Krister Wennerberg

Publications

Research Output per year

1996 2020

• 109 Article
• 10 Review Article
• 7 Meeting Abstract
• 2 Chapter
• 2 More
  • 2 Abstract

Research Output per year

Research Output per year

Search results

• 2017

  Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

  Malani, D., Murumagi, A., Yadav, B., Kontro, M., Eldfors, S., Kumar, A., Karjalainen, R., Majumder, M. M., Ojamies, P., Pemovska, T., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M., Aittokallio, T. & Kallioniemi, O., May 2017, In : Leukemia. 31, 5, p. 1187-1195 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• High-Throughput Dual Screening Method for Ras Activities and Inhibitors

  Kopra, K., van Adrichem, A. J., Salo-Ahen, O. M. H., Peltonen, J., Wennerberg, K. & Harma, H., 18 Apr 2017, In : Analytical Chemistry. 89, 8, p. 4508-4516 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia

  Kontro, M., Kumar, A., Majumder, M. M., Eldfors, S., Parsons, A., Pemovska, T., Saarela, J. S., Yadav, B., Malani, D. R., Fløisand, Y., Höglund, M., Remes, K., Gjertsen, B-T., Kallioniemi, O-P., Wennerberg, J. K., Heckman, C. A. & Porkka, K. V. K., 2017, In : Leukemia. 31, 2, p. 301-309 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  File

• Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

  Eldfors, S., Kuusanmäki, H., Kontro, M., Majumder, M. M., Parsons, A., Edgren, H., Pemovska, T., Kallioniemi, O., Wennerberg, K., Gökbuget, N., Burmeister, T., Porkka, K. & Heckman, C. A., 2017, In : Leukemia. 31, 1, p. 51-57 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

  Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Safont, M. M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 others, Knowles, J. & Heckman, C. A., 10 Aug 2017, In : Blood. 130, 6, p. 789-802 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

  Ojamies, P., Kontro, M., Edgren, H., Ellonen, P., Lagström, S., Almusa, H., Miettinen, T., Eldfors, S., Tamborero, D., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M. & Kallioniemi, O., 2017, In : Leukemia. 31, 5, p. 1048-1058 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells

  Jaiswal, A., Peddinti, G., Akimov, Y., Wennerberg, K., Kuznetsov, S., Tang, J. & Aittokallio, T., 1 Jun 2017, In : Genome medicine. 9, 15 p., 51.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells

  Haltia, U-M., Andersson, N., Yadav, B., Farkkila, A., Kulesskiy, E., Kankainen, M., Tang, J., Butzow, R., Riska, A., Leminen, A., Heikinheimo, M., Kallioniemi, O., Unkila-Kallio, L., Wennerberg, K., Aittokallio, T. & Anttonen, M., Mar 2017, In : Gynecologic Oncology. 144, 3, p. 621-630 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Systematic identification of feature combinations for predicting drug response with Bayesian multi-view multi-task linear regression

  Ammad-ud-din, M., Khan, S. A., Wennerberg, K. & Aittokallio, T., 15 Jul 2017, In : Bioinformatics. 33, 14, p. I359-I368 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
• 2016

  c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease

  Lindholm, D., Pham, D. D., Cascone, A., Eriksson, O., Wennerberg, K. & Saarma, M., 26 Oct 2016, In : Frontiers in aging neuroscience. 8, 6 p., 254.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File

• Cancer Cell Drug Response Transcriptomes in 3D

  Wennerberg, K., 17 Nov 2016, In : Cell chemical biology. 23, 11, p. 1323-1324 2 p.

  Research output: Contribution to journal › Article › Scientific

  Open Access

  File

• Consistency in drug response profiling

  Mpindi, J. P., Yadav, B., Ostling, P., Gautam, P., Malani, D., Murumagi, A., Hirasawa, A., Kangaspeska, S., Wennerberg, K., Kallioniemi, O. & Aittokallio, T., 1 Dec 2016, In : Nature. 540, 7631, p. E5-E6 2 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

  Sieberts, S. K., Zhu, F., Garcia-Garcia, J., Stahl, E., Pratap, A., Pandey, G., Pappas, D., Aguilar, D., Anton, B., Bonet, J., Eksi, R., Fornes, O., Guney, E., Li, H., Marin, M. A., Panwar, B., Planas-Iglesias, J., Poglayen, D., Cui, J., Falcao, A. O. & 31 others, Suver, C., Hoff, B., Balagurusamy, V. S. K., Dillenberger, D., Neto, E. C., Norman, T., Aittokallio, T., Ammad-ud-din, M., Azencott, C-A., Bellon, V., Boeva, V., Bunte, K., Chheda, H., Cheng, L., Corander, J., Dumontier, M., Goldenberg, A., Gopalacharyulu, P., Hajiloo, M., Hidru, D., Jaiswal, A., Kaski, S., Khalfaoui, B., Khan, S. A., Kramer, E. R., Marttinen, P., Pirinen, M., Saarela, J., Tang, J., Wennerberg, K. & Rheumatoid Arth Challenge, Aug 2016, In : Nature Communications. 7, 9 p., 12460.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses

  Varghese, F. S., Kaukinen, P., Glasker, S., Bespalov, M., Hanski, L., Wennerberg, K., Kummerer, B. M. & Ahola, T., Feb 2016, In : Antiviral Research. 126, p. 117-124 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells

  Gautam, P., Karhinen, L., Szwajda, A., Jha, S. K., Yadav, B., Aittokallio, T. & Wennerberg, K., 10 May 2016, In : Molecular Cancer. 15, 16 p., 34.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

  Hayes, T. K., Neel, N. F., Hu, C., Gautam, P., Chenard, M., Long, B., Aziz, M., Kassner, M., Bryant, K. L., Pierobon, M., Marayati, R., Kher, S., George, S. D., Xu, M., Wang-Gillam, A., Samatar, A. A., Maitra, A., Wennerberg, K., Petricoin, E. F., Yin, H. H. & 4 others, Nelkin, B., Cox, A. D., Yeh, J. J. & Der, C. J., 11 Jan 2016, In : Cancer Cell. 29, 1, p. 75-89 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing

  Kulesskiy, E., Saarela, J., Turunen, L. & Wennerberg, K., Feb 2016, In : Journal of Laboratory Automation. 21, 1, p. 27-36 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2015

  Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

  Pemovska, T., Johnson, E., Kontro, M., Repasky, G. A., Chen, J., Wells, P., Cronin, C. N., McTigue, M., Kallioniemi, O., Porkka, K., Murray, B. W. & Wennerberg, K., 5 Mar 2015, In : Nature. 519, 7541, p. 102-U225 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening

  Duellman, S. J., Zhou, W., Meisenheimer, P., Vidugiris, G., Cali, J. J., Gautam, P., Wennerberg, K. & Vidugiriene, J., 1 Oct 2015, In : Assay and drug development technologies. 13, 8, p. 456-465 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

  van Adrichem, A. J., Fagerholm, A., Turunen, L., Lehto, A., Saarela, J., Koskinen, A., Repasky, G. A. & Wennerberg, K., 2015, In : Combinatorial Chemistry & High Throughput Screening. 18, 1, p. 3-17 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• From drug response profiling to target addiction scoring in cancer cell models

  Yadav, B., Gopalacharyulu, P., Pemovska, T., Khan, S. A., Szwajda, A., Tang, J., Wennerberg, K. & Aittokallio, T., Oct 2015, In : Disease Models & Mechanisms. 8, 10, p. 1255-1264 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• High-throughput drug sensitivity and resistance testing of ovarian cancer cell lines provides useful strategy for assessing drug repositioning and therapeutic possibilities of emerging drugs

  Hirasawa, A., Murumagi, A., Arjama, M., Yadav, B., Mpindi, J. P., Wennerberg, K., Aittokallio, T., Aoki, D. & Kallioniemi, O., 15 Aug 2015, In : Clinical Cancer Research. 21, 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data

  Mpindi, J-P., Potdar, S., Bychkov, D., Saarela, J., Saeed, K., Wennerberg, K., Aittokallio, T., Östling, P. & Kallioniemi, O., 1 Dec 2015, In : Bioinformatics. 31, 23, p. 3815-3821 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• KIFC1 is a novel potential therapeutic target for breast cancer

  Li, Y., Lu, W., Chen, D., Boohaker, R. J., Zhai, L., Padmalayam, I., Wennerberg, K., Xu, B. & Zhang, W., Sep 2015, In : Cancer Biology & Therapy. 16, 9, p. 1316-1322 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity

  van Adrichem, A. J. & Wennerberg, K., 21 Dec 2015, In : FEBS Letters. 589, 24, p. 3859-3865 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

  Kibble, M., Saarinen, N., Tang, J., Wennerberg, K., Makela, S. & Aittokallio, T., 2015, In : Natural Product Reports. 32, 8, p. 1249-1266 18 p.

  Research output: Contribution to journal › Review Article › peer-review

• Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

  Pietarinen, P. O., Pemovska, T., Kontro, M., Yadav, B., Mpindi, J. P., Andersson, E. I., Majumder, M. M., Kuusanmaki, H., Koskenvesa, P., Kallioniemi, O., Wennerberg, K., Heckman, C. A., Mustjoki, S. & Porkka, K., May 2015, In : Blood cancer journal. 5, 6 p., 309.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Pecision systems medicine: Next-generation precision cancer medicine and drug positioning

  Pemovska, T., Östling, P., Heckman, C., Kallioniemi, O. & Wennerberg, K., 2015, In : DDW. Drug discovery world. 16, 3, p. 47-53 7 p.

  Research output: Contribution to journal › Article › Scientific

• Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth

  Al-Ali, H., Lee, D-H., Danzi, M. C., Nassif, H., Gautam, P., Wennerberg, K., Zuercher, B., Drewry, D. H., Lee, J. K., Lemmon, V. P. & Bixby, J. L., Aug 2015, In : ACS Chemical Biology. 10, 8, p. 1939-1951 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data

  Pokharel, Y. R., Saarela, J., Szwajda, A., Rupp, C., Rokka, A., Karna, S. K. L., Teittinen, K., Corthals, G., Kallioniemi, O., Wennerberg, K., Aittokallio, T. & Westermarck, J., Dec 2015, In : Molecular & Cellular Proteomics. 14, 12, p. 3274-3283 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model

  Yadav, B., Wennerberg, K., Aittokallio, T. & Tang, J., 2015, In : Computational and Structural Biotechnology Journal. 13, p. 504 - 513 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles

  Szwajda, A., Gautam, P., Karhinen, L., Jha, S. K., Saarela, J., Shakyawar, S., Turunen, L., Yadav, B., Tang, J., Wennerberg, K. & Aittokallio, T., 20 Aug 2015, In : Chemistry & Biology. 22, 8, p. 1144-1155 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• TIMMA-R: an R package for predicting synergistic multi-targeted drug combinations in cancer cell lines or patient-derived samples

  He, L., Wennerberg, K., Aittokallio, T. & Tang, J., 1 Jun 2015, In : Bioinformatics. 31, 11, p. 1866-1868 3 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• What is synergy? The Saariselka agreement revisited

  Tang, J., Wennerberg, K. & Aittokallio, T., 1 Sep 2015, In : Frontiers in Pharmacology. 6, 5 p., 181.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File
• 2014

  A community effort to assess and improve drug sensitivity prediction algorithms

  Costello, J. C., Heiser, L. M., Georgii, E., Gonen, M., Menden, M. P., Wang, N. J., Bansal, M., Ammad-ud-din, M., Hintsanen, P., Khan, S. A., Mpindi, J-P., Kallioniemi, O., Honkela, A., Aittokallio, T., Wennerberg, K., Collins, J. J., Gallahan, D., Singer, D., Saez-Rodriguez, J., Kaski, S. & 3 others, Gray, J. W., Stolovitzky, G. & NCI DREAM Community, Dec 2014, In : Nature Biotechnology. 32, 12, p. 1202-U57 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Antifungal Application of Nonantifungal Drugs

  Stylianou, M., Kulesskiy, E., Lopes, J. P., Granlund, M., Wennerberg, K. & Urban, C. F., Feb 2014, In : Antimicrobial Agents and Chemotherapy. 58, 2, p. 1055-1062 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Bioluminescent Cell-Based NAD(P)/NAD(P)H Assays for Rapid Dinucleotide Measurement and Inhibitor Screening

  Vidugiriene, J., Leippe, D., Sobol, M., Vidugiris, G., Zhou, W., Meisenheimer, P., Gautam, P., Wennerberg, K. & Cali, J. J., 1 Dec 2014, In : Assay and drug development technologies. 12, 9-10, p. 514-526 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza

  Atkins, C., Evans, C. W., Nordin, B., Patricelli, M. P., Reynolds, R., Wennerberg, K. & Noah, J. W., Jul 2014, In : Journal of Biomolecular Screening. 19, 6, p. 936-946 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis

  Khan, S. A., Virtanen, S., Kallioniemi, O. P., Wennerberg, K., Poso, A. & Kaski, S., 1 Sep 2014, In : Bioinformatics. 30, 17, p. I497-I504 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Integrative and Personalized QSAR Analysis in Cancer by Kernelized Bayesian Matrix Factorization

  Amnnad-ud-din, M., Georgii, E., Gonen, M., Laitinen, T., Kallioniemi, O., Wennerberg, K., Poso, A. & Kaski, S., Aug 2014, In : Journal of Chemical Information and Modeling. 54, 8, p. 2347-2359 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Making Sense of Large-Scale Kinase Inhibitor Bioactivity Data Sets: A Comparative and Integrative Analysis

  Tang, J., Szwajda, A., Shakyawar, S., Xu, T., Hintsanen, P., Wennerberg, K. & Aittokallio, T., Mar 2014, In : Journal of Chemical Information and Modeling. 54, 3, p. 735-743 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

  Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumagi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, K. & Aittokallio, T., 5 Jun 2014, In : Scientific Reports. 4, 10 p., 5193.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Systematic high-throughput drug sensitivity and resistance testing (DSRT) of ovarian cancer cell lines indicates novel therapeutic possibilities with existing and emerging drugs

  Hirasawa, A., Murumagi, A., Arjama, M., Yadav, B., Mpindi, J. P., Wennerberg, K., Aittokallio, T., Aoki, D. & Kallioniemi, O., 1 Oct 2014, In : Cancer Research. 74, 19, 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• The High Throughput Biomedicine Unit at the Institute for Molecular Medicine Finland: High Throughput Screening Meets Precision Medicine

  Pietiainen, V., Saarela, J., von Schantz, C., Turunen, L., Ostling, P. & Wennerberg, K., May 2014, In : Combinatorial Chemistry & High Throughput Screening. 17, 4, p. 377-386 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

  Antila, H., Autio, H., Turunen, L., Harju, K., Tammela, P., Wennerberg, K., Yli-Kauhaluoma, J., Huttunen, H. J., Castren, E. & Rantamaki, T., 30 Jan 2014, In : Journal of Neuroscience Methods. 222, p. 142-146 5 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2013

  A Chemical Proteomics Approach to Profiling the ATP-binding Proteome of Mycobacterium tuberculosis

  Wolfe, L. M., Veeraraghavan, U., Idicula-Thomas, S., Schuerer, S., Wennerberg, K., Reynolds, R., Besra, G. S. & Dobos, K. M., Jun 2013, In : Molecular & Cellular Proteomics. 12, 6, p. 1644-1660 17 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

  Koskela, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J. . A., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, K., Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In : Blood. 121, 22, p. 4541-4550 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• High-throughput drug screening and molecular profiling for therapeutic targeting of NUP98-NSD1-positive AML

  Kontro, M. P., Pemovska, T., Heckman, C. A., Kallioniemi, O-P., Wennerberg, J. K. & Porkka, K. V. K., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S18

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

  Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundan, T., Majumder, M. M., Marti, J. M. L., Mattila, P. & 16 others, Murumagi, A., Mustjoki, S., Palva, A., Parsons, A., Pirttinen, T., Ramet, M. E., Suvela, M., Turunen, L., Vastrik, I., Wolf, M., Knowles, J., Aittokallio, T., Heckman, C. A., Porkka, K., Kallioniemi, O. & Wennerberg, K., Dec 2013, In : Cancer Discovery. 3, 12, p. 1416-1429 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Stromal cell supported high-throughput screening of primary acute myeloid leukemia cells for assessing sensitivity to cytotoxic drugs

  Karjalainen, R. J., Pemovska, T., Yadav, B., Wennerberg, J. K. & Heckman, C. A., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S17

  Research output: Contribution to journal › Meeting Abstract › peer-review