Photo of Lauri Aaltonen

Lauri Aaltonen, Professor

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1992 …2020
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Publications 1992 2020

Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families

Nyström-Lahti, M., Sistonen, P., Mecklin, J. P., Pylkkänen, L., Aaltonen, L. A., Järvinen, H., Weissenbach, J., de la Chapelle, A. & Peltomäki, P., 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, p. 6054-6058 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Clues to the pathogenesis of familial colorectal cancer

AALTONEN, L. A., Peltomäki, P., LEACH, F. S., SISTONEN, P., PYLKKANEN, L., MECKLIN, J. P., Järvinen, H., POWELL, S. M., JEN, J., HAMILTON, S. R., PETERSEN, G. M., KINZLER, K. W., VOGELSTEIN, B. & de la Chapelle, A., 1993, In : Science. 260, p. 812-816 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Clusterin expression in normal mucosa and colorectal cancer

Andersen, C. L., Schepeler, T., Thornsen, K., Birkenkamp-Demtröder, K., Mansilla, F., Aaltonen, L. A., Laurberg, S. & Ørntoft, T. F., 2007, In : Molecular & Cellular Proteomics. 6, 6, p. 1039-1048 10 p.

Research output: Contribution to journalArticleScientificpeer-review

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

Tomlinson, I. P. M., Dunlop, M., Campbell, H., Zanke, B., Gallinger, S., Hudson, T., Koessler, T., Pharoah, P. D., Niittymäki, I., Tuupanen, S., Aaltonen, L. A., Hemminki, K., Lindblom, A., Forsti, A., Sieber, O., Lipton, L., van Wezel, T., Morreau, H., Wijnen, J. T., Devilee, P. & 31 others, Matsuda, K., Nakamura, Y., Castellvi-Bel, S., Ruiz-Ponte, C., Castells, A., Carracedo, A., Ho, J. W. C., Sham, P., Hofstra, R. M. W., Vodicka, P., Brenner, H., Hampe, J., Schafmayer, C., Tepel, J., Schreiber, S., Volzke, H., Lerch, M. M., Schmidt, C. A., Buch, S., Moreno, V., Villanueva, C. M., Peterlongo, P., Radice, P., Echeverry, M. M., Velez, A., Carvajal-Carmona, L., Scott, R., Penegar, S., Broderick, P., Tenesa, A. & Houlston, R. S., 2010, In : British Journal of Cancer. 102, 2, p. 447-454 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Dunlop, M. G., Dobbins, S. E., Farrington, S. M., Jones, A. M., Palles, C., Whiffin, N., Tenesa, A., Spain, S., Broderick, P., Ooi, L-Y., Domingo, E., Smillie, C., Henrion, M., Frampton, M., Martin, L., Grimes, G., Gorman, M., Semple, C., Ma, Y. P., Barclay, E. & 31 others, Prendergast, J., Cazier, J-B., Olver, B., Penegar, S., Lubbe, S., Chander, I., Carvajal-Carmona, L. G., Ballereau, S., Lloyd, A., Vijayakrishnan, J., Zgaga, L., Rudan, I., Theodoratou, E., Starr, J. M., Deary, I., Kirac, I., Kovacevic, D., Aaltonen, L. A., Renkonen-Sinisalo, L., Mecklin, J-P., Matsuda, K., Nakamura, Y., Okada, Y., Gallinger, S., Duggan, D. J., Conti, D., Newcomb, P., Hopper, J., Jenkins, M. A., Schumacher, F. & Swedish Low-Risk Colorectal Canc, Coin Collaborative Grp, Colorectal Tumour Gene Identificat, 2012, In : Nature Genetics. 44, 7, p. 770-U197 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer

Kondelin, J., Salokas, K., Saarinen, L., Ovaska, K., Rauanheimo, H., Plaketti, R-M., Hamberg, J., Liu, X., Yadav, L., Gylfe, A. E., Cajuso, T., Hänninen, U. A., Palin, K., Ristolainen, H., Katainen, R., Kaasinen, E., Tanskanen, T., Aavikko, M., Taipale, M., Taipale, J. & 17 others, Renkonen-Sinisalo, L., Lepistö, A., Koskensalo, S., Böhm, J., Mecklin, J-P., Ongen, H., Dermitzakis, E. T., Kilpivaara, O., Vahteristo, P., Turunen, M., Hautaniemi, S., Tuupanen, S., Karhu, A., Välimäki, N., Varjosalo, M., Pitkänen, E. & Aaltonen, L. A., 2018, In : EMBO molecular medicine. 10, 9, 20 p., e8552.

Research output: Contribution to journalArticleScientificpeer-review

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Comprehensive Evaluation of Protein Coding Mononucleotide Microsatellites in Microsatellite-Unstable Colorectal Cancer

Kondelin, J., Gylfe, A. E., Lundgren, S., Tanskanen, T., Hamberg, J., Aavikko, M., Palin, K., Ristolainen, H., Katainen, R., Kaasinen, E., Taipale, M., Taipale, J., Renkonen-Sinisalo, L., Jarvinen, H., Bohm, J., Mecklin, J-P., Vahteristo, P., Tuupanen, S., Aaltonen, L. A. & Pitkanen, E., 1 Aug 2017, In : Cancer Research. 77, 15, p. 4078-4088 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Computational identification of candidate loci for recessively inherited mutation using high-throughput SNP arrays: genetics and population analysis

Laakso, M., Tuupanen, S., Karhu, A., Lehtonen, R., Aaltonen, L. A. & Hautaniemi, S., 2007, In : Bioinformatics. 23, 15, p. 1952-1961 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Contribution of allelic imbalance to colorectal cancer

Palin, K., Pitkänen, E., Turunen, M., Sahu, B., Pihlajamaa, P., Kivioja, T., Kaasinen, E., Välimäki, N., Hänninen, U. A., Cajuso, T., Aavikko, M., Tuupanen, S., Kilpivaara, O., van den Berg, L., Kondelin, J., Tanskanen, T., Katainen, R., Grau, M., Rauanheimo, H., Plaketti, R-M. & 20 others, Taira, A., Sulo, P., Hartonen, T., Dave, K., Schmierer, B., Botla, S., Sokolova, M., Vähärautio, A., Gladysz, K., Ongen, H., Dermitzakis, E., Bramsen, J. B., Orntoft, T. F., Andersen, C. L., Ristimäki, A., Lepistö, A., Renkonen-Sinisalo, L., Mecklin, J-P., Taipale, J. & Aaltonen, L. A., 10 Sep 2018, In : Nature Communications. 9, 9 p., 3664.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer

Järvinen, H. J., Aarnio, M., Mustonen, H., Aktan-Collan, K., Aaltonen, L. A., Peltomäki, P., de la Chapelle, A. & Mecklin, J. P., 2000, In : Gastroenterology. 118, p. 829-834 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Conventional renal cancer in a patient with fumarate hydratase mutation

Lehtonen, H. J., Blanco, I., Piulats, J. M., Herva, R., Launonen, V. & Aaltonen, L. A., 2007, In : Human Pathology. 38, 5, p. 793-796 4 p.

Research output: Contribution to journalArticleScientificpeer-review

CTCF/cohesin-binding sites are frequently mutated in cancer

Katainen, R., Dave, K., Pitkänen, E., Palin, K., Kivioja, T., Valimaki, N., Gylfe, A. E., Ristolainen, H., Hanninen, U. A., Cajuso, T., Kondelin, J., Tanskanen, T., Mecklin, J-P., Järvinen, H., Renkonen-Sinisalo, L., Lepisto, A., Kaasinen, E., Kilpivaara, O., Tuupanen, S., Enge, M. & 2 others, Taipale, J. & Aaltonen, L. A., 1 Jul 2015, In : Nature Genetics. 47, 7, p. 818-+

Research output: Contribution to journalArticleScientificpeer-review

Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals

Dunlop, M. G., Tenesa, A., Farrington, S. M., Ballereau, S., Brewster, D. H., Koessler, T., Pharoah, P., Schafmayer, C., Hampe, J., Voelzke, H., Chang-Claude, J., Hoffmeister, M., Brenner, H., von Holst, S., Picelli, S., Lindblom, A., Jenkins, M. A., Hopper, J. L., Casey, G., Duggan, D. & 26 others, Newcomb, P. A., Abuli, A., Bessa, X., Ruiz-Ponte, C., Castellvi-Bel, S., Niittymaeki, I., Tuupanen, S., Karhu, A., Aaltonen, L., Zanke, B., Hudson, T., Gallinger, S., Barclay, E., Martin, L., Gorman, M., Carvajal-Carmona, L., Walther, A., Kerr, D., Lubbe, S., Broderick, P., Chandler, I., Pittman, A., Penegar, S., Campbell, H., Tomlinson, I. & Houlston, R. S., Jun 2013, In : Gut. 62, 6, p. 871-881 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region

Vanharanta, S., Wortham, N. C., Langford, C., El-Bahrawy, M., van der Spuy, Z., Sjöberg, J., Lehtonen, R., Karhu, A., Tomlinson, I. P. M. & Aaltonen, L. A., 2007, In : Genes, Chromosomes & Cancer. 46, 5, p. 451-458 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome

Mecklin, J-P., Aarnio, M., Läärä, E., Kairaluoma, M., Pylvänäinen, K., Peltomäki, P., Aaltonen, L. A. & Järvinen, H. J., 2007, In : Gastroenterology. 133, 4, p. 1093-1098 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Diagnostic Cancer Genome Sequencing and the Contribution of Germline Variants

Kilpivaara, O. & Aaltonen, L. A., 29 Mar 2013, In : Science. 339, 6127, p. 1559-1562 4 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups

Mansilla, F., Birkenkamp-Demtröder, K., Kruhøffer, M., Sørensen, F. B., Andersen, C. L., Laiho, P., Aaltonen, L. A., Verspaget, H. W. & Ørntoft, T. F., 2007, In : British Journal of Cancer. 96, 12, p. 1896-1903 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid

Birkenkamp-Demtröder, K., Olesen, S. H., Sørensen, F. B., Laurberg, S., Laiho, P., Aaltonen, L. A. & Ørntoft, T. F., 2005, In : Gut. 54, 3, p. 374-384 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing

Aktan-Collan, K., Haukkala, A., Pylvänäinen, K., Järvinen, H. J., Aaltonen, L. A., Peltomäki, P., Rantanen, E., Kääriäinen, H. & Mecklin, J-P., 2007, In : Journal of Medical Genetics. 44, 11, p. 732-738 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Distinct expression profile in fumarate-hydratase-deficient uterine fibroids

Vanharanta, S., Pollard, P. J., Lehtonen, H. J., Laiho, P., Sjöberg, J., Leminen, A., Aittomäki, K., Arola, J., Kruhøffer, M., Ørntoft, T. F., Tomlinson, I. P., Kiuru, M., Arango, D. & Aaltonen, L. A., 2006, In : Human Molecular Genetics. 15, 1, p. 97-103 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status

Oliveira, C., Westra, J. L., Arango, D., Ollikainen, M., Domingo, E., Ferreira, A., Velho, S., Niessen, R., Lagerstedt, K., Alhopuro, P., Laiho, P., Veiga, I., Teixeira, M. R., Ligtenberg, M., Kleibeuker, J. H., Sijmons, R. H., Plukker, J. T., Imai, K., Lage, P., Hamelin, R. & 8 others, Albuquerque, C., Schwartz, S., Lindblom, A., Peltomäki, P., Yamamoto, H., Aaltonen, L. A., Seruca, R. & Hofstra, R. M. W., 2004, In : Human Molecular Genetics. 13, p. 2303-2311 9 p.

Research output: Contribution to journalArticleScientificpeer-review

DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

Jorissen, R. N., Lipton, L., Gibbs, P., Chapman, M., Desai, J., Jones, I. T., Yeatman, T. J., East, P., Tomlinson, I. P. M., erspaget, H. W., Aaltonen, L. A., Kruhøffer, M., Ørntoft, T. F., Andersen, C. L. & Sieber, O. M., 2008, In : Clinical Cancer Research. 14, 24, p. 8061-8069 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Dna-tieto liian tulkinnanvaraista jokamiehen huvitukseksi

Translated title of the contribution: DNA data too ambiguous for layman interpretationsAaltonen, L. A., 3 Jan 2008, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas

Raimundo, N., Vanharanta, S., Aaltonen, L. A., Hovatta, I. & Suomalainen, A., 2009, In : Oncogene. 28, 9, p. 1261-1273 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Downregulation of the hedgehog receptor PTCH1 in colorectal serrated adenocarcinomas is not caused by PTCH1 mutations

Stefanius, K., Kantola, T., Tuomisto, A., Vahteristo, P., Karttunen, T. J., Aaltonen, L. A., Makinen, M. J. & Karhu, A., 2011, In : Virchows Archiv. 458, 2, p. 213-219 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer

Andersen, C. L., Christensen, L. L., Thorsen, K., Schepeler, T., Sorensen, F. B., Verspaget, H. W., Simon, R., Kruhoffer, M., Aaltonen, L. A., Laurberg, S. & Ørntoft, T. F., 2009, In : British Journal of Cancer. 100, 3, p. 511-523 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma

Vanharanta, S., Buchta, M., McWhinney, S. R., Virta, S. K., Peczkowska, M., Morrison, C. D., Lehtonen, R., Januszewicz, A., Jarvinen, H., Juhola, M., Mecklin, J. P., Pukkala, E., Herva, R., Kiuru, M., Nupponen, N. N., Aaltonen, L. A., Neumann, H. P. H. & Eng, C., 2004, In : American Journal of Human Genetics. 74, p. 153-159 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Eleven Candidate Susceptibility Genes for Common Familial Colorectal Cancer

Gylfe, A. E., Katainen, R., Kondelin, J., Tanskanen, T., Cajuso Pons, T., Hänninen, U., Taipale, J., Taipale, M., Renkonen-Sinisalo, L., Järvinen, H., Mecklin, J-P., Kilpivaara, O., Pitkänen, E., Vahteristo, P., Tuupanen, S., Karhu, A. & Aaltonen, L. A., 18 Oct 2013, In : PLoS Genetics. 9, 10, 8 p., e1003876.

Research output: Contribution to journalArticleScientificpeer-review

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EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis

Kokko, A., Laiho, P., Lehtonen, R., Korja, S., Carvajal-Carmona, L., Järvinen, H. J., Mecklin, J-P., Eng, C., Schleutker, J., Tomlinson, I. P. M., Vahteristo, P. & Aaltonen, L. A., 2006, In : BMC Cancer. 6, 145, 6 p.

Research output: Contribution to journalArticleScientificpeer-review

EPHB4 and survival of colorectal cancer patients

Davalos, V., Dopeso, H., Castano, J., Wilson, A. J., Vilardell, F., Romero-Gimenez, J., Espin, E., Armengol, M., Capella, G., Mariadason, J. M., Aaltonen, L. A., Schwartz, S. & Arango, D., 2006, In : Cancer Research. 66, 18, p. 8943-8948 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Epigenetic phenotypes distinguish microsatellite stable and unstable colorectal cancers

Kuismanen, S. A., Holmberg, M. T., Salovaara, R., Schweizer, P., Aaltonen, L. A., de la Chapelle, A., Nyström-Lahti, M. & Peltomäki, P., 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, p. 12661-12666 6 p.

Research output: Contribution to journalArticleScientificpeer-review

EVIDENCE THAT THE MCC-APC GENE REGION IN 5Q21 IS NOT THE SITE FOR SUSCEPTIBILITY TO HEREDITARY NONPOLYPOSIS COLORECTAL-CARCINOMA

PELTOMAKI, P., SISTONEN, P., MECKLIN, J. P., PYLKKANEN, L., AALTONEN, L., NORDLING, S., KERE, J., JARVINEN, H., HAMILTON, S. R., PETERSEN, G., KINZLER, K. W., VOGELSTEIN, B. & DELACHAPELLE, A., 1992, In : Cancer Research. 1992, 52, p. 4530-4533 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome

Marsh, D. J., Roth, S., Lunetta, K. L., Hemminki, A., Dahia, P. L. M., Sistonen, P., Zheng, Z. M., Caron, S., vanOrsouw, N. J., Bodmer, W. F., Cottrell, S. E., Dunlop, M. G., Eccles, D., Hodgson, S. V., Jarvinen, H., Kellokumpu, I., Markie, D., Neale, K., Phillips, R., Rozen, P. & 5 others, Syngal, S., Vijg, J., Tomlinson, I. P. M., Aaltonen, L. A. & Eng, C., 1997, In : Cancer Research. 57, p. 5017-5021 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers

Hanninen, U. A., Wirta, E-V., Katainen, R., Tanskanen, T., Hamberg, J., Taipale, M., Böhm, J., Renkonen-Sinisalo, L., Lepistö, A., Forsström, L. M., Pitkänen, E., Palin, K., Seppälä, T. T., Mäkinen, N., Mecklin, J-P. & Aaltonen, L. A., 30 Apr 2019, In : British Journal of Cancer. 120, 9, p. 922-930 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients

Tanskanen, T., Gylfe, A. E., Katainen, R., Taipale, M., Renkonen-Sinisalo, L., Mecklin, J-P., Järvinen, H., Tuupanen, S., Kilpivaara, O., Vahteristo, P. & Aaltonen, L. A., Jun 2013, In : Scandinavian Journal of Gastroenterology. 48, 6, p. 672-678 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma

Saarinen, S., Aavikko, M., Aittomaki, K., Launonen, V., Lehtonen, R., Franssila, K., Lehtonen, H. J., Kaasinen, E., Broderick, P., Tarkkanen, J., Bain, B. J., Bauduer, F., Unal, A., Swerdlow, A. J., Cooke, R., Makinen, M. J., Houlston, R., Vahteristo, P. & Aaltonen, L. A., 2011, In : Blood. 118, 3, p. 493-498 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer

Donner, I., Kiviluoto, T., Ristimaki, A., Aaltonen, L. A. & Vahteristo, P., Jun 2015, In : Familial Cancer. 14, 2, p. 241-246 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Exome-wide somatic mutation characterization of small bowel adenocarcinoma

Hänninen, U. A., Katainen, R., Tanskanen, T., Plaketti, R-M., Laine, R., Hamberg, J., Ristimäki, A., Pukkala, E., Taipale, M., Mecklin, J-P., Forsström, L. M., Pitkänen, E., Palin, K., Välimäki, N., Mäkinen, N. & Aaltonen, L. A., Mar 2018, In : PLoS Genetics. 14, 3, 23 p., 1007200.

Research output: Contribution to journalArticleScientificpeer-review

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Exomic landscape of MED12 mutation-negative and -positive uterine leiomyomas

Mäkinen, N., Vahteristo, P., Butzow, R., Sjoberg, J. & Aaltonen, L. A., 1 Feb 2014, In : International Journal of Cancer. 134, 4, p. 1008-1012 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors

Aaltonen, L. A., Johns, L., Järvinen, H. J., Mecklin, J-P. & Houlston, R. S., 2007, In : Clinical Cancer Research. 13, 1, p. 356-361 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Ashrafian, H., O'Flaherty, L., Adam, J., Steeples, V., Chung, Y-L., East, P., Vanharanta, S., Lehtonen, H., Nye, E., Hatipoglu, E., Miranda, M., Howarth, K., Shukla, D., Troy, H., Griffiths, J., Spencer-Dene, B., Yusuf, M., Volpi, E., Maxwell, P. H., Stamp, G. & 11 others, Poulsom, R., Pugh, C. W., Costa, B., Bardella, C., Di Renzo, M. F., Kotlikoff, M. I., Launonen, V., Aaltonen, L., El-Bahrawy, M., Tomlinson, I. & Pollard, P. J., 2010, In : Cancer Research. 70, 22, p. 9153-9165 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Extensive somatic microsatellite mutations in normal human tissue

Vilkki, S., Tsao, JL., Loukola, A., Poyhonen, P., Vierimaa, O., Herva, R., Aaltonen, LA. & Shibata, D., 1 Jun 2001, In : Cancer Research. 61, 11, p. 4541-4544 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Familial Isolated Pituitary Adenomas (FIPA) and the Pituitary Adenoma Predisposition due to Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene

Beckers, A., Aaltonen, L. A., Daly, A. F. & Karhu, A., Apr 2013, In : Endocrine Reviews. 34, 2, p. 239-277 39 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Few FH mutations in sporadic counterparts of tumor types observed in hereditary Leiomyomatosis and renal cell cancer families

Kiuru, M., Lehtonen, R., Arola, J., Salovaara, R., Jarvinen, H., Aittomaki, K., Sjoberg, J., Visakorpi, T., Knuutila, S., Isola, J., Delahunt, B., Herva, R., Launonen, V., Karhu, A. & Aaltonen, L. A., 2002, In : Clinical Cancer Research. 62, p. 4554-4557 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Founding mutations and Alu-mediated recombination in hereditary colon cancer

Nyström-Lahti, M., KRISTO, P., NICOLAIDES, N. C., CHANG, S. Y., Aaltonen, L. A., MOISIO, A. L., Järvinen, H. J., MECKLIN, J. P., KINZLER, K. W., VOGELSTEIN, B., de la Chapelle, A. & Peltomäki, P., 1995, In : Nature Medicine. 1, 11, p. 1203-1206 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Frequent L1 retrotranspositions originating from TTC28 in colorectal cancer

Pitkanen, E., Cajuso Pons, T., Katainen, R., Kaasinen, E., Valimaki, N., Palin, K., Taipale, J., Aaltonen, L. A. & Kilpivaara, O., 2014, In : Oncotarget. 5, 3, p. 853-859 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Frequent loss of SMAD4/DPC4 protein in colorectal cancers

Salovaara, R., Roth, S., Loukola, A., Launonen, T., Sistonen, P., Avizienyte, E., Kristo, P., Jarvinen, H., Souchelnytskyi, S., Sarlomo-Rikala, M. & Aaltonen, LA., Jul 2002, In : Gut. 51, 1, p. 56-59 4 p.

Research output: Contribution to journalArticleScientificpeer-review