21 Jul 2015, In: European Journal of Medicinal Chemistry. 102, p. 68-79 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
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A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides
Keurulainen, L., Vahermo, M., Puente-Felipe, M., Sandoval-Izquierdo, E., Crespo-Fernandez, B., Guijarro-Lopez, L., Huertas-Valentin, L., de las Heras-Duena, L., Leino, T. O., Siiskonen, A., Balla-Pages, L., Sanz, L. M., Castaneda-Casado, P., Belen Jimenez-Diaz, M., Martinez-Martinez, M. S., Viera, S., Kiuru, P., Calderon, F. & Yli-Kauhaluoma, J., 11 Jun 2015, In: Journal of Medicinal Chemistry. 58, 11, p. 4573-4580 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Pyrofosfaatti lääketieteessä
Translated title of the contribution :Pyrophosphate in Medicine Research output: Contribution to journal › Article › Scientific › peer-review
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Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo
Laavola, M., Haavikko, R., Hämäläinen, M., Leppänen, T., Nieminen, R., Alakurtti, S., Moreira, V. M., Yli-Kauhaluoma, J. & Moilanen, E., Feb 2016, In: Journal of Natural Products. 79, 2, p. 274-280 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi
Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S., Feb 2016, In: Journal of Natural Products. 79, 2, p. 362-368 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
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DisRUPT: Mykobakteeribiofilmien estäminen tuberkuloosin lääkehoidon tehostamiseksi
Yli-Kauhaluoma, J. & Savijoki, K.
Suomen Akatemia Projektilaskutus
01/09/2022 → 31/08/2026
Project: Academy of Finland: Academy Project
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SUDDEN: Sustainable Drug Discovery and Development with End-of-Life Yield
Karlsson, S., Yli-Kauhaluoma, J., Sikanen, T., Xhaard, H., Pihlaja, T., Järvinen, P., Sirna, K., Provenzani, R. & Briand, M. A.
01/01/2022 → 31/12/2023
Project: Research project
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SPRINGBOARD for excellence in advanced development of antibacterials
Zalubovskis, R., Tammela, P., Yli-Kauhaluoma, J., Supuran, C., Björkling, F. & Cos, P.
01/09/2020 → 31/08/2023
Project: Research project
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Generation Green
Sikanen, T., Yli-Kauhaluoma, J., Hirvonen, J., Vuorela, P., Kärkkäinen, R., Vuorensola, K., Teppo, J., Salminen, O., Sivula, S. & Teräsalmi, E.
01/01/2015 → …
Project: Other project
Prizes
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Alfred Kordelinin yleinen edistys- ja sivistysrahasto: Tieteen palkinto 2015
Yli-Kauhaluoma, Jari (Recipient), 6 Nov 2015
Prize: Prizes and awards
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Bioorganic and Medicinal Chemistry, one of the best reviewers
Yli-Kauhaluoma, Jari (Recipient), 13 Jan 2016
Prize: Prizes and awards
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Medal of the Flemish Science Foundation, Fonds Wetenschappelijk Onderzoek – Vlaanderen (FWO)
Yli-Kauhaluoma, Jari (Recipient), 12 Sep 2014
Prize: Prizes and awards
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Technical Research Centre of Finland (VTT) Award
Yli-Kauhaluoma, Jari (Recipient), 1998
Prize: Prizes and awards
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Activities
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Current Regulatory Actions Addressing Pharmaceuticals in the Environment
Sanja Karlsson (Member of organizing committee), Tiina Sikanen (Member of organizing committee) & Jari Yli-Kauhaluoma (Member of organizing committee)
3 Nov 2022Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Sustainable Approach to Pharmaceuticals in the Environment
Jari Yli-Kauhaluoma (Speaker)
10 Aug 2022Activity: Talk or presentation types › Invited talk
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Art Meets Science Exhibition 6.-23.4.2022
Virpi Talman (Chair of organizing committee), Qasim Majid (Member of organizing committee), Yvonne Holm (Member of organizing committee), Jouni Hirvonen (Member of organizing committee), Jari Yli-Kauhaluoma (Member of organizing committee), Eva Ramsay (Member of organizing committee), Safak Er (Member of organizing committee) & Leena Maria Salmio (Member of organizing committee)
6 Apr 2022 → 23 Apr 2022Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Research and studies at the Faculty of Pharmacy; Visit by the Helsinki School of Natural Sciences (Finn. Helsingin luonnontiedelukio)
Tanja Riina Bruun (Invited speaker), Jukka Saarinen (Invited speaker), Katia Sirna (Invited speaker), Mia Siven (Invited speaker) & Jari Yli-Kauhaluoma (Speaker)
1 Jun 2022Activity: Talk or presentation types › Oral presentation
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Uppsala University, Faculty of Pharmacy (External organisation)
Jari Yli-Kauhaluoma (Assessment)
14 May 2022Activity: Membership types › Assessment of candidates for academic posts
Press/Media
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-UNIVERSITY OF HELSINKI: PhD students collaborated and designed new anti-microbial compounds against Staphylococcus aureus
Ashenafi Legehar & Jari Yli-Kauhaluoma
17/05/2021
1 item of Media coverage
Press/Media: Press / Media
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University of Helsinki: PhD Students Collaborated and Designed New Antimicrobial Compounds Against Staphylococcus Aureus
Ashenafi Legehar & Jari Yli-Kauhaluoma
14/05/2021
1 item of Media coverage
Press/Media: Press / Media
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PhD students collaborated and designed new antimicrobial compounds against Staphylococcus aureus
Ashenafi Legehar & Jari Yli-Kauhaluoma
14/05/2021
2 items of Media coverage
Press/Media: Press / Media
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University of Helsinki: Tree Resin Could Cure Infections Caused by MRSA Bacteria
13/02/2021
1 item of Media coverage
Press/Media: Press / Media
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Tree resin could cure infections caused by MRSA bacteria
11/02/2021 → 12/02/2021
2 items of Media coverage
Press/Media: Press / Media