Juha Klefström

Publications

Research output per year 1990 1994 1997 2007 2012 2013 2015 2016 2018 2019 2020 2021 2022 2023 2023

• 51 Article
• 9 Review Article
• 2 Chapter
• 1 Anthology or special issue
• 1 More
  • 1 Meeting Abstract

Research output per year

Research output per year

Search results

• 2023

  Fibrin Stiffness Regulates Phenotypic Plasticity of Metastatic Breast Cancer Cells

  Heilala, M., Lehtonen, A., Arasalo, O., Peura, A., Pokki, J., Ikkala, O., Nonappa, Klefström, J. & Munne, P. M., Sep 2023, (E-pub ahead of print) In: Advanced Healthcare Materials. 17 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis

  Belitskin, D., Munne, P., Pant, S. M., Anttila, J. M., Suleymanova, I., Belitskina, K., Kirchhofer, D., Janetka, J., Käsper, T., Jalil, S., Pouwels, J., Tervonen, T. A. & Klefström, J., 13 Nov 2023, In: Molecular oncology. 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• MYC-an emerging player in mitochondrial diseases

  Purhonen, J., Klefström, J. & Kallijärvi, J., 4 Sep 2023, In: Frontiers in Cell and Developmental Biology. 11, 12 p., 1257651.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File
• 2022

  Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer

  Lee, J., Housley, F., Yau, C., Nakagawa, R., Winkler, J., Anttila, J. M., Munne, P. M., Savelius, M., Houlahan, K. E., Van de Mark, D., Hemmati, G., Hernandez, G. A., Zhang, Y., Samson, S., Baas, C., Esserman, L. J., van 't Veer, L. J., Rugo, H. S., Curtis, C., Klefström, J., & 2 othersMatloubian, M. & Goga, A., 27 Jun 2022, In: Nature Communications. 13, 1, 12 p., 3671.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Hepsin promotes breast tumor growth signaling via TGF beta-EGFR axis

  Tervonen, T., Belitskin, D., Munne, P., Pant, S., Anttila, J., Belitskina, K., Pouwels, J. & Klefström, J., Oct 2022, In: European Journal of Cancer. 174, Supplement 1 , p. S98 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

• Laminin matrix adhesion regulates basal mammary epithelial cell identity

  Englund, J., Bui, H., Dinc, D. D., Paavolainen, O., McKenna, T., Laitinen, S., Munne, P., Klefström, J., Peuhu, E. & Katajisto, P., Dec 2022, In: Journal of Cell Science. 135, 23, 15 p., jcs260232.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Metformiini ja syöpä

  Anttila, J. M., Savelius, M., Tran Minh, M. & Klefström, J., 2022, In: Duodecim. 138, 11, p. 994-1002 9 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• Sortilin-related receptor is a druggable therapeutic target in breast cancer

  Al-Akhrass, H., Pietilä, M., Lilja, J., Vesilahti, E-M., Anttila, J. M., Haikala, H. M., Munne, P. M., Klefström, J., Peuhu, E. & Ivaska, J., Jan 2022, In: Molecular oncology. 16, 1, p. 116-129 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2021

  ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma

  Filippou, A., Pehkonen, H., Karhemo, P-R., Väänänen, J., Nieminen, A. I., Klefström, J., Grenman, R., Mäkitie, A., Joensuu, H. & Monni, O., 9 Mar 2021, In: Cancers. 13, 5, 21 p., 1170.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Compressive stress-mediated p38 activation required for ER alpha plus phenotype in breast cancer

  Munne, P. M., Martikainen, L., Räty, I., Bertula, K., Nonappa, Ruuska, J., Ala-Hongisto, H., Peura, A., Hollmann, B., Euro, L., Yavuz, K., Patrikainen, L., Salmela, M., Pokki, J., Kivento, M., Väänänen, J., Suomi, T., Nevalaita, L., Mutka, M., Kovanen, P., & 14 othersLeidenius, M., Meretoja, T., Hukkinen, K., Monni, O., Pouwels, J., Sahu, B., Mattson, J., Joensuu, H., Heikkilä, P., Elo, L. L., Metcalfe, C., Junttila, M. R., Ikkala, O. & Klefström, J., 29 Nov 2021, In: Nature Communications. 12, 1, 17 p., 6967.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Hepsin regulates TGF beta signaling via fibronectin proteolysis

