Photo of Lauri Aaltonen
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

  • Finland

  • PL 63 (Haartmaninkatu 8), B514b2

    HELSINGIN YLIOPISTO

    Finland

1992 …2018
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Personal profile

Description of research and teaching

Tumor Genomics research group (Kasvaingenomiikan tutkimusryhmä)

Tumor Genomics research group (Kasvaingenomiikan tutkimusryhmä) works in close contact with clinical researchers to unravel molecular background of human tumor susceptibility, utilizing tools provided by the Human Genome Project and other recent advances in biosciences. The aim is to create information on human tumorigenesis and to facilitate cancer prevention, diagnosis, and treatment.

Research

The research of the group focuses on human tumor susceptibility. Particular focus of interest has been hereditary colorectal cancer, where the group has contributed to several key discoveries; see the link for selected publications. Molecular background events in microsatellite unstable colorectal cancer is one of our long term interests.

More recently, we have identified and characterized a novel cancer predisposition syndrome, hereditary leiomyomatosis and renal cell cancer (HLRCC), and with our collaborators identified the gene behind the condition as fumarase (see publications). The most recent gene discovery is identification of germline mutations in the AIP gene in pituitary adenoma predisposition, published in Science 2006.

The future focus is in utilizing registry-based approaches to identify unique cancer family materials, for chip-based analysis and disease gene identification. Finland provides excellent resources for this work, and an effort to systematically utilize the National Cancer Registry (operating since 1953) and Population Registry databases in cancer gene identification is being launched.

This group is also one of six groups forming the Academy of Finland 's Center of Excellence in Translational Genome-Scale Biology, as well as a member of the Nordic Network of Excellence in Disease Genetics 2004-2009. MD PhD Maija Kiuru from the Aaltonen group received the University of Helsinki Thesis Prize 2004. The group was short-listed for the 2005 Descartes Prize.

The group was also honoured with the University of Helsinki Occupational Safety and Health Award 2005 (Yliopiston työsuojelupalkinto 2005). This prize is awarded yearly by the Labour Protection Committee of the University of Helsinki for improving quality, safety, and atmosphere of the working environment.

Keywords

  • 3111 Biomedicine

International and National Collaboration Publications and projects within past five years.

Selected Publications 1992 2018

Clues to the pathogenesis of familial colorectal cancer

AALTONEN, L. A., Peltomäki, P., LEACH, F. S., SISTONEN, P., PYLKKANEN, L., MECKLIN, J. P., Järvinen, H., POWELL, S. M., JEN, J., HAMILTON, S. R., PETERSEN, G. M., KINZLER, K. W., VOGELSTEIN, B. & de la Chapelle, A., 1993, In : Science. 260, p. 812-816 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

Hemminki, A., Peltomäki, P., MECKLIN, J. P., Järvinen, H., Salovaara, R., Nyström-Lahti, M., de la Chapelle, A. & Aaltonen, L. A., 1994, In : Nature Genetics. 8, p. 405-410 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic microsatellite mutations as molecular tumor clocks

Shibata, D., Navidi, W., Salovaara, R., Li, Z. H. & Aaltonen, L. A., 1996, In : Nature Medicine. 2, p. 676-681 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

Hemminki, A., Tomlinson, I., Markie, D., Jarvinen, H., Sistonen, P., Bjorkqvist, A. M., Knuutila, S., Salovaara, R., Bodmer, W., Shibata, D., delaChapelle, A. & Aaltonen, L. A., 1997, In : Nature Genetics. 15, p. 87-90 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease

Aaltonen, L. A., Salovaara, R., Kristo, P., Canzian, F., Hemminki, A., Peltomäki, P., Chadwick, R. B., Kääriäinen, H., Eskelinen, M., Jarvinen, H., Mecklin, J. P., de la Chapelle, A., Percesepe, A., Ahtola, H., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J. & ValKamo, E., 1998, In : New England Journal of Medicine. 338, 21, p. 1481-1487 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Jarvinen, H. J., Sistonen, P., Tomlinson, I. P. M., Houlston, R. S., Bevan, S., Mitros, F. A., Stone, E. M. & Aaltonen, L. A., 1998, In : Informing Science. 280, p. 1086-1088 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

Tomlinson, I. P. M., Alam, N. A., Rowan, A. J., Barclay, E., Jaeger, E. E. M., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R. R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R. S., Kiuru, M., Lehtonen, R., Karhu, A., Vilkki, S. & 12 othersLaiho, P., Eklund, C., Vierimaa, O., Aittomaki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V., Aaltonen, L. A. & Multiple Leiomyoma Consortium, 2002, In : Nature Genetics. 30, p. 406-410 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Pituitary adenoma predisposition caused by germline mutations in the AIP gene

Vierimaa, O., Georgitsi, M., Lehtonen, R., Vahteristo, P., Kokko, A., Raitila, A., Tuppurainen, K., Ebeling, T., Salmela, P. I., Paschke, R., Gundogdu, S., De Menis, E., Mäkinen, M. J., Launonen, V., Karhu, A. & Aaltonen, L. A., 2006, In : Science. 312, 5777, p. 1228-1230 3 p.

Research output: Contribution to journalArticleScientificpeer-review

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

Tuupanen, S., Turunen, M., Lehtonen, R., Hallikas, O., Vanharanta, S., Kivioja, T., Björklund, M., Wei, G., Yan, J., Niittymäki, I., Mecklin, J-P., Järvinen, H., Ristimäki, A., Di-Bernardo, M., East, P., Carvajal-Carmona, L., Houlston, R. S., Tomlinson, I., Palin, K., Ukkonen, E. & 3 othersKarhu, A., Taipale, J. & Aaltonen, L. A., 2009, In : Nature Genetics. 41, 8, p. 885-890 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Prizes

Academy Professor

Lauri Antti Aaltonen (Recipient), 2009

Prize: Prizes and awards

ERC Advanced Grant

Lauri Antti Aaltonen (Recipient), 2010

Prize: Prizes and awards

Matti Äyräpää Prize

Lauri Antti Aaltonen (Recipient), 2006

Prize: Prizes and awards

Nominee for Descartes Prize

Lauri Antti Aaltonen (Recipient), 2005

Prize: Prizes and awards

Professor of Tumor Genomics

Lauri Antti Aaltonen (Recipient), Aug 2007

Prize: Prizes and awards

Activities 1986 2015

Doctoral thesis supervision / Heinonen

Lauri Aaltonen (Supervisor)
2015 → …

Activity: Examination typesSupervisor or co-supervisor of doctoral thesis

Doctoral thesis supervision / Mäkinen

Lauri Aaltonen (Supervisor)
2015

Activity: Examination typesSupervisor or co-supervisor of doctoral thesis

Doctoral thesis supervision / Donner

Lauri Aaltonen (Supervisor)
2014 → …

Activity: Examination typesSupervisor or co-supervisor of doctoral thesis

Doctoral thesis supervision / Ristolainen

Lauri Aaltonen (Supervisor)
2013 → …

Activity: Examination typesSupervisor or co-supervisor of doctoral thesis

Doctoral thesis supervision / Cajuso

Lauri Aaltonen (Supervisor)
2012 → …

Activity: Examination typesSupervisor or co-supervisor of doctoral thesis

Press / Media

Interview in YleTeema

Lauri Antti Aaltonen

30/11/2005

1 media contribution

Press/Media: Press / Media

Participation in Radio Helsinki podcast

Lauri Antti Aaltonen

14/11/2005

1 media contribution

Press/Media: Press / Media

Interviews in newspaper / Helsingin Sanomat

Lauri Antti Aaltonen

06/01/2005

1 media contribution

Press/Media: Press / Media