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Publications 1988 2019

2019

Continuous-flow LVADs in the Nordic countries: complications and mortality and its predictors

Braun, O. Ö., Nilsson, J., Gustafsson, F., Dellgren, G., Fiane, A. E., Lemström, K., Hubbert, L., Hellgren, L. & Lund, L. H., 2019, In : Scandinavian Cardiovascular Journal. 53, 1, p. 14-20 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of Donor Simvastatin Treatment on Gene Expression Profiles in Human Cardiac Allografts during Ischemia-Reperfusion Injury

Krebs, R., Kankainen, M., Holmström, E., Dhaygude, K., Lukac, J., Ojala, T., Mattila, P., Nykänen, A. & Lemström, K., Apr 2019, In : Journal of Heart and Lung Transplantation. 38, 4, Supplement, p. S75-S76

Research output: Contribution to journalConference articleScientificpeer-review

Extracorporeal membrane oxygenation for refractory cardiogenic shock: patient survival and health-related quality of life

Jäämaa-Holmberg, S., Salmela, B., Suojaranta, R., Jokinen, J. J., Lemström, K. B. & Lommi, J., Apr 2019, In : European Journal of Cardio-Thoracic Surgery. 55, 4, p. 780-787 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Hypoxia-inducible factor controls immunoregulatory properties of myeloid cells in mouse cardiac allografts - an experimental study

Keränen, M. A. I., Raissadati, A., Nykänen, A. I., Dashkevich, A., Tuuminen, R., Krebs, R., Johnson, R. S., Syrjälä, S. O. & Lemström, K. B., Jan 2019, In : Transplant International. 32, 1, p. 95-106 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Label-Free Proteomics Approach Characterizes Plasma Protein Signature of Donor Brain Death

Lukac, J., Saraswata, M., Joenvääräa, S., Holmström, E., Dhaygude, K., Krebs, R., Nykänen, A., Renkonen, R. & Lemström, K., Apr 2019, In : Journal of Heart and Lung Transplantation. 38, 4, Supplement, p. S159

Research output: Contribution to journalConference articleScientificpeer-review

Transcriptome Profiles of the Circulating Extracellular Vesicles in Acute Lung Allograft Rejection

Joo, S., Puhka, M., Krebs, R., Mattila, P., Kankainen, M., Dhaygude, K., Rouvinen, E. & Lemström, K., Apr 2019, p. S146.

Research output: Conference materialsAbstractResearchpeer-review

2018

(242) - Donor Plasma VEGF as a Biomarker for Early Graft Failure After Heart Transplantation: ISHLT 38th Annual Meeting and Scientific Sessions

Holmström, E., Tuuminen, R., Krebs, R., Rouvinen, E., Nykänen, A. & Lemström, K., Apr 2018, In : Journal of Heart and Lung Transplantation. 37, 4, Supplement, p. S103

Research output: Contribution to journalMeeting AbstractResearchpeer-review

(245) - Proinflammatory Cytokines as Biomarkers for Severe Primary Graft Dysfunction After Heart Transplantation: ISHLT 38th Annual Meeting and Scientific Sessions

Holmström, E., Tuuminen, R., Syrjälä, S., Krebs, R., Rouvinen, E., Nykänen, A. & Lemström, K., Apr 2018, In : Journal of Heart and Lung Transplantation. 37, 4, Supplement, p. S104

Research output: Contribution to journalMeeting AbstractResearchpeer-review

(348) - Worldwide Experience of Adult Patients with Small Body Size Supported by a Continuous-Flow Left Ventricular Assist Device - An IMACS Analysis: ISHLT 38th Annual Meeting and Scientific Sessions

Lee, S., Xie, R., Lemstrom, K., Dickinson, M. G., Boeve, T., Leacche, M., Cowger, J., de By, T. & Kirklin, J. K., Apr 2018, In : Journal of Heart and Lung Transplantation. 37, 4, Supplement, p. S145 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Donor Simvastatin Treatment Alters Protein Expression in the Recipient after Heart Transplantation: ISHLT 38th Annual Meeting and Scientific Sessions

Lukac, J., Holmström, E., Joenväärä, S., Saraswat, M., Krebs, R., Tohmola, T., Nykänen, A., Renkonen, R. & Lemström, K., Apr 2018, In : Journal of Heart and Lung Transplantation. 37, 4, p. S169-S170 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Keuhkonsiirto ja sydämen ja keuhkojen yhteissiirto

Lemström, K., 2018, Kirurgia. Leppäniemi, A., Kuokkanen, H. & Salminen, P. (eds.). 3. uud. p. ed. Helsinki : Duodecim, p. 1067 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Propranolol for gastrointestinal bleeding in two patients with continuous flow left ventricle assist device

Stark, C., Kiss, J. & Lemström, K., Jun 2018, In : European Journal of Cardio-Thoracic Surgery. 53, 6, p. 1284-1285 2 p.

Research output: Contribution to journalEditorialScientific

Sydämen mekaaninen tukihoito

Lemström, K., 2018, Kirurgia. Leppäniemi, A., Kuokkanen, H. & Salminen, P. (eds.). 3. uud. p. ed. Helsinki : Duodecim, p. 1066 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Sydämensiirto

Lemström, K., 2018, Kirurgia. Leppäniemi, A., Kuokkanen, H. & Salminen, P. (eds.). 3. uud. p. ed. Helsinki : Duodecim, p. 1064-1066 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

2017

Dual antiplatelet and anticoagulant APAC prevents experimental ischemia-reperfusion-induced acute kidney injury

Tuuminen, R., Jouppila, A., Salvail, D., Laurent, C-E., Benoit, M-C., Syrjälä, S., Helin, H., Lemstrom, K. & Lassila, R., 2017, In : Clinical and Experimental Nephrology. 21, 3, p. 436–445 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Mekaaniset tukilaitteet sydämen vajaatoiminnassa

Varpula, M., Pentikäinen, M., Suojaranta, R., Kiss, J. & Lemström, K., 2017, In : Sydänääni : Suomen kardiologisen seuran lehti. 28, 3A, p. 333-340 8 p.

Research output: Contribution to journalArticleProfessional

Miten varautua sydänsiirteiden uhkaavaan vajeeseen?

Kiss, J., Stark, C., Lemström, K. & Lommi, J., 2017, In : Duodecim. 133, 24, p. 2413-2417 5 p.

Research output: Contribution to journalArticleProfessional

Open Access
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2016

Decreased maximum clot firmness in rotational thromboelastometry (ROTEM (R)) is associated with bleeding during extracorporeal mechanical circulatory support

Laine, A., Niemi, T., Suojaranta-Ylinen, R., Raivio, P., Soininen, L., Lemstrom, K., Hammainen, P. & Schramko, A., Nov 2016, In : Perfusion. 31, 8, p. 625-633 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma

Seppälä, M., Pohjola, K., Laranne, J., Rautiainen, M., Huhtala, H., Renkonen, R., Lemstrom, K., Paavonen, T. & Toppila-Salmi, S., Dec 2016, In : European Archives of Oto-Rhino-Laryngology. 273, 12, p. 4515-4524 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Increased myeloid cell hypoxia-inducible factor-1 delays obliterative airway disease in the mouse

Ropponen, J. O., Keränen, M. A., Raissadati, A., Nykänen, A. I., Krebs, R., Lemstrom, K. B. & Tikkanen, J. M., May 2016, In : Journal of Heart and Lung Transplantation. 35, 5, p. 671-678 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts

Dashkevich, A., Raissadati, A., Syrjala, S. O., Zarkada, G., Keranen, M. A. I., Tuuminen, R., Krebs, R., Anisimov, A., Jeltsch, M., Leppanen, V. -M., Alitalo, K., Nykanen, A. I. & Lemstrom, K. B., Apr 2016, In : American Journal of Transplantation. 16, 4, p. 1160-1172 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Platelet-derived Growth Factor-B Protects Rat Cardiac Allografts From Ischemia-reperfusion Injury

Tuuminen, R., Dashkevich, A., Keränen, M. A. I., Raissadati, A., Krebs, R., Jokinen, J. J., Arnaudova, R., Rouvinen, E., Yla-Herttuala, S., Nykänen, A. & Lemstrom, K. B., Feb 2016, In : Transplantation. 100, 2, p. 303-313 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion

Tuuminen, R., Holmstrom, E., Raissadati, A., Saharinen, P., Rouvinen, E., Krebs, R. & Lemstrom, K. B., Jul 2016, In : Transplant Immunology. 37, p. 40-45 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Simvastatin Treatment Upregulates Anti-Fibrotic Bone Morphogenetic Protein-7 Expression at Rat Cardiac Allograft Rejection