  Belitskin, D., Pant, S. M., Munne, P., Suleymanova, I., Belitskina, K., Ala-Hongisto, H., Englund, J., Raatikainen, T., Klezovitch, O., Vasioukhin, V., Li, S., Wu, Q., Monni, O., Kuure, S., Laakkonen, P., Pouwels, J., Tervonen, T. A. & Klefström, J., 4 Nov 2021, In: EMBO Reports. 22, 11, 16 p., 52532.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin

  Tervonen, T. A., Pant, S. M., Belitskin, D., Englund, J. I., Närhi, K., Haglund, C., Kovanen, P. E., Verschuren, E. W. & Klefström, J., 15 Mar 2021, In: Cancer Research. 81, 6, p. 1513-1527 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2020

  Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis

  Utz, B., Turpin, R., Lampe, J., Pouwels, J. & Klefström, J., 30 Oct 2020, In: Scientific Reports. 10, 1, 11 p., 18733.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Huippuluokan hoidot – voiko syövästä parantua?

  Klefström, J., 2020, Terve elämä: Näin voimme paremmin tulevaisuudessa. Asumaa, A. (ed.). Gaudeamus, p. 135-158 23 p. (Tiedekulmapokkari ; no. 1).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › General public

• Terve elämä! näin voimme paremmin tulevaisuudessa

  Pesonen, A-K., Erkkola, M., Jalanka, J., Haahtela, T., Särkämö, T., Mars, N., Ripatti, S., Nyström, M., Klefström, J. & Kemppainen, L., 15 Jan 2020, Gaudeamus. 190 p. (Tiedekulmapokkari 1: Terve elämä!)

  Research output: Book/Report › Anthology or special issue › General public

• UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis

  Qiao, X., Liu, Y., Prada, M. L., Mohan, A. K., Gupta, A., Jaiswal, A., Sharma, M., Merisaari, J., Haikala, H. M., Talvinen, K., Yetukuri, L., Pylvänäinen, J. W., Klefström, J., Kronqvist, P., Meinander, A., Aittokallio, T., Hietakangas, V., Eilers, M. & Westermarck, J., 1 Apr 2020, In: Cancer Research. 80, 7, p. 1414-1427 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2019

  Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology

  Damalanka, V. C., Han, Z., Karmakar, P., O'Donoghue, A. J., La Greca, F., Kim, T., Pant, S. M., Helander, J., Klefström, J., Craik, C. S. & Janetka, J. W., 24 Jan 2019, In: Journal of Medicinal Chemistry. 62, 2, p. 480-490 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Mistä merkitys ykkösille ja nollille?

  Klefström, J., 2019, In: Sic! Lääketietoa Fimeasta. 9, 3-4, p. 22-23 2 p.

  Research output: Contribution to journal › Article › Professional

• Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

  Haikala, H. M., Anttila, J. M., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., Von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A. I., Otonkoski, T., Schüler, J., Laajala, T. D., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P., & 7 othersLeidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J. D. & Klefström, J., 6 Feb 2019, In: Nature Communications. 10, 17 p., 620.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Strain-Stiffening of Agarose Gels

  Bertula, K., Martikainen, L., Munne, P., Hietala, S., Klefström, J., Ikkala, O. & Nonappa, D., Jun 2019, In: Acs macro letters. 8, 6, p. 670-675 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2018

  Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture

  Pant, S. M., Belitskin, D., Ala-Hongisto, H., Klefström, J. & Tervonen, T. A., 2018, PROTEASES AND CANCER: METHODS AND PROTOCOLS . Cal, S. & Obaya, A. J. (eds.). TOTOWA, NJ : Humana press, p. 169-178 10 p. (Methods in Molecular Biology ; vol. 1731).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review

• Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

  Pant, S. M., Mukonoweshuro, A., Desai, B., Ramjee, M. K., Selway, C. N., Tarver, G. J., Wright, A. G., Birchall, K., Chapman, T. M., Tervonen, T. A. & Klefström, J., 24 May 2018, In: Journal of Medicinal Chemistry. 61, 10, p. 4335-4347 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Kuinka pitää syöpä hengissä?

  Munne, P. M., Savelius, M., Juopperi, I., Räty, I. & Klefström, J., 2018, In: Duodecim. 134, 8, p. 784-792 9 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• Myc requires RhoA/SRF to reprogram glutamine metabolism

  Haikala, H. M., Marques, E., Turunen, M. & Klefström, J., 4 May 2018, In: Small GTPases. 9, 3, p. 274-282 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Phenotype-driven identification of epithelial signalling clusters

  Marques, E., Peltola, T., Kaski, S. & Klefstrom, J., 5 Mar 2018, In: Scientific Reports. 8, 13 p., 4034.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2017

  MYC and AMPK-Save Energy or Die!

  Haikala, H. M., Anttila, J. M. & Klefström, J., 11 Apr 2017, In: Frontiers in Cell and Developmental Biology. 5, 12 p., 38.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File
• 2016

  Data integration to prioritize drugs using genomics and curated data

  Louhimo, R. I., Laakso, M., Belitskin, D., Klefstrom, J., Lehtonen, R. & Hautaniemi, S., 26 May 2016, In: BioData mining. 9, 13 p., 21.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

  Tervonen, T. A., Belitskin, D., Pant, S. M., Englund, J. I., Marques, E., Ala-Hongisto, H., Nevalaita, L., Sihto, H., Heikkila, P., Leidenius, M., Hewitson, K., Ramachandra, M., Moilanen, A., Joensuu, H., Kovanen, P. E., Poso, A. & Klefstrom, J., 7 Apr 2016, In: Oncogene. 35, 14, p. 1832-1846 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures

  Haikala, H. M., Klefstrom, J., Eilers, M. & Wiese, K. E., 1 Feb 2016, In: Cell Cycle. 15, 3, p. 316-323 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers

  Marques, E., Englund, J. I., Tervonen, T. A., Virkunen, E., Laakso, M., Myllynen, M., Mäkelä, A., Ahvenainen, M., Lepikhova, T., Monni, O., Hautaniemi, S. & Klefstrom, J., 17 Mar 2016, In: Oncogene. 35, 11, p. 1386-1398 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
• 2015

  Par6 family proteins in cancer

  De Oliveira Marques, E. & Klefström, J. T., 2015, In: Oncoscience. 2, 11, p. 894-895 2 p.

  Research output: Contribution to journal › Review Article › peer-review

• Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells

  Wiese, K. E., Haikala, H. M., von Eyss, B., Wolf, E., Esnault, C., Rosenwald, A., Treisman, R., Klefstrom, J. & Eilers, M., 3 Jun 2015, In: EMBO Journal. 34, 11, p. 1554-1571 18 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Seriiniproteaasi hepsiini avaa ikkunaa rintasyövän syntymekanismeihin

  Tervonen, T. A. & Klefström, J. T., 2015, In: BestPractice - Lääketieteen asiantuntijoiden ammattilehti. 15

  Research output: Contribution to journal › Article › Professional

• Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation

  Myant, K., Qiao, X., Halonen, T., Come, C., Laine, A., Janghorban, M., Partanen, J. I., Cassidy, J., Ogg, E-L., Cammareri, P., Laitera, T., Okkeri, J., Klefstrom, J., Sears, R. C., Sansom, O. J. & Westermarck, J., 11 Aug 2015, In: Cell Reports. 12, 6, p. 1019-1031 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Suppression of Early Hematogenous Dissemination of Human Breast Cancer Cells to Bone Marrow by Retinoic Acid-Induced 2

  Werner, S., Brors, B., Eick, J., Marques, E., Pogenberg, V., Parret, A., Kemming, D., Wood, A. W., Edgren, H., Neubauer, H., Streichert, T., Riethdorf, S., Bedi, U., Baccelli, I., Juecker, M., Eils, R., Fehm, T., Trumpp, A., Johnsen, S. A., Klefstrom, J., & 4 othersWilmanns, M., Mueller, V., Pantel, K. & Wikman, H., May 2015, In: Cancer Discovery. 5, 5, p. 506-519 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2014

  Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

  Hickman, J. A., Graeser, R., de Hoogt, R., Vidic, S., Brito, C., Gutekunst, M., van der Kuip, H., IMI PREDECT Consortium, Kallioniemi, O., Klefström, J. & Monni, O. M., Sept 2014, In: Biotechnology Journal. 9, 9, p. 1115-1128 14 p.

