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  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1989 …2018
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Publications 1989 2018

2018

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Balboa, D., Saarimäki-Vire, J., Borshagovski, D., Survila, M., Lindholm, P., Galli, E., Eurola, S., Ustinov, J., Grym, H., Huopio, H., Partanen, J., Wartiovaara, K. & Otonkoski, T., 9 Nov 2018, In : eLife. 7, 35 p., 38519.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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MANF protects human pancreatic beta cells against stress-induced cell death

Hakonen, E., Chandra, V., Fogarty, C. L., Yu, N. Y-L., Ustinov, J., Katayama, S., Galli, E., Danilova, T., Lindholm, P., Vartiainen, A., Einarsdottir, E., Krjutskov, K., Kere, J., Saarma, M., Lindahl, M. & Otonkoski, T., Oct 2018, In : Diabetologia. 61, 10, p. 2202-2214 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

Saarimaki-Vire, J., Balboa, D., Russell, M. A., Saarikettu, J., Kinnunen, M., Keskitalo, S., Malhi, A., Valensisi, C., Andrus, C., Eurola, S., Grym, H., Ustinov, J., Wartiovaara, K., Hawkins, R. D., Silvennoinen, O., Varjosalo, M., Morgan, N. G. & Otonkoski, T., 11 Apr 2017, In : Cell Reports. 19, 2, p. 281-294 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

sept7b is required for the differentiation of pancreatic endocrine progenitors

Dash, S., Hakonen, E., Ustinov, J., Otonkoski, T., Andersson, O. & Lehtonen, S., 26 Apr 2016, In : Scientific Reports. 6, 14 p., 24992.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

Hyvonen, M. E., Dumont, V., Tienari, J., Lehtonen, E., Ustinov, J., Havana, M., Jalanko, H., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., 2015, In : BioMed Research International. 11 p., 102969.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

EGFR Signaling Promotes beta-Cell Proliferation and Survivin Expression during Pregnancy

Hakonen, E., Ustinov, J., Palgi, J., Miettinen, P. J. & Otonkoski, T., 2 Apr 2014, In : PLoS One. 9, 4, 11 p., 93651.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes

Hakonen, E., Ustinov, J., Eizirik, D. L., Sariola, H., Miettinen, P. & Otonkoski, T., May 2014, In : Diabetologia. 57, 5, p. 970-979 10 p.

Research output: Contribution to journalArticleScientificpeer-review

MANF is indispensable for the proliferation and survival of pancreatic beta-cells

Lindahl, M., Danilova, T., Palm, E., Lindholm, P., Voikar, V., Hakonen, E., Ustinov, J., Andressoo, J-O., Harvey, B. K., Otonkoski, T., Rossi, J. & Saarma, M., Apr 2014, In : Cell Reports. 7, 2, p. 366-375 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

Activin A and Wnt-dependent specification of human definitive endoderm cells

Toivonen, S., Lundin, K., Balboa, D., Ustinov, J., Tamminen, K., Palgi, J., Trokovic, R., Tuuri, T. & Otonkoski, T., 15 Oct 2013, In : Experimental Cell Research. 319, 17, p. 2535-2544 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1

Shimomura, K., Tusa, M., Iberl, M., Brereton, M. F., Kaizik, S., Proks, P., Lahmann, C., Yaluri, N., Modi, S., Huopio, H., Ustinov, J., Otonkoski, T., Laakso, M. & Ashcroft, F. M., Nov 2013, In : Diabetes. 62, 11, p. 3797-3806 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A Novel Feeder-Free Culture System for Human Pluripotent Stem Cell Culture and Induced Pluripotent Stem Cell Derivation

Vuoristo, S., Toivonen, S., Weltner, J., Mikkola, M., Ustinov, J., Trokovic, R., Palgi, J., Lund, R., Tuuri, T. & Otonkoski, T., 2 Oct 2013, In : PLoS One. 8, 10, p. Article Number: UNSP e76205 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Conditional expression of a constitutively active EGF-R in beta cells protects against diabetes

Hakonen, E., Ustinov, J., Eizirik, D. L., Miettinen, P. J. & Otonkoski, T., Sep 2013, In : Diabetologia. 56, p. S73-S73 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Electron and confocal microscopy of diabetic E1-DN mouse glomeruli revealed thickening of basement membrane and decreased nephrin expression

Dumont, V., Hyvonen, M. E., Lehtonen, E., Ustinov, J., Tienari, J., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., Sep 2013, In : Diabetologia. 56, p. S478-S479 2 p.

