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  • PL 22 (Haartmaninkatu 4)

    00014

    Finland

19982019
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Publications 1998 2019

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2019

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data

CARDIo-GRAMPlusC4D Consortium, Patel, R. S., Schmidt, A. F., Kuukasjarvi, P., Nikus, K., Vlachopoulou, E., Lokki, M-L. & Sinisalo, J., Apr 2019, In : Circulation-Genomic and precision medicine. 12, 4, 12 p., 002471.

Research output: Contribution to journalArticleScientificpeer-review

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Tabassum, R., Rämö, J. T., Ripatti, P., Koskela, J. T., Kurki, M., Karjalainen, J., Palta, P., Hassan, S., Nunez-Fontarnau, J., Kiiskinen, T. T. J., Söderlund, S., Matikainen, N., Gerl, M. J., Surma, M. A., Klose, C., Stitziel, N. O., Laivuori, H., Havulinna, A. S., Service, S. K., Salomaa, V. & 240 othersPirinen, M., Jalanko, A., Kaprio, J., Donner, K., Kaunisto, M., Mars, N., Dada, A., Shcherban, A., Ganna, A., Lehisto, A., Kilpeläinen, E., Brein, G., Awaisa, G., Harju, J., Pärn, K., Parolo, P. D. B., Kajanne, R., Lemmelä, S., Sipilä, T. P., Sipilä, T., Lyhs, U., Llorens, V., Niiranen, T., Kristiansson, K., Männikkö, L., Jiménez, M. G., Perola, M., Wong, R., Kilpi, T., Hiekkalinna, T., Järvensivu, E., Kaiharju, E., Mattsson, H., Laukkanen, M., Laiho, P., Lähteenmäki, S., Sistonen, T., Soini, S., Ziemann, A., Lehtonen, A., Lertratanakul, A., Georgantas, B., Riley-Gillis, B., Quarless, D., Rahimov, F., Heap, G., Jacob, H., Waring, J., Davis, J. W., Smaoui, N., Popovic, R., Esmaeeli, S., Waring, J., Matakidou, A., Challis, B., Close, D., Petrovski, S., Karlsson, A., Schleutker, J., Pulkki, K., Virolainen, P., Kallio, L., Mannermaa, A., Heikkinen, S., Kosma, V-M., Chen, C-Y., Runz, H., Liu, J., Bronson, P., John, S., Lahdenperä, S., Eaton, S., Zhou, W., Hendolin, M., Tuovila, O., Pakkanen, R., Maranville, J., Usiskin, K., Hochfeld, M., Plenge, R., Yang, R., Biswas, S., Greenberg, S., Laakkonen, E., Kononen, J., Paloneva, J., Kujala, U., Kuopio, T., Laukkanen, J., Kangasniemi, E., Savinainen, K., Laaksonen, R., Arvas, M., Ritari, J., Partanen, J., Hyvärinen, K., Wahlfors, T., Peterson, A., Oh, D., Chang, D., Teng, E., Strauss, E., Kerchner, G., Chen, H., Chen, H., Schutzman, J., Michon, J., Hunkapiller, J., McCarthy, M., Bowers, N., Lu, T., Bhangale, T., Pulford, D., Waterworth, D., Kulkarni, D., Xu, F., Betts, J., Gordillo, J. E., Hoffman, J., Auro, K., McCarthy, L., Ghosh, S., Ehm, M., Pitkänen, K., Mäkelä, T., Loukola, A., Joensuu, H., Sinisalo, J., Eklund, K., Aaltonen, L., Färkkilä, M., Carpen, O., Kauppi, P., Tienari, P., Ollila, T., Tuomi, T., Meretoja, T., Pitkäranta, A., Turunen, J., Hannula-Jouppi, K., Pikkarainen, S., Seitsonen, S., Koskinen, M., Palomäki, A., Rinne, J., Metsärinne, K., Elenius, K., Pirilä, L., Koulu, L., Voutilainen, M., Juonala, M., Peltonen, S., Aaltonen, V., Loboda, A., Podgornaia, A., Chhibber, A., Chu, A., Fox, C., Diogo, D., Holzinger, E., Eicher, J., Gormley, P., Mehta, V., Wang, X., Kettunen, J., Pylkäs, K., Kalaoja, M., Karjalainen, M., Hinttala, R., Kaarteenaho, R., Vainio, S., Mantere, T., Remes, A., Huhtakangas, J., Junttila, J., Tasanen, K., Huilaja, L., Luodonpää, M., Hautala, N., Karihtala, P., Kauppila, S., Harju, T., Blomster, T., Soininen, H., Harvima, I., Pihlajamäki, J., Kaarniranta, K., Pelkonen, M., Laakso, M., Hiltunen, M., Kiviniemi, M., Kaipiainen-Seppänen, O., Auvinen, P., Kälviäinen, R., Julkunen, V., Malarstig, A., Hedman, Å., Marshall, C., Whelan, C., Lehtonen, H., Parkkinen, J., Linden, K., Kalpala, K., Miller, M., Bing, N., McDonough, S., Chen, X., Hu, X., Wu, Y., Auranen, A., Jussila, A., Uusitalo-Järvinen, H., Kankaanranta, H., Uusitalo, H., Peltola, J., Kähönen, M., Isomäki, P., Laitinen, T., Salmi, T., Muslin, A., Wang, C., Chatelain, C., Xu, E., Auge, F., Call, K., Klinger, K., Crohns, M., Gossel, M., Palin, K., Rivas, M., Siirtola, H., Tabuenca, J. G., Jauhiainen, M., Daly, M. J., Freimer, N. B., Palotie, A., Taskinen, M-R., Simons, K., Ripatti, S. & Project, F., 24 Sep 2019, In : Nature Communications. 10, 1

Research output: Contribution to journalArticleScientificpeer-review

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Saliva and serum immune responses in apical periodontitis

Pietiäinen, M., Liljestrand, J. M., Akhi, R., Buhlin, K., Johansson, A., Paju, S., Salminen, A., Mäntylä, P., Sinisalo, J., Tjäderhane, L., Hörkkö, S. & Pussinen, P., 21 Jun 2019, In : Journal of clinical medicine. 8, 6, 16 p., 889.

Research output: Contribution to journalArticleScientificpeer-review

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Salivary IgA to MAA-LDL and Oral Pathogens Are Linked to Coronary Disease

Akhi, R., Wang, C., Nissinen, A. E., Kankaanpaa, J., Bloigu, R., Paju, S., Mantyla, P., Buhlin, K., Sinisalo, J., Pussinen, P. J. & Horkko, S., Mar 2019, In : Journal of Dental Research. 98, 3, p. 296-303 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO): echocardiography performance protocol

Saeed, S., Gerdts, E., Waje-Andreassen, U., Sinisalo, J. & Putaala, J., Sep 2019, In : Echo research and practice. 6, 3, p. 53-61 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Smoking confounds the periodontal diagnostics using saliva biomarkers

Lahdentausta, L., Paju, S., Mäntylä, P., Buhlin, K., Pietiainen, M., Tervahartiala, T., Nieminen, M. S., Sinisalo, J., Sorsa, T. & Pussinen, P. J., May 2019, In : Journal of Periodontology. 90, 5, p. 475-483 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium

Patel, R. S., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M., Howe, L. J., Direk, K., Akerblom, A., Leander, K., Virani, S. S., Kaminski, K. A., Muehlschlegel, J. D., Allayee, H., Almgren, P., Alver, M., Baranova, E., Behloui, H., Boeckx, B., Braund, P. S., Breitling, L. P. & 161 othersDelgado, G., Duarte, N. E., Dube, M-P., Dufresne, L., Eriksson, N., Foco, L., Scholz, M., Gijsberts, C. M., Glinge, C., Gong, Y., Hartiala, J., Heydarpour, M., Hubacek, J. A., Kleber, M., Kofink, D., Kotti, S., Kuukasjarvi, P., Lee, V-V., Leiherer, A., Lenzini, P. A., Levin, D., Lyytikainen, L-P., Martinelli, N., Mons, U., Nelson, C. P., Nikus, K., Pilbrow, A. P., Ploski, R., Sun, Y., Tanck, M. W. T., Tang, W. H. W., Trompet, S., van der Laan, S. W., Van Setten, J., Vilmundarson, R. O., Anselmi, C. V., Vlachopoulou, E., Al Ali, L., Boerwinkle, E., Briguori, C., Carlquist, J. F., Carruthers, K. F., Casu, G., Deanfield, J., Deloukas, P., Dudbridge, F., Engstrom, T., Fitzpatrick, N., Fox, K., Gigante, B., James, S., Lokki, M-L., Lotufo, P. A., Marziliano, N., Mordi, I. R., Muhlestein, J. B., Newton-Cheh, C., Pitha, J., Saely, C. H., Samman-Tahhan, A., Sandesara, P. B., Teren, A., Timmis, A., Van de Werf, F., Wauters, E., Wilde, A. A. M., Ford, I., Stott, D. J., Algra, A., Andreassi, M. G., Ardissino, D., Arsenault, B. J., Ballantyne, C. M., Bergmeijer, T. O., Bezzina, C. R., Body, S. C., Boersma, E. H., Bogaty, P., Bots, M. L., Brenner, H., Brugts, J. J., Burkhardt, R., Carpeggiani, C., Condorelli, G., Cooper-DeHoff, R. M., Cresci, S., Danchin, N., de Faire, U., Doughty, R. N., Drexel, H., Engert, J. C., Fox, K. A. A., Girelli, D., Grobbee, D. E., Hagstrom, E., Hazen, S. L., Held, C., Hemingway, H., Hoefer, I. E., Hovingh, G. K., Jabbari, R., Johnson, J. A., Jukema, J. W., Kaczor, M. P., Kahonen, M., Kettner, J., Kiliszek, M., Klungel, O. H., Lagerqvist, B., Lambrechts, D., Laurikka, J. O., Lehtimaki, T., Lindholm, D., Mahmoodi, B. K., Maitland-van der Zee, A. H., McPherson, R., Melander, O., Metspalu, A., Niemcunowicz-Janica, A., Olivieri, O., Opolski, G., Palmer, C. N., Pasterkamp, G., Pepine, C. J., Pereira, A. C., Pilote, L., Quyyumi, A. A., Richards, A. M., Sanak, M., Siegbahn, A., Simon, T., Sinisalo, J., Smith, J. G., Spertus, J. A., Stender, S., Stewart, A. F. R., Szczeklik, W., Szpakowicz, A., Tardif, J-C., ten Berg, J. M., Tfelt-Hansen, J., Thanassoulis, G., Thiery, J., Torp-Pedersen, C., van der Graaf, Y., Visseren, F. L. J., Waltenberger, J., Weeke, P. E., Van der Harst, P., Lang, C. C., Sattar, N., Cameron, V. A., Anderson, J. L., Brophy, J. M., Pare, G., Horne, B. D., Marz, W., Wallentin, L., Samani, N. J., Hingorani, A. D. & Asselbergs, F. W., Apr 2019, In : Circulation-Genomic and precision medicine. 12, 4, 16 p., 002470.

Research output: Contribution to journalArticleScientificpeer-review

Takotsubokardiomyopatia

Parkkonen, O. & Sinisalo, J., 2019, In : Sydänääni : Suomen kardiologisen seuran lehti. 30, 1A, p. 205-209 5 p.

Research output: Contribution to journalArticleProfessional

Use of antihypertensive medication after ischemic stroke in young adults and its association with long-term outcome

van Dongen, M. M. E., Aarnio, K., Martinez-Majander, N., Pirinen, J., Sinisalo, J., Lehto, M., Kaste, M., Tatlisumak, T., de Leeuw, F-E. & Putaala, J., 2 Jan 2019, In : Annals of Medicine. 51, 1, p. 68-77 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Aggregatibacter actinomycetemcomitans serotypes associate with periodontal and coronary artery disease status

Pietiäinen, M., Kopra, K. A. E., Vuorenkoski, J., Salminen, A., Paju, S., Mäntylä, P., Buhlin, K., Liljestrand, J. M., Nieminen, M. S., Sinisalo, J., Hyvärinen, K. & Pussinen, P. J., Apr 2018, In : Journal of Clinical Periodontology. 45, 4, p. 413-421 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

Atrial Fibrillation Genetics Conso, Int Stroke Genetics Consortium, Pulit, S. L., Lyytikäinen, L-P., Seppälä, I., Malik, R., Sinisalo, J., Vlachopoulou, E., Lokki, M-L., Tatlisumak, T. & Happola, O., Dec 2018, In : Neurology Genetics. 4, 6, 8 p., 293.

Research output: Contribution to journalArticleScientificpeer-review

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Embolic strokes of undetermined source in young adults: baseline characteristics and long-term outcome

Martinez-Majander, N., Aarnio, K., Pirinen, J., Lumikari, T., Nieminen, T., Lehto, M., Sinisalo, J., Kaste, M., Tatlisumak, T. & Putaala, J., Mar 2018, In : European Journal of Neurology. 25, 3, p. 535-541 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

LifeLines Cohort Study, CHARGE Inflammation Working Grp & Räikkönen, K., 1 Nov 2018, In : American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Immunologic burden links periodontitis to acute coronary syndrome

Liljestrand, J. M., Paju, S., Pietiäinen, M., Buhlin, K., Persson, G. R., Nieminen, M. S., Sinisalo, J., Mäntylä, P. & Pussinen, P. J., Jan 2018, In : Atherosclerosis. 268, p. 177-184 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Kardiologian tutkimustoiminta Suomessa viimeisten 10 vuoden aikana

Huikuri, H., Hartikainen, J., Ylä-Herttuala, S., Sinisalo, J., Airaksinen, J. & Nikus, K., 2018, In : Sydänääni : Suomen kardiologisen seuran lehti. 29, 1A, p. 207-211 5 p.

Research output: Contribution to journalArticleProfessional

Multi-ethnic genome-wide association study for atrial fibrillation

Roselli, C., Chaffin, M. D., Weng, L-C., Aeschbacher, S., Ahlberg, G., Albert, C. M., Almgren, P., Alonso, A., Anderson, C. D., Aragam, K. G., Arking, D. E., Barnard, J., Bartz, T. M., Benjamin, E. J., Bihlmeyer, N. A., Bis, J. C., Bloom, H. L., Boerwinkle, E., Bottinger, E. B., Brody, J. A. & 198 othersCalkins, H., Campbell, A., Cappola, T. P., Carlquist, J., Chasman, D. I., Chen, L. Y., Chen, Y-D. I., Choi, E-K., Choi, S. H., Christophersen, I. E., Chung, M. K., Cole, J. W., Conen, D., Cook, J., Crijns, H. J., Cutler, M. J., Damrauer, S. M., Daniels, B. R., Darbar, D., Delgado, G., Denny, J. C., Dichgans, M., Doerr, M., Dudink, E. A., Dudley, S. C., Esa, N., Esko, T., Eskola, M., Fatkin, D., Felix, S. B., Ford, I., Franco, O. H., Geelhoed, B., Grewal, R. P., Gudnason, V., Guo, X., Gupta, N., Gustafsson, S., Gutmann, R., Hamsten, A., Harris, T. B., Hayward, C., Heckbert, S. R., Hernesniemi, J., Hocking, L. J., Hofman, A., Horimoto, A. R. V. R., Huang, J., Huang, P. L., Huffman, J., Ingelsson, E., Ipek, E. G., Ito, K., Jimenez-Conde, J., Johnson, R., Jukema, J. W., Kaeaeb, S., Kahonen, M., Kamatani, Y., Kane, J. P., Kastrati, A., Kathiresan, S., Katschnig-Winter, P., Kavousi, M., Kessler, T., Kietselaer, B. L., Kirchhof, P., Kleber, M. E., Knight, S., Krieger, J. E., Kubo, M., Launer, L. J., Laurikka, J., Lehtimaki, T., Leineweber, K., Lemaitre, R. N., Li, M., Lim, H. E., Lin, H. J., Lin, H., Lind, L., Lindgren, C. M., Lokki, M-L., London, B., Loos, R. J. F., Low, S-K., Lu, Y., Lyytikainen, L-P., Macfarlane, P. W., Magnusson, P. K., Mahajan, A., Malik, R., Mansur, A. J., Marcus, G. M., Margolin, L., Margulies, K. B., Maerz, W., McManus, D. D., Melander, O., Mohanty, S., Montgomery, J. A., Morley, M. P., Morris, A. P., Mueller-Nurasyid, M., Natale, A., Nazarian, S., Neumann, B., Newton-Cheh, C., Niemeijer, M. N., Nikus, K., Nilsson, P., Noordam, R., Oellers, H., Olesen, M. S., Orho-Melander, M., Padmanabhan, S., Pak, H-N., Pare, G., Pedersen, N. L., Pera, J., Pereira, A., Porteous, D., Psaty, B. M., Pulit, S. L., Pullinger, C. R., Rader, D. J., Refsgaard, L., Ribases, M., Ridker, P. M., Rienstra, M., Risch, L., Roden, D. M., Rosand, J., Rosenberg, M. A., Rost, N., Rotter, J. I., Saba, S., Sandhu, R. K., Schnabel, R. B., Schramm, K., Schunkert, H., Schurman, C., Scott, S. A., Seppala, I., Shaffer, C., Shah, S., Shalaby, A. A., Shim, J., Shoemaker, M. B., Siland, J. E., Sinisalo, J., Sinner, M. F., Slowik, A., Smith, A. V., Smith, B. H., Smith, J. G., Smith, J. D., Smith, N. L., Soliman, E. Z., Sotoodehnia, N., Stricker, B. H., Sun, A., Sun, H., Svendsen, J. H., Tanaka, T., Tanriverdi, K., Taylor, K. D., Teder-Laving, M., Teumer, A., Theriault, S., Trompet, S., Tucker, N. R., Tveit, A., Uitterlinden, A. G., Van Der Harst, P., Van Gelder, I. C., Van Wagoner, D. R., Verweij, N., Vlachopoulou, E., Voelker, U., Wang, B., Weeke, P. E., Weijs, B., Weiss, R., Weiss, S., Wells, Q. S., Wiggins, K. L., Wong, J. A., Woo, D., Worrall, B. B., Yang, P-S., Yao, J., Yoneda, Z. T., Zeller, T., Zeng, L., Lubitz, S. A., Lunetta, K. L. & Ellinor, P. T., Sep 2018, In : Nature Genetics. 50, 9, p. 1225-+ 12 p.

Research output: Contribution to journalArticleScientificpeer-review

New medications targeting triglyceride-rich lipoproteins: Can inhibition of ANGPTL3 or apoC-III reduce the residual cardiovascular risk?

Olkkonen, V. M., Sinisalo, J. & Jauhiainen, M., 2018, In : Atherosclerosis. 272, p. 27-32 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Relation of Use of Red Blood Cell Transfusion After Acute Coronary Syndrome to Long-Term Mortality

Allonen, J., Nieminen, M. S., Hiippala, S. & Sinisalo, J., 15 Jun 2018, In : American Journal of Cardiology. 121, 12, p. 1496-1504 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Saliva and serum biomarkers in periodontitis and coronary artery disease

Lahdentausta, L. S. J., Paju, S., Mäntylä, P., Buhlin, K., Tervahartiala, T., Pietiäinen, M., Alfthan, H. V., Nieminen, M. S., Sinisalo, J., Sorsa, T. A. & Pussinen, P. J., Sep 2018, In : Journal of Clinical Periodontology. 45, 9, p. 1045-1055 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype

Liukkonen, J., Gursoy, U. K., Könönen, E., Gürsoy, M., Metso, J., Salminen, A., Kopra, E., Jauhiainen, M., Mäntylä, P., Buhlin, K., Paju, S., Sorsa, T., Nieminen, M. S., Lokki, M-L., Sinisalo, J. & Pussinen, P. J., Oct 2018, In : Innate Immunity. 24, 7, p. 439-447 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

Ruuth, M., Nguyen, S. D., Vihervaara, T. M., Hilvo, M., Laajala, T. D., Kondadi, P. K., Gistera, A., Lähteenmäki, H., Kittilä, T., Huusko, J., Uusitupa, M., Schwab, U., Savolainen, M. J., Sinisalo, J., Lokki, M-L., Nieminen, M. S., Jula, A., Perola, M., Ylä-Herttula, S., Rudel, L. & 12 othersÖörni, A., Baumann, M., Baruch, A., Laaksonen, R., Ketelhuth, D. F. J., Aittokallio, T., Jauhiainen, M., Käkelä, R., Boren, J., Williams, K. J., Kovanen, P. T. & Öörni, K., 14 Jul 2018, In : European Heart Journal. 39, 27, p. 2562-2573 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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The Accuracy of Left Ventricular and Left Atrial Volumetry Using 64-Slice Computed Tomography: In Vitro Validation Study With Human Cardiac Cadaveric Casts

Järvinen, V., Uusitalo, V., Tolvanen, T., Saraste, A., Kuusisto, J., Sinisalo, J. & Knuuti, J., 2018, In : Journal of Computer Assisted Tomography. 42, 5, p. 754-759 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Validation of 3D echocardiographic volume detection of left atrium by human cadaveric casts

Kuusisto, J. K., Järvinen, V. M. & Sinisalo, J. P., 15 Nov 2018, In : BMC Medical Imaging. 18, 8 p., 43.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Mace, A., Tuke, M. A., Deelen, P., Kristiansson, K., Mattsson, H., Noukas, M., Sapkota, Y., Schick, U., Porcu, E., Rueger, S., McDaid, A. F., Porteous, D., Winkler, T. W., Salvi, E., Shrine, N., Liu, X., Ang, W. Q., Zhang, W., Feitosa, M. F., Venturini, C. & 86 othersvan der Most, P. J., Rosengren, A., Wood, A. R., Beaumont, R. N., Jones, S. E., Ruth, K. S., Yaghootkar, H., Tyrrell, J., Havulinna, A. S., Boers, H., Magi, R., Kriebel, J., Mueller-Nurasyid, M., Perola, M., Nieminen, M., Lokki, M-L., Kahonen, M., Viikari, J. S., Geller, F., Lahti, J., Palotie, A., Koponen, P., Lundqvist, A., Rissanen, H., Bottinger, E. P., Afaq, S., Wojczynski, M. K., Lenzini, P., Nolte, I. M., Sparso, T., Schupf, N., Christensen, K., Perls, T. T., Newman, A. B., Werge, T., Snieder, H., Spector, T. D., Chambers, J. C., Koskinen, S., Melbye, M., Raitakari, O. T., Lehtimaki, T., Tobin, M. D., Wain, L. V., Sinisalo, J., Peters, A., Meitinger, T., Martin, N. G., Wray, N. R., Montgomery, G. W., Medland, S. E., Swertz, M. A., Vartiainen, E., Borodulin, K., Mannisto, S., Murray, A., Bochud, M., Jacquemont, S., Rivadeneira, F., Hansen, T. F., Oldehinkel, A. J., Mangino, M., Province, M. A., Deloukas, P., Kooner, J. S., Freathy, R. M., Pennell, C., Feenstra, B., Strachan, D. P., Lettre, G., Hirschhorn, J., Cusi, D., Heid, I. M., Hayward, C., Mannik, K., Beckmann, J. S., Loos, R. J. F., Nyholt, D. R., Metspalu, A., Eriksson, J. G., Weedon, M. N., Salomaa, V., Franke, L., Reymond, A., Frayling, T. M. & Kutalik, Z., 29 Sep 2017, In : Nature Communications. 8, 11 p., 744.

Research output: Contribution to journalArticleScientificpeer-review

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Epicardial delivery of autologous atrial appendage micrografts during coronary artery bypass surgery-safety and feasibility study

Nummi, A., Nieminen, T., Pätilä, T., Lampinen, M., Lehtinen, M. L., Kivistö, S., Holmström, M., Wilkman, E., Teittinen, K., Laine, M., Sinisalo, J., Kupari, M., Kankuri, E., Juvonen, T., Vento, A., Suojaranta, R., Harjula, A. & The AADC consortium, 2017, In : Pilot and Feasibility Studies. 3, 9 p., 74.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Hydroxychloroquine for the prevention of recurrent cardiovascular events in myocardial infarction patients: rationale and design of the OXI trial

Hartman, O., Kovanen, P. T., Lehtonen, J., Eklund, K. K. & Sinisalo, J-P., 2017, In : European Heart Journal - Cardiovascular Pharmacotherapy. 3, 2, p. 92-97 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Christophersen, I. E., Rienstra, M., Roselli, C., Yin, X., Geelhoed, B., Barnard, J., Lin, H., Arking, D. E., Smith, A. V., Albert, C. M., Chaffin, M., Tucker, N. R., Li, M., Klarin, D., Bihlmeyer, N. A., Low, S-K., Weeke, P. E., Mueller-Nurasyid, M., Smith, J. G., Brody, J. A. & 33 othersNiemeijer, M. N., Doerr, M., Trompet, S., Huffman, J., Gustafsson, S., Schurmann, C., Kleber, M. E., Lyytikainen, L-P., Seppala, I., Malik, R., Horimoto, A. R. V. R., Perez, M., Sinisalo, J., Aeschbacher, S., Theriault, S., Yao, J., Radmanesh, F., Weiss, S., Teumer, A., Choi, S. H., Weng, L-C., Clauss, S., Deo, R., Rader, D. J., Shah, S. H., Sun, A., Hopewell, J. C., Debette, S., Vlachopoulou, E., Lokki, M-L., METASTROKE Consortium ISGC, Neurology Working Grp CHARGE & AFGen Consortium, Jun 2017, In : Nature Genetics. 49, 6, p. 946-+ 10 p.