Holmstrom, E. J., Lemstrom, K. B. & Tuuminen, R., 2016, In : Pharmacology. 98, 5-6, p. 204-208 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Sydämen vajaatoiminnan kirurginen hoito ja sydämensiirto

Lommi, J. & Lemström, K., 2016, Kardiologia. Airaksinen, J., Aalto-Setälä, K., Hartikainen, J., Huikuri, H., Laine, M., Lommi, J., Raatikainen, P. & Saraste, A. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 751-766 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Vasemman kammion mekaaninen tukihoito : siltahoito tai vaihtoehto sydämensiirrolle

Lemström, K., Jokinen, J. J., Kiss, J., Nykänen, A., Yesil, C., Lommi, J., Pentikäinen, M., Suojaranta-Ylinen, R. & Hiippala, S., 2016, In : Suomen lääkärilehti. 71, 34, p. 2043-2050 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

VEGF Pathways in the Lymphatics of Healthy and Diseased Heart

Dashkevich, A., Hagl, C., Beyersdorf, F., Nykänen, A. & Lemstrom, K. B., Jan 2016, In : Microcirculation. 23, 1, p. 5-14 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2015

Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts

Syrjala, S. O., Nykänen, A. I., Tuuminen, R., Raissadati, A., Keränen, M. A. I., Arnaudova, R., Krebs, R., Koh, G. Y., Alitalo, K. & Lemstrom, K. B., Aug 2015, In : American Journal of Transplantation. 15, 8, p. 2075-2084 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Kansalliset ohjeet elinluovuttajan hoidosta ja elinten talteenotosta : (tämä ohje astui voimaan 3.2.2015)

Isoniemi, H., Lempinen, M., Nordin, A., Hartikka, E., Lemström, K., Hämmäinen, P., Suojaranta-Ylinen, R., Yesil, C., Soininen, L., Koivusalo, A-M. & Kaartinen, J., 2015, In : Tehohoito. 33, 1, p. 50-53 4 p.

Research output: Contribution to journalArticleProfessional

Systemic overexpression of matricellular protein CCN1 exacerbates obliterative bronchiolitis in mouse tracheal allografts

Raissadati, A., Nykänen, A. I., Tuuminen, R., Syrjala, S. O., Krebs, R., Arnaudova, R., Rouvinen, E., Wang, X., Poller, W. & Lemstrom, K. B., Dec 2015, In : Transplant International. 28, 12, p. 1416-1425 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Angiopoietin-2 Inhibition Prevents Transplant Ischemia- Reperfusion Injury and Chronic Rejection in Rat Cardiac Allografts

Syrjala, S. O., Tuuminen, R., Nykanen, A. I., Raissadati, A., Dashkevich, A., Keranen, M. A. I., Arnaudova, R., Krebs, R., Leow, C. C., Saharinen, P., Alitalo, K. & Lemstrom, K. B., May 2014, In : American Journal of Transplantation. 14, 5, p. 1096-1108 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Combined Donor Simvastatin and Methylprednisolone Treatment Prevents Ischemia-Reperfusion Injury in Rat Cardiac Allografts Through Vasculoprotection and Immunomodulation

Tuuminen, R., Syrjala, S., Krebs, R., Arnaudova, R., Rouvinen, E., Nykanen, A. I. & Lemstrom, K. B., 15 May 2013, In : Transplantation. 95, 9, p. 1084-1091 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential Effects of Pharmacological HIF Preconditioning of Donors Versus Recipients in Rat Cardiac Allografts

Keränen, M. A. I., Tuuminen, R., Syrjala, S., Krebs, R., Walkinshaw, G., Flippin, L. A., Arend, M., Koskinen, P. K., Nykänen, A. & Lemström, K. B., Mar 2013, In : American Journal of Transplantation. 13, 3, p. 600-610 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Donor simvastatin treatment and cardiac allograft ischemia/reperfusion injury

Nykänen, A. I., Tuuminen, R. & Lemstrom, K. B., Apr 2013, In : Trends in Cardiovascular Medicine. 23, 3, p. 85-90 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Donor Simvastatin Treatment Prevents Ischemia-Reperfusion and Acute Kidney Injury by Preserving Microvascular Barrier Function

Tuuminen, R., Nykänen, A., Saharinen, P., Gautam, P., Keränen, M. A. I., Arnaudova, R., Rouvinen, E., Helin, H., Tammi, R., Rilla, K., Krebs, R. & Lemström, K. B., Aug 2013, In : American Journal of Transplantation. 13, 8, p. 2019-2034 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants

Raissadati, A., Jokinen, J. J., Syrjala, S. O., Keränen, M. A. I., Krebs, R., Tuuminen, R., Arnaudova, R., Rouvinen, E., Anisimov, A., Soronen, J., Pajusola, K., Alitalo, K., Nykänen, A. I. & Lemström, K. B., Nov 2013, In : Transplant International. 26, 11, p. 1126-1137 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Sydämensiirtopotilaan akuutit ongelmat

Lommi, J. & Lemström, K., 2013, In : Sydänääni : Suomen kardiologisen seuran lehti. 24, 1A, p. 98-102 5 p.

Research output: Contribution to journalArticleProfessional

Sydän- ja keuhkonsiirrot. Tutkimukset, indikatiot ja seuranta. Valtakunnallinen hoito-ohje.

Lemström, K. B., Hämmäinen, P., Lommi, J. J., Halme, R. M. K., Hellstedt, M-L. & Yesil, C., 2013, (Submitted) Helsinki: Unigrafia. 124 p.

Research output: Book/ReportBookProfessional

Three decades of heart transplantation in Scandinavia: long-term follow-up

Dellgren, G., Geiran, O., Lemstrom, K., Gustafsson, F., Eiskjaer, H., Koul, B., Hagerman, I., Selimovic, N. & Nord Thorac Transplant Study Grp, Mar 2013, In : European Journal of Heart Failure. 15, 3, p. 308-315 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Critical Role of VEGF-C/VEGFR-3 Signaling in Innate and Adaptive Immune Responses in Experimental Obliterative Bronchiolitis

Krebs, R., Tikkanen, J. M., Ropponen, J. O., Jeltsch, M., Jokinen, J. J., Yla-Herttuala, S., Nykanen, A. I. & Lemstrom, K. B., Nov 2012, In : The American Journal of Pathology. 181, 5, p. 1607-1620 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of simvastatin on development of obliterative airway disease: An experimental study

Ropponen, J. O., Syrjala, S. O., Hollmen, M., Tuuminen, R., Krebs, R., Keränen, M. A. I., Vaali, K., Nykanen, A. I., Lemstrom, K. B. & Tikkanen, J. M., 2012, In : Journal of Heart and Lung Transplantation. 31, 2, p. 194-203 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Aikuisten sydämensiirrot: [katsaus]

Jokinen, J. J., Lommi, J. & Lemström, K. B., 2011, In : Suomen lääkärilehti. 66, 33, p. 2327-2331 5 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Donor Simvastatin Treatment Abolishes Rat Cardiac Allograft Ischemia/Reperfusion Injury and Chronic Rejection Through Microvascular Protection

Tuuminen, R., Syrjala, S., Krebs, R., Keränen, M. A. I., Koli, K., Abo Ramadan, U., Neuvonen, P. J., Tikkanen, J. M., Nykänen, A. & Lemström, K. B., 2011, In : Circulation . 124, 10, p. 1138-1150 12 p.

Research output: Contribution to journalArticleScientificpeer-review

ECMO eli kehonulkoinen happeuttaminen aikuisten vaikeassa hengitysvajauksessa: [katsaus]

Mildh, L., Lemström, K. B., Jokinen, J. J., Raivio, P., Suojaranta-Ylinen, R. T. & Hämmäinen, P., 2011, In : Duodecim. 127, 19, p. 2055-2062 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Elin- ja kudossiirrot

Renkonen, R., Lemström, K. B. & Mäkisalo, H., 2011, Immunologia: Mikrobiologia, immunologia ja infektiosairaudet, kirja 2. Hedman, K., Heikkinen, T., Huovinen, P., Järvinen, A., Meri, S. & Vaara, M. (eds.). Helsinki: Duodecim, p. 394-400 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Immunosuppressio

Koskinen, P. & Lemström, K. B., 2011, Kliininen farmakologia ja lääkehoito. Neuvonen, P. J., Backman, J. T., Himberg, J-J., Huupponen, R., Keränen, T. & Kivistö, K. T. (eds.). 2. p. ed. Kandidaattikustannus Oy/ Lääketieteen kandidaattiseura ry, p. 691-704 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional