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Publications 1988 2019

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2019

Continuous-flow LVADs in the Nordic countries: complications and mortality and its predictors

Braun, O. Ö., Nilsson, J., Gustafsson, F., Dellgren, G., Fiane, A. E., Lemström, K., Hubbert, L., Hellgren, L. & Lund, L. H., 2019, In : Scandinavian Cardiovascular Journal. 53, 1, p. 14-20 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Extracorporeal membrane oxygenation for refractory cardiogenic shock: patient survival and health-related quality of life

Jäämaa-Holmberg, S., Salmela, B., Suojaranta, R., Jokinen, J. J., Lemström, K. B. & Lommi, J., Apr 2019, In : European Journal of Cardio-Thoracic Surgery. 55, 4, p. 780-787 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Hypoxia-inducible factor controls immunoregulatory properties of myeloid cells in mouse cardiac allografts - an experimental study

Keränen, M. A. I., Raissadati, A., Nykänen, A. I., Dashkevich, A., Tuuminen, R., Krebs, R., Johnson, R. S., Syrjälä, S. O. & Lemström, K. B., Jan 2019, In : Transplant International. 32, 1, p. 95-106 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

Dual antiplatelet and anticoagulant APAC prevents experimental ischemia-reperfusion-induced acute kidney injury

Tuuminen, R., Jouppila, A., Salvail, D., Laurent, C-E., Benoit, M-C., Syrjälä, S., Helin, H., Lemstrom, K. & Lassila, R., 2017, In : Clinical and Experimental Nephrology. 21, 3, p. 436–445 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Mekaaniset tukilaitteet sydämen vajaatoiminnassa

Varpula, M., Pentikäinen, M., Suojaranta, R., Kiss, J. & Lemström, K., 2017, In : Sydänääni : Suomen kardiologisen seuran lehti. 28, 3A, p. 333-340 8 p.

Research output: Contribution to journalArticleProfessional

Miten varautua sydänsiirteiden uhkaavaan vajeeseen?

Kiss, J., Stark, C., Lemström, K. & Lommi, J., 2017, In : Duodecim. 133, 24, p. 2413-2417 5 p.

Research output: Contribution to journalArticleProfessional

Open Access
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2016

Decreased maximum clot firmness in rotational thromboelastometry (ROTEM (R)) is associated with bleeding during extracorporeal mechanical circulatory support

Laine, A., Niemi, T., Suojaranta-Ylinen, R., Raivio, P., Soininen, L., Lemstrom, K., Hammainen, P. & Schramko, A., Nov 2016, In : Perfusion. 31, 8, p. 625-633 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma

Seppälä, M., Pohjola, K., Laranne, J., Rautiainen, M., Huhtala, H., Renkonen, R., Lemstrom, K., Paavonen, T. & Toppila-Salmi, S., Dec 2016, In : European Archives of Oto-Rhino-Laryngology. 273, 12, p. 4515-4524 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Increased myeloid cell hypoxia-inducible factor-1 delays obliterative airway disease in the mouse

Ropponen, J. O., Keränen, M. A., Raissadati, A., Nykänen, A. I., Krebs, R., Lemstrom, K. B. & Tikkanen, J. M., May 2016, In : Journal of Heart and Lung Transplantation. 35, 5, p. 671-678 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts

Dashkevich, A., Raissadati, A., Syrjala, S. O., Zarkada, G., Keranen, M. A. I., Tuuminen, R., Krebs, R., Anisimov, A., Jeltsch, M., Leppanen, V. -M., Alitalo, K., Nykanen, A. I. & Lemstrom, K. B., Apr 2016, In : American Journal of Transplantation. 16, 4, p. 1160-1172 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Platelet-derived Growth Factor-B Protects Rat Cardiac Allografts From Ischemia-reperfusion Injury

Tuuminen, R., Dashkevich, A., Keränen, M. A. I., Raissadati, A., Krebs, R., Jokinen, J. J., Arnaudova, R., Rouvinen, E., Yla-Herttuala, S., Nykänen, A. & Lemstrom, K. B., Feb 2016, In : Transplantation. 100, 2, p. 303-313 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion

Tuuminen, R., Holmstrom, E., Raissadati, A., Saharinen, P., Rouvinen, E., Krebs, R. & Lemstrom, K. B., Jul 2016, In : Transplant Immunology. 37, p. 40-45 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Simvastatin Treatment Upregulates Anti-Fibrotic Bone Morphogenetic Protein-7 Expression at Rat Cardiac Allograft Rejection

Holmstrom, E. J., Lemstrom, K. B. & Tuuminen, R., 2016, In : Pharmacology. 98, 5-6, p. 204-208 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts

Syrjala, S. O., Nykänen, A. I., Tuuminen, R., Raissadati, A., Keränen, M. A. I., Arnaudova, R., Krebs, R., Koh, G. Y., Alitalo, K. & Lemstrom, K. B., Aug 2015, In : American Journal of Transplantation. 15, 8, p. 2075-2084 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Kansalliset ohjeet elinluovuttajan hoidosta ja elinten talteenotosta : (tämä ohje astui voimaan 3.2.2015)

Isoniemi, H., Lempinen, M., Nordin, A., Hartikka, E., Lemström, K., Hämmäinen, P., Suojaranta-Ylinen, R., Yesil, C., Soininen, L., Koivusalo, A-M. & Kaartinen, J., 2015, In : Tehohoito. 33, 1, p. 50-53 4 p.

Research output: Contribution to journalArticleProfessional

Systemic overexpression of matricellular protein CCN1 exacerbates obliterative bronchiolitis in mouse tracheal allografts

Raissadati, A., Nykänen, A. I., Tuuminen, R., Syrjala, S. O., Krebs, R., Arnaudova, R., Rouvinen, E., Wang, X., Poller, W. & Lemstrom, K. B., Dec 2015, In : Transplant International. 28, 12, p. 1416-1425 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Angiopoietin-2 Inhibition Prevents Transplant Ischemia- Reperfusion Injury and Chronic Rejection in Rat Cardiac Allografts

Syrjala, S. O., Tuuminen, R., Nykanen, A. I., Raissadati, A., Dashkevich, A., Keranen, M. A. I., Arnaudova, R., Krebs, R., Leow, C. C., Saharinen, P., Alitalo, K. & Lemstrom, K. B., May 2014, In : American Journal of Transplantation. 14, 5, p. 1096-1108 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Combined Donor Simvastatin and Methylprednisolone Treatment Prevents Ischemia-Reperfusion Injury in Rat Cardiac Allografts Through Vasculoprotection and Immunomodulation

Tuuminen, R., Syrjala, S., Krebs, R., Arnaudova, R., Rouvinen, E., Nykanen, A. I. & Lemstrom, K. B., 15 May 2013, In : Transplantation. 95, 9, p. 1084-1091 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential Effects of Pharmacological HIF Preconditioning of Donors Versus Recipients in Rat Cardiac Allografts

Keränen, M. A. I., Tuuminen, R., Syrjala, S., Krebs, R., Walkinshaw, G., Flippin, L. A., Arend, M., Koskinen, P. K., Nykänen, A. & Lemström, K. B., Mar 2013, In : American Journal of Transplantation. 13, 3, p. 600-610 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Donor Simvastatin Treatment Prevents Ischemia-Reperfusion and Acute Kidney Injury by Preserving Microvascular Barrier Function

Tuuminen, R., Nykänen, A., Saharinen, P., Gautam, P., Keränen, M. A. I., Arnaudova, R., Rouvinen, E., Helin, H., Tammi, R., Rilla, K., Krebs, R. & Lemström, K. B., Aug 2013, In : American Journal of Transplantation. 13, 8, p. 2019-2034 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants

Raissadati, A., Jokinen, J. J., Syrjala, S. O., Keränen, M. A. I., Krebs, R., Tuuminen, R., Arnaudova, R., Rouvinen, E., Anisimov, A., Soronen, J., Pajusola, K., Alitalo, K., Nykänen, A. I. & Lemström, K. B., Nov 2013, In : Transplant International. 26, 11, p. 1126-1137 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Sydämensiirtopotilaan akuutit ongelmat

Lommi, J. & Lemström, K., 2013, In : Sydänääni : Suomen kardiologisen seuran lehti. 24, 1A, p. 98-102 5 p.

Research output: Contribution to journalArticleProfessional

Three decades of heart transplantation in Scandinavia: long-term follow-up

Dellgren, G., Geiran, O., Lemstrom, K., Gustafsson, F., Eiskjaer, H., Koul, B., Hagerman, I., Selimovic, N. & Nord Thorac Transplant Study Grp, Mar 2013, In : European Journal of Heart Failure. 15, 3, p. 308-315 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Critical Role of VEGF-C/VEGFR-3 Signaling in Innate and Adaptive Immune Responses in Experimental Obliterative Bronchiolitis

Krebs, R., Tikkanen, J. M., Ropponen, J. O., Jeltsch, M., Jokinen, J. J., Yla-Herttuala, S., Nykanen, A. I. & Lemstrom, K. B., Nov 2012, In : The American Journal of Pathology. 181, 5, p. 1607-1620 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of simvastatin on development of obliterative airway disease: An experimental study

Ropponen, J. O., Syrjala, S. O., Hollmen, M., Tuuminen, R., Krebs, R., Keränen, M. A. I., Vaali, K., Nykanen, A. I., Lemstrom, K. B. & Tikkanen, J. M., 2012, In : Journal of Heart and Lung Transplantation. 31, 2, p. 194-203 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Donor Simvastatin Treatment Abolishes Rat Cardiac Allograft Ischemia/Reperfusion Injury and Chronic Rejection Through Microvascular Protection

Tuuminen, R., Syrjala, S., Krebs, R., Keränen, M. A. I., Koli, K., Abo Ramadan, U., Neuvonen, P. J., Tikkanen, J. M., Nykänen, A. & Lemström, K. B., 2011, In : Circulation . 124, 10, p. 1138-1150 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Innate and adaptive immune responses in obliterative airway disease in rat tracheal allografts

Ropponen, J. O., Syrjala, S. O., Krebs, R., Nykanen, A., Tikkanen, J. M. & Lemström, K. B., 2011, In : Journal of Heart and Lung Transplantation. 30, 6, p. 707-716 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Sydämen ja verenkierron mekaaninen tuki aikuisilla

Jokinen, J. J., Mildh, L., Hämmäinen, P., Taal, G., Raivio, P., Suojaranta-Ylinen, R. T., Lommi, J., Sipponen, J. & Lemström, K. B., 2011, In : Duodecim. 127, 19, p. 2045-2053 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Usefulness of extracorporeal membrane oxygenation as a bridge to lung transplantation: A descriptive study

Hämmäinen, P., Schersten, H., Lemström, K. B., Riise, G. C., Kukkonen, S., Swärd, K., Sipponen, J., Silverborn, M. & Dellgren, G., 2011, In : Journal of Heart and Lung Transplantation. 30, 1, p. 103-107 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Association between gastrointestinal symptoms and health-related quality of life after heart transplantation

Jokinen, J. J., Hämmäinen, P., Lemström, K. B., Lommi, J., Sipponen, J. & Harjula, A. L. J., 2010, In : Journal of Heart and Lung Transplantation. 29, 12, p. 1388-1394 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Cardiomyocyte-targeted HIF-1 alpha gene therapy inhibits cardiomyocyte apoptosis and cardiac alllograft vasculopathy in the rat

Keränen, M. A. I., Nykänen, A., Krebs, R., Pajusola, K., Tuuminen, R., Alitalo, K. & Lemström, K. B., 2010, In : Journal of Heart and Lung Transplantation. 29, 9, p. 1058-1066 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased Th17 rather than Th1 alloimmune response is associated with cardiac allograft vasculopathy after hypothermic preservation in the rat

Syrjälä, S. O., Keränen, M. A. I., Tuuminen, R., Nykänen, A., Tammi, M., Krebs, R. & Lemström, K. B., 2010, In : Journal of Heart and Lung Transplantation. 29, 9, p. 1047-1057 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts

Nykänen, A., Sandelin, H., Krebs, R., Keränen, M. A. I., Tuuminen, R., Kärpänen, T., Wu, Y., Pytowski, B., Koskinen, P. K., Yla-Herttuala, S., Alitalo, K. & Lemström, K. B., 2010, In : Circulation . 121, 12, p. 1413-1422 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

Bry, M., Kivelä, R., Holopainen, T., Anisimov, A., Tammela, T., Soronen, J., Silvola, J., Saraste, A., Jeltsch, M., Korpisalo, P., Carmeliet, P., Lemström, K. B., Shibuya, M., Yla-Herttuala, S., Alhonen, L., Mervaala, E., Andersson, L. C., Knuuti, J. & Alitalo, K., 2010, In : Circulation . 122, 17, p. 1725-1733 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Ohjeet elintenluovuttajan hoidosta sekä elinten talteenotosta

Höckerstedt, K., Isoniemi, H., Mäkisalo, H., Koivusalo, A-M., Ilmakunnas, M., Hartikka, E., Lemström, K., Hämmäinen, P., Salmenperä, M. & Yesil, C., 2009, In : Tehohoito. 27, 2, p. 122-125 4 p.

Research output: Contribution to journalArticleScientific

PDGF-A, -C, and -D but not PDGF-B increase TGF-[beta]1 and chronic rejection in rat cardiac allografts

Tuuminen, R., Nykänen, A. I., Krebs, R., Soronen, J., Pajusola, K., Keränen, M. A. I., Koskinen, P. K., Alitalo, K. & Lemstrom, K. B., 2009, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 29, 5, p. 691-698 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Sydämensiirtojen tulokset ja pullonkaulat

Lemström, K., Jokinen, J. J., Lommi, J. & Sipponen, J., 2009, In : Sydänääni : Suomen kardiologisen seuran lehti. 20, 3A, p. 11-16 6 p.

Research output: Contribution to journalArticleScientific

Sydänluovuttajan arviointi ja hoito

Hämmäinen, P., Kukkonen, S. & Lemström, K., 2009, In : Sydänääni : Suomen kardiologisen seuran lehti. 20, 3A, p. 17-20 4 p.

Research output: Contribution to journalArticleScientific

Yksilöllinen immunosuppressio on nykyaikaa

Lemström, K. & Lommi, J., 2009, In : Sydänääni : Suomen kardiologisen seuran lehti. 20, 3A, p. 21-24 4 p.

Research output: Contribution to journalArticleScientific

Vascular endothelial growth factor in chronic rat allograft nephropathy

Malmström, N. K., Kallio, E. A., Rintala, J. M., Nykänen, A., Räisänen-Sokolowski, A. K., Paavonen, T., Lemström, K. B. & Koskinen, P. K., 2008, In : Transplant Immunology. 19, 2, p. 136-144 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and arteriosclerosis in chronically rejecting cardiac allografts

Raisky, O., Nykänen, A. I., Krebs, R., Hollmen, M., Keränen, M. A. I., Tikkanen, J. M., Sihvola, R., Alhonen, L., Salven, P., Wu, Y., Hicklin, D. J., Alitalo, K., Koskinen, P. K. & Lemström, K. B., 2007, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 27, p. 819-825 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Common protective and diverse smooth muscle cell effects of AAV-mediated angiopoietin-1 and -2 expression in rat cardiac allograft vasculopathy

Nykänen, A. I., Pajusola, K., Krebs, R., Keränen, M. A. I., Raisky, O., Koskinen, P. K., Alitalo, K., Lemström, K., Lemström, K. B., Nykänen, A. & Keränen, M., 2006, In : Circulation Research. 98, p. 1373-1380 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of graft preservation and acute rejection on hypoxia-inducible factor-1 in rat cardiac allografts

Keränen, M. A. I., Nykänen, A. I., Krebs, R., Tuuminen, R., Sandelin, H., Koskinen, P. K., Lemström, K. & Keränen, M., 2006, In : Transplantation Proceedings. 38, 10, p. 3372-3373 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of tumor necrosis factor-[alpha] attenuates myocardial remodeling in rat cardiac allografts

Sihvola, R., Koskinen, P. K., Pulkkinen, V. P., Tikkanen, J. M., Lemström, K., Lemström, K. B. & Sihvola, R. K., 2006, In : Journal of Heart and Lung Transplantation. 25, p. 569-578 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Interplay between inflammation and angiogenesis in cardiac allografts - Therapeutic applications for VEGFR-1 and-2 inhibition

Nykanen, A. I., Raisky, O., Hollmen, M., Krebs, R., Tikkanen, J. M., Wu, Y., Hicklin, D. J., Koskinen, P. K. & Lemstrom, K. B., 2006, In : Journal of Heart and Lung Transplantation. 25, p. S89-S90 2 p.

Research output: Contribution to journalArticleScientificpeer-review