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Personal profile

Curriculum vitae

CURRICULUM VITAE

FULL NAME                     Sinisalo,  Juha-Pekka

DATE AND PLACE OF BIRTH  1964, Helsinki              

POSITION ON THE CLOSING DATE

Head of the Department, Heart and Lung Centre HUCH, Cardiovascular laboratory, Helsinki University Central Hospital, Helsinki, Finland

Professor of Cardiology (temp), Helsinki University

EDUCATION AND TRAINING

Licentiate of Medicine, University of Tampere                                                      1990

Doctor of Philosophy in Medical Sciences, University of Helsinki                             2000

Specialist in Internal Medicine, University of Helsinki                                            2001

Specialist in Cardiology, University of Helsinki                                                      2003

Docent in Cardiology, University of Helsinki                                                          2010

PREVIOUS PROFESSIONAL APPOINTMENTS

Interventional Cardiologist in Helsinki University Central Hospital / Cardiovascular laboratory 12th Aug 2003à Jan 2015

Medical teacher in Helsinki University, faculty of Medicine, 5 Months in 2004

Visiting Specialist in Helsinki University Central Hospital / Children Hospital / Department of Congenital Cardiology 12 Months between 2008 and 2012

Head of the Department, Heart and Lung Center HUCH, Cardiovascular laboratory, Jan 2015

Professor of Cardiology (temp), Helsinki University, August 2015

LIST OF PUBLICATIONS

Thesis: J. Sinisalo. Endothelial function in patients with coronary heart disease. Department of Medicine, Divisionof Cardiology, University of Helsinki, Helsinki, Finland. Dissertation 2000.

Hirsh-index = 23 (Sum of Times Cited without self-citations: 6664 on 21th of Dec 2016).

Total of 102 peer reviewed articles.

Average number of publications / year in last 3 years = 14.3

MEMBERSHIPS IN SCIENTIFIC SOCIETIES

The Finnish Medical Society Duodecim- Member                                                      1990→

Finnish Cardiac Society – Member                                                                             1998→         

Secretary of Division of Thrombosis in Finnish Cardiac Society                               2001-2003

OTHER ACADEMIC AND PROFESSIONAL MERITS AND ACTIVITIES

Scientific activity

Part time scientist for 11 years in Prof Markku Nieminen study group 1995→ in Meilahti Hospital, Department of cardiology.

Own study group 2006→ in Heart and Lung Center HUCH:

Main theme: Acute Coronary Syndrome, clinical aspects, genetics and inflammation.

Participating international consortiums

AFGen

CARDIOGRAMplusCD4

GENIUS-CHD consortium

GIANT

ROHGen

NORDCON

MELODY

Supervising 10 thesis at the moment

  1. MD, Johanna Nokelainen, ”Significance of immunology in coronary artery disease. Recognizing antigens ” (in Finnish ”Immunologian merkitys sepelvaltimotaudissa: Sepelvaltimotaudille altistavien antigeenien tunnistaminen”) (Supervising in collaboration with Ass Prof M Lokki).

  2. MD, Satu Vaara, ”Clinical and genetical factors affecting causes of death in acute coronary syndrome” (IN Finnish: Akuutin koronaarisyndroman tyyppiin ja ennusteeseen vaikuttavat kliiniset ja geneettiset tekijät”).

  3. M.Sc Marja Marchesani, ”Characterization of MHC related genes involved in acute coronary syndrome”. (Supervising in collaboration with Ass Prof M Lokki).

  4. M.Sc Elisa Lahtela, “HLA haplotypes predisposing to coronary artery disease”. (Supervising in collaboration with Ass Prof M Lokki).

  5. MD, Jaakko Allonen, “Prognostic factors in ACS” (In Finnish “AKS:n sairastaneiden potilaiden lyhyen- ja pitkänajan ennusteeseen vaikuttavia tekijöitä”). (Supervising in collaboration with Prof M Nieminen).

  6. MD, Mirjami Laivuori, ”Atherosclerosis in peripheral artery disease”. (Supervising in collaboration with Prof  M Venermo).

  7. MD, Harri Hietanen,”Repolarization evaluation with ECG and 24h ambulatory ECG; prognostic value for rhythm problems”. (Supervising in collaboration with MD PhD H Parikka).

