Photo of Kari Keinänen
  • Finland

  • PL 56 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

20002019
If you made any changes in Pure these will be visible here soon.

Personal profile

Description of research and teaching

RESEARCH in my laboratory focuses on AMPA receptors, tetrameric ion channels that mediate glutamate signaling in the brain and other tissues. AMPA receptors are important regulators of the efficiency of synaptic transmission, a key property underlying learning and memory, and contribute - when malfunctioning - to numerous neuropathologies. We are using a combination of biochemical, molecular biological and electrophysiological methods to study the mechanisms which determine the subunit composition, cellular localization and protein interactions of AMPA receptors in order to understand their function in normal and diseased brain in molecular detail. 

Current topics:

1. Cytosolic protein interactions of long-tailed AMPA receptor subunits GluA1 and GluA4

2. Modulation of AMPA receptor function by interacting proteins

3. Quality control of AMPA receptor trafficking

 

 

Keywords

  • 118 Biological sciences
  • 1182 Biochemistry, cell and molecular biology
  • 318 Medical biotechnology

International and National Collaboration Publications and projects within past five years.

Publications 2000 2019

  • 36 Article
  • 1 Conference contribution
  • 1 Review Article
  • 1 Doctoral Thesis

Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors

von Ossowski, L., Li, L-L., Möykkynen, T., Coleman, S. K., Courtney, M. J. & Keinänen, K., 2 Feb 2017, In : PLoS One. 12, 2, 15 p., 0171489.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Aggregation Limits Surface Expression of Homomeric GluA3 Receptors

Coleman, S. K., Hou, Y., Willibald, M., Semenov, A., Möykkynen, T. & Keinänen, K., 15 Apr 2016, In : Journal of Biological Chemistry. 291, 16, p. 8784-8794 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

The N-terminal Domain Modulates alpha-Amino-3-hydroxy-5methyl-4-isoxazolepropionic acid ( AMPA) Receptor Desensitization

Moykkynen, T., Coleman, S. K., Semenov, A. & Keinanen, K., 9 May 2014, In : Journal of Biological Chemistry. 289, 19, p. 13197-13205 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors

Luchkina, N. V., Huupponen, J., Clarke, V. R. J., Coleman, S. K., Keinanen, K., Taira, T. & Lauri, S. E., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. 4321-4326 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Dysregulated Ca2+-Permeable AMPA Receptor Signaling in Neural Progenitors Modeling Fragile X Syndrome

Danesi, C., Keinänen, K. P. & Castren, M. L., 8 Feb 2019, In : Frontiers in Synaptic Neuroscience. 11, 8 p., 2.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Projects 2013 2017

Activities 2017 2017

  • 1 Member of doctoral thesis committee / follow-up group

Doctoral Thesis Committee Member (8 students)

Kari Keinänen (Member of thesis committee / follow-up group)
1 Jan 2017 → …

Activity: Examination typesMember of doctoral thesis committee / follow-up group