Photo of Kari Keinänen

Kari Keinänen

  • PL 56 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

20002019

Research activity per year

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Personal profile

Description of research and teaching

RESEARCH in my laboratory focuses on AMPA receptors, tetrameric ion channels that mediate glutamate signaling in the brain and other tissues. AMPA receptors are important regulators of the efficiency of synaptic transmission, a key property underlying learning and memory, and contribute - when malfunctioning - to numerous neuropathologies. We are using a combination of biochemical, molecular biological and electrophysiological methods to study the mechanisms which determine the subunit composition, cellular localization and protein interactions of AMPA receptors in order to understand their function in normal and diseased brain in molecular detail. 

Current topics:

1. Cytosolic protein interactions of long-tailed AMPA receptor subunits GluA1 and GluA4

2. Modulation of AMPA receptor function by interacting proteins

3. Quality control of AMPA receptor trafficking

Fields of Science

  • 1182 Biochemistry, cell and molecular biology
  • 318 Medical biotechnology

International and National Collaboration

Publications and projects within past five years.
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