No photo of Jyrki (P) Kukkonen
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1991 …2019
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Publications 1991 2019

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2019

CRK2 Enhances Salt Tolerance by Regulating Callose Deposition in Connection with PLDα1

Hunter, K., Kimura, S., Rokka, A., Huy Cuong Tran, Toyota, M., Kukkonen, J. P. & Wrzaczek, M., Aug 2019, In : Plant Physiology. 180, 4, p. 2004-2021 18 p.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Azulene-based compounds for targeting orexin receptors

Leino, T. O., Turku, A., Yli-Kauhaluoma, J. T., Kukkonen, J. P., Xhaard, H. & Wallén, E. A. A., 5 Sep 2018, In : European Journal of Medicinal Chemistry. 157, p. 88-100 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels

Turunen, P. M., Louhivuori, L. M., Louhivuori, V., Kukkonen, J. P. & Akerman, K. E., 1 Apr 2018, In : Neuroscience. 375, p. 135-148 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Pharmacological characterization of the orexin/hypocretin receptor agonist Nag 26

Rinne, M. K., Leino, T. O., Turku, A., Turunen, P. M., Steynen, Y., Xhaard, H., Wallen, E. A. A. & Kukkonen, J. P., 15 Oct 2018, In : European Journal of Pharmacology. 837, p. 137-144 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Stapled truncated orexin peptides as orexin receptor agonists

Karhu, L., Weisell, J., Turunen, P. M., Leino, T. O., Pätsi, H., Xhaard, H., Kukkonen, J. P. & Wallén, E. A. A., Apr 2018, In : Peptides. 102, p. 54-60 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017
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2016

G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells

Kukkonen, J. P., 5 Aug 2016, In : Biochemical and Biophysical Research Communications. 476, 4, p. 379-385 7 p.

Research output: Contribution to journalArticleScientificpeer-review

G-protein inhibition profile of the reported G(q/11) inhibitor UBO-QIC

Kukkonen, J. P., 1 Jan 2016, In : Biochemical and Biophysical Research Communications. 469, 1, p. 101-107 7 p.

Research output: Contribution to journalArticleScientificpeer-review

OX2 orexin/hypocretin receptor signal transduction in recombinant Chinese hamster ovary cells

Kukkonen, J. P., Feb 2016, In : Cellular Signalling. 28, 2, p. 51-60 10 p.

Research output: Contribution to journalArticleScientificpeer-review

p75 Neurotrophin Receptor Signaling Activates Sterol Regulatory Element-binding Protein-2 in Hepatocyte Cells via p38 Mitogen-activated Protein Kinase and Caspase-3

Pham, D. D., Do, H. T., Bruelle, C., Kukkonen, J. P., Eriksson, O., Mogollon, I., Korhonen, L., Arumae, U. & Lindholm, D., 13 May 2016, In : Journal of Biological Chemistry. 291, 20, p. 10747-10758 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands

Turku, A., Borrel, A., Leino, T. O., Karhu, L., Kukkonen, J. P. & Xhaard, H., 22 Sep 2016, In : Journal of Medicinal Chemistry. 59, 18, p. 8263-8275 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery

Putula, J., Pihlajamaa, T. & Kukkonen, J. P., 2014, In : British Journal of Pharmacology. 171, 24, p. 5816-5828 13 p.

Research output: Contribution to journalArticleScientificpeer-review

OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Thompson, M. D., Xhaard, H., Sakurai, T., Rainero, I. & Kukkonen, J. P., 6 May 2014, In : Frontiers in Neuroscience. 8, 12 p., 57.

Research output: Contribution to journalArticleScientificpeer-review

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2013

Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling

Jäntti, M., Putula, J. S., Turunen, P., Näsman, J., Reijonen, S. P., Lindqvist, C. & Kukkonen, J. P., Mar 2013, In : Molecular pharmacology : an international journal. 83, 3, p. 621-632 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Communication Between the Calcium and cAMP Pathways Regulate the Expression of the TSH Receptor: TRPC2 in the Center of Action

Löf, C., Sukumaran, P., Viitanen, T., Vainio, M., Kemppainen, K., Pulli, I., Näsman, J., Kukkonen, J. P. & Törnquist, K., 2012, In : Molecular Endocrinology. 26, 12, p. 2046-2057 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Mapping of the binding sites for the OX(1) orexin receptor antagonist, SB-334867, using orexin/hypocretin receptor chimaeras

Putula, J. S. & Kukkonen, J. P., 6 Jan 2012, In : Neuroscience Letters. 506, 1, p. 111-115 5 p.

