Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Chen, Z., Guo, X., Tao, R., Huyghe, J. R., Law, P. J., Fernandez-Rozadilla, C., Ping, J., Jia, G., Long, J., Li, C., Shen, Q., Xie, Y., Timofeeva, M. N., Thomas, M., Schmit, S. L., Díez-Obrero, V., Devall, M., Moratalla-Navarro, F., Fernandez-Tajes, J. & Palles, C. & 185 others, Sherwood, K., Briggs, S. E. W., Svinti, V., Donnelly, K., Farrington, S. M., Blackmur, J., Vaughan-Shaw, P. G., Shu, X. O., Lu, Y., Broderick, P., Studd, J., Harrison, T. A., Conti, D. V., Schumacher, F. R., Melas, M., Rennert, G., Obón-Santacana, M., Martín-Sánchez, V., Oh, J. H., Kim, J., Jee, S. H., Jung, K. J., Kweon, S. S., Shin, M. H., Shin, A., Ahn, Y. O., Kim, D. H., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y. T., Jia, W. H., Hopper, J. L., Jenkins, M. A., Win, A. K., Pai, R. K., Figueiredo, J. C., Haile, R. W., Gallinger, S., Woods, M. O., Newcomb, P. A., Duggan, D., Cheadle, J. P., Kaplan, R., Kerr, R., Kerr, D., Kirac, I., Böhm, J., Mecklin, J. P., Jousilahti, P., Knekt, P., Aaltonen, L. A., Rissanen, H., Pukkala, E., Eriksson, J. G., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-Sinisalo, L., Männistö, S., Albanes, D., Weinstein, S. J., Ruiz-Narvaez, E., Palmer, J. R., Buchanan, D. D., Platz, E. A., Visvanathan, K., Ulrich, C. M., Siegel, E., Brezina, S., Gsur, A., Campbell, P. T., Chang-Claude, J., Hoffmeister, M., Brenner, H., Slattery, M. L., Potter, J. D., Tsilidis, K. K., Schulze, M. B., Gunter, M. J., Murphy, N., Castells, A., Castellví-Bel, S., Moreira, L., Arndt, V., Shcherbina, A., Bishop, D. T., Giles, G. G., Southey, M. C., Idos, G. E., McDonnell, K. J., Abu-Ful, Z., Greenson, J. K., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y. R., Steinfelder, R., Keku, T. O., van Guelpen, B., Hudson, T. J., Hampel, H., Pearlman, R., Berndt, S. I., Hayes, R. B., Martinez, M. E., Thomas, S. S., Pharoah, P. D. P., Larsson, S. C., Yen, Y., Lenz, H. J., White, E., Li, L., Doheny, K. F., Pugh, E., Shelford, T., Chan, A. T., Cruz-Correa, M., Lindblom, A., Hunter, D. J., Joshi, A. D., Schafmayer, C., Scacheri, P. C., Kundaje, A., Schoen, R. E., Hampe, J., Stadler, Z. K., Vodicka, P., Vodickova, L., Vymetalkova, V., Edlund, C. K., Gauderman, W. J., Shibata, D., Toland, A., Markowitz, S., Kim, A., Chanock, S. J., van Duijnhoven, F., Feskens, E. J. M., Sakoda, L. C., Gago-Dominguez, M., Wolk, A., Pardini, B., FitzGerald, L. M., Lee, S. C., Ogino, S., Bien, S. A., Kooperberg, C., Li, C. I., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Yamaji, T., Sawada, N., Iwasaki, M., Le Marchand, L., Wu, A. H., Qu, C., McNeil, C. E., Coetzee, G., Hayward, C., Deary, I. J., Harris, S. E., Theodoratou, E., Reid, S., Walker, M., Ooi, L. Y., Lau, K. S., Zhao, H., Hsu, L., Cai, Q., Dunlop, M. G., Gruber, S. B., Houlston, R. S., Moreno, V., Casey, G., Peters, U., Tomlinson, I. & Zheng, W., 2024, In: Nature Communications. 15, 1, 17 p., 3557.

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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Fernandez-Rozadilla, C., Timofeeva, M., Chen, Z., Law, P., Thomas, M., Bien, S., Diez-Obrero, V., Li, L., Fernandez-Tajes, J., Palles, C., Sherwood, K., Harris, S., Svinti, V., McDonnell, K., Farrington, S., Studd, J., Vaughan-Shaw, P., Shu, X.-O., Long, J. & Cai, Q. & 190 others, Guo, X., Lu, Y., Scacheri, P., Studd, J., Huyghe, J., Harrison, T., Shibata, D., Haiman, C., Devall, M., Schumacher, F., Melas, M., Rennert, G., Obon-Santacana, M., Martin-Sanchez, V., Moratalla-Navarro, F., Oh, J. H., Kim, J., Jee, S. H., Jung, K. J., Kweon, S.-S., Shin, M.-H., Shin, A., Ahn, Y.-O., Kim, D.-H., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y.-T., Jia, W.-H., Potter, J., Jenkins, M., Win, A. K., Pai, R., Figueiredo, J., Haile, R., Gallinger, S., Woods, M., Newcomb, P., Shibata, D., Cheadle, J., Kaplan, R., Maughan, T., Kerr, R., Kerr, D., Kirac, I., Boehm, J., Mecklin, L.-P., Jousilahti, P., Knekt, P., Aaltonen, L., Rissanen, H., Pukkala, E., Eriksson, J., Cajuso, T., Hanninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-Sinisalo, L., Zanke, B., Männistö, S., Albanes, D., Weinstein, S., Ruiz-Narvaez, E., Palmer, J., Buchanan, D., Platz, E., Visvanathan, K., Ulrich, C., Siegel, E., Brezina, S., Gsur, A., Campbell, P., Chang-Claude, J., Hoffmeister, M., Brenner, H., Slattery, M., Potter, J., Tsilidis, K., Schulze, M., Gunter, M., Murphy, N., Castells, A., Castellvi-Bel, S., Moreira, L., Arndt, V., Shcherbina, A., Stern, M., Pardamean, B., Bishop, T., Giles, G., Southey, M., Idos, G., McDonnell, K., Abu-Ful, Z., Greenson, J., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y.-R., Steinfelder, R., Keku, T., van Guelpen, B., Hudson, T., Hampel, H., Pearlman, R., Berndt, S., Hayes, R., Martinez, M. E., Thomas, S., Corley, D., Pharoah, P., Larsson, S., Yen, Y., Lenz, H.-J., White, E., Li, L., Doheny, K., Pugh, E., Shelford, T., Chan, A., Cruz-Correa, M., Lindblom, A., Shibata, D., Joshi, A., Schafmayer, C., Scacheri, P., Kundaje, A., Nickerson, D., Schoen, R., Hampe, J., Stadler, Z., Vodicka, P., Vodickova, L., Vymetalkova, V., Papadopoulos, N., Edlund, C., Gauderman, W., Thomas, D., Shibata, D., Toland, A., Markowitz, S., Kim, A., Gruber, S., van Duijnhoven, F., Feskens, E., Sakoda, L., Gago-Dominguez, M., Wolk, A., Naccarati, A., Pardini, B., FitzGerald, L., Lee, S. C., Ogino, S., Bien, S., Kooperberg, C., Li, C., Lin, Y., Prentice, R., Qu, C., Bezieau, S., Tangen, C., Mardis, E., Yamaji, T., Sawada, N., Iwasaki, M., Haiman, C., Le Marchand, L., Wu, A., Qu, C., McNeil, C., Coetzee, G., Hayward, C., Deary, I., Harris, S., Theodoratou, E., Reid, S., Walker, M., Ooi, L. Y., Moreno, V., Casey, G., Gruber, S., Tomlinson, I., Zheng, W., Dunlop, M., Houlston, R. & Peters, U., Jan 2023, In: Nature Genetics. 55, 1, p. 89-+ 18 p.

Research output: Contribution to journal › Article › Scientific › peer-review

No evidence of EMAST in whole genome sequencing data from 248 colorectal cancers

Kondelin, J., Martin, S., Katainen, R., Renkonen-Sinisalo, L., Lepistö, A., Koskensalo, S., Böhm, J., Mecklin, J.-P., Cajuso, T., Hänninen, U. A., Välimäki, N., Ravantti, J., Rajamäki, K., Palin, K. & Aaltonen, L. A., Jul 2021, In: Genes, Chromosomes & Cancer. 60, 7, p. 463-473 11 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

PRACTICAL Consortium, Law, P. J., Timofeeva, M., Fernandez-Rozadilla, C., Palin, K., Hänninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A.-P., Eriksson, J. G., Jousilahti, P., Ripatti, S., Palotie, A., Renkonen-Sinisalo, L., Lepistö, A., Aaltonen, L. A., Rissanen, H. & Salomaa, V. & 3 others, Böhm, J., Mecklin, J.-P. & Pukkala, E., 14 May 2019, In: Nature Communications. 10, 15 p., 2154.

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Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans

Kaasinen, E., Kuismin, O., Rajamäki, K., Ristolainen, H., Aavikko, M., Kondelin, J., Saarinen, S., Berta, D. G., Katainen, R., Hirvonen, E. A. M., Karhu, A., Taira, A., Tanskanen, T., Alkodsi, A., Taipale, M., Morgunova, E., Franssila, K., Lehtonen, R., Mäkinen, M. & Aittomäki, K. & 15 others, Palotie, A., Kurki, M., Pietiläinen, O., Hilpert, M., Saarentaus, E., Niinimäki, J., Junttila, J., Kaikkonen, K., Vahteristo, P., Skoda, R. C., Seppänen, M. R. J., Eklund, K. K., Taipale, J., Kilpivaara, O. & Aaltonen, L. A., 19 Mar 2019, In: Nature Communications. 10, 17 p., 1252.

Research output: Contribution to journal › Article › Scientific › peer-review