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Publications 1994 2019

  • 126 Article
  • 12 Conference article
  • 3 Conference contribution
  • 3 Meeting Abstract

Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours

Linder, N., Taylor, J. C., Colling, R., Pell, R., Alveyn, E., Joseph, J., Protheroe, A., Lundin, M., Lundin, J. & Verrill, C., Feb 2019, In : Journal of Clinical Pathology. 72, 2, p. 157-164 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Detection of breast cancer lymph node metastases in frozen sections with a point-of care low-cost microscope scanner

Holmström, O., Linder, N., Moilanen, H., Suutala, A., Nordling, S., Ståhls, A., Lundin, M., Diwan, V. & Lundin, J., 19 Mar 2019, In : PLoS One. 14, 3, 15 p., 0208366.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Deep learning based tissue analysis predicts outcome in colorectal cancer

Bychkov, D., Linder, N., Turkki, R., Nordling, S., Kovanen, P. E., Verrill, C., Walliander, M., Lundin, M., Haglund, C. & Lundin, J., 21 Feb 2018, In : Scientific Reports. 8, 11 p., 3395.

Research output: Contribution to journalArticleScientificpeer-review

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Increased HSF1 expression predicts shorter disease-specific survival of prostate cancer patients following radical prostatectomy

Björk, J. K., Ahonen, I., Mirtti, T., Erickson, A., Rannikko, A., Butzow, A., Nordling, S., Lundin, J., Lundin, M., Sistonen, L., Nees, M. & Akerfelt, M., 2018, In : Oncotarget. 9, 58, p. 31200-31213 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours

Närhi, K., Nagaraj, A. S., Parri, E., Turkki, R., van Duijn, P. W., Hemmes, A., Lahtela, J., Uotinen, V., Mäyränpää, M. I., Salmenkivi, K., Räsänen, J., Linder, N., Trapman, J., Rannikko, A., Kallioniemi, O., Af Hällström, T. M., Lundin, J., Sommergruber, W., Anders, S. & Verschuren, E. W., May 2018, In : Journal of Pathology. 245, 1, p. 101-113 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

The prognostic significance of tall cells in papillary thyroid carcinoma: A case-control study

Stenman, S., Siironen, P., Mustonen, H., Lundin, J., Haglund, C. & Arola, J., 2018, In : Tumor Biology. 40, 7, 7 p., 1010428318787720.

Research output: Contribution to journalArticleScientificpeer-review

2017

A roadmap for the implementation of mHealth innovations for image-based diagnostic support in clinical and public-health settings: a focus on front-line health workers and health-system organizations

Wallis, L., Hasselberg, M., Barkman, C., Bogoch, I., Broomhead, S., Dumont, G., Groenewald, J., Lundin, J., Bergendahl, J. N., Nyasulu, P., Olofsson, M., Weinehall, L. & Laflamme, L., 2017, In : Global health action. 10, 10 p., 1340254.

Research output: Contribution to journalArticleScientificpeer-review

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Exploration of tissue morphologies in breast cancer samples using unsupervised machine learning

Turkki, R., Bychkov, D., Linder, N., Isola, J., Joensuu, H. T. & Lundin, J., 1 Jul 2017, In : Cancer Research. 77, 13 Supplement, p. 673 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Medical mobile technologies - what is needed for a sustainable and scalable implementation on a global scale?

Lundin, J. & Dumont, G., 2017, In : Global health action. 10, Suppl. 3, 4 p., 1344046.

Research output: Contribution to journalArticleScientificpeer-review

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Mobile phone and handheld microscopes for public health applications

Bogoch, I. I., Lundin, J., Lo, N. C. & Andrews, J. R., 2 Aug 2017, In : The Lancet Public Health. 2, 8, 1 p., 355.

Research output: Contribution to journalArticleScientific

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Point-of-care mobile digital microscopy and deep learning for the detection of soil-transmitted helminths and Schistosoma haematobium

Holmstrom, O., Linder, N., Ngasala, B., Martensson, A., Linder, E., Lundin, M., Moilanen, H., Suutala, A., Diwan, V. & Lundin, J., 2017, In : Global health action. 10, 9 p., 1337325.

Research output: Contribution to journalArticleScientificpeer-review

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Systems pathology by multiplexed immunohistochemistry and whole-slide digital image analysis

Blom, S., Paavolainen, L., Bychkov, D., Turkki, R., Maki-Teeri, P., Hemmes, A., Valimaki, K., Lundin, J., Kallioniemi, O. & Pellinen, T., 14 Nov 2017, In : Scientific Reports. 7, 13 p., 15580.

Research output: Contribution to journalArticleScientificpeer-review

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A Smartphone App and Cloud-Based Consultation System for Burn Injury Emergency Care

Wallis, L. A., Fleming, J., Hasselberg, M., Laflamme, L. & Lundin, J., 26 Feb 2016, In : PLoS One. 11, 2, 19 p., 0147253.

Research output: Contribution to journalArticleScientificpeer-review

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Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

Taipale, K., Liikanen, I., Juhila, J., Turkki, R., Tahtinen, S., Kankainen, M., Vassilev, L., Ristimaki, A., Koski, A., Kanerva, A., Diaconu, I., Cerullo, V., Vaha-Koskela, M., Oksanen, M., Linder, N., Joensuu, T., Lundin, J. & Hemminki, A., Jan 2016, In : Molecular therapy. 24, 1, p. 175-183 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Deep learning for tissue microarray image-based outcome prediction in patients with colorectal cancer

Bychkov, D., Turkki, R., Haglund, C., Linder, N. & Lundin, J., 2016, Medical Imaging 2016: Digital Pathology. Gurcan, M. N. & Madabhushi, A. (eds.). SPIE - INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, p. 979115 6 p. (Proceedings of SPIE; vol. 9791).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Identification of immune cell infiltration in hematoxylin-eosin stained breast cancer samples: Texture-based classification of tissue morphologies

Turkki, R., Linder, N., Kovanen, P. E., Pellinen, T. & Lundin, J., 2016, MEDICAL IMAGING 2016: DIGITAL PATHOLOGY. Gurcan, MN. & Madabhushi, A. (eds.). SPIE - INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, 7 p. 979110. (Proceedings of SPIE; vol. 9791).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Immune cell profiling in CML bone marrow by multiplex IHC

Bruck, O., Blom, S., Turkki, R., Kovanen, P., Ribeiro, A., Linder, N., Lundin, J., Kallioniemi, O., Pellinen, T. & Mustjoki, S., Nov 2016, In : Annals of Oncology. 27, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Immune Cell Profiling in CML Bone Marrow By Multiplex Immunohistochemistry

Oscar, B., Blom, S., Turkki, R., Kovanen, P. E., Ribeiro, A., Linder, N., Lundin, J., Kallioniemi, O., Pellinen, T. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Loss of PTEN expression in ERG-negative prostate cancer predicts secondary therapies and leads to shorter disease-specific survival time after radical prostatectomy

Lahdensuo, K., Erickson, A., Saarinen, I., Seikkula, H., Lundin, J., Lundin, M., Nordling, S., Butzow, A., Vasarainen, H., Bostrom, P. J., Taimen, P., Rannikko, A. & Mirtti, T., Dec 2016, In : Modern Pathology. 29, 12, p. 1565-1574 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Phase I study with ONCOS-102 for the treatment of solid tumors - an evaluation of clinical response and exploratory analyses of immune markers

Ranki, T., Pesonen, S., Hemminki, A., Partanen, K., Kairemo, K., Alanko, T., Lundin, J., Linder, N., Turkki, R., Ristimäki, A., Jaeger, E., Karbach, J., Wahle, C., Kankainen, M., Backman, C., von Euler, M., Haavisto, E., Hakonen, T., Heiskanen, R., Jaderberg, M. & 6 othersJuhila, J., Priha, P., Suoranta, L., Vassilev, L., Vuolanto, A. & Joensuu, T., 15 Mar 2016, In : Journal for Immunotherapy of Cancer. 4, 18 p., 17.

Research output: Contribution to journalArticleScientificpeer-review

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2015

Androgen receptor-interacting protein HSPBAP1 facilitates growth of prostate cancer cells in androgen-deficient conditions

Saeed, K., Östling, P. K., Björkman, M., Mirtti, T., Alanen, K., Vesterinen, T., Sankila, A., Lundin, J., Lundin, M., Rannikko, A., Nordling, S., Mpindi, J-P., Kohonen, P., Iljin, K., Kallioniemi, O. & Rantala, J. K., 2015, In : International Journal of Cancer. 136, 11, p. 2535-2545 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis

Turkki, R., Linder, N., Holopainen, T., Wang, Y., Grote, A., Lundin, M., Alitalo, K. & Lundin, J., Aug 2015, In : Journal of Clinical Pathology. 68, 8, p. 614-621 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Benefit of adjuvant interferon alfa-2b (IFN-alpha) therapy in melanoma patients with high serum MMP-8 levels

Vihinen, P., Tervahartiala, T., Sorsa, T., Hansson, J., Bastholt, L., Aamdal, S., Stierner, U., Pyrhonen, S., Syrjanen, K., Lundin, J. & Hernberg, M., Feb 2015, In : Cancer Immunology, Immunotherapy. 64, 2, p. 173-180 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Exploring viewing behavior data from whole slide images to predict correctness of students' answers during practical exams in oral pathology

Walkowski, S., Lundin, M., Szymas, J. & Lundin, J., 2015, In : Journal of pathology informatics. 6, 28.

Research output: Contribution to journalArticleScientificpeer-review

Immunological data from cancer patients treated with Ad5/3-E2F-Delta 24-GMCSF suggests utility for tumor immunotherapy

Hemminki, O., Parviainen, S., Juhila, J., Turkki, R., Linder, N., Lundin, J., Kankainen, M., Ristimaki, A., Koski, A., Liikanen, I., Oksanen, M., Nettelbeck, D. M., Kairemo, K., Partanen, K., Joensuu, T., Kanerva, A. & Hemminki, A., 28 Feb 2015, In : Oncotarget. 6, 6, p. 4467-4481 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8(+) T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer

Vassilev, L., Ranki, T., Joensuu, T., Jaeger, E., Karbach, J., Wahle, C., Partanen, K., Kairemo, K., Alanko, T., Turkki, R., Linder, N., Lundin, J., Ristimaki, A., Kankainen, M., Hemminki, A., Backman, C., Dienel, K., von Euler, M., Haavisto, E., Hakonen, T. & 5 othersJuhila, J., Jaderberg, M., Priha, P., Vuolanto, A. & Pesonen, S., 2015, In : OncoImmunology. 4, 7, 5 p., 1017702.

Research output: Contribution to journalArticleScientificpeer-review

T-cell Subsets in Peripheral Blood and Tumors of Patients Treated With Oncolytic Adenoviruses

Taipale, K., Liikanen, I., Juuso, J., Aila, K-K., Oksanen, M., Turkki, R., Linder, N., Lundin, J., Ristimäki, A., Kanerva, A., Koski, A., Joensuu, T., Vähä-Koskela, M. & Hemminki, A., May 2015, In : Molecular therapy. 23, 5, p. 964-973 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

A Malaria Diagnostic Tool Based on Computer Vision Screening and Visualization of Plasmodium falciparum Candidate Areas in Digitized Blood Smears

Linder, N., Turkki, R., Walliander, M., Martensson, A., Diwan, V., Rahtu, E., Pietikainen, M., Lundin, M. & Lundin, J., 21 Aug 2014, In : PLoS One. 9, 8, 12 p., 104855.

Research output: Contribution to journalArticleScientificpeer-review

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Exploring the spatial dimension of estrogen and progesterone signaling: detection of nuclear labeling in lobular epithelial cells in normal mammary glands adjacent to breast cancer

Grote, A., Abbas, M., Linder, N., Kreipe, H. H., Lundin, J. & Feuerhake, F., 19 Dec 2014, In : Diagnostic Pathology. 9, Suppl 1, 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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Exploring Viewing Behavior Data from Whole Slide Images to Predict Correctness of Students' Answers during Practical Exams in Oral Pathology

Walkowski, S., Lundin, M., Szymas, J. & Lundin, J., 2014, In : Analytical cellular pathology. 2014, 2 p., 706470.

Research output: Contribution to journalArticleScientificpeer-review

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Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8(+) T-cell response, prominent infiltration of CD8(+) lymphocytes and Th1 type polarization

Ranki, T., Joensuu, T., Jaeger, E., Karbach, J., Wahle, C., Kairemo, K., Alanko, T., Partanen, K., Turkki, R., Linder, N., Lundin, J., Ristimaki, A., Kankainen, M., Hemminki, A., Backman, C., Dienel, K., von Euler, M., Haavisto, E., Hakonen, T., Juhila, J. & 5 othersJaderberg, M., Priha, P., Vassilev, L., Vuolanto, A. & Pesonen, S., 2014, In : OncoImmunology. 3, 10, 4 p., 958937.

Research output: Contribution to journalArticleScientificpeer-review

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Students' performance during practical examination on whole slide images using view path tracking

Walkowski, S., Lundin, M., Szymas, J. & Lundin, J., 30 Oct 2014, In : Diagnostic Pathology. 9, 8 p., 208.

Research output: Contribution to journalArticleScientificpeer-review

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2013

An open-source, MATLAB based annotation tool for virtual slides

Turkki, R., Walliander, M., Ojansivu, V., Linder, N., Lundin, M. & Lundin, J., 2013, In : Diagnostic Pathology. 8, Suppl. 1, 4 p., S30.

Research output: Contribution to journalArticleScientificpeer-review

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Automated classification of breast cancer morphology in histopathological images

Ojansivu, V., Linder, N., Rahtu, E., Pietikäinen, M., Lundin, M., Joensuu, H. & Lundin, J., 2013, In : Diagnostic Pathology. 8, Suppl. 1, p. S29 4 p.

Research output: Contribution to journalArticleScientificpeer-review

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On-Chip Imaging of Schistosoma haematobium Eggs in Urine for Diagnosis by Computer Vision

Linder, E., Grote, A., Varjo, S., Linder, N., Lebbad, M., Lundin, M., Diwan, V., Hannuksela, J. & Lundin, J., Dec 2013, In : PLoS Neglected Tropical Diseases. 7, 12, 9 p., 2547.

Research output: Contribution to journalArticleScientificpeer-review

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2012

A web-based prognostic tool for extremity and trunk wall soft tissue sarcomas and its external validation

Sampo, M. M., Tarkkanen, M., Tukiainen, E., Popov, P., Gustafson, P., Lundin, M., Böhling, T., Blomqvist, C. & Lundin, J. E., 2012, In : British Journal of Cancer. 106, 6, p. 1076-1082 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Decreased xanthine oxidoreductase (XOR) is associated with a worse prognosis in patients with serous ovarian carcinoma

Linder, N., Butzow, R., Lassus, H., Lundin, M. & Lundin, J., 2012, In : Gynecologic Oncology. 124, 2, p. 311-318 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of image compression and scaling on automated scoring of immunohistochemical stainings and segmentation of tumor epithelium

Konsti, J., Lundin, M., Linder, N., Haglund, C., Blomqvist, C., Nevanlinna, H., Aaltonen, K., Nordling, S. & Lundin, J., 2012, In : Diagnostic Pathology. 7, Article Number: 29, p. - 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of tumor epithelium and stroma in tissue microarrays using texture analysis

Linder, N., Konsti, J., Turkki, R., Rahtu, E., Lundin, M., Nordling, F. S. A., Haglund, C., Ahonen, T., Pietikainen, M. & Lundin, J., 2012, In : Diagnostic Pathology. 7, p. Article Number 22 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer

Karhemo, P-R., Rivinoja, A., Lundin, J. E., Hyvönen, M., Chernenko, A., Lammi, J., Sihto, H., Lundin, M. E., Heikkilä, P., Joensuu, H., Bono, P. & Laakkonen, P. M., 2011, In : The American Journal of Pathology. 179, 2, p. 1004-1014 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study

Sihto, H., Lundin, J., Lundin, M., Lehtimaki, T., Ristimaki, A., Holli, K., Sailas, L., Kataja, V., Turpeenniemi-Hujanen, T., Isola, J., Heikkila, P. & Joensuu, H., 2011, In : Breast Cancer Research. 13, p. R87 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer

Konsti, J. P., Lundin, M. E., Joensuu, H., Lehtimäki, T. E., Sihto, H., Holli, K., Turpeenniemi-Hujanen, T., Kataja, V., Sailas, L., Isola, J. & Lundin, J. E., 25 Jan 2011, In : BMC Clinical Pathology. 11, p. art. no. 3

Research output: Contribution to journalArticleScientificpeer-review

Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer

Sahu, B., Laakso, M., Ovaska, K., Mirtti, T., Lundin, J., Rannikko, A., Sankila, A., Turunen, J-P., Lundin, M., Konsti, J., Vesterinen, T., Nordling, S., Kallioniemi, O., Hautaniemi, S. & Janne, O. A., 2011, In : EMBO Journal. 30, 19, p. 3962-3976 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Expression and prognostic value of transcription factor PROX1 in colorectal cancer

Skog, M., Bono, P., Lundin, M., Lundin, J., Louhimo, J., Linder, N., Petrova, T. V., Andersson, L. C., Joensuu, H., Alitalo, K. & Haglund, C. H., 2011, In : British Journal of Cancer. 105, 9, p. 1346-1351 6 p.

Research output: Contribution to journalArticleScientificpeer-review

High CIP2A immunoreactivity is an independent prognostic indicator in early-stage tongue cancer

Böckelman, C., Hagström, J., Mäkinen, L. K., Keski-Säntti, H., Häyry, V., Lundin, J., Atula, T., Ristimäki, A. & Haglund, C., 2011, In : British Journal of Cancer. 104, 12, p. 1890-1895 6 p.

Research output: Contribution to journalArticleScientificpeer-review