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  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1977 …2019
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Publications 1977 2019

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2019

Dural lymphatics regulate clearance of extracellular tau from the CNS

Patel, T. K., Habimana-Griffin, L., Gao, X., Xu, B., Achilefu, S., Alitalo, K., McKee, C. A., Sheehan, P. W., Musiek, E. S., Xiong, C., Coble, D. & Holtzman, D. M., 27 Feb 2019, In : Molecular Neurodegeneration. 14, 9 p., 11.

Research output: Contribution to journalArticleScientificpeer-review

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Genetic Variants of VEGFA and FLT4 Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib

Crona, D. J., Skol, A. D., Leppänen, V-M., Glubb, D. M., Etheridge, A. S., Hilliard, E., Pena, C. E., Peterson, Y. K., Klauber-DeMore, N., Alitalo, K. K. & Innocenti, F., 1 Jan 2019, In : Cancer Research. 79, 1, p. 231-241 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages

Suh, S. H., Choe, K., Hong, S. P., Jeong, S., Mäkinen, T., Kim, K. S., Alitalo, K., Surh, C. D., Koh, G. Y. & Song, J-H., Apr 2019, In : EMBO Reports. 20, 4, 20 p., 46927.

Research output: Contribution to journalArticleScientificpeer-review

High baseline Tie1 level predicts poor survival in metastatic breast cancer

Tiainen, L., Korhonen, E. A., Leppänen, V-M., Luukkaala, T., Hämäläinen, M., Tanner, M., Lahdenperä, O., Vihinen, P., Jukkola, A., Karihtala, P., Aho, S., Moilanen, E., Alitalo, K. & Kellokumpu-Lehtinen, P-L., 24 Jul 2019, In : BMC Cancer. 19, 1, 10 p., 732.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

Jha, S. K., Rauniyar, K., Chronowska, E., Mattonet, K., Maina, E., Koistinen, H., Stenman, U. H., Alitalo, K. & Jeltsch, M., 17 May 2019, In : eLife. 8, 30 p., 44478.

Research output: Contribution to journalArticleScientificpeer-review

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Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury

Magga, J., Vainio, L., Kilpio, T., Hulmi, J. J., Taponen, S., Lin, R., Räsänen, M., Szabo, Z., Gao, E., Rahtu-Korpela, L., Alakoski, T., Ulvila, J., Laitinen, M., Pasternack, A., Koch, W. J., Alitalo, K., Kivela, R., Ritvos, O. & Kerkelä, R., 6 Mar 2019, In : Molecular therapy. 27, 3, p. 600-610 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy

Onions, K. L., Gamez, M., Buckner, N. R., Baker, S. L., Betteridge, K. B., Desideri, S., Dallyn, B. P., Ramnath, R. D., Neal, C. R., Farmer, L. K., Mathieson, P. W., Gnudi, L., Alitalo, K., Bates, D. O., Salmon, A. H. J., Welsh, G. I., Satchell, S. C. & Foster, R. R., Jan 2019, In : Diabetes. 68, 1, p. 172-187 16 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Zhang, Y., Ulvmar, M. H., Stanczuk, L., Martinez-Corral, I., Frye, M., Alitalo, K. & Mäkinen, T., 3 Apr 2018, In : Nature Communications. 9, 15 p., 1296.

Research output: Contribution to journalArticleScientificpeer-review

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Local adventitial anti-angiogenic gene therapy reduces growth of vasa-vasorum and in-stent restenosis in WHHL rabbits

Hytonen, J. P., Taavitsainen, J., Laitinen, J. T. T., Partanen, A., Alitalo, K., Leppänen, O. & Ylä-Herttuala, S., Aug 2018, In : Journal of Molecular and Cellular Cardiology. 121, p. 145-154 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Mechanosensing by beta 1 integrin induces angiocrine signals for liver growth and survival

Lorenz, L., Axnick, J., Buschmann, T., Henning, C., Urner, S., Fang, S., Nurmi, H., Eichhorst, N., Holtmeier, R., Bodis, K., Hwang, J-H., Müssig, K., Eberhard, D., Stypmann, J., Kuss, O., Roden, M., Alitalo, K., Häussinger, D. & Lammert, E., 4 Oct 2018, In : Nature. 562, 7725, p. 128-+ 18 p.

Research output: Contribution to journalArticleScientificpeer-review

PROX1 is a transcriptional regulator of MMP14

Gramolelli, S., Cheng, J., Martinez-Corral, I., Vähä-Koskela, M., Elbasani, E., Kaivanto, E., Rantanen, V., Tuohinto, K., Hautaniemi, S., Bower, M., Haglund, C., Alitalo, K., Mäkinen, T., Petrova, T. V., Lehti, K. & Ojala, P. M., 22 Jun 2018, In : Scientific Reports. 8, 13 p., 9531.

Research output: Contribution to journalArticleScientificpeer-review

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Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells

Högström, J., Heino, S., Kallio, P., Lähde, M., Leppänen, V-M., Balboa, D., Wiener, Z. & Alitalo, K., 15 Oct 2018, In : Cancer Research. 78, 20, p. 5820-5832 13 p.

Research output: Contribution to journalArticleScientificpeer-review

uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis

Durre, T., Morfoisse, F., Erpicum, C., Ebroin, M., Blacher, S., Garcia-Caballero, M., Deroanne, C., Louis, T., Balsat, C., Van de Velde, M., Kaijalainen, S., Kridelka, F., Engelholm, L., Struman, I., Alitalo, K., Behrendt, N., Paupert, J. & Noel, A., 5 Dec 2018, In : Nature Communications. 9, 16 p., 5178.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Vascular endothelial growth factor signaling in development and disease

Karaman, S., Leppänen, V-M. & Alitalo, K., 15 Jul 2018, In : Development. 145, 14, 8 p., 151019.

Research output: Contribution to journalArticleScientificpeer-review

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VEGF-C promotes the development of lymphatics in bone and bone loss

Hominickn, D., Silva, A., Khurana, N., Liu, Y., Dechow, P. C., Feng, J. Q., Pytowski, B., Rutkowski, J. M., Alitalo, K. & Dellinger, M. T., 5 Apr 2018, In : eLife. 7, 22 p., 34323.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis

Rademakers, T., van der Vorst, E. P. C., Daissormont, I. T. M. N., Otten, J. J. T., Theodorou, K., Theelen, T. L., Gijbels, M., Anisimov, A., Nurmi, H., Lindeman, J. H. N., Schober, A., Heeneman, S., Alitalo, K. & Biessen, E. A. L., 28 Mar 2017, In : Scientific Reports. 7, 10 p., 45263.

Research output: Contribution to journalArticleScientificpeer-review

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Development and plasticity of meningeal lymphatic vessels

Antila, S., Karaman, S., Nurmi, H., Airavaara, M., Voutilainen, M. H., Mathivet, T., Chilov, D., Li, Z., Koppinen, T., Park, J-H., Fang, S., Aspelund, A., Saarma, M., Eichmann, A., Thomas, J-L. & Alitalo, K., Dec 2017, In : Journal of Experimental Medicine. 214, 12, p. 3645-3667 23 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

Jha, S. K., Rauniyar, K., Kärpänen, T., Leppänen, V-M., Brouillard, P., Vikkula, M., Alitalo, K. & Jeltsch, M., 7 Jul 2017, In : Scientific Reports. 7, 13 p., 4916.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Midkine and Melanoma Metastasis: A Malevolent Mix

Karaman, S. & Alitalo, K., 7 Aug 2017, In : Developmental Cell. 42, 3, p. 205-207 4 p.

Research output: Contribution to journalArticleScientific

Open Access
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ORAI1 Controls the Unique Adjustment of Lymphatics to Fluid Flow

Karaman, S. & Alitalo, K., 28 Apr 2017, In : Circulation Research. 120, 9, p. 1373-1375 3 p.

Research output: Contribution to journalArticleScientific

Open Access

Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations

Nitschke, M., Bell, A., Karaman, S., Amouzgar, M., Rutkowski, J. M., Scherer, P. E., Alitalo, K. & McDonald, D. M., Sep 2017, In : The American Journal of Pathology. 187, 9, p. 1984-1997 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization

Leppanen, V-M., Saharinen, P. & Alitalo, K., 25 Apr 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 17, p. 4376-4381 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart

Naumenko, N., Huusko, J., Tuomainen, T., Koivumaki, J. T., Merentie, M., Gurzeler, E., Alitalo, K., Kivela, R., Yla-Herttuala, S. & Tavi, P., 31 May 2017, In : Frontiers in Physiology. 8, 10 p., 373.

Research output: Contribution to journalArticleScientificpeer-review

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VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis

Jang, J. Y., Choi, S. Y., Park, I., Park, D. Y., Choe, K., Kim, P., Kim, Y. K., Lee, B-J., Hirashima, M., Kubota, Y., Park, J-W., Cheng, S-Y., Nagy, A., Park, Y. J., Alitalo, K., Shong, M. & Koh, G. Y., Jun 2017, In : EMBO molecular medicine. 9, 6, p. 750-769 20 p.

Research output: Contribution to journalArticleScientificpeer-review

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VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling

Heinolainen, K., Karaman, S., D'Amico, G., Tammela, T., Sormunen, R., Eklund, L., Alitalo, K. & Zarkada, G., 28 Apr 2017, In : Circulation Research. 120, 9, p. 1414-+ 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2016

Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

Chu, M., Li, T., Shen, B., Cao, X., Zhong, H., Zhang, L., Zhou, F., Ma, W., Jiang, H., Xie, P., Liu, Z., Dong, N., Xu, Y., Zhao, Y., Xu, G., Lu, P., Luo, J., Wu, Q., Alitalo, K., Koh, G. Y. & 2 othersAdams, R. H. & He, Y., 22 Dec 2016, In : eLife. 5, 16 p., 21032.

Research output: Contribution to journalArticleScientificpeer-review

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Critical requirement of VEGF-C in transition to fetal erythropoiesis

Fang, S., Nurmi, H., Heinolainen, K., Chen, S., Salminen, E., Saharinen, P., Mikkola, H. K. A. & Alitalo, K., 4 Aug 2016, In : Blood. 128, 5, p. 710-720 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors

Honkanen, H-K., Izzi, V., Petaisto, T., Holopainen, T., Harjunen, V., Pihlajaniemi, T., Alitalo, K. & Heljasvaara, R., Jul 2016, In : NeoPlasia. 18, 7, p. 436-446 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis

Johns, S. C., Yin, X., Jeltsch, M., Bishop, J. R., Schuksz, M., El Ghazal, R., Wilcox-Adelman, S. A., Alitalo, K. & Fuster, M. M., 8 Jul 2016, In : Circulation Research. 119, 2, p. 210-+ 24 p.

Research output: Contribution to journalArticleScientificpeer-review

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Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts

Dashkevich, A., Raissadati, A., Syrjala, S. O., Zarkada, G., Keranen, M. A. I., Tuuminen, R., Krebs, R., Anisimov, A., Jeltsch, M., Leppanen, V. -M., Alitalo, K., Nykanen, A. I. & Lemstrom, K. B., Apr 2016, In : American Journal of Transplantation. 16, 4, p. 1160-1172 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

Lund, A. W., Wagner, M., Fankhauser, M., Steinskog, E. S., Broggi, M. A., Sprenger, S., Gajewski, T. F., Alitalo, K., Eikesdal, H. P., Wiig, H. & Swartz, M. A., Sep 2016, In : Journal of Clinical Investigation. 126, 9, p. 3389-3402 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

Kim, M., Allen, B., Korhonen, E. A., Nitschke, M., Yang, H. W., Baluk, P., Saharinen, P., Alitalo, K., Daly, C., Thurston, G. & McDonald, D. M., Sep 2016, In : Journal of Clinical Investigation. 126, 9, p. 3511-3525 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

Bui, H. M., Enis, D., Robciuc, M. R., Nurmi, H. J., Cohen, J., Chen, M., Yang, Y., Dhillon, V., Johnson, K., Zhang, H., Kirkpatrick, R., Traxler, E., Anisimov, A., Alitalo, K. & Kahn, M. L., 2016, In : Journal of Clinical Investigation. 126, 6, p. 2167-2180 14 p.

Research output: Contribution to journalArticleScientificpeer-review

PROX1 and beta-catenin are prognostic markers in pancreatic ductal adenocarcinoma

Saukkonen, K., Hagstrom, J., Mustonen, H., Juuti, A., Nordling, S., Kallio, P., Alitalo, K., Seppanen, H. & Haglund, C., 13 Jul 2016, In : BMC Cancer. 16, 12 p., 472.

Research output: Contribution to journalArticleScientificpeer-review

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Simultaneous targeting of VEGF-receptors 2 and 3 with immunoliposomes enhances therapeutic efficacy

Orleth, A., Mamot, C., Rochlitz, C., Ritschard, R., Alitalo, K., Christofori, G. & Wicki, A., 2 Jan 2016, In : Journal of Drug Targeting. 24, 1, p. 80-89 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation

Kivela, R., Salmela, I., Nguyen, Y. H., Petrova, T. V., Koistinen, H. A., Wiener, Z. & Alitalo, K., 12 Oct 2016, In : Nature Communications. 7, 11 p., 13124.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Tie1 controls angiopoietin function in vascular remodeling and inflammation

Korhonen, E. A., Lampinen, A., Giri, H., Anisimov, A., Kim, M., Allen, B., Fang, S., D'Amico, G., Sipila, T. J., Lohela, M., Strandin, T., Vaheri, A., Yla-Herttuala, S., Koh, G. Y., McDonald, D. M., Alitalo, K. & Saharinen, P., Sep 2016, In : Journal of Clinical Investigation. 126, 9, p. 3495-3510 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice

Karaman, S., Hollmen, M., Yoon, S-Y., Alkan, H. F., Alitalo, K., Wolfrum, C. & Detmar, M., 11 Aug 2016, In : Scientific Reports. 6, 12 p., 31566.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

Robciuc, M. R., Kivela, R., Williams, I. M., de Boer, J. F., van Dijk, T. H., Elamaa, H., Tigistu-Sahle, F., Molotkov, D., Leppanen, V-M., Kakela, R., Eklund, L., Wasserman, D. H., Groen, A. K. & Alitalo, K., 12 Apr 2016, In : Cell Metabolism. 23, 4, p. 712-724 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection

Rasanen, M., Degerman, J., Nissinen, T. A., Miinalainen, I., Kerkela, R., Siltanen, A., Backman, J. T., Mervaala, E., Hulmi, J., Kivela, R. & Alitalo, K., 15 Nov 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 46, p. 13144-13149 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2015

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H. & Alitalo, K., 29 Jun 2015, In : Journal of Experimental Medicine. 212, 7, p. 991-999 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice

Theelen, T. L., Lappalainen, J. P., Sluimer, J. C., Gurzeler, E., Cleutjens, J. P., Gijbels, M. J., Biessen, E. A. L., Daemen, M. J. A. P., Alitalo, K. & Yla-Herttuala, S., Aug 2015, In : Atherosclerosis. 241, 2, p. 297-304 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis

Turkki, R., Linder, N., Holopainen, T., Wang, Y., Grote, A., Lundin, M., Alitalo, K. & Lundin, J., Aug 2015, In : Journal of Clinical Pathology. 68, 8, p. 614-621 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet

Karaman, S., Hollmen, M., Robciuc, M. R., Alitalo, A., Nurmi, H., Morf, B., Buschle, D., Alkan, H. F., Ochsenbein, A. M., Alitalo, K., Wolfrum, C. & Detmar, M., Feb 2015, In : Molecular metabolism. 4, 2, p. 93-105 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels

Stanczuk, L., Martinez-Corral, I., Ulvmar, M. H., Zhang, Y., Lavina, B., Fruttiger, M., Adams, R. H., Saur, D., Betsholtz, C., Ortega, S., Alitalo, K., Graupera, M. & Makinen, T., 17 Mar 2015, In : Cell Reports. 10, 10, p. 1708-1721 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts

Syrjala, S. O., Nykänen, A. I., Tuuminen, R., Raissadati, A., Keränen, M. A. I., Arnaudova, R., Krebs, R., Koh, G. Y., Alitalo, K. & Lemstrom, K. B., Aug 2015, In : American Journal of Transplantation. 15, 8, p. 2075-2084 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling

Holopainen, T., Rasanen, M., Anisimov, A., Tuomainen, T., Zheng, W., Tvorogov, D., Hulmi, J. J., Andersson, L. C., Cenni, B., Tavi, P., Mervaala, E., Kivela, R. & Alitalo, K., 20 Oct 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. 13063-13068 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Endothelial destabilization by angiopoietin-2 via integrin beta 1 activation

Hakanpaa, L., Sipila, T., Leppanen, V-M., Gautam, P., Nurmi, H., Jacquemet, G., Eklund, L., Ivaska, J., Alitalo, K. & Saharinen, P., Jan 2015, In : Nature Communications. 6, 12 p., 5962.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Functional Dissection of the CCBE1 Protein A Crucial Requirement for the Collagen Repeat Domain

Roukens, M. G., Peterson-Maduro, J., Padberg, Y., Jeltsch, M., Leppanen, V-M., Bos, F. L., Alitalo, K., Schulte-Merker, S. & Schulte, D., 8 May 2015, In : Circulation Research. 116, 10, p. 1660-U153 22 p.

Research output: Contribution to journalArticleScientificpeer-review

Growth factor therapy and lymph node graft for lymphedema

Tervala, T. V., Hartiala, P., Tammela, T., Visuri, M. T., Yla-Herttuala, S., Alitalo, K. & Saarikko, A. M., 1 Jun 2015, In : Journal of Surgical Research. 196, 1, p. 200-207 8 p.

Research output: Contribution to journalArticleScientificpeer-review