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  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1988 …2022
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Publications 1988 2017

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2016

Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism

Kettunen, K. M., Karikoski, R., Hamalainen, R. H., Toivonen, T. T., Antonenkov, V. D., Kulesskaya, N., Voikar, V., Holtta-Vuori, M., Ikonen, E., Sainio, K., Jalanko, A., Karlberg, S., Karlberg, N., Lipsanen-Nyman, M., Toppari, J., Jauhiainen, M., Hiltunen, J. K., Jalanko, H. & Lehesjoki, A-E., 15 May 2016, In : Biology open. 5, 5, p. 584-595 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

Congenital Aural Atresia Associated With Agenesis of Internal Carotid Artery in a Girl With a FOXI3 Deletion

Tassano, E., Jagannathan, V., Drogemuller, C., Leoni, M., Hytonen, M. K., Severino, M., Gimelli, S., Cuoco, C., Di Rocco, M., Sainio, K., Groves, A. K., Leeb, T. & Gimelli, G., Mar 2015, In : American Journal of Medical Genetics. Part A. 167A, 3, p. 537-544 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes

Shirokova, V., Jussila, M., Hytönen, M. K., Perälä, N., Droegemueller, C., Leeb, T., Lohi, H., Sainio, K., Thesleff, I. & Mikkola, M. L., Jun 2013, In : Developmental Dynamics. 242, 6, p. 593-603 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

A Novel GUSB Mutation in Brazilian Terriers with Severe Skeletal Abnormalities Defines the Disease as Mucopolysaccharidosis VII

Hytönen, M. K., Arumilli, M., Lappalainen, A. K., Kallio, H., Snellman, M., Sainio, K. & Lohi, H., 2012, In : PLoS One. 7, 7, p. e40281 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Pennun hampaita vahvistamalla voi purentakin parantua

Viranta-Kovanen, S. K. & Sainio, K., 1 Nov 2012, In : Koiramme. 2012, 11, p. 22-27

Research output: Contribution to journalArticleGeneral public

The expression of Visinin-like 1 during mouse embryonic development

Ola, R., Lefebvre, S., Braunewell, K-H., Sainio, K. & Sariola, H., 2012, In : Gene expression patterns. 12, 1-2, p. 53-62 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

beta-Catenin Causes Renal Dysplasia via Upregulation of Tgf beta 2 and Dkk1

Bridgewater, D., Di Giovanni, V., Cain, J. E., Cox, B., Jakobson, M., Sainio, K. & Rosenblum, N. D., 2011, In : Journal of the American Society of Nephrology. 22, p. 718-731 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia

Saarikangas, J., Mattila, P. K., Varjosalo, M., Bovellan, M., Hakanen, J., Calzada-Wack, J., Tost, M., Jennen, L., Rathkolb, B., Hans, W., Horsch, M., Hyvönen, M. E., Perälä, N., Fuchs, H., Gailus-Durner, V., Esposito, I., Wolf, E., de Angelis, M. H., Frilander, M. J., Savilahti, H. & 6 othersSariola, H., Sainio, K., Lehtonen, S., Taipale, J., Salminen, M. & Lappalainen, P., 2011, In : Journal of Cell Science. 124, 8, p. 1245-1255 11 p.

Research output: Contribution to journalArticleScientificpeer-review

The GDNF Target Vsnl1 Marks the Ureteric Tip

Ola, R., Jakobson, M., Kvist, J., Perala, N., Kuure, S., Braunewell, K-H., Bridgewater, D., Rosenblum, N. D., Chilov, D., Immonen, T., Sainio, K. & Sariola, H., Feb 2011, In : Journal of the American Society of Nephrology. 22, 2, p. 274-284 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Conservation, Expression, and Knockdown of Zebrafish plxnb2a and plxnb2b

Perala, N., Peitsaro, N., Sundvik, M., Koivula, H., Sainio, K., Sariola, H., Panula, P. & Immonen, T., 2010, In : Developmental Dynamics. 239, p. 2722-2734 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Hydroxysteroid (17 beta) Dehydrogenase 12 Is Essential for Mouse Organogenesis and Embryonic Survival

Rantakari, P., Lagerbohm, H., Kaimainen, M., Suomela, J-P., Strauss, L., Sainio, K., Pakarinen, P. & Poutanen, M., 2010, In : Endocrinology. 151, 4, p. 1893-1901 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Hydroxysteroid (17 beta) Dehydrogenase 7 Activity Is Essential for Fetal de Novo Cholesterol Synthesis and for Neuroectodermal Survival and Cardiovascular Differentiation in Early Mouse Embryos

Jokela, H., Rantakari, P., Lamminen, T., Strauss, L., Ola, R., Mutka, A-L., Gylling, H., Miettinen, T., Pakarinen, P., Sainio, K. & Poutanen, M., 2010, In : Endocrinology. 151, 4, p. 1884-1892 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice

Rantakari, P., Nikkila, J., Jokela, H., Ola, R., Pylkas, K., Lagerbohm, H., Sainio, K., Poutanen, M. & Winqvist, R., 2010, In : Human Molecular Genetics. 19, 15, p. 3021-3029 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Ancestral T-box mutation is present in many, but not all, short-tailed dog breeds

Hytönen, M. K., Grall, A., Hedan, B., Dreano, S., Seguin, S. J., Delattre, D., Thomas, A., Galibert, F., Paulin, L., Lohi, H., Sainio, K. & Andre, C., 2009, In : Journal of Heredity. 100, 2, p. 236-240 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Integrin-linked kinase is an adaptor with essential functions during mouse development

Lange, A., Wickström, S., Jakobson, M., Zent, R., Sainio, K. & Fässler, R., 2009, In : Nature. 461, p. 1002-1006 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

A mutation in hairless dogs implicates FOXI3 in ectodermal development

Drögemuller, C., Karlsson, E. K., Hytönen, M. K., Perloski, M., Dolf, G., Sainio, K., Lohi, H., Lindblad-Toh, K. & Leeb, T., 2008, In : Science. 321, 5895, p. 1462 1 p.

Research output: Contribution to journalArticleScientificpeer-review

A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

Immonen, T., Alakuijala, A., Hytönen, M., Sainio, K., Poteryaev, D., Saarma, M., Pasternack, M. & Sariola, H., 2008, In : Experimental Neurology. 210, p. 793-796 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Canonical WNT/[beta]-catenin signaling is required for ureteric branching

Bridgewater, D., Cox, B., Cain, J., Lau, A., Athaide, V., Gill, P., Kuure, S., Sainio, K. & Rosenblum, N., 2008, In : Developmental Biology. 317, p. 83-94 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant

Vivatbutsiri, P., Ichinose, S., Hytönen, M., Sainio, K., Eto, K. & Iseki, S., 2008, In : Journal of Anatomy. 212, p. 603-611 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Glycogen synthase kinase-3 inactivation and stabilization of [beta]-catenin induce nephron differentiation in isolated mouse and rat kidney mesenchymes

Kuure, S., Popsueva, A., Jakobson, M., Sainio, K. & Sariola, H., 2007, In : Journal of the American Society of Nephrology. 18, p. 1130-1139 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Tissue expression of the mulibrey nanism-associated Trim37 protein in embryonic and adult mouse tissues

Kallijarvi, J., Hämäläinen, R. H., Karlberg, N., Sainio, K. & Lehesjoki, A-E., 2006, In : Histochemistry and Cell Biology. 126, p. 325-334 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Crosstalk between Jagged1 and GDNF/Ret/GFR[alpha]1 signalling regulates ureteric budding and branching

Kuure, S., Sainio, K., Vuolteenaho, R., Ilves, M., Wartiovaara, K., Immonen, T., Kvist, J., Vainio, S. & Sariola, H., 2005, In : Mechanisms of Development. 122, p. 765-780 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of Emx2 in early urogenital development

Hytonen, M., Moshnyakov, M., Sariola, H. & Sainio, K., 2005, In : Mechanisms of Development. 122, p. S63-S63 1 p.

Research output: Contribution to journalArticleScientific

2004

Five new cases of a recently described leukoencephalopathy with high brain lactate

Linnankivi, T., Lundbom, N., Autti, T., Häkkinen, A-M., Koillinen, H., Kuusi, T. T., Lonnqvist, T., Sainio, K., Valanne, L., Aarimaa, T. & Pihko, H., 24 Aug 2004, In : Neurology. 63, 4, p. 688-692 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

Kärkkäinen, M. J., Haiko, P., Sainio, K. M. H., Partanen, J. M., Taipale, J., Petrova, T. V., Jeltsch, M., Jackson, D. G., Talikka, M., Rauvala, H., Betsholtz, C. & Alitalo, K., 2004, In : Nature immunology.. 5, 1, p. 74-80 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

DC-EEG discloses prominent, very slow activity patterns during sleep in preterm infants

Vanhatalo, S., Tallgren, P., Andersson, S., Sainio, K., Voipio, J. & Kaila, K., 2002, In : Electromyography and clinical neurophysiology. 113, p. 1822-1825 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2000

An artifactual in situ hybridization signal associated with apoptosis in rat embryo

Raatikainen-Ahokas, A., Immonen, T., Rossi, P. O., Sainio, K. & Sariola, H., 2000, In : Journal of Histochemistry and Cytochemistry. 48, 7, p. 955-961 7 p.

Research output: Contribution to journalArticleScientificpeer-review

BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney

Raatikainen-Ahokas, A., Hytonen, M., Tenhunen, A., Sainio, K. & Sariola, H., 2000, In : Developmental Dynamics. 217, p. 146-158 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene

Putaala, H., Sainio, K., Sariola, H. & Tryggvason, K., 2000, In : Journal of the American Society of Nephrology. 11, p. 991-1001 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of cell fate decision of undifferentiated spermatogonia by GDNF

Meng, X. J., Lindahl, M., Hyvönen, M. E., Parvinen, M., de Rooij, D. G., Hess, M. W., Raatikainen-Ahokas, A., Sainio, K., Rauvala, H., Lakso, M., Pichel, J. G., Westphal, H., Saarma, M. & Sariola, H., 2000, In : Science. 287, p. 1489-1493 5 p.

Research output: Contribution to journalArticleScientificpeer-review

1999

Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud

Donovan, M. J., Natoli, T. A., Sainio, K., Amstutz, A., Jaenisch, R., Sariola, H. & Kreidberg, J. A., 1999, In : Genesis: the journal of genetics and development. 24, p. 252-262 11 p.

Research output: Contribution to journalArticleScientificpeer-review

1998

Cell lineages in the embryonic kidney: their inductive interactions and signalling molecules

Sariola, H. & Sainio, K., 1998, In : Biochemistry and Cell Biology. 76, p. 1009-1016 8 p.

Research output: Contribution to journalArticleScientific

Distribution of glial cell line-derived neurotrophic factor mRNA in human colon suggests roles for muscularis mucosae in innervation

Wartiovaara, K., Salo, M. E., Sainio, K., Rintala, R. & Sariola, H., 1998, In : Journal of Pediatric Surgery. 33, p. 1501-1506 6 p.

Research output: Contribution to journalArticleScientificpeer-review

1997

Differential regulation of two sets of mesonephric tubules by WT-1

Sainio, K., Hellstedt, P., Kreidberg, J. A., Saxen, L. & Sariola, H., 1997, In : Child Development. 124, p. 1293-1299 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium

Sainio, K., Suvanto, P., Davies, J., Wartiovaara, J., Wartiovaara, K., Saarma, M., Arumae, U., Meng, X. J., Lindahl, M., Pachnis, V. & Sariola, H., 1997, In : Development. 124, p. 4077-4087 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Localization of nerve cells in the developing rat tooth

Luukko, K., Sainio, K., Sariola, H., Saarma, M. & Thesleff, I., 1997, In : Indian Journal of Dental Research. 76, p. 1350-1356 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesis

Luukko, K., Arumae, U., Karavanov, A., Moshnyakov, M., Sainio, K., Sariola, M., Saarma, M. & Thesleff, I., 1997, In : Developmental Dynamics. 210, p. 117-129 13 p.

Research output: Contribution to journalArticleScientificpeer-review

The tip-top branching ureter

Sariola, H. & Sainio, K., 1997, In : Current Opinion in Cell Biology. 9, p. 877-884 8 p.

Research output: Contribution to journalArticleScientific

Localization of glial cell line-derived neurotrophic factor (GDNF) mRNA in embryonic rat by in situ hybridization

Sainio, K., Suvanto, P., Hiltunen, J. O., Arumae, U., Moshnyakov, M., Sariola, H., Sainio, K. & Saarma, M., 1996, In : European Journal of Neuroscience. 8, p. 816-822 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Structure of the human laminin gamma 2 chain gene (LAMC2): Alternative splicing with different tissue distribution of two transcripts

Airenne, T., Haakana, H., Sainio, K., Kallunki, T., Kallunki, P., Sariola, H. & Tryggvason, K., 1996, In : Genomics. 32, p. 54-64 11 p.

Research output: Contribution to journalArticleScientificpeer-review

1995

Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse

Ritvos, O., Tuuri, T., Erämaa, M., Sainio, K., Hilden, K., Saxen, L. & Gilbert, S., 1995, In : Mechanisms of Development. 50, 2-3, p. 229-245 17 p.

Research output: Contribution to journalArticleScientificpeer-review

PRIMARY STRUCTURE AND EXPRESSION OF A NOVEL HUMAN LAMININ ALPHA-4 CHAIN

IIVANAINEN, A., SAINIO, K., SARIOLA, H. & TRYGGVASON, K., 1995, In : FEBS Letters. 365, p. 183-188 6 p.

Research output: Contribution to journalArticleScientificpeer-review

THE GLOMERULAR MESANGIUM - STUDIES OF ITS DEVELOPMENTAL ORIGIN AND MARKERS IN-VIVO AND IN-VITRO

HOLTHOFER, H., SAINIO, K. & MIETTINEN, A., 1995, In : APMIS. 103, p. 354-366 13 p.

Research output: Contribution to journalArticleScientificpeer-review

THE HUMAN LAMININ BETA-2 CHAIN (S-LAMININ) - STRUCTURE, EXPRESSION IN FETAL TISSUES AND CHROMOSOMAL ASSIGNMENT OF THE LAMB2 GENE

IIVANAINEN, A., VUOLTEENAHO, R., SAINIO, K., EDDY, R., SHOWS, T. B., SARIOLA, H. & TRYGGVASON, K., 1995, In : Matrix Biology. 14, p. 489-497 9 p.

Research output: Contribution to journalArticleScientificpeer-review

1994

ANTISENSE INHIBITION OF LOW-AFFINITY NERVE GROWTH-FACTOR RECEPTOR IN KIDNEY CULTURES - POWER AND PITFALLS

SAINIO, K., SAARMA, M., NONCLERCQ, D., PAULIN, L. & SARIOLA, H., 1994, In : Cellular and Molecular Neurobiology. 14, p. 439-457 19 p.

Research output: Contribution to journalArticleScientificpeer-review

HUMAN LAMININ-M CHAIN (MEROSIN) - COMPLETE PRIMARY STRUCTURE, CHROMOSOMAL ASSIGNMENT, AND EXPRESSION OF THE M-CHAIN AND A-CHAIN IN HUMAN FETAL TISSUES

VUOLTEENAHO, R., NISSINEN, M., SAINIO, K., BYERS, M., EDDY, R., HIRVONEN, H., SHOWS, T. B., SARIOLA, H., ENGVALL, E. & TRYGGVASON, K., 1994, In : European Journal of Cell Biology. 124, p. 381-394 14 p.

Research output: Contribution to journalArticleScientificpeer-review

NEURONAL CHARACTERISTICS IN EMBRYONIC RENAL STROMA

SAINIO, K., NONCLERCQ, D., SAARMA, M., PALGI, J., SAXEN, L. & SARIOLA, H., 1994, In : International journal of plant developmental biology. 38, p. 77-84 8 p.

Research output: Contribution to journalArticleScientificpeer-review

1992

A TRUNCATED LAMININ CHAIN HOMOLOGOUS TO THE B2 CHAIN - STRUCTURE, SPATIAL EXPRESSION, AND CHROMOSOMAL ASSIGNMENT

KALLUNKI, P., SAINIO, K., EDDY, R., BYERS, M., KALLUNKI, T., SARIOLA, H., BECK, K., HIRVONEN, H., SHOWS, T. B. & TRYGGVASON, K., 1992, In : European Journal of Cell Biology. 119, p. 679-693 15 p.

Research output: Contribution to journalArticleScientificpeer-review