Research output per year
Research output per year
Personal profile
Description of research and teaching
Our group is interested in how neuronal diversity is generated during embryonic development. In particular, we study the mechanisms of intercellular communication and gene regulation, which control neuronal differentiation in a distinct region of the vertebrate brain - the midbrain.
The midbrain contains neurons, such as dopaminergic and GABAergic neurons, which control several aspects of behavior, are involved in psychiatric disease and are targets of medical treatments as well as drugs of abuse. However, their molecular diversity and regulation of their development from neuroepithelial stem cells are poorly understood. We are addressing these questions using a combination of genetic and molecular approaches.
Fields of Science
- 1184 Genetics, developmental biology, physiology
- 3112 Neurosciences
International and National Collaboration
Publications and projects within past five years.
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The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression
Saarikettu, J., Lehmusvaara, S., Pesu, M., Junttila, I., Partanen, J., Sipilä, P., Poutanen, M., Yang, J., Haikarainen, T. & Silvennoinen, O., May 2023, In: FASEB BioAdvances. 5, 5, p. 183-198 16 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Human pluripotent stem cell-derived cells endogenously expressing follicle-stimulating hormone receptors: modeling the function of an inactivating receptor mutation
Lundin, K., Sepponen, K., Väyrynen, P., Liu, X., Yohannes, D. A., Survila, M., Ghimire, B., Känsäkoski, J., Katayama, S., Partanen, J., Vuoristo, S., Paloviita, P., Rahman, N., Raivio, T., Luiro, K., Huhtaniemi, I., Varjosalo, M., Tuuri, T. & Tapanainen, J. S., 29 Apr 2022, In: Molecular Human Reproduction. 28, 5, 13 p., 012.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Neurons gating behavior-developmental, molecular and functional features of neurons in the Substantia Nigra pars reticulata
Partanen, J. & Achim, K., 6 Sept 2022, In: Frontiers in Neuroscience. 16, 13 p., 976209.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
ETV4 and ETV5 drive synovial sarcoma through cell cycle and DUX4 embryonic pathway control
DeSalvo, J., Ban, Y., Li, L., Sun, X., Jiang, Z., Kerr, D. A., Khanlari, M., Boulina, M., Capecchi, M. R., Partanen, J. M., Chen, L., Kondo, T., Ornitz, D. M., Trent, J. C. & Eid, J. E., 1 Jul 2021, In: Journal of Clinical Investigation. 131, 13, 19 p., 141908.Research output: Contribution to journal › Article › Scientific › peer-review
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ADHD-like behaviors caused by inactivation of a transcription factor controlling the balance of inhibitory and excitatory neuron development in the mouse anterior brainstem
Morello, F., Voikar, V., Parkkinen, P., Panhelainen, A., Rosenholm, M., Makkonen, A., Rantamäki, T., Piepponen, P., Aitta-aho, T. & Partanen, J., 21 Oct 2020, In: Translational Psychiatry. 10, 1, 15 p., 357.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
Projects
- 2 Active
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Gene regulation in the developing brainstem and its variation in behavioural disorders
Partanen, J. & Bodington Celma, S.
01/09/2024 → 31/08/2028
Project: Research Council of Finland: Academy Project
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Aivorungon kehityksen geenisäätely
01/04/2024 → 31/03/2025
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
Prizes
Activities
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Examination of doctoral dissertation Jokinen
Juha Partanen (Pre-examiner)
2015Activity: Examination types › Pre-examiner of doctoral thesis
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Examination of doctoral dissertation Zarkada
Juha Partanen (Pre-examiner)
2014Activity: Examination types › Pre-examiner of doctoral thesis
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Examination of doctoral dissertation Hakanen
Juha Partanen (Pre-examiner)
2014Activity: Examination types › Pre-examiner of doctoral thesis
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Suomen kehitysbiologian seura (External organisation)
Juha Partanen (Chair)
2013 → 2015Activity: Membership types › Membership or other role of body in private company/organisation
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Examination of doctoral dissertation Fang
Juha Partanen (Pre-examiner)
2013Activity: Examination types › Pre-examiner of doctoral thesis