• PL 20 (Tukholmankatu 8)

    00014

    Finland

20082016
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Personal profile

Description of research and teaching

My current work at FIMM is focused on understanding the mechanisms of pathogenesis and drug resistance in hematological malignancies, more specifically in multiple myeloma (MM) and acute myeloid leukemia (AML). This research requires the combination of high throughput drug sensitivity and resistance testing, NGS, and quantitative proteomics. Aims of the work are to identify new treatment strategies for patients with recurrent disease, identify new biomarkers for treatment response, and to develop new methods for patient stratification.

Education/Academic qualification

Biochemistry, Doctor of Philosophy, Faculty of Biological and Environmental Sciences

1 Jan 200923 Jan 2015

Biochemistry, Master of Science, Faculty of Biological and Environmental Sciences

1 Aug 200318 Jun 2008

PhD student / Reseach scientist, Institute of Biotechnology

15 Sep 200830 Apr 2015

Undergraduate student / Research assistant

1 Jun 20031 Aug 2007

University studies in biology and biochemistry, University of Eastern Finland (UEF)

15 Aug 200031 Jul 2003

Fields of Science

  • 1182 Biochemistry, cell and molecular biology
  • Proteomics
  • Immunology
  • Virology
  • 3111 Biomedicine
  • Cancer biology
  • Personalised cancer medicine
  • Haematological malignancies
  • Cancer therapy
  • Translational research
  • 318 Medical biotechnology
  • Drug sensitivity and resistance testing
  • LC-MS/MS based proteomics

International and National Collaboration Publications and projects within past five years.

Publications 2008 2016

HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression

Christensen, M. H., Jensen, S. B., Miettinen, J. J., Luecke, S., Prabakaran, T., Reinert, L. S., Mettenleiter, T., Chen, Z. J., Knipe, D. M., Sandri-Goldin, R. M., Enquist, L. W., Hartmann, R., Mogensen, T. H., Rice, S. A., Nyman, T. A., Matikainen, S. & Paludan, S. R., 27 Jul 2016, In : EMBO Journal. 2016, 35, p. 1385-1399 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Monosodium Urate Activates Src/Pyk2/PI3 Kinase and Cathepsin Dependent Unconventional Protein Secretion From Human Primary Macrophages

Välimäki, E., Miettinen, J. J., Lietzen, N., Matikainen, S. & Nyman, T. A., Mar 2013, In : Molecular & Cellular Proteomics. 12, 3, p. 749-763 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Global Secretome Characterization of Herpes Simplex Virus 1-Infected Human Primary Macrophages

Miettinen, J. J., Matikainen, S. & Nyman, T. A., Dec 2012, In : Journal of Virology. 86, 23, p. 12770-12778 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

Saharinen, P. I., Heloterä, H., Miettinen, J., Norrmen, C., D Amico Lago, G. V., Jeltsch, M., Langenberg, T., Vandevelde, W., Ny, A., Dewerchin, M., Carmeliet, P. & Alitalo, K., 2010, In : Genes & Development. 24, 9, p. 875-880 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

Saharinen, P., Eklund, L., Miettinen, J., Wirkkala, R., Anisimov, A., Winderlich, M., Nottebaum, A., Vestweber, D., Deutsch, U., Koh, G. Y., Olsen, B. R. & Alitalo, K., 2008, In : Nature Cell Biology. 10, 5, p. 527-537 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Projects 2010 2015

Luontaisen immuunivasteen solusignalointiverkostot

Nyman, T., Öhman, T., Söderholm, S., Miettinen, J., Välimäki, E. & Cypryk, W.

Unknown funder

01/08/201331/07/2015

Project: Research project

Vakavalle influenssatautimuodolle altistavat geenit ja taudin uudet biologiset merkkiaineet

Nyman, T., Cypryk, W., Öhman, T., Välimäki, E., Söderholm, S., Miettinen, J., Lietzen, N. & Paidikondala, M.

Unknown funder

01/01/201231/12/2014

Project: Research project

Luontaisen immuunivasteen solusignalointiverkostot

Nyman, T., Öhman, T., Söderholm, S., Välimäki, E., Miettinen, J., Cypryk, W. & Lietzen, N.

Unknown funder

01/08/201031/07/2013

Project: Research project

Luontaisen immuunivasteen solusignalointiverkostot

Nyman, T., Öhman, T., Lietzen, N., Miettinen, J., Söderholm, S., Korolainen, M., Välimäki, E., Cypryk, W. & Paidikondala, M.

Unknown funder

01/08/201031/07/2015

Project: Research project

Luontaisen immuunivasteen aktivoitumisen tutkiminen proteomiikan avulla

Halinen, A., Nyman, T., Lietzen, N., Öhman, T., Söderholm, S., Miettinen, J., Välimäki, E., Cypryk, W., Korolainen, M. & Paidikondala, M.

Unknown funder

01/01/201031/12/2014

Project: Research project

Activities 2004 2019

  • 6 Organisation and participation in conferences, workshops, courses, seminars
  • 1 Membership or other role in research network

24th European Hematology Association (EHA) Congress

Juho Miettinen (Attendee)
13 Jun 201916 Jun 2019

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

European Hematology Association (External organisation)

Juho Miettinen (Member)
2018 → …

Activity: Membership typesMembership or other role in research network

23rd European Hematology Association Congress

Juho Miettinen (Attendee)
14 Jun 201817 Jun 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Helsinki Hematology Day 2017

Juho Miettinen (Attendee)
16 Feb 2017

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

8th Annual Network Meeting of the Nordic EMBL Partnership for Molecular Medicine: Main Meeting

Juho Miettinen (Attendee)
6 Sep 20177 Sep 2017

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars