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  • PL 22 (Haartmaninkatu 4)

    00014

    Finland

19952019
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Publications 1995 2019

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2019

Dasatinib and navitoclax act synergistically to target NUP98-NSD1(+)/FLT3-ITD+ acute myeloid leukemia

Kivioja, J. L., Thanasopoulou, A., Kumar, A., Kontro, M., Yadav, B., Majumder, M. M., Javarappa, K. K., Eldfors, S., Schwaller, J., Porkka, K. & Heckman, C. A., Jun 2019, In : Leukemia. 33, 6, p. 1360-1372 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies

Pölönen, P., Mehtonen, J., Lin, J., Liuksiala, T., Häyrynen, S., Teppo, S., Mäkinen, A., Kumar, A., Malani, D., Pohjolainen, V., Porkka, K., Heckman, C. A., May, P., Hautamäki, V., Granberg, K. J., Lohi, O., Nykter, M. & Heinäniemi, M., 15 May 2019, In : Cancer Research. 79, 10, p. 2466-2479 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL

Hohtari, H., Bruck, O., Blom, S., Turkki, R., Sinisalo, M., Kovanen, P. E., Kallioniemi, O., Pellinen, T., Porkka, K. & Mustjoki, S., Jul 2019, In : Leukemia. 33, 7, p. 1570-1582 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Kliininen hematologia - tietolaatikko

Tarkkanen, M., Porkka, K. & Rapola, R., 2019, In : Duodecim. 135, 12, p. 1208-1208 1 p.

Research output: Contribution to journalArticleProfessional

Multi-parametric single cell evaluation defines distinct drug responses in healthy hematological cells that are retained in corresponding malignant cell types

Majumder, M. M., Leppä, A-M., Hellesøy, M., Dowling, P., Malyutina, A., Kopperud, R., Bazou, D., Andersson, E., Parsons, A., Tang, J., Kallioniemi, O., Mustjoki, S., O'Gorman, P., Wennerberg, K., Porkka, K., Gjertsen, B. T. & Heckman, C. A., 22 Aug 2019, In : Haematologica. p. haematol.2019.217414

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

Kuusanmäki, H., Leppä, A-M., Pölönen, P., Kontro, M., Dufva, O., Deb, D., Yadav, B., Bruck, O., Kumar, A., Everaus, H., Gjertsen, B. T., Heinäniemi, M., Porkka, K., Mustjoki, S. & Heckman, C., 11 Jul 2019, In : Haematologica.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Chimeric NUP98-NSD1 transcripts from the cryptic t(5;11)(q35.2;p15.4) in adult de novo acute myeloid leukemia

Kivioja, J., Lopez Marti, J. M., Kumar, A., Kontro, M., Edgren, H., Parsons, A., Lundan, T., Wolf, M., Porkka, K. & Heckman, C., 2018, In : Leukemia & lymphoma. 59, 3, p. 725-732 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Germline alterations in a consecutive series of acute myeloid leukemia

Wartiovaara-Kautto, U., Hirvonen, E. A. M., Pitkänen, E., Heckman, C., Saarela, J., Kettunen, K., Porkka, K. & Kilpivaara, O., Oct 2018, In : Leukemia. 32, 10, p. 2282-2285 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML

Bruck, O., Blom, S., Dufva, O., Turkki, R., Chheda, H., Ribeiro, A., Kovanen, P., Aittokallio, T., Koskenvesa, P., Kallioniemi, O., Porkka, K., Pellinen, T. & Mustjoki, S., Jul 2018, In : Leukemia. 32, 7, p. 1643-1656 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Dasatinib Changes Immune Cell Profiles Concomitant with Reduced Tumor Growth in Several Murine Solid Tumor Models

Hekim, C., Ilander, M., Yan, J., Michaud, E., Smykla, R., Vaha-Koskela, M., Savola, P., Tahtinen, S., Saikko, L., Hemminki, A., Kovanen, P. E., Porkka, K., Lee, F. Y. F. & Mustjoki, S., Feb 2017, In : Cancer immunology research. 5, 2, p. 157-169 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Pietarinen, P. O., Eide, C. A., Ayuda-Duran, P., Potdar, S., Kuusanmaki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, K., Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In : Oncotarget. 8, 14, p. 22606-22615 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Early BCR-ABL1 Transcript Decline after 1 Month of Tyrosine Kinase Inhibitor Therapy as an Indicator for Treatment Response in Chronic Myeloid Leukemia

