No photo of Jyrki (P) Kukkonen
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1991 …2019
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Publications 1991 2019

2019

Azulene-based compounds targeting orexin receptors

Leino, T., Turku, A., Yli-Kauhaluoma, J., Kukkonen, J., Xhaard, H. & Wallen, E., 31 Mar 2019, In : Abstracts of papers of the American Chemical Society . 257, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

CRK2 Enhances Salt Tolerance by Regulating Callose Deposition in Connection with PLDα1

Hunter, K., Kimura, S., Rokka, A., Huy Cuong Tran, Toyota, M., Kukkonen, J. P. & Wrzaczek, M., Aug 2019, In : Plant Physiology. 180, 4, p. 2004-2021 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Azulene-based compounds for targeting orexin receptors

Leino, T. O., Turku, A., Yli-Kauhaluoma, J. T., Kukkonen, J. P., Xhaard, H. & Wallén, E. A. A., 5 Sep 2018, In : European Journal of Medicinal Chemistry. 157, p. 88-100 13 p.

Research output: Contribution to journalArticleScientificpeer-review

BAT is independently affected by peripheral and central pathways

Kukkonen, J. P., Mar 2018, In : International Journal of Obesity. 42, 3, p. 584-584 1 p.

Research output: Contribution to journalLetterScientificpeer-review

Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels

Turunen, P. M., Louhivuori, L. M., Louhivuori, V., Kukkonen, J. P. & Akerman, K. E., 1 Apr 2018, In : Neuroscience. 375, p. 135-148 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Pharmacological characterization of the orexin/hypocretin receptor agonist Nag 26

Rinne, M. K., Leino, T. O., Turku, A., Turunen, P. M., Steynen, Y., Xhaard, H., Wallen, E. A. A. & Kukkonen, J. P., 15 Oct 2018, In : European Journal of Pharmacology. 837, p. 137-144 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Stapled truncated orexin peptides as orexin receptor agonists

Karhu, L., Weisell, J., Turunen, P. M., Leino, T. O., Pätsi, H., Xhaard, H., Kukkonen, J. P. & Wallén, E. A. A., Apr 2018, In : Peptides. 102, p. 54-60 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Orexin/Hypocretin Signaling

Kukkonen, J. P., 2017, Behavioral Neuroscience of Orexin/Hypocretin. Lawrence, A. J. & de Lecea, L. (eds.). Cham: Springer , Vol. 33. p. 17-50 34 p. (Current Topics in Behavioral Neurosciences; vol. 33).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Open Access
File

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Thompson, M. D., Sakurai, T., Rainero, I., Maj, M. C. & Kukkonen, J. P., 8 Oct 2017, In : Pharmaceuticals. 10, 4, 20 p., E79.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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2016

G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells

Kukkonen, J. P., 5 Aug 2016, In : Biochemical and Biophysical Research Communications. 476, 4, p. 379-385 7 p.

Research output: Contribution to journalArticleScientificpeer-review

G-protein inhibition profile of the reported G(q/11) inhibitor UBO-QIC

Kukkonen, J. P., 1 Jan 2016, In : Biochemical and Biophysical Research Communications. 469, 1, p. 101-107 7 p.

Research output: Contribution to journalArticleScientificpeer-review

OX2 orexin/hypocretin receptor signal transduction in recombinant Chinese hamster ovary cells

Kukkonen, J. P., Feb 2016, In : Cellular Signalling. 28, 2, p. 51-60 10 p.

