Photo of Kristiina Mäkinen
  • PL 56 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 1, Biocentre 3

    00790 Helsinki

    Finland

19952019
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Personal profile

Description of research and teaching

Research

Plant health is an increasingly important issue as sufficient food security is endangered by the global climate change and growing population of the world. The research in the group focuses on the molecular mechanisms underlying Potato virus A (PVA) infection. PVA is a member of genus Potyvirus, which is economically the most devastating group of plant RNA viruses. Understanding the different stages of virus infection is a prerequisite for being able to prevent infections. The research in the group is carried out with the advanced techniques of biochemistry, and molecular and cell biology. The aims of  our research are:

 1) to produce novel information of the various stages of the virus multiplication cycle (protein synthesis, RNA replication, virus movement, encapsidation), and how these functions are localized and coordinated within the infected cells.

2) to tackle the disease problem caused by the genus Potyvirus, which is economically the most devastating group of plant viruses. Host factors involved in viral multiplication represent potential targets for virus control. Their identification and functional characterization is one of the major frontiers in virus research.

3) to exploit viruses as gene vectors, viral regulatory sequences as valuable elements in plant expression vectors and virus particles in nanobiotechnology applications.

Teaching

My teaching consists of basic lecture and laboratory courses in biochemistry and gene technology. I have been an organizer and teacher on post graduate courses on plant virology, heterologous protein production in plants and protein interactions and biochemical analyses. I have supervised several MSc and PhD students.

Keywords

  • 1183 Plant biology, microbiology, virology
  • plant virology, potyviruses

International and National Collaboration Publications and projects within past five years.

Publications 1995 2019

  • 44 Article
  • 5 Chapter
  • 5 Review Article
  • 1 Anthology or special issue

Molecular insights into the function of the viral RNA silencing suppressor HCPro

Ivanov, K., Eskelin, K. J., Bašić, M., De, S., Lohmus, A., Varjosalo, M. T. & Mäkinen, K. M., 2016, In : Plant Journal. 85, 1, p. 30-45 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Formation of Potato virus A-induced RNA granules and viral translation are interrelated processes required for optimal virus accumulation

Hafren, A. J., Lohmus, A. & Mäkinen, K. M., 7 Dec 2015, In : PLoS Pathogens. 11, 12, 28 p., e1005314.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

HSP70 and Its Cochaperone CPIP Promote Potyvirus Infection in Nicotiana benthamiana by Regulating Viral Coat Protein Functions

Hafren, A., Hofius, D., Rönnholm, G., Sonnewald, U. & Mäkinen, K., 2010, In : Plant Cell. 22, p. 523-535 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Introduction to Special Issue of Molecular Plant Pathology - “Extracellular and intracellular perception of plant viruses”.

Aranda, M., Mäkinen, K. & Verchot, J., 2 Jun 2019, (Accepted/In press)

Research output: Book/ReportAnthology or special issueScientific

Open Access
File

Projects 2007 2018

Activities 1999 2019

Molecular Plant Pathology (Journal)

Kristiina Mäkinen (Editor)
1 Jan 201531 Dec 2017

Activity: Publication peer-review and editorial work typesEditor of research journal

Doctoral Programme in Plant Sciences (External organisation)

Kristiina Mäkinen (Board member)
1 Jan 201431 Dec 2017

Activity: Membership typesMembership or other role in national/international committee, council, board

Societas biochemica, biophysica et microbiologica Fenniae eli "Biobio-seura" (External organisation)

Kristiina Mäkinen (Board member)
2010 → …

Activity: Membership typesMembership or other role in national/international committee, council, board

ScanVir2019 conference

Kristiina Mäkinen (Attendee)
5 Jun 2019

Activity: Participating in or organising an event typesPublic Talks

Production of heterologous proteins and metabolites in plants

Karen Sims-Huopaniemi (Member of organizing committee), Kristiina Mäkinen (Chair of organizing committee), Teemu Teeri (Chair of organizing committee)
6 May 201910 May 2019

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars