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  • PL 22 (Kasarmikatu 11-13)

    00014

    Finland

19962019
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Publications 1996 2019

2019

Functional analysis of synovial fluid from osteoarthritic knee and carpometacarpal joints unravels different molecular profiles

Barreto, G., Soliymani, R., Baumann, M., Waris, E., Eklund, K. K., Zenobi-Wong, M. & Lalowski, M., May 2019, In : Rheumatology. 58, 5, p. 897-907 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Tabassum, R., Rämö, J. T., Ripatti, P., Koskela, J. T., Kurki, M., Karjalainen, J., Palta, P., Hassan, S., Nunez-Fontarnau, J., Kiiskinen, T. T. J., Söderlund, S., Matikainen, N., Gerl, M. J., Surma, M. A., Klose, C., Stitziel, N. O., Laivuori, H., Havulinna, A. S., Service, S. K., Salomaa, V. & 240 othersPirinen, M., Jalanko, A., Kaprio, J., Donner, K., Kaunisto, M., Mars, N., Dada, A., Shcherban, A., Ganna, A., Lehisto, A., Kilpeläinen, E., Brein, G., Awaisa, G., Harju, J., Pärn, K., Parolo, P. D. B., Kajanne, R., Lemmelä, S., Sipilä, T. P., Sipilä, T., Lyhs, U., Llorens, V., Niiranen, T., Kristiansson, K., Männikkö, L., Jiménez, M. G., Perola, M., Wong, R., Kilpi, T., Hiekkalinna, T., Järvensivu, E., Kaiharju, E., Mattsson, H., Laukkanen, M., Laiho, P., Lähteenmäki, S., Sistonen, T., Soini, S., Ziemann, A., Lehtonen, A., Lertratanakul, A., Georgantas, B., Riley-Gillis, B., Quarless, D., Rahimov, F., Heap, G., Jacob, H., Waring, J., Davis, J. W., Smaoui, N., Popovic, R., Esmaeeli, S., Waring, J., Matakidou, A., Challis, B., Close, D., Petrovski, S., Karlsson, A., Schleutker, J., Pulkki, K., Virolainen, P., Kallio, L., Mannermaa, A., Heikkinen, S., Kosma, V-M., Chen, C-Y., Runz, H., Liu, J., Bronson, P., John, S., Lahdenperä, S., Eaton, S., Zhou, W., Hendolin, M., Tuovila, O., Pakkanen, R., Maranville, J., Usiskin, K., Hochfeld, M., Plenge, R., Yang, R., Biswas, S., Greenberg, S., Laakkonen, E., Kononen, J., Paloneva, J., Kujala, U., Kuopio, T., Laukkanen, J., Kangasniemi, E., Savinainen, K., Laaksonen, R., Arvas, M., Ritari, J., Partanen, J., Hyvärinen, K., Wahlfors, T., Peterson, A., Oh, D., Chang, D., Teng, E., Strauss, E., Kerchner, G., Chen, H., Chen, H., Schutzman, J., Michon, J., Hunkapiller, J., McCarthy, M., Bowers, N., Lu, T., Bhangale, T., Pulford, D., Waterworth, D., Kulkarni, D., Xu, F., Betts, J., Gordillo, J. E., Hoffman, J., Auro, K., McCarthy, L., Ghosh, S., Ehm, M., Pitkänen, K., Mäkelä, T., Loukola, A., Joensuu, H., Sinisalo, J., Eklund, K., Aaltonen, L., Färkkilä, M., Carpen, O., Kauppi, P., Tienari, P., Ollila, T., Tuomi, T., Meretoja, T., Pitkäranta, A., Turunen, J., Hannula-Jouppi, K., Pikkarainen, S., Seitsonen, S., Koskinen, M., Palomäki, A., Rinne, J., Metsärinne, K., Elenius, K., Pirilä, L., Koulu, L., Voutilainen, M., Juonala, M., Peltonen, S., Aaltonen, V., Loboda, A., Podgornaia, A., Chhibber, A., Chu, A., Fox, C., Diogo, D., Holzinger, E., Eicher, J., Gormley, P., Mehta, V., Wang, X., Kettunen, J., Pylkäs, K., Kalaoja, M., Karjalainen, M., Hinttala, R., Kaarteenaho, R., Vainio, S., Mantere, T., Remes, A., Huhtakangas, J., Junttila, J., Tasanen, K., Huilaja, L., Luodonpää, M., Hautala, N., Karihtala, P., Kauppila, S., Harju, T., Blomster, T., Soininen, H., Harvima, I., Pihlajamäki, J., Kaarniranta, K., Pelkonen, M., Laakso, M., Hiltunen, M., Kiviniemi, M., Kaipiainen-Seppänen, O., Auvinen, P., Kälviäinen, R., Julkunen, V., Malarstig, A., Hedman, Å., Marshall, C., Whelan, C., Lehtonen, H., Parkkinen, J., Linden, K., Kalpala, K., Miller, M., Bing, N., McDonough, S., Chen, X., Hu, X., Wu, Y., Auranen, A., Jussila, A., Uusitalo-Järvinen, H., Kankaanranta, H., Uusitalo, H., Peltola, J., Kähönen, M., Isomäki, P., Laitinen, T., Salmi, T., Muslin, A., Wang, C., Chatelain, C., Xu, E., Auge, F., Call, K., Klinger, K., Crohns, M., Gossel, M., Palin, K., Rivas, M., Siirtola, H., Tabuenca, J. G., Jauhiainen, M., Daly, M. J., Freimer, N. B., Palotie, A., Taskinen, M-R., Simons, K., Ripatti, S. & Project, F., 24 Sep 2019, In : Nature Communications. 10, 1, 14 p., 4329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus

Salem, A., Almahmoudi, R., Hagström, J., Stark, H., Nordström, D., Salo, T. & Eklund, K. K., 10 Apr 2019, In : International Journal of Molecular Sciences. 20, 7, 16 p., 1780.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans

Kaasinen, E., Kuismin, O., Rajamäki, K., Ristolainen, H., Aavikko, M., Kondelin, J., Saarinen, S., Berta, D. G., Katainen, R., Hirvonen, E. A. M., Karhu, A., Taira, A., Tanskanen, T., Alkodsi, A., Taipale, M., Morgunova, E., Franssila, K., Lehtonen, R., Mäkinen, M., Aittomäki, K. & 15 othersPalotie, A., Kurki, M., Pietiläinen, O., Hilpert, M., Saarentaus, E., Niinimäki, J., Junttila, J., Kaikkonen, K., Vahteristo, P., Skoda, R. C., Seppänen, M. R. J., Eklund, K. K., Taipale, J., Kilpivaara, O. & Aaltonen, L. A., 19 Mar 2019, In : Nature Communications. 10, 17 p., 1252.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Biological treatment in ankylosing spondylitis in the Nordic countries during 2010-2016: a collaboration between five biological registries

DANBIO Registry, SRQ ARTIS Registry, ROB-FIN Registry, NOR-DMARD Registry & ICEBIO Registry, 2 Nov 2018, In : Scandinavian Journal of Rheumatology. 47, 6, p. 465-474 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Haploinsufficiency of A20 impairs protein–protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation

Rajamäki, K., Keskitalo, S., Seppänen, M., Kuismin, O., Vähäsalo, P., Trotta, L., Väänänen, A., Glumoff, V., Keskitalo, P., Kaarteenaho, R., Jartti, A., Hautala, N., Jackson, P., Nordström, D. C., Saarela, J., Hautala, T., Eklund, K. K. & Varjosalo, M., 1 Oct 2018, In : RMD open. 4, 2, e000740.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Altered Expression of Toll-Like Receptors in Human Oral Epithelium in Oral Lichenoid Reactions

Salem, A., Mustafa, R., Listyarifah, D., Al-Samadi, A., Barreto, G., Nordström, D. & Eklund, K. K., 2017, In : American Journal of Dermatopathology. 39, 11, p. 811-818 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Competitive colonization of prosthetic surfaces by staphylococcus aureus and human cells

Pérez-Tanoira, R., Han, X., Soininen, A., Aarnisalo, A. A., Tiainen, V-M., Eklund, K. K., Esteban, J. & Kinnari, T. J., Jan 2017, In : Journal of Biomedical Materials Research. Part A. 105, 1, p. 62-72 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Open Access
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Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes

Kaustio, M., Haapaniemi, E., Göös, H., Hautala, T., Park, G., Syrjänen, J., Einarsdottir, E., Sahu, B., Kilpinen, S., Rounioja, S., Fogarty, C. L., Glumoff, V., Kulmala, P., Katayama, S., Tamene, F., Trotta, L., Morgunova, E., Krjutskov, K., Nurmi, K., Eklund, K. & 9 othersLagerstedt, A., Helminen, M., Martelius, T., Mustjoki, S., Taipale, J., Saarela, J., Kere, J., Varjosalo, M. & Seppanen, M., Sep 2017, In : Journal of Allergy and Clinical Immunology. 140, 3, p. 782-796 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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DEC2 blocks the effect of the ARNTL2/NPAS2 dimer on the expression of PER3 and DBP

Olkkonen, J., Kouri, V-P., Kuusela, E., Ainola, M., Nordström, D., Eklund, K. K. & Mandelin, J., 2017, In : Journal of Circadian Rhythms. 15, 1, 10 p., 6.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Efficacy and effectiveness of tumour necrosis factor inhibitors in the treatment of rheumatoid arthritis in randomized controlled trials and routine clinical practice

Aaltonen, K. J., Ylikylä, S., Joensuu, J. T., Isomäki, P., Pirilä, L., Kauppi, M., Rannio, T., Eklund, K., Blom, M. & Nordstrom, D., May 2017, In : Rheumatology. 56, 5, p. 725-735 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation

Lorey, M. B., Rossi, K., Eklund, K., Nyman, T. A. & Matikainen, S., Apr 2017, In : Molecular & Cellular Proteomics. 16, 4, p. S187-S199 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation

Nurmi, K., Kareinen, I., Virkanen, J., Rajamaki, K., Kouri, V-P., Vaali, K., Levonen, A-L., Fyhrquist, N., Matikainen, S., Kovanen, P. T. & Eklund, K. K., 2017, In : Journal of innate immunity. 9, 1, p. 65-82 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis - a short report

Salem, A., Almahmoudi, R., Listyarifah, D., Siponen, M., Maaninka, K. A-L., Al-Samadi, A., Salo, T. & Eklund, K. K., Dec 2017, In : Cellular Oncology. 40, 6, p. 621-630 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Hydroxychloroquine for the prevention of recurrent cardiovascular events in myocardial infarction patients: rationale and design of the OXI trial

Hartman, O., Kovanen, P. T., Lehtonen, J., Eklund, K. K. & Sinisalo, J-P., 2017, In : European Heart Journal - Cardiovascular Pharmacotherapy. 3, 2, p. 92-97 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Laser-ultrasonic delivery of agents into articular cartilage

Nieminen, H. J., Correia Pinto de Almeida, G. E., Finnilä, M. A., Garcia Pérez, A., Salmi, A. H., Ranjan, S., Eklund, K. K., Pritzker, K. P. H., Saarakkala, S. & Haeggström, E. O., 2017, In : Scientific Reports. 7, 12 p., 3991.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Niveltulehdusten diagnostiikka

Julkunen, H. & Eklund, K., 2017, In : Duodecim. 133, 13-14, p. 1293-1301 9 p.

Research output: Contribution to journalArticleProfessional

Open Access
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Prevention of Biomaterial Infection by Pre-Operative Incubation with Human Cells

Pérez Tanoira, R., Aarnisalo, A. A., Eklund, K., Han, X., Soininen, A., Tiainen, V-M., Esteban, J. & Kinnari, T. J., Apr 2017, In : Surgical Infections. 18, 3, p. 336-344 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages

Valimaki, E., Cypryk, W., Virkanen, J., Nurmi, K., Turunen, P. M., Eklund, K., Akerman, K. E., Nyman, T. A. & Matikainen, S., 15 Oct 2016, In : Journal of Immunology. 197, 8, p. 3315-3325 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Cost-effectiveness of routine measuring of serum drug concentrations and anti-drug antibodies in treatment of rheumatoid arthritis patients with TNF-alpha blockers

Laine, J., Jokiranta, S., Eklund, K., Väkeväinen, M. & Puolakka, K., 1 Apr 2016, In : Biologics : targets & therapy. 2016, 10, p. 67-73 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Nivelpsoriaasi - monimuotoinen nivelsairaus

Eklund, K. K., Mykkänen, K. & Peltomaa, R., 2016, In : Suomen lääkärilehti. 71, 49, p. 3164-3169 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis

Rajamäki, K., Mäyränpää, M., Risco, A., Tuimala, J., Nurmi, K., Cuenda, A., Eklund, K. K., Öörni, K. & Kovanen, P. T., Sep 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 9, p. 1937-1946 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Sytokiinien rooli ja salpaus immuunivälitteisissä tulehdussairauksissa

Matikainen, S., Jokiranta, S. & Eklund, K. K., 2016, In : Duodecim. 132, 4, p. 349-354 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2015

Impact of physicians' adherence to treat-to-target strategy on outcomes in early rheumatoid arthritis in the NEO-RACo trial

Kuusalo, L., Puolakka, K., Kautiainen, H., Blafield, H., Eklund, K. K., Ilva, K., Kaipiainen-Seppanen, O., Karjalainen, A., Korpela, M., Valleala, H., Leirisalo-Repo, M., Rantalaiho, V. & NEO-RACo Study Grp, 2 Nov 2015, In : Scandinavian Journal of Rheumatology. 44, 6, p. 449-455 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis

Barreto, G., Soininen, A., Ylinen, P., Sandelin, J., Konttinen, Y. T., Nordstrom, D. C. & Eklund, K. K., 24 Dec 2015, In : Arthritis research & therapy. 17, 15 p., 379.

Research output: Contribution to journalArticleScientificpeer-review

Vad behöver primärvårdsläkaren veta om biologiska läkemedel?

Eklund, K. & Peltomaa, R., 2015, In : Finska Läkaresällskapets Handlingar. 175, 2, p. 82-86 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Ethanol Inhibits Activation of NLRP3 and AIM2 Inflammasomes in Human Macrophages- A Novel Anti-Inflammatory Action of Alcohol

Nurmi, K., Virkanen, J., Rajamaki, K., Niemi, K., Kovanen, P. T. & Eklund, K. K., 11 Nov 2013, In : PLoS One. 8, 11, 12 p., 78537.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Miksi nivelreumaa sairastavien sydäntautiriski on suurentunut?

Eklund, K. K. & Kovanen, P. T., 2013, In : Suomen lääkärilehti. 68, 44, p. 2811 1 p.

Research output: Contribution to journalArticleProfessional

2011

Is the "lipid paradox" in rheumatoid arthritis really a paradox? Comment on the article by Bartels et al

Strandberg, T., Kovanen, P. T. & Eklund, K. K., Nov 2011, In : Arthritis & Rheumatism. 63, 11, p. 3644-3645 2 p.

Research output: Contribution to journalArticleScientific

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X(7) Receptor and a Cathepsin B-Sensitive Pathway

Niemi, K., Teirila, L., Lappalainen, J., Rajamaki, K., Baumann, M. H., Öörni, K., Wolff, H., Kovanen, P. T., Matikainen, S. & Eklund, K. K., 2011, In : Online Journal of Immunology. 186, p. 6119-6128 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Suurten suonten vaskuliitit

Eklund, K. K. & Pettersson, T., 2011, In : Duodecim. 127, 15, p. 1539-1547 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Leg Ulcers Treated with Topical Tacrolimus in Patients with Rheumatoid Arthritis

Mandelin, J. M., Eklund, K. K. & Reitamo, S., 2010, In : Acta Dermato-Venereologica. 90, 6, p. 633-634 2 p.

Research output: Contribution to journalArticleScientific

Open Access
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2009

A case of Poncet disease diagnosed with interferon-gamma-release assays

Valleala, H., Tuuminen, T., Repo, H., Eklund, K. K. & Leirisalo-Repo, M., 2009, In : Nature reviews. Rheumatology. 5, 11, p. 643-647 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Ethanol induces apoptosis in human mast cell

Nurmi, K., Methuen, T., Mäki, T., Lindstedt, K. A., Kovanen, P. T., Sandler, C. & Eklund, K. K., 2009, In : Life Sciences. 85, p. 678-684 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Food allergy alters jejunal circular muscle contractility and induces local inflammatory cytokine expression in a mouse model

Valeur, J., Lappalainen, J., Rita, H., Lin, A. H., Kovanen, P. T., Berstad, A., Eklund, K. K. & Vaali, K., 2009, In : BMC Gastroenterology. 9, 33, p. 1-9 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Infection and arthritis

Leirisalo-Repo, M., Dijkmans, B. A. & Eklund, K. K., 2009, Eular compendium on rheumatic diseases. London: BMJ PUBLISHING GROUP, p. 166-181 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Pitäisikö kaikille nivelreumaa sairastaville määrätä statiinia? [pääkirjoitus]

Eklund, K. K. & Kovanen, P., 2009, In : Suomen lääkärilehti. 64, p. 3516 1 p.

Research output: Contribution to journalArticleScientific

2007

Inhibition of smooth muscle cell proliferation by a chemically modified tetracycline

Leskinen, M. J., Eklund, K. K., Sorsa, T., Golub, L. M., Kovanen, P. T. & Lindstedt, K. A., 2007, In : Coronary Artery Disease. 18, p. 663-667 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Mast cells in the pathogenesis of rheumatic diseases and as potential targets for anti-rheumatic therapy

Eklund, K. K., 2007, In : Immunological Reviews. 217, p. 38-52 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Selective activation of mast cells in rheumatoid synovial tissue results in production of TNF-[alpha], IL-1[beta] and IL-1Ra

Sandler, C., Lindstedt, K. A., Joutsiniemi, S., Lappalainen, J., Juutilainen, T., Kolah, J., Kovanen, P. T., Eklund, K. K. & Sandler, C., 2007, In : Inflammation Research. 56, 6, p. 230-239 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Serum IL-1[beta] levels are associated wuth the presence of erosions in recent onset rheumatoid arthritis

Eklund, K. K., Leirisalo-Repo, M., Ranta, P., Mäki, T., Kautiainen, H., Hannonen, P., Korpela, M., Hakala, M., Järvinen, P. & Möttönen, T., 2007, In : Clinical and Experimental Rheumatology. 25, p. 684-689 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Treatment of refractory plantar fasciitis with infliximab

Eklund, K., Numminen, K., Uusitalo, T., Leirisalo-Repo, M. & Uusitalo, T., 2007, In : Scandinavian Journal of Rheumatology. 36, 3, p. 233-245 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Classic disease modifying anti-rheumatic drugs (DMARDs) in combination with infliximab: the Finnish experience

Nordström, D., Konttinen, L., Korpela, M., Tiippana-Kinnunen, T., Eklund, K., Forsberg, S., Ilva, K., Kaipiainen-Seppänen, K., Malmi, T., Ylä-Kerttula, T. & Honkanen, V., 2006, In : Rheumatology International. 26, p. 741-748 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Hepsidiini - onko puuttuva lenkki tulehduksen ja anemian välillä löytynyt?

Eklund, K. & Pettersson, T., 2006, In : Suomen lääkärilehti. 61, 6, p. 559-562 4 p.

Research output: Contribution to journalArticleScientific

Imatinib mesylate inhibits platelet derived growth factor stimulated proliferation of rheumatoid synovial fibroblasts

Sandler, C., Joutsiniemi, S., Lindstedt, K. A., Juutilainen, T., Kovanen, P. T. & Eklund, K. K., 2006, In : Biochemical and Biophysical Research Communications. 347, 1, p. 31-35 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Serum amyloid A (SAA) activates human mast cells which leads into degradation of SAA and generation of an amyloidogenic SAA fragment

Niemi, K., Baumann, M., Kovanen, P. T., Eklund, K. & Eklund, K. K., 2006, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1762, p. 424-430 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The Effect of Linoleic and Gamma linolenic Acid on Serum and Mononuclear Cell Phospholipid Fatty Acids in Atopic Dermatitis

Nasu, Y., Atroshi, F., Eklund, K. K., Antila, E., Solovieva, S. A., Westermarck, T., Somerharju, P., Mussalo-Rauhamaa, H., Lehto, J. & Konttinen, Y. T., 2006, In : Journal of Plastic Dermatology . 2, 2, p. 71-74 4 p.

Research output: Contribution to journalArticleScientificpeer-review