Research output per year
Research output per year
Personal profile
Description of research and teaching
My current work at FIMM is focused on understanding the mechanisms of pathogenesis and drug resistance in hematological malignancies, more specifically in multiple myeloma (MM) and acute myeloid leukemia (AML). This research requires the combination of high throughput drug sensitivity and resistance testing, NGS, and quantitative proteomics. Aims of the work are to identify new treatment strategies for patients with recurrent disease, identify new biomarkers for treatment response, and to develop new methods for patient stratification.
Education/Academic qualification
Biochemistry, Doctor of Philosophy, Faculty of Biological and Environmental Sciences
1 Jan 2009 → 23 Jan 2015
Award Date: 23 Jan 2015
Biochemistry, Master of Science, Faculty of Biological and Environmental Sciences
1 Aug 2003 → 18 Jun 2008
Award Date: 18 Jun 2008
PhD student / Reseach scientist, Institute of Biotechnology
15 Sep 2008 → 30 Apr 2015
Undergraduate student / Research assistant
1 Jun 2003 → 1 Aug 2007
University studies in biology and biochemistry, University of Eastern Finland (UEF)
15 Aug 2000 → 31 Jul 2003
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- Proteomics
- Immunology
- Virology
- 3111 Biomedicine
- Cancer biology
- Personalised cancer medicine
- Haematological malignancies
- Cancer therapy
- Translational research
- 318 Medical biotechnology
- Drug sensitivity and resistance testing
- LC-MS/MS based proteomics
- Flow cytometry
International and National Collaboration
Publications and projects within past five years.
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Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Kuusanmäki, H., Dufva, O., Vähä-Koskela, M., Leppä, A-M., Huuhtanen, J., Vänttinen, I., Nygren, P., Klievink, J., Bouhlal, J., Pölönen, P., Zhang, Q., Adnan-Awad, S., Mancebo-Pérez, C., Saad, J., Miettinen, J., Javarappa, K. K., Aakko, S., Ruokoranta, T., Eldfors, S., Heinäniemi, M., & 9 others, 30 Mar 2023, In: Blood. 141, 13, p. 1610-1625 16 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
Casado-Izquierdo, P., Rio-Machin, A., Miettinen, J. J., Bewicke-Copley, F., Rouault-Pierre, K., Krizsán, S., Parsons, A., Rajeeve, V., Miraki-Moud, F., Taussig, D., Bödör, C., Gribben, J., Heckman, C., Fitzgibbon, J. & Cutillas, P. R., 27 Feb 2023, In: Signal Transduction and Targeted Therapy. 8, 1, 14 p., 80.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
P-374: Stratifying Multiple Myeloma Patients for Personalized Therapy Based on TP53 Mutation, Deletion, and Drug Response Profiles
Tsallos, D., Ikonen, N., Miettinen, J., Majumder, MM., Eldfors, S., Parsons, A. O., Suvela, M., Dowling, P., Bazou, D., O´Gorman, P., Lievonen, J., Silvennoinen, R., Anttila, P. & Heckman, C., 2023.Research output: Conference materials › Poster › peer-review
Open Access -
Proteomic and Metabolomic Analysis of Bone Marrow and Plasma from Patients with Extramedullary Multiple Myeloma Identifies Distinct Protein and Metabolite Signatures
Dunphy, K., Bazou, D., Henry, M., Meleady, P., Miettinen, J. J., Heckman, C. A., Dowling, P. & O'Gorman, P., Aug 2023, In: Cancers. 15, 15, 25 p., 3764.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
A Potential Role of NK Cells and ABCB9 in Modulating the Response to Melflufen in Multiple Myeloma
Sergeev, P., Adhikari, S., Miettinen, J. J., Huppunen, M-E., Suvela, M., Slipicevic, A., Nupponen, N. N., Acs, K., Lehmann, F. & Heckman, C. A., Nov 2022, p. 6000–6001. 2 p.Research output: Conference materials › Abstract › peer-review
Open Access
Projects
- 5 Finished
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Luontaisen immuunivasteen solusignalointiverkostot
Nyman, T., Öhman, T., Söderholm, S., Miettinen, J., Välimäki, E. & Cypryk, W.
01/08/2013 → 31/07/2015
Project: Research project
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Vakavalle influenssatautimuodolle altistavat geenit ja taudin uudet biologiset merkkiaineet
Nyman, T., Cypryk, W., Öhman, T., Välimäki, E., Söderholm, S., Miettinen, J., Lietzen, N. & Paidikondala, M.
01/01/2012 → 31/12/2014
Project: Research project
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Luontaisen immuunivasteen solusignalointiverkostot
Nyman, T., Öhman, T., Lietzen, N., Miettinen, J., Söderholm, S., Korolainen, M., Välimäki, E., Cypryk, W. & Paidikondala, M.
01/08/2010 → 31/07/2015
Project: Research project
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Luontaisen immuunivasteen solusignalointiverkostot
Nyman, T., Öhman, T., Söderholm, S., Välimäki, E., Miettinen, J., Cypryk, W. & Lietzen, N.
01/08/2010 → 31/07/2013
Project: Research project
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Luontaisen immuunivasteen aktivoitumisen tutkiminen proteomiikan avulla
Halinen, A., Nyman, T., Lietzen, N., Öhman, T., Söderholm, S., Miettinen, J., Välimäki, E., Cypryk, W., Korolainen, M. & Paidikondala, M.
01/01/2010 → 31/12/2014
Project: Research project
Activities
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Functional Precision Medicine for Blood Cancer
Juho Miettinen (Attendee)
5 Sep 2022 → 7 Sep 2022Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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64th ASH Annual Meeting & Exposition
Juho Miettinen (Attendee)
10 Dec 2022 → 13 Dec 2022Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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24th European Hematology Association (EHA) Congress
Juho Miettinen (Attendee)
13 Jun 2019 → 16 Jun 2019Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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European Hematology Association (External organisation)
Juho Miettinen (Member)
2018 → …Activity: Membership types › Membership or other role in research network
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23rd European Hematology Association Congress
Juho Miettinen (Attendee)
14 Jun 2018 → 17 Jun 2018Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars