Photo of Kalle Saksela
  • PL 21 (Haartmaninkatu 3)

    00014

    Finland

  • PL 21 (Haartmaninkatu 3), E354

    HELSINGIN YLIOPISTO

    Finland

  • Finland

1984 …2019
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Personal profile

Curriculum vitae

Kalle M. Saksela

     Born September 10, 1962 in Philadelphia, PA, USA.

Education:

        MD, 1989 (University of Helsinki)

        PhD, 1989 (University of Helsinki)           

Professional history:

2005- Professor of Virology and Chairman of Department of Virology,

    University of Helsinki.

2005- Chief Physician, HUSLAB, Helsinki University Hospital.

1996-2005: Professor of Molecular Medicine. Institute for Medical Technology.

    University of Tampere. Finland.

1996-2000 Adjunct Professor associated with the laboratory of James Darnell Jr.

    The Rockefeller University, New York.

1994-1996 Assistant Professor. The Rockefeller University, New York.

1991-1994: Postdoctoral Fellow with David Baltimore at the Rockefeller University,

    New York.

1991-1991: Postdoctoral Fellow with David Baltimore at the Whitehead

    Institute for Biomedical Research, Cambridge, MA.

1989-1990: Research Fellow, Department of Virology, University of Helsinki.

1984-1989: MD/PhD student with Kari Alitalo at the Department of Virology,

    University of Helsinki

Description of research and teaching

The HIV Nef protein has been a key subject of our research, Nef modifies host cell physiology to better support viral replication by binding to proteins involved in cellular signal structures via their SH3 domains. SH3 domains are the most ubiquitous class of modular protein binding units found in the nature. SH3 domains mediate many key regulatory processes in normal cells and are involved the pathomechanisms of many important diseases. It appears that many other viral proteins also share the capacity of Nef to utilize binding to host cell SH3 proteins in order to mediate their functions. Identification of normal SH3-mediated cellular protein interaction networks as well as SH3-interactions that take place between cellular and pathogenic viral proteins, and elucidation of the molecular basis of binding affinity and specificity involved in these interactions are the main topics goals of our research.

Key topics:

- Virus-host cell interplay

- Protein interactions

- SH3 domains

- miRNA and viruses

- Viral non-structural proteins

- Protein engineering

Keywords

  • 3111 Biomedicine
  • 311 Basic medicine

International and National Collaboration Publications and projects within past five years.

Publications 1984 2019

  • 63 Article
  • 4 Chapter
  • 3 Review Article
  • 1 Conference contribution

Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA

Ylösmäki, E., Hakkarainen, T., Hemminki, A., Visakorpi, T., Andino, R. & Saksela, K., 2008, In : Journal of Virology. 82, 22, p. 11009-11015 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling

Heikkinen, L. S., Kazlauskas, A., Melen, K., Wagner, R., Ziegler, T., Julkunen, I. & Saksela, K., 2008, In : Journal of Biological Chemistry. 283, 9, p. 5719-5727 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation

Vingadassalom, D., Kazlauskas, A., Skehan, B., Cheng, H-C., Magoun, L., Robbins, D., Rosen, M. K., Saksela, K. & Leong, J. M., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6754-6759 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome

Kärkkäinen, S., Hiipakka, M., Wang, J-H., Kleino, I., Vähä-Jaakkola, M., Renkema, G. H., Liss, M., Wagner, R. & Saksela, K., 2006, In : EMBO Reports. 7, 2, p. 186-191 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly

Aitio, O., Hellman, M., Kazlauskas, A., Vingadassalom, D. F., Leong, J. M., Saksela, K. & Permi, P., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21743-21748 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Prizes

Aaron Diamond Foundation Junior Faculty Award

Kalle Saksela (Recipient), 1994

Prize: Prizes and awards

Activities 2005 2011

Univeristy of Helsinki (External organisation)

Kalle Saksela (Member)
2007 → …

Activity: Membership typesMembership or other role in public Finnish or international organization

University of Helsinki (External organisation)

Kalle Saksela (Member)
2010 → …

Activity: Membership typesMembership or other role in public Finnish or international organization

University of Helsinki (External organisation)

Kalle Saksela (Member)
2009 → …

Activity: Membership typesMembership or other role in public Finnish or international organization

Kyoto University

Kalle Saksela (Other role)
7 Mar 201110 Mar 2011

Activity: Visiting an external institution typesAcademic visit to other institution

Ongoing PhD supervision - Contanze Schmotz

Kalle Saksela (Supervisor)
2011 → …

Activity: Examination typesSupervisor or co-supervisor of doctoral thesis

Press / Media

Tv-uutiset (News)

Kalle Saksela

21/05/2010

1 media contribution

Press/Media: Press / Media

Interview, Yle: Tiede ja tekniikka

Kalle Saksela

01/01/2010

1 media contribution

Press/Media: Press / Media