Klaus Olkkola

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Klaus Olkkola

 https://orcid.org/0000-0001-7872-8665

  • PL 340 (Haartmaninkatu 4)

    00014

    Finland

  • Finland

1982 …2025

Research activity per year

Personal profile

Curriculum vitae

CURRICULUM VITAE

 

Full name

Olkkola, Klaus Tapio

 

Current position

Professor and Chairman, Department of Anaesthesiology and Intensive Care Medicine, University of Helsinki and Helsinki University Central Hospital, Finland

 

2014-

Director, Clinicum, University of Helsinki

 

2015-

 

Education and training

Bachelor of medicine (MB), University of Helsinki, Finland

 

1979

Licentiate in medicine (MD), University of Helsinki, Finland

 

1983

Licensed physician, Finland

 

1983

Doctor of Medical Science (MScD), Department of Clinical Pharmacology, University of Helsinki, Finland

 

1985

Docent (=adjunct professor) in pharmacology, University of Helsinki, Finland

 

1991

Legitimated specialist in anaesthesiology, Finland

 

1992

Legitimated specialist in clinical pharmacology, Finland

 

1992

Docent (=adjunct professor) in anaesthesiology, University of Helsinki, Finland

 

1995

Special competence in medical education, Finnish Medical Association, Finland

 

2010

 

Previous professional appointments

Assistant, Department of Pharmacology, University of Helsinki, Finland

 

1983-84

Resident, Department of Anaesthesia, Children's Hospital, Helsinki University Central Hospital, Helsinki, Finland

 

1984-85

Assistant, Department of Clinical Pharmacology, University of Helsinki, Finland

 

1985, 89

Clinical lecturer, Department of Clinical Pharmacology, University of Helsinki, Finland

 

1986

Visiting scientist, Department of Anaesthesiology, University of Bonn, Germany (Hosts: Professor H Stoeckel and Professor H Schwilden)

 

1987-88

Resident, Department of Anaesthesia, Helsinki University Central Hospital, Helsinki, Finland

 

1990-91

Clinical lecturer, Department of Anaesthesia, University of Helsinki, Helsinki, Finland (total 6.5 years)

 

1992-98

Staff anaesthesiologist, Department of Anaesthesia, Helsinki University Central Hospital, Helsinki, Finland (total 6.5 years)

 

1992-98

Acting professor and chairman, Department of Anaesthesia, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland (total 7 months)

 

1997

Chief Physician, Department of Anaesthesia, Töölö Hospital, Helsinki University Central Hospital, Helsinki, Finland (total 11 months)

 

1999

Medical Director, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland

 

6/1998-9/2002

Director of research and administrative director of Neuroanaesthesia, Department of Anaesthesia and Intensive Care Medicine, Töölö Hospital, Helsinki University Central Hospital, Helsinki, Finland

 

10/2002-2/2003

Professor and Chairman, Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, Finland

 

2003-13

Director of the Institute of Clinical Medicine, University of Turku, Finland

 

2008-13

 

Research awards, honours and major grants

Stipends (funding, grants), from the Alexander von Humboldt Foundation (Germany), funds of the University of Helsinki and the Helsinki University Central Hospital, Turku University Hospital and from Finnish foundations, e.g. from the Paulo Foundation, Finnish Cultural Foundation, Instrumentarium Research Foundation and from pharmaceutical industry

 

1982-

Young scientist's award, Annual Meeting of the Finnish Society of Anaesthesiologists, Finland

 

1991

Young scientist's award, Congress of the Scandinavian Society of Anaesthesiologists, Reykjavik, Iceland

 

1995

Prize for the free paper presentation, Annual Meeting of the European Academy of Anaesthesiology, Copenhagen, Denmark

 

1996

Visiting professor: Friedrich-Alexander-Universität Erlangen Nürnberg, Erlangen, Germany

 

1997

Young Investigator's Award, Special Interest Group on Pain in Childhood, International Association for the study of Pain, 4th Symposium on Pediatric Pain, Helsinki, Finland

 

1997

Acta award (together with Teijo Saari), Annual Meeting of the Finnish Society of Anaesthesiologists, Finland

 

2006

Corresponding member, German Society of Anaesthesiology and Intensive Care Medicine

 

2011

Visiting professor: Friedrich-Alexander-Universität Erlangen Nürnberg, Erlangen, Germany

 

2013

 

Editorial board memberships

Editor for European Journal of Anaesthesiology

 

1995-2004

Associate Editor for Scandinavian Journal of Pain

 

2009-

Section Editor for Current Opinion in Anaesthesiology

 

2009-10

 

Memberships in scientific societies

Finnish Medical Society Duodecim

 

1979-

Finnish Pharmacological Society

 

1984-

Finnish Society of Anaesthesiologists, Board of Directors 2011-, President elect 2014-15, President 2016-

 

1989-

European Academy of Anaesthesiology, Academician 1995-, Member of the Senate 1998-2004, Honorary secretary 2003-04

 

1990-2004

European Society of Anaesthesiology (European Society of Anaesthesiologists), Board of Directors 2006-2009, Nominations Committee 2011-

 

1997-

Scandinavian Society of Anaesthesiology and Intensive Care Medicine, Board of Directors 2011-

 

1995-

International Association for the Study of Pain, Special Interest Group on Pain in Childhood 1997-99

 

1995-99

European Board of Anaesthesiology, the section of UEMS (European Union of Medical Specialists), vice-chairman of the standing working group for workforce, welfare and working conditions

 

2013-

 

Other academic and professional activities

Mentor for doctoral training

  1. Katri Hamunen: Ventilatory effects of opioids in children (1994)
  2. Janne Backman: Effects of drugs inhibiting or inducing CYP3A enzymes on the pharmacokinetics and pharmacodynamics of oral midazolam (1995)
  3. Harri Luurila: Effect of erythromycin on the pharmacokinetics and pharmacodynamics of intravenous and oral benzodiazepines (1996)
  4. Anu Varhe: Interactions of triazolam with inhibitors of CYP3A enzymes (1996)
  5. Jouni Ahonen: Effect of antimycotics and calcium antagonists on the pharmacokinetics and pharmacodynamics of benzodiazepines used in anaesthesiology (1996) – awarded by Finnish Medical Association (best in Finland)
  6. Maija Kansanaho: Quantifying the interaction between non-depolarizing neuromuscular blocking agents and volatile anaesthetics (1997)
  7. Maija Kaukonen: Studies on the effects of a CYP3A4-inhibitor, itraconazole, on the pharmacokinetics and pharmacodynamics of cardiovascular drugs (1997)
  8. Pertti Suominen: Pediatric prehospital emergency care (1998)
  9. Vilja Palkama: Studies on drug interactions between CYP3A4 inhibitors and anaesthetic drugs (1999)
  10. Mika Jokinen: Pharmacokinetics and interactions of ropivacaine (2003) – awarded by Finnish Society of Anaesthesiologists (best anaesthesiological thesis in Finland)
  11. Teijo Saari: Effects of cytochrome P450 enzyme inhibitors on the metabolism of drugs used in anaesthesiology (2007) – awarded by Finnish Society of Anaesthesiologists (best anaesthesiological thesis in Finland)
  12. Ville-Veikko Hynninen: Effects of cytochrome P450 enzyme inhibitors on the pharmacokinetics of nosteroidal anti-inflammatory drugs and venlafaxine (2008) – awarded by Finnish Society of Anaesthesiologists (best anaesthesiological thesis in Finland)
  13. Mika Isohanni: Effect of drugs inhibiting or inducing CYP3A enzymes on the pharmacokinetics of lidocaine (2009)
  14. Tuija Nieminen: The role of cytochrome P450 3A inducers and inhibitors in the metabolism and the effects of oxycodone (2010) – awarded by Finnish Society of Clinical Pharmacology (best clinical pharmacological thesis in Finland)
  15. Hanna Illman: Studies on neuromuscular blocking agents and their antagonists during anaesthesia (2011)
  16. Juha Grönlund: Effect of metabolic inhibitors on the pharmacokinetics and pharmacodynamics of oxycodone (2011) – awarded by Finnish Society of Clinical Pharmacology (best clinical pharmacological thesis)
  17. Antti Liukas: Pharmacokinetics of opioids and paracetamol in the elderly (2011) – awarded by Finnish Society of Anaesthesiologists (best anaesthesiological thesis in Finland)
  18. Timo Iirola: Pharmacokinetics and pharmacodynamics of dexmedetomidine. Clinical studies in intensive care patients and healthy subjects (2012) – approved with distinction
  19. Marko Peltoniemi: Effects of cytochrome P450 enzyme inhibitors and inducers on the metabolism of S-ketamine (2013)
  20. Waltteri Siirala: Optimisation of the nutrition of non-ambulatory invasively ventilated patients with severe neuromuscular disease or tetraparesis (2013)
  21. Tuukka Saarikoski: Effect of metabolic inhibitors on the pharmacokinetics and pharmacodynamics of tramadol (in progress)
  22. Mari Fihlman: Interactions of buprenorphine (in progress)
  23. Heidi Hellevuo: Quality of resuscitation (in progress)
  24. Jussi Pirneskoski: Out-of-hospital emergency medicine (in progress)
  25. Satu Poikola: Studies on pain therapy after ambulatory surgery (in progress)

 

Journals

Reviewer for several high-impact journals including, e.g., JAMA, Anesthesiology, Anaesthesia and Analgesia, Pain, Acta Anaesthesiologica Scandinavica, British Journal of Pharmacology, Clinical Pharmacokinetics

 

Review of grant proposals

Swiss National Science Foundation, several times

 

1995-

Paulo Foundation, Helsinki, Finland

 

1997-

Instrumentarium Research Foundation, Helsinki, Finland

 

2007-

Research funds of Helsinki University Hospital, Finland, Chairman of the grant committee 2011-12

 

2008-12

Health Research Council of New Zealand

 

2012

Dutch Organisation for Health Research and Development

 

2014

 

Invited international scholarly presentations and chairmanships

  1. Speaker: Treatment of intoxications using single and repeated doses of oral activated charcoal. XXVI Congrés Francais des Centres Anti-Poisons, Marseille, France, October 4-5, 1988
  2. Speaker: Use of pharmacokinetic-dynamic models in the automatic feedback control of neuromuscular blocking agents. Annual Meeting of the Finnish Society of Anaesthesiologists, Helsinki, Finland, November 9-11, 1989
  3. Speaker: Feedback-Regelung von Muskelrelaxantien. Anästhesie, Intensiv- und Notfallmedizin: Klinische Pharmakologie und rationale Arzneimitteltherapie, Bonn, Germany, October 12-13, 1990
  4. Speaker: Why pharmacokinetics: Translation of pharmacokinetics to clinical medicine. Annual Meeting of the Finnish Society of Anaesthesiologists, Helsinki, Finland, November 8-10, 1990
  5. Speaker: Closed-loop feedback control of muscle relaxants. Annual Meeting of the Finnish Society of Anaesthesiologists, Helsinki, Finland, November 8-10, 1990
  6. Speaker and panelist: Pharmakokinetik beim Neugeborenen und Säugling. Zentraleuropäischer Anästhesiekongress, Interlaken, Switzerland, September 10-14, 1991
  7. Speaker: Frequent drug interactions in anaesthesia. X World Congress of Anaesthesiologists, The Hague, The Netherlands, June 12-19, 1992
  8. Speaker and panelist: Effect of oral activated charcoal on the absorption and elimination of drugs and toxins in humans. X Conference de consensus en reanimation et medecine d'urgence: Epuration digestive lors des intoxications aigues, Nimes, France, November 27, 1992
  9. Speaker: Computer controlled infusion of neuromuscular blocking agents. Anaesthesia Update 1992, Helsinki, Finland, December 11, 1992
  10. Speaker: An evaluation of the interactions of rocuronium bromide with intravenous anesthetics. Rocuronium bromide (ORG 9426) investigators workshop, Groningen, The Netherlands, November 15-16, 1993
  11. Speaker and panelist: Model-based adaptive control of neuromuscular blocking agents. Workshop for control and automation in anaesthesia, Bonn, Germany, May 13-14, 1994
  12. Speaker and panelist: New routes for postoperative pain therapy. Paulo Symposium: Modern trends in postoperative pain therapy, Hanasaari, Espoo, Finland, September 16-17, 1994
  13. Chairman: Monitoring of neuromuscular blockade. 5th International Neuromuscular Meeting, Tokyo, November 17-20, 1994
  14. Chairman: 8th European Anaesthesia Research Group Meeting, Helsinki, Finland, August 24, 1995
  15. Speaker and panelist: Pharmacokinetics and pharmacodynamics of analgesics in children. European Academy of Anaesthesiology, 17th Annual Scientific Meeting, Helsinki, Finland, August 24-27, 1995
  16. Speaker and panelist: International Symposium of the Society of Intravenous Anesthesia (SIVA), Erlangen, Germany, September 19-21, 1996
  17. Chairman, speaker and panelist: Fourth International Symposium on Pediatric Pain, Helsinki, Finland, June 29-July 4, 1997
  18. Speaker: Relevant drug interactions. Scandinavian Association for the study of pain, Annual Meeting, Naantali, Finland, May 7-10, 1998
  19. Chairman and speaker: Total intravenous anaesthesia. 10th European Congress of Anaesthesiology, Frankfurt am Main, Germany, June 30-July 4, 1998
  20. Speaker: Closed loop feedback control of drug administration. LÄKSAK-symposium, Nobel Forum, Karolinska Institutet, Stockholm, Sweden, March 26, 1999
  21. Speaker and panelist: Molecular biology and genetics applied to anaesthesia research. European Academy of Anaesthesiology, Annual Meeting, Paris, France, September 21-23, 2000
  22. Speaker: Feedback control as a research tool in the clinical pharmacology of muscle relaxants and their interactions. Special Symposium: Heutiger Stellenwert von Pharmakokinetik und -dynamik in der klinischen Anästhesiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany, October 6, 2000
  23. Chairman, speaker and panelist: Pediatric pharmacology and NSAIDs and paracetamol. 2nd Nordic Congress “Barn och Smärta”, Stockholm, Sweden, September 12-14, 2001
  24. Speaker: Clinically important drug interactions. Euroanaesthesia 2002, Nice, France, April 6-9, 2002
  25. Speaker: Drug interactions. 7th National Conference of Anaesthesiology and Intensive Care, Varna, Bulgaria, October 3-6, 2002
  26. Speaker: Drug interactions in anaesthesia. Aktuelle Probleme und Seminarien in Anästhesiologie, Intensiv- und Notfallamedizin. Fortbildung der UniversistätSpital Zürich, Zürich, Switzerland, November 6, 2002
  27. Speaker: Statins and anaesthesia. Euroanaesthesia 2004, Lisbon, Portugal, June 5-8, 2004
  28. Speaker: Premedication, State of the art: Alternative routes of administration. Euroanaesthesia 2005, Vienna, Austria, May 28-31
  29. Speaker: Clinical use of muscle relaxants, State of the art: Rapid sequence induction: Should we stop using succinylcholine. Euroanaesthesia 2006, Madrid, Spain, June 3-6
  30. Speaker: Drug interactions in high risk patients. ESA NASC Symposium, Anaesthesia for high risk patients, 2nd International Baltic Congress of Anaesthesiology and Intensive Care, Tallinn, Estonia, October 26-28, 2006
  31. Speaker: Clinically relevant drug interactions in anaesthesia and intensive care medicine. Euroanaesthesia 2007, Munich, Germany, June 9-12, 2007
  32. Speaker: Clinical relevance of pharmacogenetics in pharmacokinetics and -dynamics. Euroanaesthesia 2008, Copenhagen, Denmark, May 31-June 3, 2008
  33. Speaker: Pharmacokinetic drug interactions in the perioperative period. EuroSIVA 2010, Helsinki, Finland, June 11, 2010
  34. Speaker: Impact of cytochrome P450 enzymes in anaesthesiology. Euroanaesthesia 2010, Helsinki, Finland, June 12-15, 2010
  35. Chairman: Developmental physiology of pain. 5th Nordic Congress on Paediatric Pain, Turku, Finland, September 9-10, 2010
  36. Speaker: Oral activated charcoal in the treatment of intoxications. Personalized drug therapy symposium, Helsinki, Finland, June 16-17, 2011
  37. Chairman: Untoward effects of local anaesthesia. ESRA Scandinavian Zone Meeting, Helsinki, Finland, December 12-13, 2011
  38. Speaker: Automated control of muscle relaxation. Euroanaesthesia 2012, Paris, France, June 9-12, 2012
  39. Speaker: Drug interactions in the perioperative period. Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine, Turku, Finland, August 26-29, 2013
  40. Speaker: Drugs and aging. Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine, Reykjavik, Iceland, June 10-12, 2015
  41. Speaker: Clinically relevant drug interactions in anaesthesia and intensive care. Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine, Reykjavik, Iceland, June 10-12, 2015
  42. Speaker: Pharmacokinetics and drugs interactions of oxycodone. Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine, Reykjavik, Iceland, June 10-12, 2015
  43. Speaker: Optimal balance between practical patient work (learn by doing), simulation and theoretical courses. Euroanaesthesia 2016, London, UK, May 28-30, 2016

 

Congresses

  1. Anaesthesia Update 1992, Helsinki, Finland: Member of the Organizing Committee
  2. Anaesthesia Update 1994, Helsinki, Finland: Member of the Organizing Committee
  3. Annual Meeting of the European Academy of Anaesthesiology, Helsinki, Finland, 1995: Member of the Scientific Committee
  4. German Congress of Anaesthesiology - International, Nuremberg, Germany, 1996: Member of the Scientific Committee
  5. Fourth International Symposium on Pediatric Pain, Helsinki, 1997: Vice-President of the Scientific Committee
  6. Annual Meeting of the European Academy of Anaesthesiology, Graz, Austria, 2001: Member of the International Scientific Committee
  7. 2nd Nordic Congress “Barn och Smärta”, Stockholm, Sweden, 2001: Member of the International Scientific Committee
  8. Euroanaesthesia 2010, Helsinki, Finland, 2010: Member of the National Organizing Committee
  9. 32nd Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine 2013, Turku, Finland: President

 

Official opponent for doctoral dissertations

Ilkka Kalli, University of Helsinki, Helsinki, Finland

 

1991

Pasi Lehto, University of Turku, Turku, Finland

 

1995

Kari Laine, University of Turku, Turku, Finland

 

1997

Outi Lapatto-Reiniluoto, University of Helsinki, Helsinki, Finland

 

2001

Leena Mildh, University of Helsinki, Helsinki, Finland

 

2007

Samuel Fanta, University of Helsinki, Helsinki, Finland

 

2009

Elina Kumpulainen, University of Eastern Finland, Kuopio, Finland

 

2010

Trine Naalsund Andreassen, Norwegian University of Science and Technology, Trondheim, Norway

 

2011

Karsten Ahlbeck, Karolinska Institutet, Stockholm, Sweden

 

2011

Pamela Hiltunen, University of Eastern Finland, Kuopio, Finland

 

2016

 

Didactic training and awards

Diploma in medical didactics, University of Helsinki, Helsinki, Finland

 

1993-94

Chosen as the Tutor of the year by the Medical Students' Association and awarded by the Medical Faculty, University of Helsinki, Helsinki, Finland

 

1996

 

Video programs

Educational video program (in Finnish) for medical students together with Dr Kari Aranko on the pharmacological treatment of convulsions

 

1985

 

Administrative training

Health care management executive programme, Helsinki School of Economics and Business Administration

 

1998-99

 

Miscellaneous

Member of the Medical Ethics Committee, Department of Anaesthesia, University of Helsinki, Helsinki, Finland

 

1993-97

Member of the Executive Group of the Department of Clinical Medicine, University of Helsinki, Helsinki, Finland

 

1995-98

Shortlisted (3rd place of preference) for the post of professor of anaesthesiology in the University of Oulu, Oulu, Finland

 

1994

Shortlisted (2nd place of preference) for the post of professor of anaesthesiology in the University of Kuopio, Kuopio, Finland

 

1996

Advisor to the Faculty of Medicine, University of Bern, Bern, Switzerland on the appointment to the post of Honorary Professor

 

2006

Advisor to the Faculty of Medicine, University of Tartu, Tartu, Estonia on the appointment to the post of Professor in Anaesthesiology and Intensive Care Medicine

 

2013

Advisor to the Faculty of Medicine, University of Helsinki, Helsinki, Finland on the appointment to the post of docent

 

1994, 1995

Advisor to the Faculty of Medicine, University of Turku, Turku, Finland on the appointment to the post of docent

 

1994

Pre-examiner for 4 doctoral dissertations

 

1994-

Advisor in anaesthesiological matters to the Finnish National Agency of Medicines

 

1995-

Founder member of Professor Tammisto’s fund for anaesthesia research at Paulo Foundation, Helsinki, Finland

 

1995

Examiner for the National Specialist Examination in Anaesthesiology and Intensive Care, Finland

 

1997, 2003-

Executive Group of the Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland, member

 

6/1998-9/2002

Advisor to the Finnish National Authority for Medicolegal Affairs

 

2000-

Examiner for the European Diploma in Anaesthesiology and Intensive Care (endorsed by the European Board of Anaesthesiology [EBA] and Union of European Medical Specialities [UEMS])

 

2001-

Advisor in clinical pharmacological matters to the Finnish National Agency of Medicines

 

2002-

Executive Group of Operative Care Subdivision, Hospital District of Southwest Finland, Turku, Finland, member

 

2003-12

Committee for professional postgraduate and continuing medical education

 

2004-13

Executive Group of the Institute of Clinical Sciences, University of Turku, Turku, Finland, member 2004-08, Chairman 2008-

 

2004-13

Scholarship Fund of the Medical Faculty of the University of Turku, Turku, Finland, Member of the Scholarship Committee 2004-06, Chairman 2007-09

 

2004-09

Travelling Grant Committee of the Medical Faculty of the University of Turku, Turku, Finland, member

 

2005-07

University Committee of Turku University Hospital and University of Turku, Turku, Finland, member

 

2008-13

Research Funds of the Hospital District of Helsinki and Uusimaa, Member of the Scholarship Committee 2008-09, Chairman 2010-11

 

2008-11

University Collegium of the University of Turku, vice member

 

2010-13

Executive Group of the National PET Centre, Turku, Finland, vice member

 

2011-13

Board of Directors, Public Utility of Emergency care of Southwest Finland, representative of the University of Turku           

 

2011-13

University Committee of Helsinki University Hospital and University of Helsinki, member

 

2015-

 

Publications

Approximately 220 original publications in English, 100 reviews/book chapters/editorials, 180 abstracts and 30 other articles. Hirsch index 43. Main areas of research: acute poisonings, interactions of intravenous anaesthetics with the inhibitors and inducers of cytochrome P-450 isozymes, pharmacokinetics and pharmacodynamics of drugs during general anaesthesia, pharmacokinetics and pharmacodynamics of analgesics in children and management of pain in children, quality of cardiopulmonary resuscitation, xenon and neuroprotection.

 

 04/02/2017

 

Klaus Olkkola

Education/Academic qualification

Lääkärikouluttajan erityispätevyys

2010 → …

Anestesiologian erikoislääkäri

1992 → …

Kliinisen farmakologian erikoislääkäri

1992 → …

External positions

Ylilääkäri, tutkimuksen ja opetuksen vastuuhenkilö, HYKS Leikkaussalit, teho- ja kivunhoito (ATeK)

2014 → …

Fields of Science

  • 3126 Surgery, anesthesiology, intensive care, radiology
  • pharmacokinetics
  • pharmacokinetic drug interactions
  • pharmacodynamics
  • pain
  • emergency medicine

International and National Collaboration

Publications and projects within past five years.
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