Research Output per year
Personal profile
Description of research and teaching
My current work at FIMM is focused on understanding the mechanisms of pathogenesis and drug resistance in hematological malignancies, more specifically in multiple myeloma (MM) and acute myeloid leukemia (AML). This research requires the combination of high throughput drug sensitivity and resistance testing, NGS, and quantitative proteomics. Aims of the work are to identify new treatment strategies for patients with recurrent disease, identify new biomarkers for treatment response, and to develop new methods for patient stratification.
Education/Academic qualification
Biochemistry, Doctor of Philosophy, Faculty of Biological and Environmental Sciences
1 Jan 2009 → 23 Jan 2015
Biochemistry, Master of Science, Faculty of Biological and Environmental Sciences
1 Aug 2003 → 18 Jun 2008
PhD student / Reseach scientist, Institute of Biotechnology
15 Sep 2008 → 30 Apr 2015
Undergraduate student / Research assistant
1 Jun 2003 → 1 Aug 2007
University studies in biology and biochemistry, University of Eastern Finland (UEF)
15 Aug 2000 → 31 Jul 2003
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- Proteomics
- Immunology
- Virology
- 3111 Biomedicine
- Cancer biology
- Personalised cancer medicine
- Haematological malignancies
- Cancer therapy
- Translational research
- 318 Medical biotechnology
- Drug sensitivity and resistance testing
- LC-MS/MS based proteomics
International and National Collaboration
Publications and projects within past five years.
Publications 2008 2016
- 5 Article
HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression
Christensen, M. H., Jensen, S. B., Miettinen, J. J., Luecke, S., Prabakaran, T., Reinert, L. S., Mettenleiter, T., Chen, Z. J., Knipe, D. M., Sandri-Goldin, R. M., Enquist, L. W., Hartmann, R., Mogensen, T. H., Rice, S. A., Nyman, T. A., Matikainen, S. & Paludan, S. R., 27 Jul 2016, In : EMBO Journal. 2016, 35, p. 1385-1399 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
Monosodium Urate Activates Src/Pyk2/PI3 Kinase and Cathepsin Dependent Unconventional Protein Secretion From Human Primary Macrophages
Välimäki, E., Miettinen, J. J., Lietzen, N., Matikainen, S. & Nyman, T. A., Mar 2013, In : Molecular & Cellular Proteomics. 12, 3, p. 749-763 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
Global Secretome Characterization of Herpes Simplex Virus 1-Infected Human Primary Macrophages
Miettinen, J. J., Matikainen, S. & Nyman, T. A., Dec 2012, In : Journal of Virology. 86, 23, p. 12770-12778 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development
Saharinen, P. I., Heloterä, H., Miettinen, J., Norrmen, C., D Amico Lago, G. V., Jeltsch, M., Langenberg, T., Vandevelde, W., Ny, A., Dewerchin, M., Carmeliet, P. & Alitalo, K., 2010, In : Genes & Development. 24, 9, p. 875-880 6 p.Research output: Contribution to journal › Article › Scientific › peer-review
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts
Saharinen, P., Eklund, L., Miettinen, J., Wirkkala, R., Anisimov, A., Winderlich, M., Nottebaum, A., Vestweber, D., Deutsch, U., Koh, G. Y., Olsen, B. R. & Alitalo, K., 2008, In : Nature Cell Biology. 10, 5, p. 527-537 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Projects 2010 2015
- 5 Finished
Luontaisen immuunivasteen solusignalointiverkostot
Nyman, T., Öhman, T., Söderholm, S., Miettinen, J., Välimäki, E. & Cypryk, W.
01/08/2013 → 31/07/2015
Project: Research project
Vakavalle influenssatautimuodolle altistavat geenit ja taudin uudet biologiset merkkiaineet
Nyman, T., Cypryk, W., Öhman, T., Välimäki, E., Söderholm, S., Miettinen, J., Lietzen, N. & Paidikondala, M.
01/01/2012 → 31/12/2014
Project: Research project
Luontaisen immuunivasteen solusignalointiverkostot
Nyman, T., Öhman, T., Söderholm, S., Välimäki, E., Miettinen, J., Cypryk, W. & Lietzen, N.
01/08/2010 → 31/07/2013
Project: Research project
Luontaisen immuunivasteen solusignalointiverkostot
Nyman, T., Öhman, T., Lietzen, N., Miettinen, J., Söderholm, S., Korolainen, M., Välimäki, E., Cypryk, W. & Paidikondala, M.
01/08/2010 → 31/07/2015
Project: Research project
Luontaisen immuunivasteen aktivoitumisen tutkiminen proteomiikan avulla
Halinen, A., Nyman, T., Lietzen, N., Öhman, T., Söderholm, S., Miettinen, J., Välimäki, E., Cypryk, W., Korolainen, M. & Paidikondala, M.
01/01/2010 → 31/12/2014
Project: Research project
Activities 2004 2019
24th European Hematology Association (EHA) Congress
Juho Miettinen (Attendee)13 Jun 2019 → 16 Jun 2019
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
European Hematology Association (External organisation)
Juho Miettinen (Member)2018 → …
Activity: Membership types › Membership or other role in research network
23rd European Hematology Association Congress
Juho Miettinen (Attendee)14 Jun 2018 → 17 Jun 2018
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Helsinki Hematology Day 2017
Juho Miettinen (Attendee)16 Feb 2017
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
8th Annual Network Meeting of the Nordic EMBL Partnership for Molecular Medicine: Main Meeting
Juho Miettinen (Attendee)6 Sep 2017 → 7 Sep 2017
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars