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  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1989 …2018
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Publications 1989 2018

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2018

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Balboa, D., Saarimäki-Vire, J., Borshagovski, D., Survila, M., Lindholm, P., Galli, E., Eurola, S., Ustinov, J., Grym, H., Huopio, H., Partanen, J., Wartiovaara, K. & Otonkoski, T., 9 Nov 2018, In : eLife. 7, 35 p., 38519.

Research output: Contribution to journalArticleScientificpeer-review

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MANF protects human pancreatic beta cells against stress-induced cell death

Hakonen, E., Chandra, V., Fogarty, C. L., Yu, N. Y-L., Ustinov, J., Katayama, S., Galli, E., Danilova, T., Lindholm, P., Vartiainen, A., Einarsdottir, E., Krjutskov, K., Kere, J., Saarma, M., Lindahl, M. & Otonkoski, T., Oct 2018, In : Diabetologia. 61, 10, p. 2202-2214 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

Saarimaki-Vire, J., Balboa, D., Russell, M. A., Saarikettu, J., Kinnunen, M., Keskitalo, S., Malhi, A., Valensisi, C., Andrus, C., Eurola, S., Grym, H., Ustinov, J., Wartiovaara, K., Hawkins, R. D., Silvennoinen, O., Varjosalo, M., Morgan, N. G. & Otonkoski, T., 11 Apr 2017, In : Cell Reports. 19, 2, p. 281-294 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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2016

sept7b is required for the differentiation of pancreatic endocrine progenitors

Dash, S., Hakonen, E., Ustinov, J., Otonkoski, T., Andersson, O. & Lehtonen, S., 26 Apr 2016, In : Scientific Reports. 6, 14 p., 24992.

Research output: Contribution to journalArticleScientificpeer-review

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2015

Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

Hyvonen, M. E., Dumont, V., Tienari, J., Lehtonen, E., Ustinov, J., Havana, M., Jalanko, H., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., 2015, In : BioMed Research International. 11 p., 102969.

Research output: Contribution to journalArticleScientificpeer-review

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2014

EGFR Signaling Promotes beta-Cell Proliferation and Survivin Expression during Pregnancy

Hakonen, E., Ustinov, J., Palgi, J., Miettinen, P. J. & Otonkoski, T., 2 Apr 2014, In : PLoS One. 9, 4, 11 p., 93651.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes

Hakonen, E., Ustinov, J., Eizirik, D. L., Sariola, H., Miettinen, P. & Otonkoski, T., May 2014, In : Diabetologia. 57, 5, p. 970-979 10 p.

Research output: Contribution to journalArticleScientificpeer-review

MANF is indispensable for the proliferation and survival of pancreatic beta-cells

Lindahl, M., Danilova, T., Palm, E., Lindholm, P., Voikar, V., Hakonen, E., Ustinov, J., Andressoo, J-O., Harvey, B. K., Otonkoski, T., Rossi, J. & Saarma, M., Apr 2014, In : Cell Reports. 7, 2, p. 366-375 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

Activin A and Wnt-dependent specification of human definitive endoderm cells

Toivonen, S., Lundin, K., Balboa, D., Ustinov, J., Tamminen, K., Palgi, J., Trokovic, R., Tuuri, T. & Otonkoski, T., 15 Oct 2013, In : Experimental Cell Research. 319, 17, p. 2535-2544 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1

Shimomura, K., Tusa, M., Iberl, M., Brereton, M. F., Kaizik, S., Proks, P., Lahmann, C., Yaluri, N., Modi, S., Huopio, H., Ustinov, J., Otonkoski, T., Laakso, M. & Ashcroft, F. M., Nov 2013, In : Diabetes. 62, 11, p. 3797-3806 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A Novel Feeder-Free Culture System for Human Pluripotent Stem Cell Culture and Induced Pluripotent Stem Cell Derivation

Vuoristo, S., Toivonen, S., Weltner, J., Mikkola, M., Ustinov, J., Trokovic, R., Palgi, J., Lund, R., Tuuri, T. & Otonkoski, T., 2 Oct 2013, In : PLoS One. 8, 10, p. Article Number: UNSP e76205 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2008

Role of EGF-receptor signalling in physiological beta cell mass expansion

Hakonen, E., Ustinov, J., Ormio, P., De Medts, N., Bouwens, L., Miettinen, P. J. & Otonkoski, T., 2008, In : Diabetologia. 51, p. S18-S18 1 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Effects of immunosuppressive drugs on in vitro neogenesis of human islets: mycophenolate mofetil inhibits the proliferation of ductal cells

Gao, R., Ustinov, J. A., Korsgren, O. & Otonkoski, T., 2007, In : American Journal of Transplantation. 7, p. 1021-26 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine

Kajanne, R., Leppä, S., Luukkainen, P., Ustinov, J., Thiel, A., Ristimäki, A. & Miettinen, P. J., 2007, In : Pediatric Research. 62, 5, p. 570-575 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Maturation of in vitro-generated human islets after transplantation in nude mice

Gao, R., Ustinov, J. A., Korsgren, O., Mikkola, M., Lundin, K. & Otonkoski, T., 2007, In : Molecular and Cellular Endocrinology. 264, 1-2, p. 28-34 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Distinct differentiation characteristics of individual human embryonic stem cell lines

Mikkola (Aho), M., Olsson, C., Palgi, J., Ustinov, J., Palomäki, T., Horelli-Kuitunen, N., Knuutila, S., Lundin, K., Otonkoski, T. & Tuuri, T., 2006, In : BMC Developmental Biology. 6 (2006), 11s

Research output: Contribution to journalArticleScientificpeer-review

Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth

Miettinen, P. J., Ustinov, J., Ormio, P., Gao, R., Palgi, J., Hakonen, E., Juntti-Berggren, L., Berggren, P-O. & Otonkoski, T., Dec 2006, In : Diabetes. 55, 12, p. 3299-3308 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells

Gao, R., Ustinov, J. A., Korsgren, O. & Otonkoski, T., 2005, In : Diabetologia. 48, p. 2296-2304 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture

Gao, R., Ustinov, J., Pulkkinen, M. A., Lundin, K., Korsgren, O. & Otonkoski, T., 2003, In : Diabetes. 52, p. 2007-2015 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release

Otonkoski, T., Kaminen, N., Ustinov, J., Lapatto, R., Meissner, T., Mayatepek, E., Kere, J. & Sipila, I., 2003, In : Diabetes. 2003, 52, p. 199-204 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture

Huotari, M. A., Miettinen, P. J., Palgi, J., Koivisto, T., Ustinov, J., Harari, D., Yarden, Y. & Otonkoski, T., 2002, In : Endocrinology. 143, p. 4437-4446 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2001

cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)

Bondestam, J., Huotari, M-A., Morén, A., Ustinov, J., Kaivo-oja, N., Kallio, J., Horelli-Kuitunen, N., Aaltonen, J., Fujii, M., Moustakas, A., ten Dijke, P., Otonkoski, T. & Ritvos, O., 2001, In : Cytogenetics and Cell Genetics. 95, 3-4, p. 157-162 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Screening enteroviruses for beta-cell tropism using foetal porcine beta-cells

Roivainen, M., Ylipaasto, P., Ustinov, J., Hovi, T. & Otonkoski, T., 2001, In : Journal of General Virology. 82, p. 1909-1916 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2000

Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors

Miettinen, P. J., Huotari, M. A., Koivisto, T., Ustinov, J., Palgi, J., Rasilainen, S., Lehtonen, E., Keski-Oja, J. & Otonkoski, T., 2000, In : Child Development. 127, p. 2617-2627 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells

Roivainen, M., Rasilainen, S., Ylipaasto, P., Nissinen, R., Ustinov, J., Bouwens, L., Eizirik, D. L., Hovi, T. & Otonkoski, T., 2000, In : Journal of Clinical Endocrinology and Metabolism. 85, p. 432-440 9 p.

