Research output per year
Research output per year
PL 21 (Haartmaninkatu 3)
00014
Finland
PL 21 (Haartmaninkatu 3), E354
HELSINGIN YLIOPISTO
Finland
Research activity per year
Kalle M. Saksela
Born September 10, 1962 in Philadelphia, PA, USA.
Education:
MD, 1989 (University of Helsinki)
PhD, 1989 (University of Helsinki)
Professional history:
2005- Professor of Virology and Chairman of Department of Virology,
University of Helsinki.
2005- Chief Physician, HUSLAB, Helsinki University Hospital.
1996-2005: Professor of Molecular Medicine. Institute for Medical Technology.
University of Tampere. Finland.
1996-2000 Adjunct Professor associated with the laboratory of James Darnell Jr.
The Rockefeller University, New York.
1994-1996 Assistant Professor. The Rockefeller University, New York.
1991-1994: Postdoctoral Fellow with David Baltimore at the Rockefeller University,
New York.
1991-1991: Postdoctoral Fellow with David Baltimore at the Whitehead
Institute for Biomedical Research, Cambridge, MA.
1989-1990: Research Fellow, Department of Virology, University of Helsinki.
1984-1989: MD/PhD student with Kari Alitalo at the Department of Virology,
University of Helsinki
The HIV Nef protein has been a key subject of our research, Nef modifies host cell physiology to better support viral replication by binding to proteins involved in cellular signal structures via their SH3 domains. SH3 domains are the most ubiquitous class of modular protein binding units found in the nature. SH3 domains mediate many key regulatory processes in normal cells and are involved the pathomechanisms of many important diseases. It appears that many other viral proteins also share the capacity of Nef to utilize binding to host cell SH3 proteins in order to mediate their functions. Identification of normal SH3-mediated cellular protein interaction networks as well as SH3-interactions that take place between cellular and pathogenic viral proteins, and elucidation of the molecular basis of binding affinity and specificity involved in these interactions are the main topics goals of our research.
Key topics:
- Virus-host cell interplay
- Protein interactions
- SH3 domains
- miRNA and viruses
- Viral non-structural proteins
- Protein engineering
Research output: Contribution to journal › Article › Scientific › peer-review
Research output: Contribution to journal › Article › Scientific › peer-review
Research output: Contribution to journal › Article › Scientific › peer-review
Research output: Contribution to journal › Article › Scientific › peer-review
Research output: Contribution to journal › Article › Scientific › peer-review
Saksela, K. (Project manager), Kesti, T. (Participant) & Ugurlu, H. (Participant)
Suomen Punainen Risti, Veripalvelu Ostoreskontra
01/01/2025 → 31/12/2025
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
Saksela, K. (Project manager)
Suomen Akatemia Projektilaskutus
01/01/2025 → 31/12/2026
Project: Research Council of Finland: Targeted Academy Project
Saksela, K. (Project manager)
Syöpäsäätiö sr Cancerstiftelsen sr
01/01/2025 → 31/12/2026
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
Saksela, K. (Project manager), Kesti, T. (Participant), Mäkelä, A. R. (Participant) & Ugurlu, H. (Participant)
Suomen Akatemia Projektilaskutus
01/09/2024 → 31/08/2028
Project: Research Council of Finland: Academy Project
Saksela, K. (Project manager) & Salminen, P. S. (Participant)
Syöpäsäätiö sr Cancerstiftelsen sr
01/01/2024 → 31/12/2025
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
Saksela, K. (Recipient), 2002
Prize: Prizes and awards
Saksela, K. (Recipient), 2003
Prize: Prizes and awards
Saksela, K. (Member)
Activity: Membership types › Membership or other role in public Finnish or international organization
Saksela, K. (Member)
Activity: Membership types › Membership or other role in public Finnish or international organization
Saksela, K. (Member)
Activity: Membership types › Membership or other role in public Finnish or international organization
Saksela, K. (Supervisor)
Activity: Examination types › Supervisor or co-supervisor of doctoral thesis
Saksela, K. (Other role)
Activity: Visiting an external institution types › Academic visit to other institution