Photo of Klaus Hedman
  • PL 21 (Haartmaninkatu 3)

    00014

    Finland

  • PL 21 (Haartmaninkatu 3), E355

    HELSINGIN YLIOPISTO

    Finland

1979 …2020

Research output per year

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Publications

2020

Longitudinal assessment of the CXCL10 blood and urine concentration in kidney transplant recipients with BK polyomavirus replication—a retrospective study

Weseslindtner, L., Hedman, L., Wang, Y., Strassl, R., Helanterä, I., Aberle, S. W., Bond, G. & Hedman, K., 13 Feb 2020, In : Transplant International. 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Microsphere-Based IgM and IgG Avidity Assays for Human Parvovirus B19, Human Cytomegalovirus, and Toxoplasma gondii

Wang, Y., Hedman, L., Nurmi, V., Ziemele, I., Perdomo, M. F., Söderlund-Venermo, M., Hedman, K. & Papasian, C. J. (ed.), 29 Apr 2020, In : Msphere. 5, 2, e00905-19.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2019

Acute human bocavirus 1 infection in child with life-threatening bilateral bronchiolitis and right-sided pneumonia: a case report

Ziemele, I., Xu, M., Vilmane, A., Rasa-Dzelzkaleja, S., Hedman, L., Hedman, K., Söderlund-Venermo, M., Nora-Krukle, Z., Murovska, M. & Gardovska, D., 14 Sep 2019, In : Journal of Medical Case Reports. 13, 1, 6 p., 290.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Comparison of phenotypic and genotypic diagnosis of acute human bocavirus 1 infection in children

Kols, N. I., Aatola, H., Peltola, V., Xu, M., Nora-Krukle, Z., Hedman, K., Zvirbliene, A., Toivola, H., Vuorinen, T., Koskinen, J. M., Bruning, A. H. L., Christensen, A., Söderlund-Venermo, M. & Koskinen, J. O., Nov 2019, In : Journal of Clinical Virology. 120, p. 17-19 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Immunoassay for serodiagnosis of Zika virus infection based on time-resolved Förster resonance energy transfer

Kareinen, L., Hepojoki, S., Huhtamo, E., Korhonen, E. M., Schmidt-Chanasit, J., Hedman, K., Hepojoki, J. & Vapalahti, O., 23 Jul 2019, In : PLoS One. 14, 7, p. e0219474 13 p., 0219474.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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LFRET, a novel rapid assay for anti-tissue transglutaminase antibody detection

Rusanen, J., Toivonen, A., Hepojoki, J., Hepojoki, S., Arikoski, P., Heikkinen, M., Vaarala, O., Ilonen, J. & Hedman, K., 29 Nov 2019, In : PLoS One. 14, 11, 12 p., e0225851.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multiplex analysis of Human Polyomavirus diversity in kidney transplant recipients with BK virus replication

Wang, Y., Strassl, R., Helanterä, I., Aberle, S. W., Bond, G., Hedman, K. & Weseslindtner, L., Nov 2019, In : Journal of Clinical Virology. 120, p. 6-11 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Serodiagnosis of Human Bocavirus 1 Infection among Hospitalised Children with Lower Respiratory Tract Infection in Latvia

Ziemele, I., Xu, M., Vilmane, A., Rasa-Dzelzkaleja, S., Hedman, K., Söderlund-Venermo, M., Gardovska, D., Nora-Krukld, Z. & Murovska, M., 2019, In : Proceedings of the Latvian Academy of Sciences. Section B, Natural, Exact and Applied Sciences. 73, 4, p. 288–295 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Urine and Free Immunoglobulin Light Chains as Analytes for Serodiagnosis of Hantavirus Infection

Hepojoki, S., Kareinen, L., Strandin, T., Vaheri, A., Holthöfer, H., Mustonen, J., Mäkelä, S., Hedman, K., Vapalahti, O. & Hepojoki, J., Sep 2019, In : Viruses. 11, 9, 14 p., 809.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Global Distribution of Human Protoparvoviruses

Vaisanen, E., Mohanraj, U., Kinnunen, P. M., Jokelainen, P., Al-Hello, H., Barakat, A. M., Sadeghi, M., Jalilian, F. A., Majlesi, A., Masika, M., Mwaengo, D., Anzala, O., Delwart, E., Vapalahti, O., Hedman, K. & Soderlund-Venermo, M., Jul 2018, In : Emerging Infectious Diseases. 24, 7, p. 1292-1299 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Humoral response to John Cunningham virus during pregnancy in multiple sclerosis

Saraste, M., Atula, S., Hedman, K., Hurme, S., Jalkanen, A., Sneck, M., Surcel, H. -M., Maghzi, A. H. & Airas, L., Apr 2018, In : Multiple sclerosis and related disorders. 21, p. 11-18 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Paleogenomiikka muinaisten ihmisten ja mikrobien jalanjäljillä

Perdomo, M. F., Toppinen, M., Hedman, K. & Sajantila, A., 2018, In : Duodecim. 134, 17, p. 1723-1729 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Polyomaviruses detectable in head and neck carcinomas

Poluschkin, L., Rautava, J., Turunen, A., Wang, Y., Hedman, K., Syrjänen, K., Grenman, R. & Syrjänen, S., 2018, In : Oncotarget. 9, 32, p. 22642-22652 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Comparative Diagnosis of Human Bocavirus 1 Respiratory Infection With Messenger RNA Reverse-Transcription Polymerase Chain Reaction (PCR), DNA Quantitative PCR, and Serology

Xu, M., Arku, B., Jartti, T., Koskinen, J., Peltola, V., Hedman, K. & Soderlund-Venermo, M., 15 May 2017, In : Journal of Infectious Diseases. 215, 10, p. 1551-1557 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Extinct type of human parvovirus B19 persists in tonsillar B cells

Pyöriä, L., Toppinen, M., Mantyla, E., Hedman, L., Aaltonen, L-M., Vihinen-Ranta, M., Ilmarinen, T., Soderlund-Venermo, M., Hedman, K. & Perdomo, M., 4 Apr 2017, In : Nature Communications. 8, 9 p., 14930.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Human Protoparvoviruses

Vaisanen, E., Fu, Y., Hedman, K. & Soderlund-Venermo, M., Nov 2017, In : Viruses. 9, 11, 13 p., 354.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Kadonnut virustyyppi löytyi ikääntyvien B-soluista

Translated title of the contribution: Extinct type of human parvovirus B19 persists in tonsillar B cellsPyöriä, L., Toppinen, M., Mäntylä, E., Hedman, L., Aaltonen, L-M., Vihinen-Ranta, M., Ilmarinen, T., Söderlund-Venermo, M., Hedman, K. & Perdomo, M. F., 2017, In : Duodecim. 133, p. 753 1 p.

Research output: Contribution to journalLetterScientific

Open Access
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Mononukleoosi

Martelius, T., Pyöriä, L. & Hedman, K., 2017, In : Duodecim. 133, 16, p. 1454-1460 7 p.

Research output: Contribution to journalArticleProfessional

Open Access
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Multiplex detection in tonsillar tissue of all known human polyomaviruses

Sadeghi, M., Wang, Y., Ramqvist, T., Aaltonen, L-M., Pyöriä, L., Toppinen, M., Soderlund-Venermo, M. & Hedman, K., 8 Jun 2017, In : BMC Infectious Diseases. 17, 8 p., 409.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Primary Polyomavirus Infection, Not Reactivation, as the Cause of Trichodysplasia Spinulosa in Immunocompromised Patients

van der Meijden, E., Horvath, B., Nijland, M., de Vries, K., Raez, E., Diercks, G. F., de Weerd, A. E., Clahsen-van Groningen, M. C., van der Blij-de Brouwer, C. S., van der Zon, A. J., Kroes, A. C. M., Hedman, K., van Kampen, J. J. A., Riezebos-Brilman, A. & Feltkamp, M. C. W., 1 Apr 2017, In : Journal of Infectious Diseases. 215, 7, p. 1080-1084 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Suomalaismenetelmästä oiva apu tuhkarokon vastaisessa kamppailussa

Paunio, M., Hedman, K., Davidkin, I. & Peltola, H. O., 2017, In : Duodecim. 133, 3, p. 237-238 2 p.

Research output: Contribution to journalArticleProfessional

Open Access
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The Chemokine CXCL-10 Is a Marker of Infection Stage in Individuals With DNAemia Due to Parvovirus B19

Weseslindtner, L., Aberle, J. H., Hedman, L. & Hedman, K., 15 Jan 2017, In : Journal of Infectious Diseases. 215, 2, p. 214-220 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Toksoplasmoosi

Lappalainen, M., Hedman, K. & Stefanovic, V., 2017, Lääkärin käsikirja. Jousimaa, J., Alenius, H., Atula, S., Berghem, N., Kattainen, A., Kunnamo, I., Pelttari, H. & Teikari, M. (eds.). 12. uud. p. ed. Helsinki: Duodecim, p. 75-77 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Viremic co-infections in children with allogeneic haematopoietic stem cell transplantation are predominated by human polyomaviruses

Koskenvuo, M., Rahiala, J., Sadeghi, M., Waris, M., Vuorinen, T., Lappalainen, M., Norjad, P., Toppinen, M., Saarinen-Pihkala, U., Allander, T., Soderlund-Venermo, M., Hedman, K., Ruuskanen, O. & Vettenranta, K., 2017, In : Infectious Diseases. 49, 1, p. 35-41 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

17th Century Variola Virus Reveals the Recent History of Smallpox

Duggan, A. T., Perdomo, M. F., Piombino-Mascali, D., Marciniak, S., Poinar, D., Emery, M. V., Buchmann, J. P., Duchene, S., Jankauskas, R., Humphreys, M., Golding, G. B., Southon, J., Devault, A., Rouillard, J-M., Sahl, J. W., Dutour, O., Hedman, K., Sajantila, A., Smith, G. L., Holmes, E. C. & 1 others, Poinar, H. N., 19 Dec 2016, In : Current Biology. 26, 24, p. 3407-3412 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Detection and monitoring of human bocavirus 1 infection by a new rapid antigen test

Bruning, A. H. L., Susi, P., Toivola, H., Christensen, A., Söderlund-Venermo, M., Hedman, K., Aatola, H., Zvirbliene, A. & Koskinen, J. O., 2016, In : New Microbes and New Infections . 11, p. 17-19 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Epidemiology of two human protoparvoviruses, bufavirus and tusavirus

Vaisanen, E., Paloniemi, M., Kuisma, I., Lithovius, V., Kumar, A., Franssila, R., Ahmed, K., Delwart, E., Vesikari, T., Hedman, K. & Soderlund-Venermo, M., 14 Dec 2016, In : Scientific Reports. 6, 8 p., 39267.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Maternal Antibodies to Herpes Virus Antigens and Risk of Gastroschisis in Offspring

Werler, M. M., Parker, S. E., Hedman, K., Gissler, M., Ritvanen, A. & Surcel, H-M., 15 Dec 2016, In : American Journal of Epidemiology. 184, 12, p. 902-912 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Microsphere-based antibody assays for human parvovirus B19V, CMV and T. gondii

Wang, Y., Hedman, L., Perdomo, M. F., Elfaitouri, A., Bolin-Wiener, A., Kumar, A., Lappalainen, M., Soderlund-Venermo, M., Blomberg, J. & Hedman, K., 8 Jan 2016, In : BMC Infectious Diseases. 16, 6 p., 8.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Polvomaviruses as causative agents of diseases

Helanterä, I., Sadeghi, M., Lautenschlager, I., Hedman, K. & Auvinen, E., 2016, In : Duodecim.

Research output: Contribution to journalArticleScientificpeer-review

Polyomaviruses BK, JC, KI, WU, MC, and TS in children with allogeneic hematopoietic stem cell transplantation

Rahiala, J., Koskenvuo, M., Sadeghi, M., Waris, M., Vuorinen, T., Lappalainen, M., Saarinen-Pihkala, U. M., Allander, T., Soderlund-Venermo, M., Hedman, K., Ruuskanen, O. & Vettenranta, K., May 2016, In : Pediatric Transplantation. 20, 3, p. 424-431 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Polyoomavirukset sairauksien aiheuttajina

Helanterä, I., Sadeghi, M., Lautenschlager, I., Hedman, K. & Auvinen, E., 2016, In : Duodecim. 132, 5, p. 439-445 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2015

Absence of novel human parvovirus (PARV4) in Danish mothers and children

von Linstow, M-L., Rosenfeldt, V., Lindberg, E., Jensen, L., Hedman, L., Li, X., Vaisanen, E., Hedman, K. & Norja, P., Apr 2015, In : Journal of Clinical Virology. 65, p. 23-25 3 p.

Research output: Contribution to journalArticleScientificpeer-review

A new quantitative PCR for human parvovirus B19 genotypes

Toppinen, M., Norja, P., Aaltonen, L. -M., Wessberg, S., Hedman, L., Soderlund-Venermo, M. & Hedman, K., 15 Jun 2015, In : Journal of Virological Methods. 218, p. 40-45 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Array-in-well serodiagnostic assay utilizing upconverting phosphor label technology

Yliharsila, M., Alaranta, S., Landenpera, S., Lahtinen, S., Arku, B., Hedman, K., Soukka, T. & Waris, M., 15 Sep 2015, In : Journal of Virological Methods. 222, p. 224-230 7 p.

Research output: Contribution to journalArticleScientificpeer-review

B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study

Kantola, K., Hedman, L., Tanner, L., Simell, V., Makinen, M., Partanen, J., Sadeghi, M., Veijola, R., Knip, M., Ilonen, J., Hyoty, H., Toppari, J., Simell, O., Hedman, K. & Soderlund-Venermo, M., 29 Sep 2015, In : PLoS One. 10, 9, 12 p., 0139096.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Bones hold the key to DNA virus history and epidemiology

Toppinen, M., Perdomo, M., Palo, J. U., Simmonds, P., Lycett, S. J., Soderlund-Venermo, M., Sajantila, A. & Hedman, K., 27 Nov 2015, In : Scientific Reports. 5, 8 p., 17226.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Competitive Homogeneous Immunoassay for Rapid Serodiagnosis of Hantavirus Disease

Hepojoki, S., Rusanen, J., Hepojoki, J., Nurmi, V., Vaheri, A., Lundkvist, A., Hedman, K. & Vapalahti, O., Jul 2015, In : Journal of Clinical Microbiology. 53, 7, p. 2292-2297 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Granzyme B mediated function of Parvovirus B19-specific CD4(+) T cells

Kumar, A., Perdomo, M. F., Kantele, A., Hedman, L., Hedman, K. P. & Franssila, R. M., 2015, In : Clinical Translational Immunology. 4, 7, 8 p., e39.

Research output: Contribution to journalArticleScientificpeer-review

Low Prevalence of Parvovirus 4 in HIV-infected Children in Denmark

Rosenfeldt, V., Norja, P., Lindberg, E., Jensen, L., Hedman, L., Väisänen, E., Li, X., Hedman, K. P. & von Linstow, M-L., 2015, In : Pediatric Infectious Disease Journal. 34, 7, p. 761-762 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Original antigenic sin with human bocaviruses 1-4

Li, X., Kantola, K., Hedman, L., Arku, B., Hedman, K. & Soderlund-Venermo, M., Sep 2015, In : Journal of General Virology. 96, 10, p. 3099-3108 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

A Protein L -Based Immunodiagnostic Approach Utilizing Time-Resolved Forster Resonance Energy Transfer

Hepojoki, S., Nurmi, V., Vaheri, A., Hedman, K., Vapalahti, O. & Hepojoki, J., 2 Sep 2014, In : PLoS One. 9, 9, 8 p., 106432.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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A two-step real-time PCR assay for quantitation and genotyping of human parvovirus 4

Vaisanen, E., Lahtinen, A., Eis-Huebinger, A. M., Lappalainen, M., Hedman, K. & Soderlund-Venermo, M., Jan 2014, In : Journal of Virological Methods. 195, p. 106-111 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Bufavirus in Feces of Patients with Gastroenteritis, Finland

Vaisanen, E., Kuisma, I., Phan, T. G., Delwart, E., Lappalainen, M., Tarkka, E., Hedman, K. & Söderlund-Venermo, M., Jun 2014, In : Emerging Infectious Diseases. 20, 6, p. 1077-1079 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Detection of TS polyomavirus DNA in tonsillar tissues of children and adults: Evidence for site of viral latency

Sadeghi, M., Aaltonen, L-M., Hedman, L., Chen, T., Söderlund-Venermo, M. & Hedman, K., Jan 2014, In : Journal of Clinical Virology. 59, 1, p. 55-58 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Diagnostic Methods for and Clinical Pictures of Polyomavirus Primary Infections in Children, Finland

Chen, T., Tanner, L., Simell, V., Hedman, L., Makinen, M., Sadeghi, M., Veijola, R., Hyoty, H., Ilonen, J., Knip, M., Toppari, J., Simell, O., Söderlund-Venermo, M. & Hedman, K., Apr 2014, In : Emerging Infectious Diseases. 20, 4, p. 689-692 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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