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Personal profile

Education information

Research interests

Medicinal chemistry of

  • combating bacterial biofilms and Gram-negative bacteria with novel antimicrobial compounds
  • chemical induction of cellular reprogramming and differentiation
  • targeting intracellular protozoan parasites (Leishmania sp., Plasmodium falciparum)
  • bioactive terpenes of marine and forest sources
  • novel synthesis methods of bioactive compounds

Topics of recent publications 

  • Design, synthesis and biological activity of compounds targeted to Pim and the C1 domain of PKC
  • Terpene-derived compounds as antileishmanial agents
  • Design, synthesis and biological activity of heterocycles and terpenoids against pathogenic parasites and Gram-negative bacteria
  • Benzo[cd]azulenes: synthesis of azulene, heptafulvene, and tropone derivatives and activity against Pim kinases

Teaching activities

  • Person-in-Charge of the organic chemistry in life sciences curriculum in the Viikki Campus

Recent administrative duties

  • Vice Dean for Research, Faculty of Pharmacy, 2018-
  • Head of the Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, 2014-2017
  • President of the Finnish Chemical Society, 2016-2018
  • Co-ordinator of the Marie Curie project PRINT-AID, 2017-
  • Vice Co-ordinator of the EC-FP7 projects MAREX, 2010-14 & GLORIA, 2013-18
  • Member of the CBRN Division of the Scientific Advisory Board for Defence, 2006-
  • Member of the Pharmacopoeia Committee of the Finnish Medicines Agency, 2010-
  • Member of the Expert Panel: FWO Research Foundation - Flanders, Belgium, 2012-2015

Keywords

  • 317 Pharmacy
  • medicinal chemistry
  • pharmaceutical chemistry
  • natural product chemistry
  • 116 Chemical sciences
  • organic chemistry

International and National Collaboration Publications and projects within past five years.

Publications 1986 2019

New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity

Manner, S., Vahermo, M., Skogman, M., Krogerus, S., Vuorela, P. M., Yli-Kauhaluoma, J., Fallarero, A. & Moreira, V. M., 21 Jul 2015, In : European Journal of Medicinal Chemistry. 102, p. 68-79 12 p.

Research output: Contribution to journalArticleScientificpeer-review

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides

Keurulainen, L., Vahermo, M., Puente-Felipe, M., Sandoval-Izquierdo, E., Crespo-Fernandez, B., Guijarro-Lopez, L., Huertas-Valentin, L., de las Heras-Duena, L., Leino, T. O., Siiskonen, A., Balla-Pages, L., Sanz, L. M., Castaneda-Casado, P., Belen Jimenez-Diaz, M., Martinez-Martinez, M. S., Viera, S., Kiuru, P., Calderon, F. & Yli-Kauhaluoma, J., 11 Jun 2015, In : Journal of Medicinal Chemistry. 58, 11, p. 4573-4580 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Pyrofosfaatti lääketieteessä

Goldman, A., Boije af Gennäs, P. G., Xhaard, H. G. M., Meri, S. K. & Yli-Kauhaluoma, J. T., 2016, In : Duodecim. 132, 12, p. 1111-1117 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo

Laavola, M., Haavikko, R., Hämäläinen, M., Leppänen, T., Nieminen, R., Alakurtti, S., Moreira, V. M., Yli-Kauhaluoma, J. & Moilanen, E., Feb 2016, In : Journal of Natural Products. 79, 2, p. 274-280 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi

Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S., Feb 2016, In : Journal of Natural Products. 79, 2, p. 362-368 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Projects 2000 2021

TWIN-A: Transforming waste into new antibiotics

Fallarero, A., Kontro, M., Peltonen, J., Sikanen, T., Vuorela, P. & Yli-Kauhaluoma, J.

01/01/201731/12/2020

Project: Research project

Generation Green

Sikanen, T., Yli-Kauhaluoma, J., Hirvonen, J., Vuorela, P., Kärkkäinen, R., Vuorensola, K., Teppo, J., Salminen, O., Sivula, S. & Teräsalmi, E.

01/01/2015 → …

Project: Other project

Activities 1992 2019

Design of selective NCX inhibitors for chronic treatments and acute on-off use

Jari Yli-Kauhaluoma (Pre-examiner)
14 May 2019

Activity: Examination typesPre-examiner of doctoral thesis

Security questions related to operations: Risk factors and controlling them

Jari Tapani Yli-Kauhaluoma (Speaker)
22 Jan 2019

Activity: Talk or presentation typesInvited talk

Pharmaceutical drug research at the University of Helsinki

Jari Yli-Kauhaluoma (Invited speaker)
6 Jun 2019

Activity: Talk or presentation typesInvited talk

Pharmaceuticals and the environment (Finn.)

Jari Yli-Kauhaluoma (Speaker)
4 Jun 2019

Activity: Talk or presentation typesOral presentation

Faculty of Pharmacy (Organisational unit)

Jari Yli-Kauhaluoma (Member)
1 Jan 201930 Jun 2019

Activity: Membership typesMembership or other role in review committee

Press / Media

2017 EuCheMS General Assembly, Rome, Italy

Jari Yli-Kauhaluoma

28/10/2017

1 media contribution

Press/Media: Press / Media

Komposti tuottaa antibiootteja

Jari Yli-Kauhaluoma & Päivi Järvinen

19/05/2017

1 item of media coverage

Press/Media: Press / Media

Turun Sanomat: Jätteistä etsitään antibiootteja (Paikalliset, web)

Jari Yli-Kauhaluoma, Jouko Peltonen & Jawad Sarfraz

12/03/2017

1 media contribution

Press/Media: Press / Media

Turun Sanomat: Jätteistä etsitään antibiootteja (Tiede, print)

Jari Yli-Kauhaluoma, Jawad Sarfraz & Jouko Peltonen

12/03/2017

1 media contribution

Press/Media: Press / Media

Report: EuCheMS:n yleiskokous (10.-11.9.2016, Sevilla, Espanja)

Jari Yli-Kauhaluoma

10/09/2016

1 media contribution

Press/Media: Press / Media