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Lipopolysaccharide, a possible molecular mediator between periodontitis and coronary artery disease

Liljestrand, J. M., Paju, S., Buhlin, K., Persson, G. R., Sarna, S., Nieminen, M. S., Sinisalo, J., Mäntylä, P. & Pussinen, P. J., 2017, In : Journal of Clinical Periodontology. 44, 8, p. 784–792 9 p.

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Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

Saleheen, D., Zhao, W., Young, R., Nelson, C. P., Ho, W., Ferguson, J. F., Rasheed, A., Ou, K., Nurnberg, S. T., Bauer, R. C., Goel, A., Do, R., Stewart, A. F. R., Hartiala, J., Zhang, W., Thorleifsson, G., Strawbridge, R. J., Sinisalo, J., Kanoni, S., Sedaghat, S. & 32 othersMarouli, E., Kristiansson, K., Zhao, J. H., Scott, R., Gauguier, D., Shah, S. H., Smith, A. V., van Zuydam, N., Cox, A. J., Willenborg, C., Kessler, T., Zeng, L., Province, M. A., Ganna, A., Lind, L., Pedersen, N. L., White, C. C., Joensuu, A., Kleber, M. E., Hall, A. S., Maerz, W., Salomaa, V., O'Donnell, C., Ingelsson, E., Feitosa, M. F., Erdmann, J., Bowden, D. W., Palmer, C. N. A., Gudnason, V., Perola, M., PROMIS & Cardiogramplusc4D, 13 Jun 2017, In : Circulation . 135, 24, p. 2336-+ 45 p.

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Low MMP-8/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIM P-1 may help to differentiate it from acute coronary syndrome

Parkkonen, O., Nieminen, M. T., Vesterinen, P., Tervahartiala, T., Perola, M., Salomaa, V., Jousilahti, P., Sorsa, T., Pussinen, P. & Sinisalo, J-P., 9 Mar 2017, In : PLoS One. 12, 3, 11 p., 0173371.

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Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Triggers, Causes, and Outcome (SECRETO): Rationale and Design

Putaala, J., Martinez-Majander, N., Saeed, S., Yesilot, N., Jäkälä, P., Nerg, O., Tsivgoulis, G., Numminen, H., Gordin, D., von Sarnowski, B., Waje-Andreassen, U., Ylikotila, P., Roine, R. O., Zedde, M., Huhtakangas, J., Fonseca, C., Redfors, P., de Leeuw, FE., Pezzini, A., Kõrv, J. & 21 othersSchneider, S., Tanislav, C., Enzinger, C., Jatuzis, D., Siegerink, B., Marinez-Sanchez, P., Grau, A., Palm, F., Groop, P-H., Lanthier, S., Ten Cate, H., Pussinen, P., Paju, S., Sinisalo, J., Lehto, M., Lindgren, A., Ferro, J., Kittner, S., Fazekas, F., Gerdts, E. & Tatlisumak, T., 2017, In : European Stroke Journal. 2, 2, p. 116-125 10 p.

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Soluble HLA-DR serum levels are associated with smoking but not with acute coronary syndrome

Tolva, J., Paakkanen, R., Jarva, H., Pussinen, P., Havulinna, A. S., Salomaa, V., Sinisalo, J. & Lokki, M-L., 2017, In : Atherosclerosis. 266, p. 58-63 6 p.

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Sydänpussin dreneeraus ja näytteenotto

Sinisalo, J. & Gunn, J., 2017, In : Duodecim. 133, 4, p. 417-423 7 p.

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The problem with non-adherence arising from medical practices

Lapatto-Reiniluoto, O., Sinisalo, J. & Roine, R., Jul 2017, In : European journal of preventive cardiology. 24, 10, p. 1093-1094 2 p.

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Twelve-lead electrocardiogram and mortality in young adults after ischaemic stroke

Pirinen, J., Putaala, J., Aarnio, K., Aro, A. L., Mustanoja, S., Sinisalo, J., Kaste, M., Haapaniemi, E., Tatlisumak, T. & Lehto, M., Mar 2017, In : European Stroke Journal. 2, 1, p. 77-86 10 p.

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2016

Acute-Phase Blood Pressure Levels Correlate With a High Risk of Recurrent Strokes in Young-Onset Ischemic Stroke

Mustanoja, S., Putaala, J., Gordin, D., Tulkki, L., Aarnio, K., Pirinen, J., Surakka, I., Sinisalo, J., Lehto, M. & Tatlisumak, T., Jun 2016, In : Stroke. 47, 6, p. 1593-U450 8 p.

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Are 12-lead ECG findings associated with the risk of cardiovascular events after ischemic stroke in young adults?

Pirinen, J., Putaala, J., Aarnio, K., Aro, A. L., Sinisalo, J., Kaste, M., Haapaniemi, E., Tatlisumak, T. & Lehto, M., 2016, In : Annals of Medicine. 48, 7, p. 532-540 9 p.

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Association of Endodontic Lesions with Coronary Artery Disease

Liljestrand, J. M., Mäntylä, P., Paju, S., Buhlin, K., Kopra, K. A. E., Persson, G. R., Hernandez, M., Nieminen, M. S., Sinisalo, J., Tjäderhane, L. & Pussinen, P. J., Nov 2016, In : Journal of Dental Research. 95, 12, p. 1358-1365 8 p.

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Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke

Seppala, I., Kleber, M. E., Bevan, S., Lyytikainen, L-P., Oksala, N., Hernesniemi, J. A., Makela, K-M., Rothwell, P. M., Sudlow, C., Dichgans, M., Mononen, N., Vlachopoulou, E., Sinisalo, J., Delgado, G. E., Laaksonen, R., Koskinen, T., Scharnagl, H., Kahonen, M., Markus, H. S., Maez, W. & 1 othersLehtimaki, T., 17 Mar 2016, In : Scientific Reports. 6, 10 p., 23207.

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Cardiovascular events after ischemic stroke in young adults: A prospective follow-up study

Aarnio, K., Siegerink, B., Pirinen, J., Sinisalo, J., Lehto, M., Haapaniemi, E., Nave, A-H., Kaste, M., Tatlisumak, T. & Putaala, J., 17 May 2016, In : Neurology. 86, 20, p. 1872-1879 8 p.

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Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides

Kauhanen, D., Sysi-Aho, M., Koistinen, K. M., Laaksonen, R., Sinisalo, J. & Ekroos, K., May 2016, In : Analytical and Bioanalytical Chemistry. 408, 13, p. 3475-3483 9 p.

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Eteiskorvakkeen sulku katetriteitse ja kirurgisesti eteisvärinän hoidossa

Eskola, M., Sinisalo, J., Mäkinen, E., Isojärvi, J., Saijonkari, M. & Keränen, T., 2016, In : Suomen lääkärilehti. 71, 49, p. 2-10 9 p.

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Genetic Risk Scores Predict Recurrence of Acute Coronary Syndrome

Vaara, S., Tikkanen, E., Parkkonen, O., Lokki, M-L., Ripatti, S., Perola, M., Nieminen, M. S. & Sinisalo, J., Apr 2016, In : Circulation. Cardiovascular genetics. 9, 2, p. 172-178 7 p.

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Genetic support for the causal role of insulin in coronary heart disease

Tikkanen, E., Pirinen, M., Sarin, A-P., Havulinna, A. S., Mannisto, S., Saltevo, J., Lokki, M-L., Sinisalo, J., Lundqvist, A., Jula, A., Salomaa, V. & Ripatti, S., 2016, In : Diabetologia. 59, 11, p. 2369-2377 9 p.

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Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential

Kyttala, A., Moraghebi, R., Valensisi, C., Kettunen, J., Andrus, C., Pasumarthy, K. K., Nakanishi, M., Nishimura, K., Ohtaka, M., Weltner, J., Van Handel, B., Parkkonen, O., Sinisalo, J., Jalanko, A., Hawkins, R. D., Woods, N-B., Otonkoski, T. & Trokovic, R., 9 Feb 2016, In : Stem cell reports. 6, 2, p. 200-212 13 p.

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Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome

Sinisalo, J., Vlachopoulou, E., Marchesani, M., Nokelainen, J., Mayranpaa, M. I., Lappalainen, J., Paakkanen, R., Wennerstrom, A., Salli, K., Niemi, H. J., Mannisto, S., Salo, P., Junttila, J., Eskola, M., Nikus, K., Arstila, T. P., Perola, M., Huikuri, H., Karhunen, P. J., Kovanen, P. T. & 8 othersPalotie, A., Havulinna, A. S., Lluis-Ganella, C., Marrugat, J., Elosua, R., Salomaa, V., Nieminen, M. S. & Lokki, M-L., Feb 2016, In : Circulation. Cardiovascular genetics. 9, 1, p. 55-63 9 p.

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