  8. MD, Jouni Kuusisto, ”Evaluation of left atrium size with 3D echo: validation, and evaluation for the use of prognosis of atrial fibrillation attacks”. (In Finnish: “Vasemman eteisen tilavuus ja toiminta eteisvärinässä 3D-ultaäänikardiografialla, menetelmän validointi ja soveltuvuus rytmihäiriöön kohdistuvien interventioiden onnistumiseen”). (Supervising in collaboration with MD PhD V Järvinen).

  9. MD, Olavi Parkkonen, “Takotsubo-cardiomyopathy: etiology and pathophysiology”. (In Finnish “Takotsubo kardiomyopatian syntyyn vaikuttavat tekijät: genetiikka ja autonominen hermosto”). Dissertation is planned to take place in December 2015. (Supervising in collaboration with Prof M Nieminen).

Superved thesis

  1. MD, PhD Anil Palikhe “ MHC region and coronary heart disease” (The dissertation on the 23rd May 2008)

  2. MD, PhD Riitta Paakkanen “Major Histocompatibility Complex Genes – Method of Analysis, Association with Acute Coronary Syndromes and Effect on Immune Reactions” (The dissertation on the 15th Mar 2013).

  3. MD, PhD Harri Lindholm “Physiological determinants and assessment of stress and recovery among media workers” (The dissertation on the 18th of October 2013).

  4. M.Sc Efthymia Vlachopoulou, ”Statistical aspects of MHC-region genetics in coronary artery disease”. (Dissertation on the August 2015).

Docent Evaluations:

Docent Hannu Päivä, Tampere University, 2011

Docent Erkki Ilveskoski, Tampere University, 2012

Doctoral Thesis Evaluations:

PhD Yan Ying, Oulu University, 2009

PhD Saara Wittfooth, Turku University, 2009

MD Tuomas Lehtinen-Svahn, Turku University, 2015

OTHER

  1. Permanent Consultant of The Ministry of Social Affairs and Health, Patient Injuries Board 2010-2014

  2. Permanent Member of Committee of Education, Teaching and Research for Heart and Lung Centre HUCH 2013à

  3. Permanent member of The Doctoral Committee of the Faculty of Medicine, Helsinki University, 2014à

  4. Member of the HALO (Controlled introducing of new technology for heath care system) -working group for left atrium appendix closure and stroke prevention for National Institute for Heath and Welfare 2015 

    Reviewer of Grant applications

    For the executive government agency of National Science Centre Poland (Narodowe Centrum Nauki - NCN; http://www.ncn.gov.pl). 2015

External positions

Osastonylilääkäri, HYKS Sydän- ja keuhkokeskus

Keywords

  • 3121 Internal medicine
  • 1184 Genetics, developmental biology, physiology

International and National Collaboration Publications and projects within past five years.

Publications 1998 2019

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data

CARDIo-GRAMPlusC4D Consortium, Patel, R. S., Schmidt, A. F., Kuukasjarvi, P., Nikus, K., Vlachopoulou, E., Lokki, M-L. & Sinisalo, J., Apr 2019, In : Circulation-Genomic and precision medicine. 12, 4, 12 p., 002471.

Research output: Contribution to journalArticleScientificpeer-review

Salivary IgA to MAA-LDL and Oral Pathogens Are Linked to Coronary Disease

Akhi, R., Wang, C., Nissinen, A. E., Kankaanpaa, J., Bloigu, R., Paju, S., Mantyla, P., Buhlin, K., Sinisalo, J., Pussinen, P. J. & Horkko, S., Mar 2019, In : Journal of Dental Research. 98, 3, p. 296-303 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium

Patel, R. S., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M., Howe, L. J., Direk, K., Akerblom, A., Leander, K., Virani, S. S., Kaminski, K. A., Muehlschlegel, J. D., Allayee, H., Almgren, P., Alver, M., Baranova, E., Behloui, H., Boeckx, B., Braund, P. S., Breitling, L. P. & 161 othersDelgado, G., Duarte, N. E., Dube, M-P., Dufresne, L., Eriksson, N., Foco, L., Scholz, M., Gijsberts, C. M., Glinge, C., Gong, Y., Hartiala, J., Heydarpour, M., Hubacek, J. A., Kleber, M., Kofink, D., Kotti, S., Kuukasjarvi, P., Lee, V-V., Leiherer, A., Lenzini, P. A., Levin, D., Lyytikainen, L-P., Martinelli, N., Mons, U., Nelson, C. P., Nikus, K., Pilbrow, A. P., Ploski, R., Sun, Y., Tanck, M. W. T., Tang, W. H. W., Trompet, S., van der Laan, S. W., Van Setten, J., Vilmundarson, R. O., Anselmi, C. V., Vlachopoulou, E., Al Ali, L., Boerwinkle, E., Briguori, C., Carlquist, J. F., Carruthers, K. F., Casu, G., Deanfield, J., Deloukas, P., Dudbridge, F., Engstrom, T., Fitzpatrick, N., Fox, K., Gigante, B., James, S., Lokki, M-L., Lotufo, P. A., Marziliano, N., Mordi, I. R., Muhlestein, J. B., Newton-Cheh, C., Pitha, J., Saely, C. H., Samman-Tahhan, A., Sandesara, P. B., Teren, A., Timmis, A., Van de Werf, F., Wauters, E., Wilde, A. A. M., Ford, I., Stott, D. J., Algra, A., Andreassi, M. G., Ardissino, D., Arsenault, B. J., Ballantyne, C. M., Bergmeijer, T. O., Bezzina, C. R., Body, S. C., Boersma, E. H., Bogaty, P., Bots, M. L., Brenner, H., Brugts, J. J., Burkhardt, R., Carpeggiani, C., Condorelli, G., Cooper-DeHoff, R. M., Cresci, S., Danchin, N., de Faire, U., Doughty, R. N., Drexel, H., Engert, J. C., Fox, K. A. A., Girelli, D., Grobbee, D. E., Hagstrom, E., Hazen, S. L., Held, C., Hemingway, H., Hoefer, I. E., Hovingh, G. K., Jabbari, R., Johnson, J. A., Jukema, J. W., Kaczor, M. P., Kahonen, M., Kettner, J., Kiliszek, M., Klungel, O. H., Lagerqvist, B., Lambrechts, D., Laurikka, J. O., Lehtimaki, T., Lindholm, D., Mahmoodi, B. K., Maitland-van der Zee, A. H., McPherson, R., Melander, O., Metspalu, A., Niemcunowicz-Janica, A., Olivieri, O., Opolski, G., Palmer, C. N., Pasterkamp, G., Pepine, C. J., Pereira, A. C., Pilote, L., Quyyumi, A. A., Richards, A. M., Sanak, M., Siegbahn, A., Simon, T., Sinisalo, J., Smith, J. G., Spertus, J. A., Stender, S., Stewart, A. F. R., Szczeklik, W., Szpakowicz, A., Tardif, J-C., ten Berg, J. M., Tfelt-Hansen, J., Thanassoulis, G., Thiery, J., Torp-Pedersen, C., van der Graaf, Y., Visseren, F. L. J., Waltenberger, J., Weeke, P. E., Van der Harst, P., Lang, C. C., Sattar, N., Cameron, V. A., Anderson, J. L., Brophy, J. M., Pare, G., Horne, B. D., Marz, W., Wallentin, L., Samani, N. J., Hingorani, A. D. & Asselbergs, F. W., Apr 2019, In : Circulation-Genomic and precision medicine. 12, 4, 16 p., 002470.

Research output: Contribution to journalArticleScientificpeer-review

Use of antihypertensive medication after ischemic stroke in young adults and its association with long-term outcome

van Dongen, M. M. E., Aarnio, K., Martinez-Majander, N., Pirinen, J., Sinisalo, J., Lehto, M., Kaste, M., Tatlisumak, T., de Leeuw, F-E. & Putaala, J., 2 Jan 2019, In : Annals of Medicine. 51, 1, p. 68-77 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Aggregatibacter actinomycetemcomitans serotypes associate with periodontal and coronary artery disease status

Pietiäinen, M., Kopra, K. A. E., Vuorenkoski, J., Salminen, A., Paju, S., Mäntylä, P., Buhlin, K., Liljestrand, J. M., Nieminen, M. S., Sinisalo, J., Hyvärinen, K. & Pussinen, P. J., Apr 2018, In : Journal of Clinical Periodontology. 45, 4, p. 413-421 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Projects 2015 2016