Photo of Lauri Aaltonen

Lauri Aaltonen, Professor

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1992 …2020
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Publications 1992 2020

Stress-induced expression of a novel variant of human fumarate hydratase (FH)

Lehtonen, H. J., Ylisaukko-oja, S. K., Kiuru, M., Karhu, A., Lehtonen, R., Vanharanta, S., Jalanko, A., Aaltonen, L. A. & Launonen, V., 2007, In : Gene Expression. 14, p. 59-69 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Strong family history of uterine leiomyomatosis warrants fumarate hydratase mutation screening

Tolvanen, J., Uimari, O., Ryynanen, M., Aaltonen, L. A. & Vahteristo, P., 2012, In : Human Reproduction. 27, 6, p. 1865-1869 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Susceptibility to pituitary neoplasia related to MEN-1, CDKN1B and AIP mutations: an update

Karhu, A. & Aaltonen, L. A., 2007, In : Human Molecular Genetics. 16, Rev.is, p. 1, s. R73-R79

Research output: Contribution to journalReview ArticleScientificpeer-review

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci

Niittymäki, I., Tuupanen, S., Li, Y., Järvinen, H., Mecklin, J-P., Tomlinson, I. P. M., Houlston, R. S., Karhu, A. & Aaltonen, L. A., 2011, In : BMC Medical Genetics. 12, 6 p., 23.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Systematic search for rare variants in Finnish early-onset colorectal cancer patients

Tanskanen, T., Gylfe, A. E., Katainen, R., Taipale, M., Renkonen-Sinisalo, L., Järvinen, H., Mecklin, J-P., Bohm, J., Kilpivaara, O., Pitkanen, E., Palin, K., Vahteristo, P., Tuupanen, S. & Aaltonen, L. A., 2015, In : Cancer Genetics. 208, 1-2, p. 35-U100 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members

Järvinen, H. J., Renkonen-Sinisalo, L., Aktan-Collan, K., Peltomäki, P., Aaltonen, L. A. & Mecklin, J-P., 2009, In : Journal of Clinical Oncology. 27, 28, p. 4793-4797 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population

Rasinpera, H., Forsblom, C., Enattah, N. S., Halonen, P., Salo, K., Victorzon, M., Mecklin, J. P., Jarvinen, H., Enholm, S., Sellick, G., Alazzouzi, H., Houlston, R., Robinson, J., Groop, P. H., Tomlinson, I., Schwartz, S., Aaltonen, L. A., Jarvela, I. & FinnDiane Study Grp, 2005, In : Gut. 54, p. 643-647 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

Tuupanen, S., Turunen, M., Lehtonen, R., Hallikas, O., Vanharanta, S., Kivioja, T., Björklund, M., Wei, G., Yan, J., Niittymäki, I., Mecklin, J-P., Järvinen, H., Ristimäki, A., Di-Bernardo, M., East, P., Carvajal-Carmona, L., Houlston, R. S., Tomlinson, I., Palin, K., Ukkonen, E. & 3 others, Karhu, A., Taipale, J. & Aaltonen, L. A., 2009, In : Nature Genetics. 41, 8, p. 885-890 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

Riccio, A., Aaltonen, LA., Godwin, AK., Loukola, A., Percesepe, A., Salovaara, R., Masciullo, T., Genuardi, M., Paravatou-Petsotas, M., Bassi, DE., Ruggeri, BA., Klein-Szanto, AJP., Testa, T., Neri, G. & Bellacosa, A., Nov 1999, In : Nature Genetics. 23, 3, p. 266-268 3 p.

Research output: Contribution to journalArticleScientificpeer-review

The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas

Heliövaara, E., Raitila, A., Launonen, V., Paetau, A., Arola, J., Lehtonen, H., Sane, T., Weil, R. J., Vierimaa, O., Salmela, P., Tuppurainen, K., Mäkinen, M., Aaltonen, L. A. & Karhu, A., 2009, In : The American Journal of Pathology. 175, 6, p. 2501-2507 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The I1307K polymorphism of the APC gene in colorectal cancer

Prior, TW., Chadwick, RB., Papp, AC., Arcot, AN., Isa, AM., Pearl, DK., Stemmermann, G., Percesepe, A., Loukola, A., Aaltonen, LA. & de la Chapelle, A., Jan 1999, In : Gastroenterology. 116, 1, p. 58-63 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck

Alhopuro, P., Ylisaukko-oja, S., Koskinen, W., Bono, P., Arola, J., Järvinen, H. J., Mecklin, J-P., Atula, T., Kontio, R., Mäkitie, A., Suominen, S., Leivo, I., Vahteristo, P., Aaltonen, L-M., Aaltonen, L. A. & Suominen, S., 2005, In : Journal of Medical Genetics. 42, 9, p. 694-698 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian Cancer in Caucasians

Knappskog, S., Bjornslett, M., Myklebust, L. M., Huijts, P. E. A., Vreeswijk, M. P., Edvardsen, H., Guo, Y., Zhang, X., Yang, M., Ylisaukko-oja, S. K., Alhopuro, P., Arola, J., Tollenaar, R. A. E. M., van Asperen, C. J., Seynaeve, C., Staalesen, V., Chrisanthar, R., Lokkevik, E., Salvesen, H. B., Evans, D. G. & 13 others, Newman, W. G., Lin, D., Aaltonen, L. A., Borresen-Dale, A-L., Tell, G. S., Stoltenberg, C., Romundstad, P., Hveem, K., Lillehaug, J. R., Vatten, L., Devilee, P., Dorum, A. & Lonning, P. E., 2011, In : Cancer Cell. 19, 2, p. 273-282 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI plus sporadic colorectal cancers

Wheeler, JMD., Loukola, A., Aaltonen, LA., Mortensen, NJM. & Bodmer, WF., Aug 2000, In : Journal of Medical Genetics. 37, 8, p. 588-592 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype

Petrova, T., Nykänen, A., Norrmen, C., Ivanov, K. I., Andersson, L. C., Haglund, C., Puolakkainen, P., Wempe, F., von Melchner, H., Gradwohl, G., Vanharanta, S., Aaltonen, L. A., Saharinen, J. M. N., Gentile, M., Clarke, A., Taipale, J., Oliver, G. & Alitalo, K., 2008, In : Cancer Cell. 13, 5, p. 407-419 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Trilateral Retinoblastoma in a Patient With Peutz-Jeghers Syndrome

Raizis, A. M., Van Mater, D., Aaltonen, L. A., Lohmann, D., Cheale, M. S., Bickley, V. M., George, P. M., Zhou, Y. & Rosoff, P. M., May 2013, In : American Journal of Medical Genetics. Part A. 161A, 5, p. 1096-1100 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells

Alazzouzi, H., Suriano, G., Guerra, A., Plaja, A., Espin, E., Armengol, M., Alhopuro, P., Velho, S., Shinomura, Y., Gonzales-Aguilera, J. J., Yamamoto, H., Aaltonen, L. A., Moreno, V., Capella, G., Peinado, M. A., Seruca, R., Arango, D. & Schwartz, S., 2007, In : Journal of Medical Genetics. 44, 1, p. 75-80 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Unregulated smooth-muscle myosin in human intestinal neoplasia

Alhopuro, P., Phichith, D., Tuupanen, S., Sammalkorpi, H., Nybondas, M., Saharinen, J., Robinson, J. P., Yang, Z., Chen, L-Q., Ørntoft, T. F., Mecklin, J-P., Järvinen, H., Eng, C., Moeslein, G., Shibata, D., Houlston, R. S., Lucassen, A., Tomlinson, I. P. M., Launonen, V., Ristimäki, A. & 4 others, Arango, D., Karhu, A., Sweeney, H. L. & Aaltonen, L. A., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5513-5518 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity

Turunen, M., Spaeth, J. M., Keskitalo, S., Park, M. J., Kivioja, T., Clark, A. D., Mäkinen, N., Gao, F., Palin, K., Nurkkala, H., Vaharautio, A., Aavikko, M., Kampjarvi, K., Vahteristo, P., Kim, C. A., Aaltonen, L. A., Varjosalo, M., Taipale, J. & Boyer, T. G., May 2014, In : Cell Reports. 7, 3, p. 654-660 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Variants in the Netrin-1 Receptor UNC5C Prevent Apoptosis and Increase Risk of Familial Colorectal Cancer

Coissieux, M-M., Tomsic, J., Castets, M., Hampel, H., Tuupanen, S., Andrieu, N., Comeras, I., Drouet, Y., Lasset, C., Liyanarachchi, S., Mazelin, L., Puisieux, A., Saurin, J-C., Scoazec, J-Y., Wang, Q., Aaltonen, L., Tanner, S. M., de la Chapelle, A., Bernet, A. & Mehlen, P., 2011, In : Gastroenterology. 141, 6, p. 2039-2046 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

Orlando, G., Law, P. J., Palin, K., Tuupanen, S., Gylfe, A., Hanninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Kaprio, J., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Ripatti, S., Palotie, A. & 37 others, Järvinen, H., Renkonen-Sinisalo, L., Lepisto, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Tenesa, A., Farrington, S., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Buchanan, D. D., Win, A. K., Hopper, J., Jenkins, M., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Taipale, J., Cheadle, J. P., Dunlop, M. G., Tomlinson, I. P., Aaltonen, L. A. & Houlston, R. S., 1 Jun 2016, In : Human Molecular Genetics. 25, 11, p. 2349-2359 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Villin Expression Is Frequently Lost in Poorly Differentiated Colon Cancer

Arango, D., Al-Obaidi, S., Williams, D. S., Dopeso, H., Mazzolini, R., Corner, G., Byun, D-S., Carr, A. A., Murone, C., Toegel, L., Zeps, N., Aaltonen, L. A., Iacopetta, B. & Mariadason, J. M., 2012, In : The American Journal of Pathology. 180, 4, p. 1509-1521 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Whole-exome sequencing identifies novel candidate predisposition genes for familial polycythemia vera

Hirvonen, E. A. M., Pitkanen, E., Hemminki, K., Aaltonen, L. A. & Kilpivaara, O., 20 Apr 2017, In : Human Genomics. 11, 6 p., 6.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Whole-Genome Sequencing Identifies STAT4 as a Putative Susceptibility Gene in Classic Kaposi Sarcoma

Aavikko, M., Kaasinen, E., Nieminen, J. K., Byun, M., Donner, I., Mancuso, R., Ferrante, P., Clerici, M., Brambilla, L., Tourlaki, A., Sarid, R., Guttman-Yassky, E., Taipale, M., Morgunova, E., Pekkonen, P., Ojala, P. M., Pukkala, E., Casanova, J-L., Vaarala, O., Vahteristo, P. & 1 others, Aaltonen, L. A., 1 Jun 2015, In : Journal of Infectious Diseases. 211, 11, p. 1842-1851 10 p.

Research output: Contribution to journalArticleScientificpeer-review