Photo of Jayendra Patel
  • PL 56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

20062019
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Publications 2006 2019

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2016

Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alpha/beta-hydrolase domain containing 11 (ABHD11)

Navia-Paldanius, D., Patel, J. Z., Navarro, M. L., Jakupovic, H., Goffart, S., Pasonen-Seppanen, S., Nevalainen, T. J., Jaaskelainen, T., Laitinen, T., Laitinen, J. T. & Savinainen, J. R., 10 Oct 2016, In : European Journal of Pharmaceutical Sciences. 93, p. 253-263 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Comparative molecular field analysis and molecular dynamics studies of alpha/beta hydrolase domain containing 6 (ABHD6) inhibitors

Kaczor, A. A., Targowska-Duda, K. M., Patel, J. Z., Laitinen, T., Parkkari, T., Adams, Y., Nevalainen, T. J. & Poso, A., Oct 2015, In : Journal of Molecular Modeling. 21, 10, p. 250 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Loratadine analogues as MAGL inhibitors

Patel, J. Z., Ahenkorah, S., Vaara, M., Staszewski, M., Adams, Y., Laitinen, T., Navia-Paldanius, D., Parkkari, T., Savinainen, J. R., Walczynski, K., Laitinen, J. T. & Nevalainen, T. J., 1 Apr 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 7, p. 1436-1442 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Optimization of 1,2,5-Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors

Patel, J. Z., Nevalainen, T. J., Savinainen, J. R., Adams, Y., Laitinen, T., Runyon, R. S., Vaara, M., Ahenkorah, S., Kaczor, A. A., Navia-Paldanius, D., Gynther, M., Aaltonen, N., Joharapurkar, A. A., Jain, M. R., Haka, A. S., Maxfield, F. R., Laitinen, J. T. & Parkkari, T., Feb 2015, In : ChemMedChem : chemistry enabling drug discovery.. 10, 2, p. 253-265 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors

Patel, J. Z., van Bruchem, J., Laitinen, T., Kaczor, A. A., Navia-Paldanius, D., Parkkari, T., Savinainen, J. R., Laitinen, J. T. & Nevalainen, T. J., 1 Oct 2015, In : Bioorganic & Medicinal Chemistry. 23, 19, p. 6335-6345 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A)

Savinainen, J. R., Patel, J. Z., Parkkari, T., Navia-Paldanius, D., Marjamaa, J. J. T., Laitinen, T., Nevalainen, T. & Laitinen, J. T., 7 Oct 2014, In : PLoS One. 9, 10, 17 p., 109869.

Research output: Contribution to journalArticleScientificpeer-review

Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)

Korhonen, J., Kuusisto, A., van Bruchem, J., Patel, J. Z., Laitinen, T., Navia-Paldanius, D., Laitinen, J. T., Savinainen, J. R., Parkkari, T. & Nevalainen, T. J., 1 Dec 2014, In : Bioorganic & Medicinal Chemistry. 22, 23, p. 6694-6705 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling

Kasnanen, H., Minkkila, A., Taupila, S., Patel, J. Z., Parkkari, T., Lahtela-Kakkonen, M., Saario, S. M., Nevalainen, T. & Poso, A., 14 Jun 2013, In : European Journal of Pharmaceutical Sciences. 49, 3, p. 423-433 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Chiral 1,3,4-Oxadiazol-2-ones as Highly Selective FAAH Inhibitors

Patel, J. Z., Parkkari, T., Laitinen, T., Kaczor, A. A., Saario, S. M., Savinainen, J. R., Navia-Padanius, D., Cipriano, M., Leppänen, J., Koshevoy, I. O., Poso, A., Fowler, C. J., Laitinen, J. T. & Nevalainen, T., 14 Nov 2013, In : Journal of Medicinal Chemistry. 56, 21, p. 8484-8496 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

New in Vitro Tools to Study Human Constitutive Androstane Receptor (CAR) Biology: Discovery and Comparison of Human CAR Inverse Agonists

Kublbeck, J., Jyrkkarinne, J., Molnar, F., Kuningas, T., Patel, J., Windshugel, B., Nevalainen, T., Laitinen, T., Sippl, W., Poso, A. & Honkakoski, P., 2011, In : Molecular Pharmaceutics. 8, 6, p. 2424-2433 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a cb1 receptor antagonist with in vivo antiobesity effect

Srivastava, B. K., Soni, R., Patel, J. Z., Joharapurkar, A. A., Sadhwani, N., Kshirsagar, S., Mishra, B., Takale, V., Gupta, S., Pandya, P., Kapadnis, P., Solanki, M., Mitra, P., Jain, M. R. & Patel, P. R., 1 May 2009, In : Bioorganic & Medicinal Chemistry Letters. 19, 9, p. 2546-2550 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole

Srivastava, B. K., Soni, R., Joharapurkar, A. A., Sairam, K. V. V. M., Patel, J. Z., Goswami, A., Shedage, S. A., Kar, S. S., Salunke, R. P., Gugale, S. B., Dhawas, A., Kadam, P., Mishra, B., Sadhwani, N., Unadkat, V. B., Mitra, P., Jain, M. R. & Patel, P. R., 1 Feb 2008, In : Bioorganic & Medicinal Chemistry Letters. 18, 3, p. 963-968 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist.

Srivastava, B. K., Soni, R., Patel, J. Z., Jha, S., Shadage, S. A., Gandhi, N., Sairam, K. V. V. M., Pawar, V., Sadhwani, N., Mitra, P., Jain, M. R. & Patel, P. R., 15 Jul 2008, In : Bioorganic & Medicinal Chemistry Letters. 18, 14, p. 3882-3886 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Synthesis and in vitro antibacterial activities of novel oxazolidinones

Srivastava, B. K., Jain, M. R., Solanki, M., Soni, R., Valani, D., Gupta, S., Mishra, B., Takale, V., Kapadnis, P., Patel, H., Pandya, P., Patel, J. Z. & Patel, P. R., Apr 2008, In : European Journal of Medicinal Chemistry. 43, 4, p. 683-693 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Diaryl dihydropyrazole-3-carboxamides with significant in vivo antiobesity activity related to CBI receptor antagonism: Synthesis, biological evaluation, and molecular modeling in the homology model

Srivastava, B. K., Joharapurkar, A., Raval, S., Patel, J. Z., Soni, R., Raval, P., Gite, A., Goswami, A., Sadhwani, N., Gandhi, N., Patel, H., Mishra, B., Solanki, M., Pandey, B., Jain, M. R. & Patel, P. R., 29 Nov 2007, In : Journal of Medicinal Chemistry. 50, 24, p. 5951-5966 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones

Srivastava, B. K., Soni, R., Patel, J. Z., Solanki, M., Valani, D., Gupta, S., Mishra, B., Takale, V., Pandya, P., Jain, M. R. & Patel, P. R., 15 Sep 2007, In : Bioorganic & Medicinal Chemistry Letters. 17, 18, p. 5227-5232 6 p.

Research output: Contribution to journalArticleScientificpeer-review