Research output: Contribution to journalArticleScientificpeer-review

p75 Neurotrophin Receptor Signaling Activates Sterol Regulatory Element-binding Protein-2 in Hepatocyte Cells via p38 Mitogen-activated Protein Kinase and Caspase-3

Pham, D. D., Do, H. T., Bruelle, C., Kukkonen, J. P., Eriksson, O., Mogollon, I., Korhonen, L., Arumae, U. & Lindholm, D., 13 May 2016, In : Journal of Biological Chemistry. 291, 20, p. 10747-10758 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands

Turku, A., Borrel, A., Leino, T. O., Karhu, L., Kukkonen, J. P. & Xhaard, H., 22 Sep 2016, In : Journal of Medicinal Chemistry. 59, 18, p. 8263-8275 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery

Putula, J., Pihlajamaa, T. & Kukkonen, J. P., 2014, In : British Journal of Pharmacology. 171, 24, p. 5816-5828 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipid signaling cascades of orexin/hypocretin receptors

Kukkonen, J. P., Jan 2014, In : Biochimie. 96, p. 158-165 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Orexin/hypocretin receptor signalling: a functional perspective

Leonard, C. S. & Kukkonen, J. P., Jan 2014, In : British Journal of Pharmacology. 171, 2, p. 294-313 20 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Orexin/hypocretin receptor signalling cascades

Kukkonen, J. P. & Leonard, C. S., 2014, In : British Journal of Pharmacology. 171, 2, p. 314-331 18 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Thompson, M. D., Xhaard, H., Sakurai, T., Rainero, I. & Kukkonen, J. P., 6 May 2014, In : Frontiers in Neuroscience. 8, 12 p., 57.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling

Jäntti, M., Putula, J. S., Turunen, P., Näsman, J., Reijonen, S. P., Lindqvist, C. & Kukkonen, J. P., Mar 2013, In : Molecular pharmacology : an international journal. 83, 3, p. 621-632 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Physiology of the orexinergic/hypocretinergic system: a revisit in 2012

Kukkonen, J. P., 2013, In : American Journal of Physiology: Cell Physiology. 304, 1, p. C2-C32 31 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

THE CONCISE GUIDE TO PHARMACOLOGY 2013/14: OVERVIEW

Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., McGrath, J. C., Catterall, W. A., Spedding, M., Peters, J. A., Harmar, A. J., Abul-Hasn, N., Anderson, CM., Anderson, CMH., Airaksinen, M., Arita, M., Arthofer, E., Barker, EL., Barratt, C., Barnes, NM., Bathgate, R. & 160 othersBeart, PM., Belelli, D., Bennett, AJ., Birdsall, NJ., Boison, D., Bonner, TI., Brailsford, L., Bröer, S., Brown, P., Calo, G., Carter, WG., Catterall, WA., Chan, SL., Chao, MV., Chiang, N., Christopoulos, A., Chun, JJ., Cidlowski, J., Clapham, DE., Cockcroft, S., Connor, MA., Cox, HM., Cuthbert, A., Dautzenberg, FM., Davenport, AP., Dawson, PA., Dent, G., Dijksterhuis, JP., Dollery, CT., Dolphin, AC., Donowitz, M., Dubocovich, ML., Eiden, L., Eidne, K., Evans, BA., Fabbro, D., Fahlke, C., Farndale, R., Fitzgerald, GA., Fong, TM., Fowler, CJ., Fry, JR., Funk, CD., Futerman, AH., Ganapathy, V., Gaisnier, B., Gershengorn, MA., Goldin, A., Goldman, ID., Gundlach, AL., Hagenbuch, B., Hales, TG., Hammond, JR., Hamon, M., Hancox, JC., Hauger, RL., Hay, DL., Hobbs, AJ., Hollenberg, MD., Holliday, ND., Hoyer, D., Hynes, NA., Inui, KI., Ishii, S., Jacobson, KA., Jarvis, GE., Jarvis, MF., Jensen, R., Jones, CE., Jones, RL., Kaibuchi, K., Kanai, Y., Kennedy, C., Kerr, ID., Khan, AA., Klienz, MJ., Kukkonen, J. P., Lapoint, JY., Leurs, R., Lingueglia, E., Lippiat, J., Lolait, SJ., Lummis, SC., Lynch, JW., MacEwan, D., Maguire, JJ., Marshall, IL., May, JM., McArdle, CA., McGrath, JC., Michel, MC., Millar, NS., Miller, LJ., Mitolo, V., Monk, PN., Moore, PK., Moorhouse, AJ., Mouillac, B., Murphy, PM., Neubig, RR., Neumaier, J., Niesler, B., Obaidat, A., Offermanns, S., Ohlstein, E., Panaro, MA., Parsons, S., Pwrtwee, RG., Petersen, J., Pin, JP., Poyner, DR., Prigent, S., Prossnitz, ER., Pyne, NJ., Pyne, S., Quigley, JG., Ramachandran, R., Richelson, EL., Roberts, RE., Roskoski, R., Ross, RA., Roth, M., Rudnick, G., Ryan, RM., Said, SI., Schild, L., Sanger, GJ., Scholich, K., Schousboe, A., Schulte, G., Schulz, S., Serhan, CN., Sexton, PM., Sibley, DR., Siegel, JM., Singh, G., Sitsapesan, R., Smart, TG., Smith, DM., Soga, T., Stahl, A., Stewart, G., Stoddart, LA., Summers, RJ., Thorens, B., Thwaites, DT., Toll, L., Traynor, JR., Usdin, TB., Vandenberg, RJ., Villalon, C., Vore, M., Waldman, SA., Ward, DT., Willars, GB., Wonnacott, SJ., Wright, E., Ye, RD., Yonezawa, A. & Zimmermann, M., 2013, In : British Journal of Pharmacology. 170, 8, p. 1449-1458 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2012

Communication Between the Calcium and cAMP Pathways Regulate the Expression of the TSH Receptor: TRPC2 in the Center of Action

Löf, C., Sukumaran, P., Viitanen, T., Vainio, M., Kemppainen, K., Pulli, I., Näsman, J., Kukkonen, J. P. & Törnquist, K., 2012, In : Molecular Endocrinology. 26, 12, p. 2046-2057 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Mapping of the binding sites for the OX(1) orexin receptor antagonist, SB-334867, using orexin/hypocretin receptor chimaeras

Putula, J. S. & Kukkonen, J. P., 6 Jan 2012, In : Neuroscience Letters. 506, 1, p. 111-115 5 p.

Research output: Contribution to journalArticleScientificpeer-review

OX1 orexin/hypocretin receptor activation of phospholipase D

Jäntti, M., Putula, J., Somerharju, P., Frohman, M. A. & Kukkonen, J. P., 2012, In : British Journal of Pharmacology. 165, 4B, p. 1109-1123 15 p.

Research output: Contribution to journalArticleScientificpeer-review

OX1 Orexin/Hypocretin Receptor Signaling through Arachidonic Acid and Endocannabinoid Release

Turunen, P. M., Jäntti, M. H. & Kukkonen, J. P., 2012, In : Molecular pharmacology : an international journal. 82, 2, p. 156-167 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Recent progress in orexin/hypocretin physiology and pharmacology

Kukkonen, J. P., 2012, In : Biomolecular concepts. 3, 5, p. 447–463

Research output: Contribution to journalReview ArticleScientificpeer-review

2011

Adrenoceptor Activity of Muscarinic Toxins identified from Mamba Venoms

Näreoja, K., Kukkonen, J. P., Rondinelli, S., Toivola, D., Meriluoto, J. & Näsman, J., 2011, In : British Journal of Pharmacology. 164, 2b, p. 538–550

Research output: Contribution to journalArticleScientificpeer-review

Agonist ligand discrimination by the two orexin receptors depends on the expression system

Putula, J. S., Turunen, P., Jäntti, M., Ekholm, M. E. & Kukkonen, J. P., 2011, In : Neuroscience Letters. 494, 1, p. 57-60

Research output: Contribution to journalArticleScientificpeer-review

A ménage à trois made in heaven: G-protein-coupled receptors, lipids and TRP channels

Kukkonen, J. P., 2011, In : Cell Calcium. 50, 1, p. 9-26 18 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus

Putkonen, N., Kukkonen, J. P., Mudo, G., Putula, J., Belluardo, N., Lindholm, D. & Korhonen, L., 2011, In : European Journal of Neuroscience. 34, 8, p. 1212-1221

Research output: Contribution to journalArticleScientificpeer-review

Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction

Putula, J. S., Turunen, P., Johansson, L., Näsman, J., Ra, S-G. R., Korhonen, L. & Kukkonen, J. P., 2011, In : FEBS Letters. 585, 9, p. 1368-1374

Research output: Contribution to journalArticleScientificpeer-review

2010

Arachidonic acid release mediated by OX1 orexin receptors

Turunen, P. M., Ekholm, M. E., Somerharju, P. & Kukkonen, J. P., 2010, In : British Journal of Pharmacology. 159, 1, p. 212-221 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Downregulation of NF-kappa B signaling by mutant huntingtin proteins induces oxidative stress and cell death

Reijonen, S., Kukkonen, J. P., Hyrskyluoto, A., Kivinen, J., Kairisalo, M., Takei, N., Lindholm, D. & Korhonen, L., 2010, In : Cellular and Molecular Life Sciences. 67, 11, p. 1929-1941 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Filtration assay for arachidonic acid release

Turunen, P. M., Putula, J. & Kukkonen, J. P., 2010, In : Analytical Biochemistry. 407, 2, p. 233-236 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Många inträdesprov mäter reflektiva aspekter

Kukkonen, J. P., 29 Apr 2010, In : Hufvudstadsbladet. p. 15 1 p.

Research output: Contribution to journalArticleGeneral public

Octopamine receptors from the barnacle Balanus improvisus are activated by the α2-adrenoceptor agonist medetomidine

Lind, U., Alm Rosenblad, M., Hasselberg Frank, L., Falkbring, S., Brive, L., Laurila, J. M., Pohjanoksa, K., Vuorenpää, A., Kukkonen, J. P., Gunnarsson, L., Scheinin, M., Mårtensson Lindblad, L. G. E. & Blomberg, A., 2010, In : Molecular pharmacology : an international journal. 78, 2, p. 237-48 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Rapid and easy semi-quantitative evaluation method for diacylglycerol and inositol-1,4,5,-trisphosphate generation in orexin receptor signalling

Ekholm, M. E., Johansson, L. & Kukkonen, J. P., 2010, In : Acta Physiologica. 198, 3, p. 387-392 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

An easy ratiometric compensation for the extracellular Ca² indicator-caused fluorescence artifact

Kukkonen, J. P., 2009, In : Analytical Biochemistry. 390, 2, p. 212-214 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Involvement of TRPC3 channels in calcium oscillations mediated by OX orexin receptors

Peltonen, H. M., Magga, J. M., Bart, G., Turunen, P. M., Antikainen, M. S. H., Kukkonen, J. P. & Åkerman, K., 2009, In : Biochemical and Biophysical Research Communications. 385, 3, p. 408-412 5 p.

Research output: Contribution to journalArticleScientificpeer-review

NF-kappa B-dependent regulation of brain-derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein

Kairisalo, M., Korhonen, L., Sepp, M., Pruunsild, P., Kukkonen, J. P., Kivinen, J., Timmusk, T., Blomgren, K. & Lindholm, D., 2009, In : European Journal of Neuroscience. 30, 6, p. 958-966 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Multiple phospholipase activation by OX orexin/hypocretin receptors

Johansson, L., Ekholm, M. E. & Kukkonen, J. P., 2008, In : Cellular and Molecular Life Sciences. 65, 12, p. 1948-1956 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Orexin receptors

Kukkonen, J., 2008, xPharm. Enna, S. J. & Bylund, D. B. (eds.). Elsevier Scientific Publ. Co, p. 5 s.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

OX1 Receptor

Kukkonen, J., 2008, xPharm. Enna, S. J. & Bylund, D. B. (eds.). Elsevier Scientific Publ. Co, p. 11 s.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review