  Research output: Contribution to journal › Review Article › peer-review
• 2013

  Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4

  Partanen, J. I., Tervonen, T. A. & Klefstrom, J., 5 Nov 2013, In: Philosophical Transactions of the Royal Society. Biological Sciences. 368, 1629, 12 p., 20130111.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells

  Khanna, A., Kauko, O., Böckelman, C., Laine, A., Schreck, I., Partanen, J. I., Szwajda, A., Bormann, S., Bilgen, T., Helenius, M., Pokharel, Y. R., Pimanda, J., Russel, M. R., Haglund, C., Cole, K. A., Klefstrom, J., Aittokallio, T., Weiss, C., Ristimaki, A., Visakorpi, T., & 1 othersWestermarck, J., 15 Nov 2013, In: Cancer Research. 73, 22, p. 6757-6769 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis

  Nieminen, A. I., Eskelinen, V. M., Haikala, H. M., Tervonen, T. A., Yan, Y., Partanen, J. I. & Klefström, J., 14 May 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 20, p. E1839-E1848 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2012

  Impact of Epithelial Organization on Myc Expression and Activity

  Partanen, J. I. & Klefstrom, J., 2012, In: Cancer Research. 72, 4, p. 1035-1035 1 p.

  Research output: Contribution to journal › Article › Scientific

• Miksi syöpä leviää, voiko sitä estää?

  Klefström, J., 2012, In: Duodecim. 128, 18, p. 1830-1832 3 p.

  Research output: Contribution to journal › Article › Scientific

• Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

  Partanen, J. I., Tervonen, T. A., Myllynen, M., Lind, E., Imai, M., Katajisto, P., Dijkgraaf, G. J. P., Kovanen, P. E., Makela, T. P., Werb, Z. & Klefstrom, J., 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, p. E388-E397 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2011

  Faulty Epithelial Polarity Genes and Cancer

  Tervonen, T. A., Partanen, J. I., Saarikoski, S. T., Myllynen, M., Marques, E., Paasonen, K., Moilanen, A., Wohlfahrt, G., Kovanen, P. E. & Klefström, J., 2011, In: Advances in Cancer Research. 111, p. 97-161 65 p.

  Research output: Contribution to journal › Review Article › peer-review
• 2010

  GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis

  Kyrönlahti, A., Kauppinen, M., Lind, E., Unkila-Kallio, L., Butzow, R., Klefström, J., Wilson, D. B., Anttonen, M. & Heikinheimo, M., 2010, In: Endocrine - Related Cancer. 17, 3, p. 709-717 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Regulation of cell death in human fetal and adult ovaries-Role of Bok and Bcl-X-L

  Jääskeläinen, M., Nieminen, A., Pökkylä, R-M., Kauppinen, M., Liakka, A., Heikinheimo, M., Vaskivuo, T. E., Klefström, J. & Tapanainen, J. S., 2010, In: Molecular and Cellular Endocrinology. 330, p. 17-24 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2009

  3D view to tumor suppression Lkb1, polarity and the arrest of oncogenic c-Myc

  Partanen, J. I., Nieminen, A. I. & Klefström, J., 2009, In: Cell Cycle. 8, p. 716-724 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation

  Rajecki, M., af Hällström, T., Hakkarainen, T., Nokisalmi, P., Hautaniemi, S., Nieminen, A. I., Tenhunen, M., Rantanen, V., Desmond, R. A., Chen, D-T., Guse, K., Stenman, U-H., Gargini, R., Kapanen, M., Klefström, J., Kanerva, A., Pesonen, S., Ahtiainen, L. & Hemminki, A., 2009, In: International Journal of Cancer. 125, 10, p. 2441-2449 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2008

  Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer

  Heinonen, H., Nieminen, A., Saarela, M., Kallioniemi, A., Klefström, J., Hautaniemi, S. & Monni, O., 2008, In: BMC Genomics. 9, 348, p. 1-12 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Soluviljelyn uudet ulottuvuudet: muovilta matriksiin

  Partanen, J. & Klefström, J., 2008, In: Duodecim. 124, p. 2444-2451 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 2007

  c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc

  Nieminen, A., Partanen, J. & Klefström, J., 2007, In: Cell Cycle. 6, 20, p. 2464-2472 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review