Research output: Contribution to journalArticleScientificpeer-review

1999

Differentiation and maturation of porcine fetal islet cells in vitro and after transplantation

Otonkoski, T., Ustinov, J., Rasilainen, S., Kallio, E., Korsgren, O. & Hayry, P., 1999, In : Transplantation. 68, p. 1674-1683 10 p.

Research output: Contribution to journalArticleScientificpeer-review

1998

Culture of adult human islet preparations with hepatocyte growth factor and 804G matrix is mitogenic for duct cells but not for beta-cells

Lefebvre, V. H., Otonkoski, T., Ustinov, J., Huotari, M. A., Pipeleers, D. G. & Bouwens, L., 1998, In : Diabetes. 47, p. 134-137 4 p.

Research output: Contribution to journalArticleScientificpeer-review

1994

CMV-induced class II antigen expression in various rat organs

Ustinov, J. A., Loginov, R., Bruggeman, C., Suni, J. I., Häyry, P. & Lautenschlager, I., 1994, In : Transplant International. 7, 4, p. 302-308 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Hyperlipidemia accelerates allocraft arteriosclerosis (chronic rejection) in the rat

Räisänen-Sokolowski, A., Tilly-Kiesi, M., Ustinov, J., Mennander, A., Paavonen, T., Tikkanen, M. J. & Häyry, P., 1994, In : Arteriosclerosis and thrombosis. 14, p. 2032-2042 11 p.

Research output: Contribution to journalArticleScientificpeer-review

1993

ADHESION MOLECULES INVOLVED IN PROTEIN-KINASE A-DEPENDENT AND C-DEPENDENT LYMPHOCYTE ADHERENCE TO MICROVASCULAR ENDOTHELIAL-CELLS

TURUNEN, J. P., USTINOV, J. & RENKONEN, R., 1993, In : Scandinavian Journal of Immunology. 37, p. 282-288 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Chronic rejection in rat aortic allografts: IV. Effect of hypercholesterolemia in allograft arteriosclerosis

Mennander, A., Tikkanen, M. J., Räisänen-Sokolowski, A., Paavonen, T., Ustinov, J. & Häyry, P., 1993, In : Journal of Heart and Lung Transplantation. 12, p. 123-132 10 p.

Research output: Contribution to journalArticleScientificpeer-review

EFFECT OF PLATELET-ACTIVATING-FACTOR (PAF) RECEPTOR BLOCKERS ON SMOOTH-MUSCLE CELL REPLICATION IN-VITRO AND ALLOGRAFT ARTERIOSCLEROSIS IN-VIVO

RAISANEN, A., MENNANDER, A., USTINOV, J., PAAVONEN, T. & HAYRY, P., 1993, In : Transplant International. 6, p. 251-257 7 p.

Research output: Contribution to journalArticleScientificpeer-review

SOMATOSTATIN ANALOG LANREOTIDE INHIBITS MYOCYTE REPLICATION AND SEVERAL GROWTH-FACTORS IN ALLOGRAFT ARTERIOSCLEROSIS

HAYRY, P., RAISANEN, A., USTINOV, J., MENNANDER, A. & PAAVONEN, T., 1993, In : FASEB Journal. 7, p. 1055-1060 6 p.

Research output: Contribution to journalArticleScientificpeer-review

1992

CHRONIC REJECTION OF RAT AORTIC ALLOGRAFTS .3. SYNTHESIS OF MAJOR EICOSANOIDS BY VASCULAR WALL COMPONENTS AND EFFECT OF INHIBITION OF THE THROMBOXANE CASCADE

MENNANDER, A., TIISALA, S., USTINOV, J., RAISANEN, A., PAAVONEN, T. & HAYRY, P., 1992, In : Arteriosclerosis and thrombosis. 12, p. 1380-1386 7 p.

Research output: Contribution to journalArticleScientificpeer-review

CHRONIC REJECTION OF RAT AORTIC ALLOGRAFTS - EFFECT OF INHIBITION OF THE THROMBOXANE CASCADE

MENNANDER, A., USTINOV, J., PAAVONEN, T., RAISANEN, A. & HAYRY, P., 1992, In : Transplant International. 5, p. S587-S588 2 p.

Research output: Contribution to journalArticleScientificpeer-review

1991

CARBOHYDRATE SYNTHESIS INHIBITORS DECREASE INTERLEUKIN-1-STIMULATED LYMPHOCYTE BINDING TO ENDOTHELIAL-CELLS

RENKONEN, R. & USTINOV, J., 1991, In : European Journal of Immunology. 21, p. 777-781 5 p.

Research output: Contribution to journalArticleScientificpeer-review

1990

ACTIVATION OF PROTEIN-KINASE-C IS CRUCIAL IN THE REGULATION OF ICAM-1 EXPRESSION ON ENDOTHELIAL-CELLS BY INTERFERON-GAMMA

RENKONEN, R., MENNANDER, A., USTINOV, J. & MATTILA, P., 1990, In : International Immunology. 2, p. 719-724 6 p.

Research output: Contribution to journalArticleScientificpeer-review

INTERFERON-GAMMA AUGMENTS HYDROLYSIS OF LTA4 TO LTB4 BY ENDOTHELIAL-CELLS

RENKONEN, R. & USTINOV, J., 1990, In : Prostaglandins, Leukotrienes and Cancer. 39, p. 205-211 7 p.

Research output: Contribution to journalArticleScientificpeer-review

INTERLEUKIN-1-INDUCED LYMPHOCYTE BINDING TO ENDOTHELIAL-CELLS - ROLE OF CAMP AS A 2ND MESSENGER

RENKONEN, R., MATTILA, P., HAYRY, P. & USTINOV, J., 1990, In : European Journal of Immunology. 20, p. 1563-1567 5 p.

Research output: Contribution to journalArticleScientificpeer-review

PROPERTIES OF B-CELLS AND THY-1-ANTIGEN-EXPRESSING CELLS INFILTRATING RAT RENAL-ALLOGRAFTS

LESZCZYNSKI, D., HALTTUNEN, J., TIISALA, S., USTINOV, J., RENKONEN, R. & HAYRY, P., 1990, In : Human Immunology. 29, p. 103-109 7 p.

Research output: Contribution to journalArticleScientificpeer-review

PROTEIN-KINASE C-REGULATED PRODUCTION OF PROSTACYCLIN BY RAT ENDOTHELIUM IS INCREASED IN THE PRESENCE OF LIPOXIN-A4

LESZCZYNSKI, D. & USTINOV, J., 1990, In : FEBS Letters. 263, p. 117-120 4 p.

Research output: Contribution to journalArticleScientificpeer-review

SIGNAL TRANSDUCTION DURING INVITRO LYMPHOCYTE HOMING

RENKONEN, R., MENNANDER, A., MATTILA, P. & USTINOV, J., 1990, In : Human Immunology. 28, p. 134-140 7 p.

Research output: Contribution to journalArticleScientificpeer-review

SIGNAL TRANSDUCTION DURING PLATELET-ACTIVATING FACTOR-INDUCED LYMPHOCYTE BINDING TO ENDOTHELIAL-CELLS

RENKONEN, R., MATTILA, P. & USTINOV, J., 1990, In : Scandinavian Journal of Immunology. 31, p. 523-527 5 p.

Research output: Contribution to journalArticleScientificpeer-review

1989

Regulation of antigen expression in different parenchymal cell types of rat kidney and heart.

Mattila, P. M., Nietosvaara, Y., Ustinov, J. A., Renkonen, R. & Häyry, P., 1989, In : Kidney International. 36, p. 228-233 6 p.

Research output: Contribution to journalArticleScientificpeer-review