• PL 56 (Viikinkaari 5)

    00014

    Finland

20022020

Research output per year

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Publications

2020

Localized reconstruction in Scipion expedites the analysis of symmetry mismatches in cryo-EM data

Abrishami, V., Ilca, S. L., Gómez-Blanco, J., Rissanen, I., de la Rosa-Trevín, J. M., Reddy, V. S., Carazo, J. M. & Huiskonen, J. T., 26 May 2020, (Accepted/In press) In : Progress in Biophysics & Molecular Biology. 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2019

Assembly of complex viruses exemplified by a halophilic euryarchaeal virus

De Colibus, L., Roine, E., Walter, T. S., Ilca, S. L., Wang, X., Wang, N., Roseman, A. M., Bamford, D., Huiskonen, J. T. & Stuart, D., 29 Mar 2019, In : Nature Communications. 10, 9 p., 1456.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Assessment of Immunogenicity and Efficacy of a Zika Vaccine Using Modified Vaccinia Ankara Virus as Carriers.

López-Camacho, C., Kim, Y. C., Abbink, P., Larocca, R. A., Huiskonen, J. T., Barouch, D. H. & Reyes-Sandoval, A., 2 Nov 2019, In : Pathogens. 8, 4, 11 p., E216.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus

Lopez-Camacho, C., Kim, Y. C., Blight, J., Moreli, M. L., Montoya-Diaz, E., Huiskonen, J. T., Kuemmerer, B. M. & Reyes-Sandoval, A., Apr 2019, In : Viruses. 11, 4, 17 p., 322.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus

Ilca, S., Sun, X., El Omari, K., Kotecha, A., Haas, F. D., DiMaio, F., Grimes, J. M., Stuart, D. I., Poranen, M. M. & Huiskonen, J. T., 13 Jun 2019, In : Nature. 570, p. 252-+

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Structures of enveloped virions determined by cryogenic electron microscopy and tomography: Advances in Virus Research

Stass, R., Ng, W. M., Kim, Y. C. & Huiskonen, J. T., 1 Aug 2019, Complementary Strategies to Study Virus Structure and Function. Rey, F. A. (ed.). Academic Press, Vol. 105. p. 35-71 37 p. (Advances in Virus Research).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Open Access
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The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

Bushell, S. R., Pike, A. C. W., Falzone, M. E., Rorsman, N. J. G., Ta, C. M., Corey, R. A., Newport, T. D., Christianson, J. C., Scofano, L. F., Shintre, C. A., Tessitore, A., Chu, A., Wang, Q., Shrestha, L., Mukhopadhyay, S. M. M., Love, J. D., Burgess-Brown, N. A., Sitsapesan, R., Stansfeld, P. J., Huiskonen, J. T. & 3 others, Tammaro, P., Accardi, A. & Carpenter, E. P., 2 Sep 2019, In : Nature Communications. 10, 16 p., 3956.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

El Omari, K., Li, S., Kotecha, A., Walter, T. S., Bignon, E., Harlos, K., Somerharju, P., Haas, F. D., Clare, D., Molin, M., Hurtado, F., Li, M., Grimes, J. M., Bamford, D. H., Tischler, N. D., Huiskonen, J. T., Stuart, D. I. & Roine, E., 19 Feb 2019, In : Nature Communications. 10, 11 p., 846.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways.

Wu, Q., Liang, S., Ochi, T., Chirgadze, D. Y., Huiskonen, J. T. & Blundell, T. L., 20 Jan 2019, In : Progress in Biophysics & Molecular Biology.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus

Allen, E. R., Krumm, S. A., Raghwani, J., Halldorsson, S., Elliott, A., Graham, V. A., Koudriakova, E., Harlos, K., Wright, D., Warimwe, G. M., Brennan, B., Huiskonen, J. T., Dowall, S. D., Elliott, R. M., Pybus, O. G., Burton, D. R., Hewson, R., Doores, K. J. & Bowden, T. A., 26 Dec 2018, In : Cell Reports. 25, 13, p. 3750-+ 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Beyond structures of highly symmetric purified viral capsids by cryo-EM

Stass, R., Ilca, S. L. & Huiskonen, J. T., Oct 2018, In : Current Opinion in Structural Biology. 52, p. 25-31 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

Renner, M., Flanagan, A., Dejnirattisai, W., Puttikhunt, C., Kasinrerk, W., Supasa, P., Wongwiwat, W., Chawansuntati, K., Duangchinda, T., Cowper, A., Midgley, C. M., Malasit, P., Huiskonen, J. T., Mongkolsapaya, J., Screaton, G. R. & Grimes, J. M., Nov 2018, In : Nature immunology.. 19, 11, p. 1248-+ 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dual Role of a Viral Polymerase in Viral Genome Replication and Particle Self-Assembly

Sun, X., Ilca, S. L., Huiskonen, J. T. & Poranen, M. M., 2018, In : mBio. 9, 5, 14 p., ARTN e01242-18.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes

Huiskonen, J. T., 27 Apr 2018, In : Bioscience Reports. 38, 2, 13 p., 20170203.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

Kaur, G., Kaundal, S., Kapoor, S., Grimes, J. M., Huiskonen, J. T. & Thakur, K. G., 4 Jul 2018, In : Scientific Reports. 8, 13 p., 10124.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Shielding and activation of a viral membrane fusion protein

Halldorsson, S., Li, S., Li, M., Harlos, K., Bowden, T. A. & Huiskonen, J. T., 24 Jan 2018, In : Nature Communications. 9, 1, 9 p., 349.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Structure of the Lassa virus glycan shield provides a model for immunological resistance

Watanabe, Y., Raghwani, J., Allen, J. D., Seabright, G. E., Li, S., Moser, F., Huiskonen, J. T., Strecker, T., Bowden, T. A. & Crispin, M., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. 7320-7325 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Towards in cellulo virus crystallography

Duyvesteyn, H. M. E., Ginn, H. M., Pietila, M. K., Wagner, A., Hattne, J., Grimes, J. M., Hirvonen, E., Evans, G., Parsy, M-L., Sauter, N. K., Brewster, A. S., Huiskonen, J. T., Stuart, D. I., Sutton, G. & Bamford, D. H., 28 Feb 2018, In : Scientific Reports. 8, 7 p., 3771.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Building bridges between cellular and molecular structural biology

Patwardhan, A., Brandt, R., Butcher, S. J., Collinson, L., Gault, D., Grunewald, K., Hecksel, C., Huiskonen, J. T., Iudin, A., Jones, M. L., Korir, P. K., Koster, A. J., Lagerstedt, I., Lawson, C. L., Mastronarde, D., McCormick, M., Parkinson, H., Rosenthal, P. B., Saalfeld, S., Saibil, H. R. & 7 others, Sarntivijai, S., Valero, I. S., Subramaniam, S., Swedlow, J. R., Tudose, I., Winn, M. & Kleywegt, G. J., 6 Jul 2017, In : eLife. 6, 11 p., 25835.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Double-stranded RNA virus outer shell assembly by bona fide domain-swapping

Sun, Z., El Omari, K., Sun, X., Ilca, S., Kotecha, A., Stuart, D., Poranen, M. M. & Huiskonen, J. T., Mar 2017, In : Nature Communications. 8, p. 14814

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

Wilkes, M., Madej, M. G., Kreuter, L., Rhinow, D., Heinz, V., De Sanctis, S., Ruppel, S., Richter, R. M., Joos, F., Grieben, M., Pike, A. C. W., Huiskonen, J. T., Carpenter, E. P., Kuhlbrandt, W., Witzgall, R. & Ziegler, C., Feb 2017, In : Nature Structural and Molecular Biology. 24, 2, p. 123-+ 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability

Wang, X., Li, S-H., Zhu, L., Nian, Q-G., Yuan, S., Gao, Q., Hu, Z., Ye, Q., Li, X-F., Xie, D-Y., Shaw, N., Wang, J., Walter, T. S., Huiskonen, J. T., Fry, E. E., Qin, C-F., Stuart, D. I. & Rao, Z., 26 Apr 2017, In : Nature Communications. 8, 9 p., 14.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus

Kotecha, A., Wang, Q., Dong, X., Ilca, S. L., Ondiviela, M., Zihe, R., Seago, J., Charleston, B., Fry, E. E., Abrescia, N. G. A., Springer, T. A., Huiskonen, J. T. & Stuart, D. I., 23 May 2017, In : Nature Communications. 8, 8 p., 15408.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope

Rissanen, I., Stass, R., Zeltina, A., Li, S., Hepojoki, J., Harlos, K., Gilbert, R. J. C., Huiskonen, J. T. & Bowden, T. A., Nov 2017, In : Journal of Virology. 91, 21, 11 p., UNSP e00378-17.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

Grieben, M., Pike, A. C. W., Shintre, C. A., Venturi, E., El-Ajouz, S., Tessitore, A., Shrestha, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Burgess-Brown, N. A., Sitsapesan, R., Huiskonen, J. T. & Carpenter, E. P., Feb 2017, In : Nature Structural and Molecular Biology. 24, 2, p. 114-+ 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation

Malik, N., Kotecha, A., Gold, S., Asfor, A., Ren, J., Huiskonen, J. T., Tuthill, T. J., Fry, E. E. & Stuart, D. I., Sep 2017, In : PLoS Pathogens. 13, 9, 14 p., 1006607.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging

Ptchelkine, D., Gillum, A., Mochizuki, T., Lucas-Staat, S., Liu, Y., Krupovic, M., Phillips, S. E. V., Prangishvili, D. & Huiskonen, J. T., 10 Nov 2017, In : Nature Communications. 8, 6 p., 1436.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Virus found in a boreal lake links ssDNA and dsDNA viruses

Laanto, E., Mantynen, S., De Colibus, L., Marjakangas, J., Gillum, A., Stuart, D. I., Ravantti, J. J., Huiskonen, J. T. & Sundberg, L-R., 1 Aug 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8378-8383 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike

Li, S., Sun, Z., Pryce, R., Parsy, M-L., Fehling, S. K., Schlie, K., Siebert, C. A., Garten, W., Bowden, T. A., Strecker, T. & Huiskonen, J. T., Feb 2016, In : PLoS Pathogens. 12, 2, 18 p., 1005418.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

A Molecular-Level Account of the Antigenic Hantaviral Surface

Li, S., Rissanen, I., Zeltina, A., Hepojoki, J., Raghwani, J., Harlos, K., Pybus, O. G., Huiskonen, J. T. & Bowden, T. A., 3 May 2016, In : Cell Reports. 15, 5, p. 959-967 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Editorial overview: Virus structure and assembly: Virions - from structure and physics to design principles

Zlotnick, A. & Huiskonen, J. T., Jun 2016, In : Current opinion in virology. 18, p. VII-VIII 2 p.

Research output: Contribution to journalArticleScientific

Open Access
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Low pH and Anionic Lipid-dependent Fusion of Uukuniemi Phlebovirus to Liposomes

Bitto, D., Halldorsson, S., Caputo, A. & Huiskonen, J. T., 18 Mar 2016, In : Journal of Biological Chemistry. 291, 12, p. 6412-6422 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

Renner, M., Bertinelli, M., Leyrat, C., Paesen, G. C., de Oliveira, L. F. S., Huiskonen, J. T. & Grimes, J. M., 15 Feb 2016, In : eLife. 5, 12 p., 12627.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

Halldorsson, S., Behrens, A-J., Harlos, K., Huiskonen, J. T., Elliott, R. M., Crispin, M., Brennan, B. & Bowden, T. A., 28 Jun 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7154-7159 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2015

Determination of N-linked Glycosylation in Viral Glycoproteins by Negative Ion Mass Spectrometry and Ion Mobility.

Bitto, D., Harvey, D. J., Halldorsson, S., Doores, K. J., Pritchard, L. K., Huiskonen, J. T., Bowden, T. A. & Crispin, M., 2015, In : Methods in molecular biology. 1331, p. 93-121 29 p.

Research output: Contribution to journalArticleScientificpeer-review

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

Ilca, S. L., Kotecha, A., Sun, X., Poranen, M. M., Stuart, D. I. & Huiskonen, J. T., 4 Nov 2015, In : Nature Communications. 6, 8 p., 8843.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design

Kotecha, A., Seago, J., Scott, K., Burman, A., Loureiro, S., Ren, J., Porta, C., Ginn, H. M., Jackson, T., Perez-Martin, E., Siebert, C. A., Paul, G., Huiskonen, J. T., Jones, I. M., Esnouf, R. M., Fry, E. E., Maree, F. F., Charleston, B. & Stuart, D. I., Oct 2015, In : Nature Structural and Molecular Biology. 22, 10, p. 788-794 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Structure of the bacteriophage phi6 nucleocapsid solved to 3.9 angstrom resolution using electron cryomicroscopy

Sun, Z., Sun, X., Ilca, S., De Colibus, L., Stuart, D. I., Poranen, M. M. & Huiskonen, J. T., Jul 2015, In : The FEBS Journal. 282, S1, p. 51-52 2 p.

Research output: Contribution to journalMeeting AbstractResearch

2014

Averaging of Viral Envelope Glycoprotein Spikes from Electron Cryotomography Reconstructions using Jsubtomo

Huiskonen, J. T., Parsy, M-L., Li, S., Bitto, D., Renner, M. & Bowden, T. A., Oct 2014, In : Journal of Visualized Experiments. 92, 11 p., 51714.

Research output: Contribution to journalArticleScientificpeer-review

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

Leyrat, C., Renner, M., Harlos, K., Huiskonen, J. T. & Grimes, J. M., 19 May 2014, In : eLife. 3, 43 p., 02674.

Research output: Contribution to journalArticleScientificpeer-review

Structural Plasticity of the Semliki Forest Virus Glycome upon Interspecies Transmission

Crispin, M., Harvey, D. J., Bitto, D., Bonomelli, C., Edgeworth, M., Scrivens, J. H., Huiskonen, J. T. & Bowden, T. A., Mar 2014, In : Journal of Proteome Research. 13, 3, p. 1702-1712 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Structure and Self-Assembly of the Calcium Binding Matrix Protein of Human Metapneumovirus

Leyrat, C., Renner, M., Harlos, K., Huiskonen, J. T. & Grimes, J. M., 7 Jan 2014, In : Structure. 22, 1, p. 136-148 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome

Crispin, M., Harvey, D. J., Bitto, D., Halldorsson, S., Bonomelli, C., Edgeworth, M., Scrivens, J. H., Huiskonen, J. T. & Bowden, T. A., Sep 2014, In : Journal of Virology. 88, 17, p. 10244-10251 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Crystal Structure of Venezuelan Hemorrhagic Fever Virus Fusion Glycoprotein Reveals a Class 1 Postfusion Architecture with Extensive Glycosylation

Parsy, M-L., Harlos, K., Huiskonen, J. T. & Bowden, T. A., Dec 2013, In : Journal of Virology. 87, 23, p. 13070-13075 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus

York, A., Hengrung, N., Vreede, F. T., Huiskonen, J. T. & Fodor, E., 5 Nov 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 45, p. E4238-E4245 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Orthobunyavirus Ultrastructure and the Curious Tripodal Glycoprotein Spike

Bowden, T. A., Bitto, D., McLees, A., Yeromonahos, C., Elliott, R. M. & Huiskonen, J. T., May 2013, In : PLoS Pathogens. 9, 5, 10 p., 1003374.

Research output: Contribution to journalArticleScientificpeer-review

The Structure of Herpesvirus Fusion Glycoprotein B-Bilayer Complex Reveals the Protein-Membrane and Lateral Protein-Protein Interaction

Maurer, U. E., Zeev-Ben-Mordehai, T., Pandurangan, A. P., Cairns, T. M., Hannah, B. P., Whitbeck, J. C., Eisenberg, R. J., Cohen, G. H., Topf, M., Huiskonen, J. T. & Gruenewald, K., 6 Aug 2013, In : Structure. 21, 8, p. 1396-1405 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Cryo Electron Tomography of Herpes Simplex Virus during Axonal Transport and Secondary Envelopment in Primary Neurons

Ibiricu, I., Huiskonen, J. T., Doehner, K., Bradke, F., Sodeik, B. & Gruenewald, K., Dec 2011, In : PLoS Pathogens. 7, 12, 11 p., 1002406.

Research output: Contribution to journalArticleScientificpeer-review

Eisosome-driven plasma membrane organization is mediated by BAR domains

Ziolkowska, N. E., Karotki, L., Rehman, M., Huiskonen, J. T. & Walther, T. C., Jul 2011, In : Nature Structural and Molecular Biology. 18, 7, p. 854-856 3 p.

Research output: Contribution to journalArticleScientificpeer-review