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Personal profile

Description of research and teaching

 

Epigenetic Alterations Involved in Colorectal Cancer Susceptibility

– Effects of Western-type Diet on Epigenetic Changes in Intestinal Mucosa


Our research project aims to elucidate the effects of Western-type diet on epigenetic alterations involved in early stages of colorectal carcinogenesis in histologically normal intestinal mucosa.

Three mouse models for intestinal cancer are used in the project. Wild-type mice are used as a model for sporadic human CRC, while ApcMin/+ and Mlh1+/- mice model the most common inherited human CRC predisposition syndromes FAP (familial adenomatous polyposis) and Lynch syndrome (HNPCC, hereditary non-polyposis colorectal cancer), respectively.

Research members: Prof. Minna Nyström, Laura Sarantaus, Ph.D., Denis Dermadi Bebek, M.Sc., Marjaana Pussila, M.Sc., Satu Lowndes, B.Sc. 

Education/Academic qualification

Sairaalageneetikko, Faculty of Biological and Environmental Sciences

Fields of Science

  • 118 Biological sciences
  • Cancer Genetics, Molecular biology, Cell biology
  • 311 Basic medicine
  • 3122 Cancers
  • 1184 Genetics, developmental biology, physiology
  • 1182 Biochemistry, cell and molecular biology

International and National Collaboration Publications and projects within past five years.

Publications 1997 2017

Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein

Ollila, S., Sarantaus, L., Kariola, R., Chan, P., Hampel, H., Holinski-Feder, E., Macrae, F., Kohonen-Corish, M., Gerdes, A-M., Peltomäki, P., Mangold, E., Chapelle, A. D. L., Greenblatt, M. & Nyström, M., 2006, In : Gastroenterology. 131, p. 1408-1417 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC

Ollila, S., Fitzpatrick, R., Sarantaus, L., Kariola, R., Ambus, I., Velsher, L., Hsieh, E., Klarskov-Andersen, M., Raevaara, T. E., Gerdes, A-M., Mangold, E., Peltomäki, P., Lynch, H. T. & Nyström, M., 2006, In : International Journal of Oncology. 28, p. 149-153 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Multiple founder effects and geographical clustering of BRCA1 and BRCA2 families in Finland

Sarantaus, L., Huusko, P., Eerola, H., Launonen, V., Vehmanen, P., Rapakko, K., Gillanders, E., Syrjakoski, K., Kainu, T., Vahteristo, P., Krahe, R., Paakkonen, K., Hartikainen, J., Blomqvist, C., Lopponen, T., Holli, K., Ryynänen, M., Butzow, R., Borg, A., Arver, B. W. & 6 others, Holmberg, E., Mannermaa, A., Kere, J., Kallioniemi, O. P., Winqvist, R. & Nevanlinna, H., 2000, In : European Journal of Human Genetics. 2000, 8, p. 757-763 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon

Dermadi, D., Valo, S., Ollila, S., Soliymani, R., Sipari, N., Pussila, M., Sarantaus, L., Linden, J., Baumann, M. & Nystrom, M., 15 Jun 2017, In : Cancer Research. 77, 12, p. 3352-3363 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Activities 1998 2011

  • 11 Organisation and participation in conferences, workshops, courses, seminars
  • 1 Member of doctoral thesis committee / follow-up group
  • 1 Supervisor or co-supervisor of doctoral thesis
  • 1 Academic visit to other institution

PhD thesis supervision

Laura Sarantaus (Co-supervisor)
1 Jan 2010 → …

Activity: Examination typesSupervisor or co-supervisor of doctoral thesis

PhD thesis advisory committee membership

Laura Sarantaus (Member of thesis committee / follow-up group)
16 Nov 2010 → …

Activity: Examination typesMember of doctoral thesis committee / follow-up group

Extended Studies in Education for Subject Teachers, Adult Education (60 ECTS)

Laura Sarantaus (Attendee)
1 Aug 200717 Sep 2009

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Microarray Data Analysis with Chipster

Laura Sarantaus (Attendee)
12 Jan 201114 Jan 2011

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Laboratory Animal Necropsy Course

Laura Sarantaus (Attendee)
24 Feb 2011

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars