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Personal profile

Description of research and teaching

Cell surface glycoconjugates in cell interactions of the nervous system and in bacterial adhesion

Polysialic acid is a neurodevelopmental antigen shared by the neural cell adhesion molecule NCAM and capsular polysaccharides of meningitis-causing bacteria. Polysialic acid regulates cell interactions in neural and other tissues during development, and in learning and memory consolidation. Polysialic acid has a central role in many cellular functions, such as migration, cytokine response and cell contact-dependent differentiation. Altered levels of polysialic acid are detected in various neurological diseases, as well as malignancies including neuroblastoma. The objectives of the project are to elucidate the molecular basis of the regulation of polysialic acid expression and to investigate whether polysialic acid could be used as a target for cytotoxicity of neuroblastoma cells.

Meningitis-causing and other pathogenic bacteria attach to their tissue receptors by adhesin molecules binding to specific carbohydrate ligands on cell surfaces. Characterisation of these molecular interactions sheds light on the pathogenic mechanisms of bacterial diseases, and enables the development of new vaccines and new types of drugs that interfere with bacterial adhesion. We are studying carbohydrate-binding proteins to determine their interaction mechanisms and to develop inhibitors of adhesion that could be used as antibacterials.

See also Glycoscience Group

Education information

Found qualified and competent for Professor of Biochemistry and Pharmaceutical Chemistry, Åbo Akademi, 1982
Found qualified and competent for Professor of Biochemistry, University of Turku, 1983
Found qualified and competent for Professor of Physiological Chemistry, University of Kuopio, 1985
Found qualified and competent for Professor of Medical Chemistry, University of Turku, 1986
Found qualified and competent for Professor of Glycobiology, University of Helsinki, 2007
Found qualified and competent for Professor of Cell and Molecular Biology, University of Helsinki, 2009

Education/Academic qualification

Found qualified and competent for Professor of Biochemistry and Pharmaceutical Chemistry, Åbo Akademi, 1982

Found qualified and competent for Professor of Biochemistry, University of Turku, 1983

Found qualified and competent for Professor of Physiological Chemistry, University of Kuopio, 1985

Found qualified and competent for Professor of Medical Chemistry, University of Turku, 1986

Found qualified and competent for Professor of Glycobiology, University of Helsinki, 2007

Found qualified and competent for Professor of Cell and Molecular Biology, University of Helsinki, 2009

Keywords

  • 1182 Biochemistry, cell and molecular biology
  • 1183 Plant biology, microbiology, virology
  • Microbiology
  • 3111 Biomedicine
  • 3112 Neurosciences
  • 3122 Cancers

International and National Collaboration Publications and projects within past five years.

Publications 1974 2018

Rationally designed chemically modified glycodendrimer inhibits Streptococcus suis adhesin SadP at picomolar concentrations

Haataja, S., Verma, P., Fu, O., Papageorgiou, A. C., Pöysti, S., Pieters, R. J., Nilsson, U. J. & Finne, J., 2018, In : Chemistry: A European Journal. 24, 8, p. 1905-1912 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells

Lehti, T. A., Pajunen, M. I., Skog, M. S. & Finne, J., 4 Dec 2017, In : Nature Communications. 8, 12 p., 1915.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells

Skog, M. S., Nystedt, J., Korhonen, M., Anderson, H., Lehti, T. A., Pajunen, M. I. & Finne, J., 2016, In : Stem Cell Research & Therapy. 7, 12 p., 113.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Endosialidases: Versatile tools for the study of polysialic acid

Jakobsson, E., Schwarzer, D., Jokilammi, A. & Finne, J., 2015, SialoGlyco Chemistry and Biology II : Tools and Techniques to Identify and Capture Sialoglycans. Gerardy-Schahn, R., Delannoy, P. & von Itzstein, M. (eds.). Cham: Springer International Publishing AG, p. 29-73 45 p. (Topics in Current Chemistry; vol. 367).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Projects

Towards picomolar inhibitors of bacterial adhesion

Finne, J., Haataja, S., Nilsson, U. & Pieters, R.

Project: Research project

Role of polysialic acid in human neuroblastoma

Finne, J., Vettenranta, K., Sariola, H., Porkka, K. & Lehti, T.

Project: Research project

Cytotoxic constructs targeting polysialic acid

Lehti, T., Skog, M., Lilie, H., Nacher, J. & Finne, J.

Project: Research project

Activities 1978 2019

The Scientific Board of the University of Helsinki (External organisation)

Jukka Finne (Member)
20132014

Activity: Membership typesMembership or other role in national/international committee, council, board

The Finnish Society of Sciences and Letters (External organisation)

Jukka Finne (Member)
2010 → …

Activity: Membership typesMembership or other role in national/international committee, council, board

Societas Biophysica, Biochimica et Microbiologica Fenniae (External organisation)

Jukka Finne (Board member)
20102012

Activity: Membership typesMembership or other role in national/international committee, council, board

Member of the Council of the Finnish Union of University Professors

Jukka Finne (Participant)
20192020

Activity: Other activity typesTypes for other activities - Other

Societas Biophysica, Biochimica et Microbiologica Fenniae (External organisation)

Jukka Finne (Board member)
2019

Activity: Membership typesMembership or other role in national/international committee, council, board

Press / Media

Interviewed for an article in Acatiimi

Jukka Finne

01/01/2016

1 media contribution

Press/Media: Press / Media

Interviewed for an article in Yliopisto-lehti

Jukka Finne

01/01/2015

1 media contribution

Press/Media: Press / Media

Interviewed for an article in Teknia Journal

Jukka Finne

01/01/1995

1 media contribution

Press/Media: Press / Media

Interviewed for local news program in radio

Jukka Finne

01/01/1989

1 media contribution

Press/Media: Press / Media

Interviewed for local news program in radio

Jukka Finne

01/01/1988

1 media contribution

Press/Media: Press / Media