El Missiry, M., Hjorth-Hansen, H., Richter, J., Olson-Stromberg, U., Stenke, L., Porkka, K., Kreutzman, A. & Mustjoki, S., 30 Jan 2017, In : PLoS One. 12, 1, 17 p., 0171041.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

Malani, D., Murumagi, A., Yadav, B., Kontro, M., Eldfors, S., Kumar, A., Karjalainen, R., Majumder, M. M., Ojamies, P., Pemovska, T., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M., Aittokallio, T. & Kallioniemi, O., May 2017, In : Leukemia. 31, 5, p. 1187-1195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Genomilääketieteen sovelluksia sairauksien hoidossa

Porkka, K., Niemi, M., Leppä, E., Västrik, I., Partanen, J., Ihalainen, J., Jokiranta, S. & Pöllänen, P., 2017, In : Duodecim. 133, 8, p. 782-790 9 p.

Research output: Contribution to journalArticleProfessional

Open Access
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HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia

Kontro, M., Kumar, A., Majumder, M. M., Eldfors, S., Parsons, A., Pemovska, T., Saarela, J. S., Yadav, B., Malani, D. R., Fløisand, Y., Höglund, M., Remes, K., Gjertsen, B-T., Kallioniemi, O-P., Wennerberg, J. K., Heckman, C. A. & Porkka, K. V. K., 2017, In : Leukemia. 31, 2, p. 301-309 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

Eldfors, S., Kuusanmäki, H., Kontro, M., Majumder, M. M., Parsons, A., Edgren, H., Pemovska, T., Kallioniemi, O., Wennerberg, K., Gökbuget, N., Burmeister, T., Porkka, K. & Heckman, C. A., 2017, In : Leukemia. 31, 1, p. 51-57 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing

Majumder, M. M., Silvennoinen, R., Anttila, P., Tamborero, D., Eldfors, S., Yadav, B., Karjalainen, R., Kuusanmaki, H., Lievonen, J., Parsons, A., Suvela, M., Jantunen, E., Porkka, K. & Heckman, C. A., 22 Aug 2017, In : Oncotarget. 8, 34, p. 56338-56350 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia

Ilander, M., Olsson-Stromberg, U., Schlums, H., Guilhot, J., Bruck, O., Lahteenmaki, H., Kasanen, T., Koskenvesa, P., Soderlund, S., Hoglund, M., Markevarn, B., Sjalander, A., Lotfi, K., Dreimane, A., Lubking, A., Holm, E., Bjoreman, M., Lehmann, S., Stenke, L., Ohm, L. & 11 othersGedde-Dahl, T., Majeed, W., Ehrencrona, H., Koskela, S., Saussele, S., Mahon, F-X., Porkka, K., Hjorth-Hansen, H., Bryceson, Y. T., Richter, J. & Mustjoki, S., May 2017, In : Leukemia. 31, 5, p. 1108-1116 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Safont, M. M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 othersKnowles, J. & Heckman, C. A., 10 Aug 2017, In : Blood. 130, 6, p. 789-802 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion

Kaartinen, T., Luostarinen, A., Maliniemi, P., Keto, J., Arvas, M., Belt, H., Koponen, J., Loskog, A., Mustjoki, S., Porkka, K., Yla-Herttuala, S. & Korhonen, M., Jun 2017, In : Cytotherapy. 19, 6, p. 689-702 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

Ojamies, P., Kontro, M., Edgren, H., Ellonen, P., Lagström, S., Almusa, H., Miettinen, T., Eldfors, S., Tamborero, D., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M. & Kallioniemi, O., 2017, In : Leukemia. 31, 5, p. 1048-1058 11 p.

Research output: Contribution to journalArticleScientificpeer-review

NK cell dynamics and association with molecular response in early chronic phase chronic myelogenous leukemia (CML-CP) patients treated with nilotinib

Sopper, S., Mustjoki, S., Gjertsen, B. T., Giles, F., Hochhaus, A., Janssen, J. J. W. M., Porkka, K. & Wolf, D., Oct 2017, In : Leukemia. 31, 10, p. 2264-2267 5 p.

Research output: Contribution to journalArticleScientific

Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia

Sopper, S., Mustjoki, S., White, D., Hughes, T., Valent, P., Burchert, A., Gjertsen, B. T., Gastl, G., Baldauf, M., Trajanoski, Z., Giles, F., Hochhaus, A., Ernst, T., Schenk, T., Janssen, J. J. W. M., Ossenkoppele, G. J., Porkka, K. & Wolf, D., 10 Jan 2017, In : Journal of Clinical Oncology. 35, 2, p. 175-+ 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib

Gullaksen, S-E., Skavland, J., Gavasso, S., Tosevski, V., Warzocha, K., Dumrese, C., Ferrant, A., Gedde-Dahl, T., Hellmann, A., Janssen, J., Labar, B., Lang, A., Majeed, W., Mihaylov, G., Stentoft, J., Stenke, L., Thaler, J., Thielen, N., Verhoef, G., Voglova, J. & 9 othersOssenkoppele, G., Hochhaus, A., Hjorth-Hansen, H., Mustjoki, S., Sopper, S., Giles, F., Porkka, K., Wolf, D. & Gjertsen, B. T., Aug 2017, In : Haematologica. 102, 8, p. 1361-1367 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis

Savola, P., Kelkka, T., Rajala, H. L., Kuuliala, A., Kuuliala, K., Eldfors, S., Ellonen, P., Lagstrom, S., Lepisto, M., Hannunen, T., Andersson, E. I., Khajuria, R. K., Jaatinen, T., Koivuniemi, R., Repo, H., Saarela, J., Porkka, K., Leirisalo-Repo, M. & Mustjoki, S., 21 Jun 2017, In : Nature Communications. 8, 14 p., 15869.

Research output: Contribution to journalArticleScientificpeer-review

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2016

Assessment of bone marrow lymphocytic status during tyrosine kinase inhibitor therapy and its relation to therapy response in chronic myeloid leukaemia

El Missiry, M., Awad, S. A., Koskela, H. L. M., Al-Samadi, A., Ekblom, M., Markevan, B., Astrand-Grundstrom, I., Wold, M., Svedahl, E. R., Juhl, B. R., Bjerrum, O. W., Haulin, I., Porkka, K., Olsson-Stromberg, U., Hjorth-Hansen, H. & Mustjoki, S., May 2016, In : Journal of Cancer Research and Clinical Oncology. 142, 5, p. 1041-1050 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Design of the randomized, Phase III, QUAZAR AML Maintenance trial of CC-486 (oral azacitidine) maintenance therapy in acute myeloid leukemia

Roboz, G. J., Montesinos, P., Selleslag, D., Wei, A., Jang, J-H., Falantes, J., Voso, M. T., Sayar, H., Porkka, K., Marlton, P., Almeida, A., Mohan, S., Ravandi, F., Garcia-Manero, G., Skikne, B. & Kantarjian, H., 2016, In : Future Oncology. 12, 3, p. 293-302 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Enrichment of rare variants in population isolates: single AICDA mutation responsible for hyper-IgM syndrome type 2 in Finland

Trotta, L., Hautala, T., Hamalainen, S., Syrjanen, J., Viskari, H., Almusa, H., Lepisto, M., Kaustio, M., Porkka, K., Palotie, A., Seppanen, M. & Saarela, J., Oct 2016, In : European Journal of Human Genetics. 24, 10, p. 1473-1478 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the European ENEST1st study

Hochhaus, A., Rosti, G., Cross, N. C. P., Steegmann, J. L., le Coutre, P., Ossenkoppele, G., Petrov, L., Masszi, T., Hellmann, A., Griskevicius, L., Wiktor-Jedrzejczak, W., Rea, D., Coriu, D., Bruemmendorf, T. H., Porkka, K., Saglio, G., Gastl, G., Mueller, M. C., Schuld, P., Di Matteo, P. & 5 othersPellegrino, A., Dezzani, L., Mahon, F-X., Baccarani, M. & Giles, F. J., Jan 2016, In : Leukemia. 30, 1, p. 57-64 8 p.

Research output: Contribution to journalArticleScientificpeer-review

IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

Agerstam, H., Hansen, N., von Palffy, S., Sanden, C., Reckzeh, K., Karlsson, C., Lilljebjorn, H., Landberg, N., Askmyr, M., Hogberg, C., Rissler, M., Porkka, K., Wadenvik, H., Mustjoki, S., Richter, J., Jaras, M. & Fioretos, T., 8 Dec 2016, In : Blood. 128, 23, p. 2683-2693 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Intrinsic resistance to PIM kinase inhibition in AML through p38a-mediated feedback activation of mTOR signaling

Brunen, D., Jose Garcia-Barchino, M., Malani, D., Basheer, N. J., Lieftink, C., Beijersbergen, R. L., Murumagi, A., Porkka, K., Wolf, M., Zwaan, C. M., Fornerod, M., Kallioniemi, O., Angel Martinez-Climent, J. & Bernards, R., 21 Jun 2016, In : Oncotarget. 7, 25, p. 37407-37419 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Leukemic Stem Cell Quantification in Newly Diagnosed Patients With Chronic Myeloid Leukemia Predicts Response to Nilotinib Therapy

Thielen, N., Richter, J., Baldauf, M., Barbany, G., Fioretos, T., Giles, F., Gjertsen, B-T., Hochhaus, A., Schuurhuis, G. J., Sopper, S., Stenke, L., Thunberg, S., Wolf, D., Ossenkoppele, G., Porkka, K., Janssen, J. & Mustjoki, S., 15 Aug 2016, In : Clinical Cancer Research. 22, 16, p. 4030-4038 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicity

Schiffer, C. A., Cortes, J. E., Hochhaus, A., Saglio, G., le Coutre, P., Porkka, K., Mustjoki, S., Mohamed, H. & Shah, N. P., 1 May 2016, In : Cancer. 122, 9, p. 1398-1407 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Safety and efficacy of the combination of pegylated interferon-alpha 2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients

Hjorth-Hansen, H., Stentoft, J., Richter, J., Koskenvesa, P., Hoeglund, M., Dreimane, A., Porkka, K., Gedde-Dahl, T., Gjertsen, B. T., Gruber, F. X., Stenke, L., Eriksson, K. M., Markevarn, B., Lubking, A., Vestergaard, H., Udby, L., Bjerrum, O. W., Persson, I., Mustjoki, S., Olsson-Stromberg, U. & 1 othersNCMLSG, Sep 2016, In : Leukemia. 30, 9, p. 1853-1860 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3

Haapaniemi, E. M., Kaustio, M., Rajala, H. L. M., van Adrichem, A. J., Kainulainen, L., Glumoff, V., Doffinger, R., Kuusanmaki, H., Heiskanen-Kosma, T., Trotta, L., Chiang, S., Kulmala, P., Eldfors, S., Katainen, R., Siitonen, S., Karjalainen-Lindsberg, M-L., Kovanen, P. E., Otonkoski, T., Porkka, K., Heiskanen, K. & 7 othersHanninen, A., Bryceson, Y. T., Uusitalo-Seppala, R., Saarela, J., Seppanen, M., Mustjoki, S. & Kere, J., 22 Jan 2015, In : Blood. 125, 4, p. 639-648 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Autologous stem cell transplantation versus novel drugs or conventional chemotherapy for patients with relapsed multiple myeloma after previous ASCT

Grovdal, M., Nahi, H., Gahrton, G., Liwing, J., Waage, A., Abildgaard, N., Pedersen, P. T., Hammerstrom, J., Laaksonen, A., Bazia, P., Terava, V., Ollikainen, H., Silvennoinen, R., Putkonen, M., Anttila, P., Porkka, K. & Remes, K., Jun 2015, In : Bone Marrow Transplantation. 50, 6, p. 808-812 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Pemovska, T., Johnson, E., Kontro, M., Repasky, G. A., Chen, J., Wells, P., Cronin, C. N., McTigue, M., Kallioniemi, O., Porkka, K., Murray, B. W. & Wennerberg, K., 5 Mar 2015, In : Nature. 519, 7541, p. 102-U225 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase-2 study (NordCML006)

Hjorth-Hansen, H., Stenke, L., Soderlund, S., Dreimane, A., Ehrencrona, H., Gedde-Dahl, T., Gjertsen, B. T., Hoglund, M., Koskenvesa, P., Lotfi, K., Majeed, W., Markevarn, B., Ohm, L., Olsson-Stromberg, U., Remes, K., Suominen, M., Simonsson, B., Porkka, K., Mustjoki, S., Richter, J. & 1 othersNCMLSG, Mar 2015, In : European Journal of Haematology. 94, 3, p. 243-250 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

Pietarinen, P. O., Pemovska, T., Kontro, M., Yadav, B., Mpindi, J. P., Andersson, E. I., Majumder, M. M., Kuusanmaki, H., Koskenvesa, P., Kallioniemi, O., Wennerberg, K., Heckman, C. A., Mustjoki, S. & Porkka, K., May 2015, In : Blood cancer journal. 5, 6 p., 309.

Research output: Contribution to journalArticleScientificpeer-review

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

Kampjarvi, K., Jaervinen, T. M., Heikkinen, T., Ruppert, A. S., Senter, L., Hoag, K. W., Dufva, O., Kontro, M., Rassenti, L., Hertlein, E., Kipps, T. J., Porkka, K., Byrd, J. C., de la Chapelle, A. & Vahteristo, P., 30 Jan 2015, In : Oncotarget. 6, 3, p. 1884-1888 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia

Rajala, H. L. M., Olson, T., Clemente, M. J., Lagstrom, S., Ellonen, P., Lundan, T., Hamm, D. E., Zaman, S. A. U., Marti, J. M. L., Andersson, E. I., Jerez, A., Porkka, K., Maciejewski, J. P., Loughran, T. P. & Mustjoki, S., Jan 2015, In : Haematologica. 100, 1, p. 91-99 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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2014

Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors

Kantarjian, H. M., Cortes, J. E., Kim, D-W., Khoury, H. J., Bruemmendorf, T. H., Porkka, K., Martinelli, G., Durrant, S., Leip, E., Kelly, V., Turnbull, K., Besson, N. & Gambacorti-Passerini, C., 27 Feb 2014, In : Blood. 123, 9, p. 1309-1318 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Chronic myeloid leukemia patients' adherence to peroral tyrosine kinase inhibitors compared with adherence as estimated by their physicians

Kekale, M., Talvensaari, K., Koskenvesa, P., Porkka, K. & Airaksinen, M., 2014, In : Patient preference and adherence. 8, p. 1619-1627 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Dasatinib promotes Th1-type responses in granzyme B expressing T-cells

Kreutzman, A., Ilander, M., Porkka, K., Vakkila, J. & Mustjoki, S., 1 May 2014, In : OncoImmunology. 3, e28925.

Research output: Contribution to journalArticleScientificpeer-review

Enlarged Memory T-Cell Pool and Enhanced Th1-Type Responses in Chronic Myeloid Leukemia Patients Who Have Successfully Discontinued IFN-alpha Monotherapy

Ilander, M., Kreutzman, A., Rohon, P., Melo, T., Faber, E., Porkka, K., Vakkila, J. & Mustjoki, S., 31 Jan 2014, In : PLoS One. 9, 1, 11 p., 87794.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Imatinib and pegylated IFN-alpha 2b discontinuation in first-line chronic myeloid leukemia patients following a major molecular response

Koskenvesa, P., Kreutzman, A., Rohon, P., Pihlman, M., Vakkila, E., Rasanen, A., Vapaatalo, M., Remes, K., Lundan, T., Hjorth-Hansen, H., Vakkila, J., Simonsson, B., Mustjoki, S. & Porkka, K., May 2014, In : European Journal of Haematology. 92, 5, p. 413-420 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

Kontro, M., Kuusanmaki, H., Eldfors, S., Burmeister, T., Andersson, E. I., Bruserud, O., Bruemmendorf, T. H., Edgren, H., Gjertsen, B. T., Itala-Remes, M., Lagström, S., Lohi, O., Lundan, T., Marti, J. M. L., Majumder, M. M., Parsons, A., Pemovska, T., Rajala, H., Vettenranta, K., Kallioniemi, O. & 3 othersMustjoki, S., Porkka, K. & Heckman, C. A., Aug 2014, In : Leukemia. 28, 8, p. 1738-1742 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumagi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, K. & Aittokallio, T., 5 Jun 2014, In : Scientific Reports. 4, 10 p., 5193.

Research output: Contribution to journalArticleScientificpeer-review

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2013

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Koskela, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J. . A., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, K., Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In : Blood. 121, 22, p. 4541-4550 10 p.

Research output: Contribution to journalArticleScientificpeer-review