Research output: Contribution to journalMeeting AbstractResearch

Hyperglycaemic E1-DN mice develop albuminuria and glomerular injury

Hyvonen, M. E., Ustinov, J., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., Sep 2011, In : Diabetologia. 54, p. S432-S432 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2008

Role of EGF-receptor signalling in physiological beta cell mass expansion

Hakonen, E., Ustinov, J., Ormio, P., De Medts, N., Bouwens, L., Miettinen, P. J. & Otonkoski, T., 2008, In : Diabetologia. 51, p. S18-S18 1 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Effects of immunosuppressive drugs on in vitro neogenesis of human islets: mycophenolate mofetil inhibits the proliferation of ductal cells

Gao, R., Ustinov, J. A., Korsgren, O. & Otonkoski, T., 2007, In : American Journal of Transplantation. 7, p. 1021-26 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine

Kajanne, R., Leppä, S., Luukkainen, P., Ustinov, J., Thiel, A., Ristimäki, A. & Miettinen, P. J., 2007, In : Pediatric Research. 62, 5, p. 570-575 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Maturation of in vitro-generated human islets after transplantation in nude mice

Gao, R., Ustinov, J. A., Korsgren, O., Mikkola, M., Lundin, K. & Otonkoski, T., 2007, In : Molecular and Cellular Endocrinology. 264, 1-2, p. 28-34 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Distinct differentiation characteristics of individual human embryonic stem cell lines

Mikkola (Aho), M., Olsson, C., Palgi, J., Ustinov, J., Palomäki, T., Horelli-Kuitunen, N., Knuutila, S., Lundin, K., Otonkoski, T. & Tuuri, T., 2006, In : BMC Developmental Biology. 6 (2006), 11s

Research output: Contribution to journalArticleScientificpeer-review

Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth

Miettinen, P. J., Ustinov, J., Ormio, P., Gao, R., Palgi, J., Hakonen, E., Juntti-Berggren, L., Berggren, P-O. & Otonkoski, T., Dec 2006, In : Diabetes. 55, 12, p. 3299-3308 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of immunosuppressive drugs on human islet neogenesis in vitro

Gao, R., Ustinov, J., Korsgren, O. & Otonkoski, T., 2006, In : Diabetologia. 49, p. 272-272 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

2005

Downregulation of EGF receptor in the islets causes diabetes due to defects in beta-cell growth and function

Otonkoski, T., Ustinov, J., Hakonen, E., Tammivuori, P., Gao, R., Palgi, J. & Miettinen, P. J., 2005, In : Diabetes. 54, p. A77-A77 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells

Gao, R., Ustinov, J. A., Korsgren, O. & Otonkoski, T., 2005, In : Diabetologia. 48, p. 2296-2304 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Clusterin expression is associated with human islet neogenesis in vitro

Gao, R., Ustinov, J., Korsgren, O., Lundin, K. & Otonkoski, T., 2004, In : Diabetologia. 47, p. A156-A156 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Mice carrying a dominant negative EGF-receptor in the islet cells are hyperglycemic with a reduced beta-cell mass

Miettinen, P. J., Ustinov, J., Gao, R., Palgi, J., Virkamaki, A. & Otonkoski, T., 2004, In : Diabetologia. 47, p. A160-A160 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

2003

Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture

Gao, R., Ustinov, J., Pulkkinen, M. A., Lundin, K., Korsgren, O. & Otonkoski, T., 2003, In : Diabetes. 52, p. 2007-2015 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release

Otonkoski, T., Kaminen, N., Ustinov, J., Lapatto, R., Meissner, T., Mayatepek, E., Kere, J. & Sipila, I., 2003, In : Diabetes. 2003, 52, p. 199-204 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

Characterization of nestin-positive cells as endocrine progenitors in adult human pancreatic tissue culture

Gao, R., Ustinov, J., Huotari, M. A., Korsgren, O. & Otonkoski, T., 2002, In : Diabetologia. 45, p. A140-A140 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture

Huotari, M. A., Miettinen, P. J., Palgi, J., Koivisto, T., Ustinov, J., Harari, D., Yarden, Y. & Otonkoski, T., 2002, In : Endocrinology. 143, p. 4437-4446 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2001

cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)

Bondestam, J., Huotari, M-A., Morén, A., Ustinov, J., Kaivo-oja, N., Kallio, J., Horelli-Kuitunen, N., Aaltonen, J., Fujii, M., Moustakas, A., ten Dijke, P., Otonkoski, T. & Ritvos, O., 2001, In : Cytogenetics and Cell Genetics. 95, 3-4, p. 157-162 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Critical factors for the endocrine differentiation of cultured adult human ductal cells

Gao, R., Ustinov, J., Huotari, M. A., Korsgren, O. & Otonkoski, T., 2001, In : Diabetologia. 44, p. A71-A71 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Screening enteroviruses for beta-cell tropism using foetal porcine beta-cells

Roivainen, M., Ylipaasto, P., Ustinov, J., Hovi, T. & Otonkoski, T., 2001, In : Journal of General Virology. 82, p. 1909-1916 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The effects of nicotinamide and dexamethasone on beta-cell maturation.

Palgi, J., Ustinov, J. & Otonkoski, T., 2001, In : Diabetologia. 44, p. A71-A71 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

2000

EGF-family ligands betacellulin and neuregulin-4 direct the differentiation of developing mouse islet cells

Huotari, M. A., Miettinen, P., Palgi, J., Ustinov, J., Koivisto, T., Harari, D., Yarden, Y. & Otonkoski, T., 2000, In : Diabetologia. 43, p. A56-A56 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors

Miettinen, P. J., Huotari, M. A., Koivisto, T., Ustinov, J., Palgi, J., Rasilainen, S., Lehtonen, E., Keski-Oja, J. & Otonkoski, T., 2000, In : Child Development. 127, p. 2617-2627 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells

Roivainen, M., Rasilainen, S., Ylipaasto, P., Nissinen, R., Ustinov, J., Bouwens, L., Eizirik, D. L., Hovi, T. & Otonkoski, T., 2000, In : Journal of Clinical Endocrinology and Metabolism. 85, p. 432-440 9 p.

Research output: Contribution to journalArticleScientificpeer-review

1999

Differentiation and maturation of porcine fetal islet cells in vitro and after transplantation

Otonkoski, T., Ustinov, J., Rasilainen, S., Kallio, E., Korsgren, O. & Hayry, P., 1999, In : Transplantation. 68, p. 1674-1683 10 p.

Research output: Contribution to journalArticleScientificpeer-review

1998

Blocking of the P13-kinase pathway induces islet cell apoptosis in serum-free conditions, whereas map-kinase inhibition has no such effect.

Rasilainen, S., Ustinov, J. & Otonkoski, T., 1998, In : Diabetologia. 41, p. A156-A156 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Culture of adult human islet preparations with hepatocyte growth factor and 804G matrix is mitogenic for duct cells but not for beta-cells

Lefebvre, V. H., Otonkoski, T., Ustinov, J., Huotari, M. A., Pipeleers, D. G. & Bouwens, L., 1998, In : Diabetes. 47, p. 134-137 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Enterovirus infection results in impaired responsiveness of insulin release in adult human and fetal porcine pancreatic beta-cells

Roivainen, M., Ylipaasto, P., Ustinov, J., Nissinen, R., Rasilainen, S., Hovi, T. & Otonkoski, T., 1998, In : Diabetes. 47, p. A222-A222 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Role of betacellulin in the differentiation of pancreatic islet cells

Huotari, M. A., Miettinen, P., Palgi, J., Ustinov, J., Koivisto, T., Lehtonen, E. & Otonkoski, T., 1998, In : Diabetologia. 41, p. A67-A67 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

1997

Nicotinamide and sodium butyrate for the induction of fetal porcine beta-cell differentiation prior to transplantation

Otonkoski, T., Ustinov, J., Huotari, M. A., Kallio, E. & Hayry, P., 1997, In : Transplantation Proceedings. 29, p. 2045-2045 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

1996

Growth and differentiation factors in pancreatic beta-cells: INS-1 rat insulinoma cell line as a model

Huotari, M. A., Ustinov, J., Aavik, E., Pakkala, S. & Otonkoski, T., 1996, In : Diabetologia. 39, p. 233-233 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Nicotinamide and sodium butyrate have potent synergistic effects on fetal porcine beta-cell differentiation

Otonkoski, T., Ustinov, J., Huotari, M. A., Kallio, E. & Hayry, P., 1996, In : Diabetologia. 39, p. 232-232 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

1995

Chronic allograft arteriosclerosis. Microcirculation in organ Transplantation.

Häyry, P., Yilmaz, S., Mennander, A., Räisänen-Sokolowski, A., Koskinen, P., Lautenschlager, I., Ustinov, J. A., Aho, P. & Paavonen, T. K., 1995, Progress in Applied Microcirculation. . Messmer, K., Menger, MD. & Land, W. (eds.). Basel: Karger, Vol. 21.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

HYPERLIPIDEMIA ENHANCES CHRONIC REJECTION IN EXPERIMENTAL RAT MODEL

TILLYKIESI, M., RAISANENSOKOLOWSKI, A., USTINOV, J., MYLLARNIEMI, M., TIKKANEN, M. J. & HAYRY, P., 1995, In : Transplantation Proceedings. 27, p. 582-582 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

1994

CLINICAL AND EXPERIMENTAL CHRONIC ALLOGRAFT-REJECTION

HAYRY, P., ISONIEMI, H., YILMAZ, S., MENNANDER, A., LEMSTROM, K., RAISANEN, A., KOSKINEN, P., USTINOV, J., LAUTENSCHALGER, I., TASKINEN, E., KROGERUS, L., AHO, P. & PAAVONEN, T., 1994, In : Transplantation Proceedings. 26, p. 1702-1703 2 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

CMV-induced class II antigen expression in various rat organs

Ustinov, J. A., Loginov, R., Bruggeman, C., Suni, J. I., Häyry, P. & Lautenschlager, I., 1994, In : Transplant International. 7, 4, p. 302-308 7 p.

Research output: Contribution to journalArticleScientificpeer-review