Photo of Juha Klefström
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1990 …2020

Research output per year

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Publications

  • 41 Article
  • 7 Review Article
  • 1 Anthology or special issue
  • 1 Chapter
2020

Terve elämä! näin voimme paremmin tulevaisuudessa

Pesonen, A-K., Erkkola, M., Jalanka, J., Haahtela, T., Särkämö, T., Mars, N., Ripatti, S., Nyström, M., Klefström, J. & Kemppainen, L., 15 Jan 2020, Gaudeamus. 190 p. (Tiedekulmapokkari 1: Terve elämä!)

Research output: Book/ReportAnthology or special issueGeneral public

UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis

Qiao, X., Liu, Y., Prada, M. L., Mohan, A. K., Gupta, A., Jaiswal, A., Sharma, M., Merisaari, J., Haikala, H. M., Talvinen, K., Yetukuri, L., Pylvänäinen, J. W., Klefström, J., Kronqvist, P., Meinander, A., Aittokallio, T., Hietakangas, V., Eilers, M. & Westermarck, J., 1 Apr 2020, In : Cancer Research. 80, 7, p. 1414-1427 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2019

Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology

Damalanka, V. C., Han, Z., Karmakar, P., O'Donoghue, A. J., La Greca, F., Kim, T., Pant, S. M., Helander, J., Klefström, J., Craik, C. S. & Janetka, J. W., 24 Jan 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 480-490 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Mistä merkitys ykkösille ja nollille?

Klefström, J., 2019, In : Sic! Lääketietoa Fimeasta. 9, 3-4, p. 22-23 2 p.

Research output: Contribution to journalArticleProfessional

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Haikala, H. M., Anttila, J. M., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., Von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A. I., Otonkoski, T., Schüler, J., Laajala, T. D., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P. & 7 others, Leidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J. D. & Klefström, J., 6 Feb 2019, In : Nature Communications. 10, 17 p., 620.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Strain-Stiffening of Agarose Gels

Bertula, K., Martikainen, L., Munne, P., Hietala, S., Klefström, J., Ikkala, O. & Nonappa, D., Jun 2019, In : Acs macro letters. 8, 6, p. 670-675 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2018

Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture

Pant, S. M., Belitskin, D., Ala-Hongisto, H., Klefström, J. & Tervonen, T. A., 2018, PROTEASES AND CANCER: METHODS AND PROTOCOLS . Cal, S. & Obaya, A. J. (eds.). TOTOWA, NJ : Humana press, p. 169-178 10 p. (Methods in Molecular Biology ; vol. 1731).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

Pant, S. M., Mukonoweshuro, A., Desai, B., Ramjee, M. K., Selway, C. N., Tarver, G. J., Wright, A. G., Birchall, K., Chapman, T. M., Tervonen, T. A. & Klefström, J., 24 May 2018, In : Journal of Medicinal Chemistry. 61, 10, p. 4335-4347 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Kuinka pitää syöpä hengissä?

Munne, P. M., Savelius, M., Juopperi, I., Räty, I. & Klefström, J., 2018, In : Duodecim. 134, 8, p. 784-792 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Myc requires RhoA/SRF to reprogram glutamine metabolism

Haikala, H. M., Marques, E., Turunen, M. & Klefström, J., 4 May 2018, In : Small GTPases. 9, 3, p. 274-282 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Phenotype-driven identification of epithelial signalling clusters

Marques, E., Peltola, T., Kaski, S. & Klefstrom, J., 5 Mar 2018, In : Scientific Reports. 8, 13 p., 4034.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2017

MYC and AMPK-Save Energy or Die!

Haikala, H. M., Anttila, J. M. & Klefström, J., 11 Apr 2017, In : Frontiers in Cell and Developmental Biology. 5, 12 p., 38.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File
2016

Data integration to prioritize drugs using genomics and curated data

Louhimo, R. I., Laakso, M., Belitskin, D., Klefstrom, J., Lehtonen, R. & Hautaniemi, S., 26 May 2016, In : BioData mining. 9, 13 p., 21.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

Tervonen, T. A., Belitskin, D., Pant, S. M., Englund, J. I., Marques, E., Ala-Hongisto, H., Nevalaita, L., Sihto, H., Heikkila, P., Leidenius, M., Hewitson, K., Ramachandra, M., Moilanen, A., Joensuu, H., Kovanen, P. E., Poso, A. & Klefstrom, J., 7 Apr 2016, In : Oncogene. 35, 14, p. 1832-1846 15 p.

Research output: Contribution to journalArticleScientificpeer-review

MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures

Haikala, H. M., Klefstrom, J., Eilers, M. & Wiese, K. E., 1 Feb 2016, In : Cell Cycle. 15, 3, p. 316-323 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers

Marques, E., Englund, J. I., Tervonen, T. A., Virkunen, E., Laakso, M., Myllynen, M., Mäkelä, A., Ahvenainen, M., Lepikhova, T., Monni, O., Hautaniemi, S. & Klefstrom, J., 17 Mar 2016, In : Oncogene. 35, 11, p. 1386-1398 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2015

Par6 family proteins in cancer

De Oliveira Marques, E. & Klefström, J. T., 2015, In : Oncoscience. 2, 11, p. 894-895 2 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells

Wiese, K. E., Haikala, H. M., von Eyss, B., Wolf, E., Esnault, C., Rosenwald, A., Treisman, R., Klefstrom, J. & Eilers, M., 3 Jun 2015, In : EMBO Journal. 34, 11, p. 1554-1571 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation

Myant, K., Qiao, X., Halonen, T., Come, C., Laine, A., Janghorban, M., Partanen, J. I., Cassidy, J., Ogg, E-L., Cammareri, P., Laitera, T., Okkeri, J., Klefstrom, J., Sears, R. C., Sansom, O. J. & Westermarck, J., 11 Aug 2015, In : Cell Reports. 12, 6, p. 1019-1031 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Suppression of Early Hematogenous Dissemination of Human Breast Cancer Cells to Bone Marrow by Retinoic Acid-Induced 2

Werner, S., Brors, B., Eick, J., Marques, E., Pogenberg, V., Parret, A., Kemming, D., Wood, A. W., Edgren, H., Neubauer, H., Streichert, T., Riethdorf, S., Bedi, U., Baccelli, I., Juecker, M., Eils, R., Fehm, T., Trumpp, A., Johnsen, S. A., Klefstrom, J. & 4 others, Wilmanns, M., Mueller, V., Pantel, K. & Wikman, H., May 2015, In : Cancer Discovery. 5, 5, p. 506-519 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

Hickman, J. A., Graeser, R., de Hoogt, R., Vidic, S., Brito, C., Gutekunst, M., van der Kuip, H., IMI PREDECT Consortium, Kallioniemi, O., Klefström, J. & Monni, O. M., Sep 2014, In : Biotechnology Journal. 9, 9, p. 1115-1128 14 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2013

Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4

Partanen, J. I., Tervonen, T. A. & Klefstrom, J., 5 Nov 2013, In : Philosophical Transactions of the Royal Society. Biological Sciences. 368, 1629, 12 p., 20130111.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells

Khanna, A., Kauko, O., Böckelman, C., Laine, A., Schreck, I., Partanen, J. I., Szwajda, A., Bormann, S., Bilgen, T., Helenius, M., Pokharel, Y. R., Pimanda, J., Russel, M. R., Haglund, C., Cole, K. A., Klefstrom, J., Aittokallio, T., Weiss, C., Ristimaki, A., Visakorpi, T. & 1 others, Westermarck, J., 15 Nov 2013, In : Cancer Research. 73, 22, p. 6757-6769 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis

Nieminen, A. I., Eskelinen, V. M., Haikala, H. M., Tervonen, T. A., Yan, Y., Partanen, J. I. & Klefström, J., 14 May 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 20, p. E1839-E1848 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Impact of Epithelial Organization on Myc Expression and Activity

Partanen, J. I. & Klefstrom, J., 2012, In : Cancer Research. 72, 4, p. 1035-1035 1 p.

Research output: Contribution to journalArticleScientific

Miksi syöpä leviää, voiko sitä estää?

Klefström, J., 2012, In : Duodecim. 128, 18, p. 1830-1832 3 p.

Research output: Contribution to journalArticleScientific

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

Partanen, J. I., Tervonen, T. A., Myllynen, M., Lind, E., Imai, M., Katajisto, P., Dijkgraaf, G. J. P., Kovanen, P. E., Makela, T. P., Werb, Z. & Klefstrom, J., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, p. E388-E397 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Faulty Epithelial Polarity Genes and Cancer

Tervonen, T. A., Partanen, J. I., Saarikoski, S. T., Myllynen, M., Marques, E., Paasonen, K., Moilanen, A., Wohlfahrt, G., Kovanen, P. E. & Klefström, J., 2011, In : Advances in Cancer Research. 111, p. 97-161 65 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2010

GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis

Kyrönlahti, A., Kauppinen, M., Lind, E., Unkila-Kallio, L., Butzow, R., Klefström, J., Wilson, D. B., Anttonen, M. & Heikinheimo, M., 2010, In : Endocrine - Related Cancer. 17, 3, p. 709-717 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of cell death in human fetal and adult ovaries-Role of Bok and Bcl-X-L

Jääskeläinen, M., Nieminen, A., Pökkylä, R-M., Kauppinen, M., Liakka, A., Heikinheimo, M., Vaskivuo, T. E., Klefström, J. & Tapanainen, J. S., 2010, In : Molecular and Cellular Endocrinology. 330, p. 17-24 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

3D view to tumor suppression Lkb1, polarity and the arrest of oncogenic c-Myc

Partanen, J. I., Nieminen, A. I. & Klefström, J., 2009, In : Cell Cycle. 8, p. 716-724 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation

Rajecki, M., af Hällström, T., Hakkarainen, T., Nokisalmi, P., Hautaniemi, S., Nieminen, A. I., Tenhunen, M., Rantanen, V., Desmond, R. A., Chen, D-T., Guse, K., Stenman, U-H., Gargini, R., Kapanen, M., Klefström, J., Kanerva, A., Pesonen, S., Ahtiainen, L. & Hemminki, A., 2009, In : International Journal of Cancer. 125, 10, p. 2441-2449 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer

Heinonen, H., Nieminen, A., Saarela, M., Kallioniemi, A., Klefström, J., Hautaniemi, S. & Monni, O., 2008, In : BMC Genomics. 9, 348, p. 1-12 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Soluviljelyn uudet ulottuvuudet: muovilta matriksiin

Partanen, J. & Klefström, J., 2008, In : Duodecim. 124, p. 2444-2451 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc

Nieminen, A., Partanen, J. & Klefström, J., 2007, In : Cell Cycle. 6, 20, p. 2464-2472 9 p.

Research output: Contribution to journalArticleScientificpeer-review

c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis

Nieminen, A., Partanen, J., Hau, A. & Klefström, J., 2007, In : EMBO Journal. 26, p. 1055-1067 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway

Klefström, J., Verschuren, E. & Evan, G., 2002, In : Journal of Biological Chemistry. 277, 45, p. 43224-43232 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo

Verschuren, E. W., Klefström, J., Evan, G. I. & Jones, N., 2002, In : Cancer Cell. 2, p. 229-241 13 p.

Research output: Contribution to journalArticleScientificpeer-review

1999

c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors

Klefström, J., Kovanen, P. E., Somersalo, K., Hueber, A. O., Littlewood, T., Evan, G. I., Greenberg, A. H., Saksela, E., Timonen, T. & Alitalo, K., 1999, In : Oncogene. 18, p. 2181-2188 8 p.

Research output: Contribution to journalArticleScientificpeer-review

1998

Similarities between TNF and exogenous oxidants on the cytotoxic response of c-Myc-expressing fibroblasts in vitro

Kinnula, V. L., Aito, H., Klefström, J., Alitalo, K. & Raivio, K. O., 1998, In : Cancer Letters. 125, 1-2, p. 191-198 8 p.

Research output: Contribution to journalArticleScientificpeer-review

1997

BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma

Monni, O., Joensuu, H., Franssila, K., Klefström, J., Alitalo, K. & Knuutila, S., 1997, In : Blood. 90, p. 1168-1174 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

Enholm, B., Paavonen, K., Ristimaki, A., Kumar, V., Gunji, Y., Klefström, J., Kivinen, L., Laiho, M., Olofsson, B., Joukov, V., Eriksson, U. & Alitalo, K., 1997, In : Oncogene. 14, p. 2475-2483 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Induction of TNF-sensitive cellular phenotype by c-myc involves p53 and impaired NF-kappa B activation

Klefström, J., Arighi, E., Littlewood, T., Jaattela, M., Saksela, E., Evan, G. I. & Alitalo, K., 1997, In : EMBO Journal. 16, p. 7382-7392 11 p.

Research output: Contribution to journalArticleScientificpeer-review

1994

C-MYC INDUCES CELLULAR-SUSCEPTIBILITY TO THE CYTOTOXIC ACTION OF TNF-ALPHA

Klefström, J., VASTRIK, I., SAKSELA, E., VALLE, J., EILERS, M. & ALITALO, K., 1994, In : EMBO Journal. 13, p. 5442-5450 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Major and minor breakpoint sites of chromosomal translocation t(14;18) in subtypes of non-Hodgkin lymphomas

Klefström, J., FRANSSILA, K., Peltomäki, P., KAARTINEN, M., SOLIN, M. L. & Knuutila, S., 1994, In : Leukemia Research. 18, p. 245-250 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Two novel human B-cell lymphoma lines of lymphatic follicle origin: cytogenetic, molecular genetic and histopathological characterisation

Knuutila, S., Klefström, J., SZYMANSKA, J., LAKKALA, T., Peltomäki, P., ERAY, M., TEERENHOVI, L., ELONEN, E., FRANSSILA, K. O. & KAARTINEN, M., 1994, In : European Journal of Haematology. 52, p. 65-72 8 p.

Research output: Contribution to journalArticleScientificpeer-review

1993

A SUB-SET OF IMMEDIATE-EARLY MESSENGER-RNAS INDUCED BY TUMOR-NECROSIS-FACTOR-ALPHA DURING CELLULAR CYTOTOXIC AND NONCYTOTOXIC RESPONSES

Klefström, J., KOSKINEN, P. J., SAKSELA, E., JAATTELA, M., BRAVO, R. & ALITALO, K., 1993, In : International Journal of Cancer. 55, p. 655-659 5 p.

Research output: Contribution to journalArticleScientificpeer-review

1990

Polymeraasiketjureaktion (PCR) käyttö non-Hodgkin-lymfoomien diagnostiikassa

Translated title of the contribution: The use of polymerase chain reaction in the diagnosis of non-Hodgkin lymphomasKlefström, J., Kaartinen, M., Peltomäki, P. T., Solin, M-L., Franssila, K. & Knuutila, S., 1990, In : Duodecim. 106, p. 1645-1653

Research output: Contribution to journalReview ArticleScientificpeer-review