Research output: Contribution to journalArticleScientificpeer-review

OX1 orexin/hypocretin receptor activation of phospholipase D

Jäntti, M., Putula, J., Somerharju, P., Frohman, M. A. & Kukkonen, J. P., 2012, In : British Journal of Pharmacology. 165, 4B, p. 1109-1123 15 p.

Research output: Contribution to journalArticleScientificpeer-review

OX1 Orexin/Hypocretin Receptor Signaling through Arachidonic Acid and Endocannabinoid Release

Turunen, P. M., Jäntti, M. H. & Kukkonen, J. P., 2012, In : Molecular pharmacology : an international journal. 82, 2, p. 156-167 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Adrenoceptor Activity of Muscarinic Toxins identified from Mamba Venoms

Näreoja, K., Kukkonen, J. P., Rondinelli, S., Toivola, D., Meriluoto, J. & Näsman, J., 2011, In : British Journal of Pharmacology. 164, 2b, p. 538–550

Research output: Contribution to journalArticleScientificpeer-review

Agonist ligand discrimination by the two orexin receptors depends on the expression system

Putula, J. S., Turunen, P., Jäntti, M., Ekholm, M. E. & Kukkonen, J. P., 2011, In : Neuroscience Letters. 494, 1, p. 57-60

Research output: Contribution to journalArticleScientificpeer-review

Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus

Putkonen, N., Kukkonen, J. P., Mudo, G., Putula, J., Belluardo, N., Lindholm, D. & Korhonen, L., 2011, In : European Journal of Neuroscience. 34, 8, p. 1212-1221

Research output: Contribution to journalArticleScientificpeer-review

Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction

Putula, J. S., Turunen, P., Johansson, L., Näsman, J., Ra, S-G. R., Korhonen, L. & Kukkonen, J. P., 2011, In : FEBS Letters. 585, 9, p. 1368-1374

Research output: Contribution to journalArticleScientificpeer-review

2010

Arachidonic acid release mediated by OX1 orexin receptors

Turunen, P. M., Ekholm, M. E., Somerharju, P. & Kukkonen, J. P., 2010, In : British Journal of Pharmacology. 159, 1, p. 212-221 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Downregulation of NF-kappa B signaling by mutant huntingtin proteins induces oxidative stress and cell death

Reijonen, S., Kukkonen, J. P., Hyrskyluoto, A., Kivinen, J., Kairisalo, M., Takei, N., Lindholm, D. & Korhonen, L., 2010, In : Cellular and Molecular Life Sciences. 67, 11, p. 1929-1941 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Filtration assay for arachidonic acid release

Turunen, P. M., Putula, J. & Kukkonen, J. P., 2010, In : Analytical Biochemistry. 407, 2, p. 233-236 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Många inträdesprov mäter reflektiva aspekter

Kukkonen, J. P., 29 Apr 2010, In : Hufvudstadsbladet. p. 15 1 p.

Research output: Contribution to journalArticleGeneral public

Octopamine receptors from the barnacle Balanus improvisus are activated by the α2-adrenoceptor agonist medetomidine

Lind, U., Alm Rosenblad, M., Hasselberg Frank, L., Falkbring, S., Brive, L., Laurila, J. M., Pohjanoksa, K., Vuorenpää, A., Kukkonen, J. P., Gunnarsson, L., Scheinin, M., Mårtensson Lindblad, L. G. E. & Blomberg, A., 2010, In : Molecular pharmacology : an international journal. 78, 2, p. 237-48 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Rapid and easy semi-quantitative evaluation method for diacylglycerol and inositol-1,4,5,-trisphosphate generation in orexin receptor signalling

Ekholm, M. E., Johansson, L. & Kukkonen, J. P., 2010, In : Acta Physiologica. 198, 3, p. 387-392 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

An easy ratiometric compensation for the extracellular Ca² indicator-caused fluorescence artifact

Kukkonen, J. P., 2009, In : Analytical Biochemistry. 390, 2, p. 212-214 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Involvement of TRPC3 channels in calcium oscillations mediated by OX orexin receptors

Peltonen, H. M., Magga, J. M., Bart, G., Turunen, P. M., Antikainen, M. S. H., Kukkonen, J. P. & Åkerman, K., 2009, In : Biochemical and Biophysical Research Communications. 385, 3, p. 408-412 5 p.

Research output: Contribution to journalArticleScientificpeer-review

NF-kappa B-dependent regulation of brain-derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein

Kairisalo, M., Korhonen, L., Sepp, M., Pruunsild, P., Kukkonen, J. P., Kivinen, J., Timmusk, T., Blomgren, K. & Lindholm, D., 2009, In : European Journal of Neuroscience. 30, 6, p. 958-966 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Multiple phospholipase activation by OX orexin/hypocretin receptors

Johansson, L., Ekholm, M. E. & Kukkonen, J. P., 2008, In : Cellular and Molecular Life Sciences. 65, 12, p. 1948-1956 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Sequence features of HLA-DRB1 locus define putative basis for gene conversion and point mutations

von Salome, J. & Kukkonen, J. P., 2008, In : BMC Genomics. 9, 228, 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

IP3-independent signalling of OX1 orexin/hypocretin receptors to Ca2+ influx and ERK

Ekholm, M. E., Johansson, L. & Kukkonen, J. P., 2007, In : Biochemical and Biophysical Research Communications. 353, 2, p. 475-80 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of OX1 orexin/hypocretin receptor-coupling to phospholipase C by Ca2+ influx

Johansson, L., Ekholm, M. E. & Kukkonen, J. P., 2007, In : British Journal of Pharmacology. 150, 1, p. 97-104 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Agonist potency differentiates G protein activation and Ca2+ signalling by the orexin receptor type 1

Magga, J., Bart, G., Oker-Blom, C., Kukkonen, J. P., Akerman, K. E. & Nasman, J., 2006, In : Biochemical Pharmacology. 71, 6, p. 827-836 10 p.

Research output: Contribution to journalArticleScientificpeer-review

G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase

Ammoun, S., Lindholm, D. B., Wotz, H., Åkerman, K. & Kukkonen, J. P., 2006, In : Journal of Biological Chemistry. 281, 2, p. 834-842 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Hippocalcin protects against caspase-12-induced and age-dependent neuronal degeneration

Korhonen, L., Hansson, I., Kukkonen, J. P., Brannvall, K., Kobayashi, M., Takamatsu, K. & Lindholm, D., 2005, In : Molecular and Cellular Neuroscience. 28, 1, p. 85-95 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution

Lagerstrom, M. C., Fredriksson, R., Bjarnadottir, T. K., Fridmanis, D., Holmquist, T., Andersson, J., Yan, Y. L., Raudsepp, T., Zoorob, R., Kukkonen, J. P., Lundin, L. G., Klovins, J., Chowdhary, B. P., Postlethwait, J. H. & Schioth, H. B., 2005, In : Genomics. 85, 6, p. 688-703 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Pharmacological characterization of ligand-receptor interactions at the zebrafish bradykinin receptor

Bromee, T., Kukkonen, J. P., Andersson, P., Conlon, J. M. & Larhammar, D., 2005, In : British Journal of Pharmacology. 144, 1, p. 11-16 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Ca2+-dependent potentiation of muscarinic receptor-mediated Ca2+ elevation

Åkerman, K., Shariatmadari, R., Krjukova, J., Larsson, K. P., Courtney, M. J. & Kukkonen, J. P., 2004, In : Cell Calcium. 36, 5, p. 397-408

Research output: Contribution to journalArticleScientificpeer-review

Explicit formulation of different receptor-G-protein interactions and effector regulation

Kukkonen, J. P., 2004, In : Bioinformatics. 20, 15, p. 2411-20 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation

Krjukova, J., Holmqvist, T., Danis, A. S., Akerman, K. E. & Kukkonen, J. P., 2004, In : British Journal of Pharmacology. 143, 1, p. 3-7 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Distinct recognition of OX1 and OX2 receptors by orexin peptides

Ammoun, S., Holmqvist, T., Shariatmadari, R., Oonk, H. B., Detheux, M., Parmentier, M., Åkerman, K. & Kukkonen, J. P., 2003, In : Journal of Pharmacology and Experimental Therapeutics. 305, 2, p. 507-14 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system

Ringholm, A., Klovins, J., Fredriksson, R., Poliakova, N., Larson, E. T., Kukkonen, J. P., Larhammar, D. & Schioth, H. B., 2003, In : European Journal of Biochemistry. 270, 2, p. 213-21 9 p.

Research output: Contribution to journalArticleScientificpeer-review