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Publications 1992 2019

2019

The effect of intakes of fish and Camelina sativa oil on atherogenic and anti-atherogenic functions of LDL and HDL particles: A randomized controlled trial

Manninen, S., Lankinen, M., Erkkilä, A., Nguyen, S. D., Ruuth, M., de Mello, V., Öörni, K. & Schwab, U., Feb 2019, In : Atherosclerosis. 281, p. 56-61 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

Nissilä, E., Hakala, P., Leskinen, K., Roig, A., Syed, S., Van Kessel, K. P. M., Metso, J., De Haas, C. J. C., Saavalainen, P., Meri, S., Chroni, A., Van Strijp, J. A. G., Öörni, K., Jauhiainen, M., Jokiranta, T. S. & Haapasalo, K., 21 Nov 2018, In : Frontiers in Immunology. 9, 14 p., 2701.

Research output: Contribution to journalArticleScientificpeer-review

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Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties

Lehti, S., Nguyen, S. D., Belevich, I., Vihinen, H., Heikkilä, H. M., Soliymani, R., Käkelä, R., Saksi, J., Jauhiainen, M., Grabowski, G. A., Kummu, O., Hörkkö, S., Baumann, M., Lindsberg, P. J., Jokitalo, E., Kovanen, P. T. & Öörni, K., Feb 2018, In : The American Journal of Pathology. 188, 2, p. 525-538 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Human mast cell neutral proteases generate modified LDL particles with increased proteoglycan binding

Maaninka, K., Nguyen, S. D., Mäyränpää, M. I., Plihtari, R., Rajamäki, K., Lindsberg, P. J., Kovanen, P. T. & Öörni, K., Aug 2018, In : Atherosclerosis. 275, p. 390-399 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Keramidit ja sepelvaltimotauti

Laaksonen, R., Öörni, K., Hilvo, M., Kovanen, P. T. & Sinisalo, J., 2018, In : Duodecim. 134, 5, p. 456-464 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

Ruuth, M., Nguyen, S. D., Vihervaara, T. M., Hilvo, M., Laajala, T. D., Kondadi, P. K., Gistera, A., Lähteenmäki, H., Kittilä, T., Huusko, J., Uusitupa, M., Schwab, U., Savolainen, M. J., Sinisalo, J., Lokki, M-L., Nieminen, M. S., Jula, A., Perola, M., Ylä-Herttula, S., Rudel, L. & 12 othersÖörni, A., Baumann, M., Baruch, A., Laaksonen, R., Ketelhuth, D. F. J., Aittokallio, T., Jauhiainen, M., Käkelä, R., Boren, J., Williams, K. J., Kovanen, P. T. & Öörni, K., 14 Jul 2018, In : European Heart Journal. 39, 27, p. 2562-2573 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Thermodynamic and kinetic approaches for evaluation of monoclonal antibody - Lipoprotein interactions

Multia, E., Sirén, H., Andersson, K., Samuelsson, J., Forssén, P., Fornstedt, T., Öörni, K., Jauhiainen, M. & Riekkola, M-L., 2017, In : Analytical Biochemistry. 518, p. 25-34 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties

Duy Nguyen, S., Maaninka, K., Lappalainen, J., Nurmi, K., Metso, J., Oorni, K., Navab, M., Fogelman, A. M., Jauhiainen, M., Lee-Rueckert, M. & Kovanen, P. T., Feb 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 2, p. 274-284 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis

Rajamäki, K., Mäyränpää, M., Risco, A., Tuimala, J., Nurmi, K., Cuenda, A., Eklund, K. K., Öörni, K. & Kovanen, P. T., Sep 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 9, p. 1937-1946 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Tailor-made approach for selective isolation and elution of low-density lipoproteins by immunoaffinity sorbent on silica

Gan, N., Multia, E., Siren, H., Ruuth, M., Öörni, K., Maier, N. M., Jauhiainen, M., Kemell, M. & Riekkola, M-L., 1 Dec 2016, In : Analytical Biochemistry. 514, p. 12-23 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Acidification of the intimal fluid: The perfect storm for atherogenesis

Oorni, K., Rajamaki, K., Su Duy Nguyen, Lahdesmaki, K., Plihtari, R., Lee-Rueckert, M. & Kovanen, P. T., Feb 2015, In : Journal of Lipid Research. 56, 2, p. 203-214 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation

Nguyen, S. D., Javanainen, M., Rissanen, S., Zhao, H., Huusko, J., Kivelä, A. M., Ylä-Herttuala, S., Navab, M., Fogelman, A. M., Vattulainen, I., Kovanen, P. T. & Öörni, K., 2015, In : Journal of Lipid Research. 56, 6, p. 1206-1221 16 p.

Research output: Contribution to journalArticleScientificpeer-review

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Electronegative LDL induces priming and inflammasome activation leading to IL-1 beta release in human monocytes and macrophages

Estruch, M., Rajamaki, K., Sanchez-Quesada, J. L., Kovanen, P. T., Öörni, K., Benitez, S. & Ordonez-Llanos, J., Nov 2015, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1851, 11, p. 1442-1449 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Activated Human Mast Cells Induce LOX-1-Specific Scavenger Receptor Expression in Human Monocyte-Derived Macrophages

Alanne-Kinnunen, M., Lappalainen, J., Öörni, K. & Kovanen, P. T., 24 Sep 2014, In : PLoS One. 9, 9, 9 p., 108352.

Research output: Contribution to journalArticleScientificpeer-review

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Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

Wang, J., Tang, T-T., Öörni, K., Wu, W., Liu, C., Secco, B., Tia, V., Sukhova, G. K., Fernandes, C., Lesner, A., Kovanen, P. T., Libby, P., Cheng, X. & Shi, G-P., 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 11, p. 2174-2183 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI CD36, and LOX-1 in aortic valve stenosis

Syvaranta, S., Kinnunen, M., Öörni, K., Oksjoki, R., Kupari, M., Kovanen, P. T. & Helske-Suihko, S., Aug 2014, In : Atherosclerosis. 235, 2, p. 398-407 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Angptl3 Deficiency Is Associated With Increased Insulin Sensitivity, Lipoprotein Lipase Activity, and Decreased Serum Free Fatty Acids

Robciuc, M. R., Maranghi, M., Lahikainen, A., Rader, D., Bensadoun, A., Öörni, K., Metso, J., Minicocci, I., Ciociola, E., Ceci, F., Montali, A., Arca, M., Ehnholm, C. & Jauhiainen, M., Jul 2013, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 7, p. 1706-1713 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome

Rajamäki, K., Nordström, T., Nurmi, K., Åkerman, K. E. O., Kovanen, P. T., Öörni, K. & Eklund, K. K., 10 May 2013, In : Journal of Biological Chemistry. 288, 19, p. 13410-13419 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Modified Lipoprotein-Derived Lipid Particles Accumulate in Human Stenotic Aortic Valves

Lehti, S., Käkelä, R., Horkko, S., Kummu, O., Helske-Suihko, S., Kupari, M., Werkkala, K., Kovanen, P. T. & Öörni, K., 7 Jun 2013, In : PLoS One. 8, 6, p. Article Number: e65810 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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Three complementary techniques for the clarification of temperature effect on low-density lipoprotein-chondroitin-6-sulfate interaction

Cilpa-Karhu, G., Lipponen, K., Samuelsson, J., Öörni, K., Fornstedt, T. & Riekkola, M-L., 15 Dec 2013, In : Analytical Biochemistry. 443, 2, p. 139-147 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Acidity and lipolysis by group V secreted phospholipase A(2) strongly increase the binding of apoB-100-containing lipoproteins to human aortic proteoglycans

Lahdesmaki, K., Öörni, K., Alanne-Kinnunen, M., Jauhiainen, M., Hurt-Camejo, E. & Kovanen, P. T., Feb 2012, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1821, 2, p. 257-267 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Capillary electrochromatography and quartz crystal microbalance, valuable techniques in the study of heparin-lipoprotein interactions

Lipponen, K., Liu, Y., Stege, P. W., Öörni, K., Kovanen, P. T. & Riekkola, M-L., 2012, In : Analytical Biochemistry. 424, 1, p. 71-78 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH

Sneck, M., Nguyen, S. D., Pihlajamaa, T., Yohannes, G., Riekkola, M-L., Milne, R., Kovanen, P. & Öörni, K., 20 Jun 2012, In : Journal of Lipid Research. 53, 9, p. 1832-1839 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Plasma low-density lipoprotein immobilized silica as stationary phase in nano-liquid chromatography

Liu, Y., Lipponen, K., Cilpa-Karhu, G., Öörni, K. & Riekkola, M-L., 2012, In : Journal of Chromatography. A. 1270, p. 104-110 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells

Nguyen, S. D., Öörni, K., Lee-Rueckert, M., Pihlajamaa, T., Metso, J., Jauhiainen, M. & Kovanen, P. T., 2012, In : Journal of Lipid Research. 53, 10, p. 2115-2125 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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2011

Acidity increases the uptake of native LDL by human monocyte-derived macrophages

Plihtari, R., Kovanen, P. T. & Öörni, K., 2011, In : Atherosclerosis. 217, 2, p. 401-406 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Immunochemical analysis of the electronegative LDL subfraction shows that abnormal N-terminal apolipoprotein B conformation is involved in increased binding to proteoglycans

Bancells, C., Benítez, S., Ordóñez-Llanos, J., Öörni, K., Kovanen, P. T., Milne, R. W. & Sánchez-Quesada, J. L., 2011, In : Journal of Biological Chemistry. 286, 2, p. 1125-1133 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X(7) Receptor and a Cathepsin B-Sensitive Pathway

Niemi, K., Teirila, L., Lappalainen, J., Rajamaki, K., Baumann, M. H., Öörni, K., Wolff, H., Kovanen, P. T., Matikainen, S. & Eklund, K. K., 2011, In : Online Journal of Immunology. 186, p. 6119-6128 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Three-Dimensional cryoEM Reconstruction of Native LDL Particles to 16 angstrom Resolution at Physiological Body Temperature

Kumar, V., Butcher, S. J., Öörni, K., Engelhardt, P., Heikkonen, J., Kaski, K., Ala-Korpela, M. & Kovanen, P. T., 2011, In : PLoS One. 6, 5, p. e18841 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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2010

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Rajamaki, K., Lappalainen, J., Öörni, K., Valimaki, E., Matikainen, S., Kovanen, P. T. & Eklund, K. K., 23 Jul 2010, In : PLoS One. 5, 7, 9 p., 11765.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Open tubular capillary electrochromatography: A useful microreactor for collagen I glycation and interaction studies with low-density lipoprotein particles

D'Ulivo, L., Witos, J., Öörni, K., Kovanen, P. T. & Riekkola, M-L., 2010, In : Analytica Chimica Acta. 664, 2, p. 185-189 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Partial filling affinity capillary electrophoresis with cationic poly(vinylpyrrolidone)-based copolymer coatings for studies on human lipoprotein-steroid interactions

Wang, A-J., Vainikka, K., Witos, J., D'Ulivo, L., Cilpa, G., Kovanen, P. T., Öörni, K., Jauhiainen, M. & Riekkola, M-L., 2010, In : Analytical Biochemistry. 399, 1, p. 93-101 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A(2) group V and secretory sphingomyelinase

Plihtari, R., Hurt-Camejo, E., Öörni, K. & Kovanen, P. T., Jul 2010, In : Journal of Lipid Research. 51, 7, p. 1801-1809 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Sugar treatment of human lipoprotein particles and their separation by capillary electrophoresis

Witos, J., Cilpa, G., Yohannes, G., Öörni, K., Kovanen, P. T., Jauhiainen, M. & Riekkola, M-L., 2010, In : Journal of Separation Science. 33, 16, p. 2528-2535 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

CEC: A tool for mimicking collagen-surface interactions with apolipoprotein B-100 peptides

D'Ulivo, L., Witos, J., Öörni, K., Kovanen, P. T. & Riekkola, M-L., 2009, In : Electrophoresis. 30, 22, p. 3838-3845 8 p.

Research output: Contribution to journalArticleScientificpeer-review

High binding affinity of electronegative LDL to human aortic proteoglycans depends on its aggregation level

Bancells, C., Benítez, S., Jauhiainen, M., Ordóñez-Llanos, J., Kovanen, P. T., Villegas, S., Sánchez-Quesada, J. L. & Öörni, K., 2009, In : Journal of Lipid Research. 50, 3, p. 446-455 10 p.

Research output: Contribution to journalArticleScientificpeer-review

High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease

Muhl, L., Galuska, S. P., Öörni, K., Hernández-Ruiz, L., Andrei-Selmer, L-C., Geyer, R., Preissner, K. T., Ruiz, F. A., Kovanen, P. T. & Kanse, S. M., 2009, In : The FEBS Journal. 276, 17, p. 4828-4839 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipoprotein modification by secretory phospholipase A2 enzymes contributes to the initiation and progression of atherosclerosis

Öörni, K. & Kovanen, P. T., 2009, In : Current Opinion in Lipidology. 20, 5, p. 421-427 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Phospholipase A2-modified LDL particles retain the generated hydrolytic products and are more atherogenic at acidic pH

Lähdesmäki, K., Plihtari, R., Soininen, P., Hurt-Camejo, E., Ala-Korpela, M., Öörni, K. & Kovanen, P. T., 2009, In : Atherosclerosis. 207, 2, p. 352-359 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

In situ delipidation of low-density lipoproteins in capillary electrochromatography yields apolipoprotein B-100-coated surfaces for interaction studies

D'Ulivo, L., Chen, J., Meinander, K., Öörni, K., Kovanen, P. T. & Riekkola, M-L., 2008, In : Analytical Biochemistry. 383, p. 38-42 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins

Soininen, P., Öörni, K., Maaheimo, H., Laatikainen, R., Kovanen, P. T., Kaski, K. & Ala-Korpela, M., 2007, In : Biochemical and Biophysical Research Communications. 360, 1, p. 290-294 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: An angiotensin II type 2 receptor-mediated effect

Kaakinen, R., Lindstedt, K. A., Sneck, M., Kovanen, P. T. & Öörni, K., 2007, In : Atherosclerosis. 192, 2, p. 323-327 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open tubular capillary electrochromatography: a new technique for in situ enzymatic modification of low density lipoprotein particles and their protein-free derivatives

D'Ulivo, L., Yohannes, G., Öörni, K., Kovanen, P. T. & Riekkola, M-L., 2007, In : Analyst. 132, 10, p. 989-996 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open tubular CE for in vitro oxidation studies of human very-low-density lipoprotein particles

Ruiz-Jimenez, J., Kuldvee, R., Öörni, K., Kovanen, P. T., Riekkola, M-L. & Chen, J., 2007, In : Electrophoresis. 28, 5, p. 779-788 10 p.

Research output: Contribution to journalArticleScientificpeer-review

PLA2-V: A real player in atherogenesis

Öörni, K. & Kovanen, P. T., 2007, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 27, 3, p. 445-447 3 p.

Research output: Contribution to journalArticleScientific

2006

Enhanced extracellular lipid accumulation in acidic environments

Öörni, K. & Kovanen, P. T., 2006, In : Current Opinion in Lipidology. 17, 5, p. 534-540 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves

Helske, S., Syväranta, S., Lindstedt, K. A., Lappalainen, J., Öörni, K., Mäyränpää, M., Lommi, J., Turto, H., Werkkala, K., Kupari, M. & Kovanen, P. T., 2006, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 8, p. 1791-1798 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Miniaturization of asymmetrical flow field-flow fractionation and application to studies on lipoprotein aggregation and fusion

Yohannes, G., Sneck, M., Varjo, S. J. O., Jussila, M., Wiedmer, S. K., Kovanen, P. T., Öörni, K. & Riekkola, M-L., 2006, In : Analytical Biochemistry. 354, p. 255-265 11 p.

Research output: Contribution to journalArticleScientificpeer-review