Photo of Lauri Aaltonen

Lauri Aaltonen, Professor

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1992 …2020
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Publications 1992 2020

Article

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

Jarvis, D., Mitchell, J. S., Law, P. J., Palin, K., Tuupanen, S., Gylfe, A., Hanninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Kaprio, J., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Ripatti, S. & 37 others, Palotie, A., Järvinen, H., Renkonen-Sinisalo, L., Lepistö, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Taipale, J., Aaltonen, L. A., Cheadle, J. P., Dunlop, M. G., Tomlinson, I. P. & Houlston, R. S., 12 Jul 2016, In : British Journal of Cancer. 115, 2, p. 266-272 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

Rodriguez-Broadbent, H., Law, P. J., Sud, A., Palin, K., Tuupanen, S., Gylfe, A., Hanninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Ripatti, S., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Palotie, A. & 36 others, Renkonen-Sinisalo, L., Lepisto, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Passarelli, M. N., Figueiredo, J. C., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Aaltonen, L. A., Cheadle, J. P., Tomlinson, I. P., Dunlop, M. G. & Houlston, R. S., 15 Jun 2017, In : International Journal of Cancer. 140, 12, p. 2701-2708 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

Houlston, R. S., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A. & CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium, 2008, In : Nature Genetics. 40, 12, p. 1426-1435 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

Houlston, R. S., Cheadle, J., Dobbins, S. E., Tenesa, A., Jones, A. M., Howarth, K., Spain, S. L., Broderick, P., Domingo, E., Farrington, S., Prendergast, J. G. D., Pittman, A. M., Theodoratou, E., Smith, C. G., Olver, B., Walther, A., Barnetson, R. A., Churchman, M., Jaeger, E. E. M., Penegar, S. & 26 others, Barclay, E., Martin, L., Gorman, M., Mager, R., Johnstone, E., Midgley, R., Niittymäki, I., Tuupanen, S., Colley, J., Idziaszczyk, S., Thomas, H. J. W., Lucassen, A. M., Evans, D. G. R., Maher, E. R., Maughan, T., Dimas, A., Dermitzakis, E., Cazier, J-B., Aaltonen, L. A., Pharoah, P., Kerr, D. J., Carvajal-Carmona, L. G., Campbell, H., Dunlop, M. G., Tomlinson, I. P. M. & CORGI Consortium, COGENT Consortium, COINB Collaborative Grp, COIN Collaborative Grp, 2010, In : Nature Genetics. 42, 11, p. 973-U89 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

Jorissen, R. N., Gibbs, P., Christie, M., Prakash, S., Lipton, L., Desai, J., Kerr, D., Aaltonen, L. A., Arango, D., Kruhoffer, M., Orntoft, T. F., Andersen, C. L., Gruidl, M., Kamath, V. P., Eschrich, S., Yeatman, T. J. & Sieber, O. M., 2009, In : Clinical Cancer Research. 15, p. 7642-7651 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors

Sur, I. K., Hallikas, O., Vähärautio, A. V., Yan, J., Turunen, M., Enge, M., Taipale, M., Karhu, A., Aaltonen, L. A. & Taipale, J., 7 Dec 2012, In : Science. 338, 6112, p. 1360-1363 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mice with Inactivation of Aryl Hydrocarbon Receptor-Interacting Protein (Aip) Display Complete Penetrance of Pituitary Adenomas with Aberrant ARNT Expression

Raitila, A., Lehtonen, H. J., Arola, J., Heliovaara, E., Ahlsten, M., Georgitsi, M., Jalanko, A., Paetau, A., Aaltonen, L. A. & Karhu, A., 2010, In : The American Journal of Pathology. 177, 4, p. 1969-1976 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer

Loukola, A., Salovaara, R., Kristo, P., Moisio, AL., Kaariainen, H., Ahtola, H., Eskelinen, M., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J., Valkamo, E., Jarvinen, H., Mecklin, JP., de la Chapelle, A. & Aaltonen, LA., Dec 1999, In : The American Journal of Pathology. 155, 6, p. 1849-1853 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy

Hemminki, A., Mecklin, J. P., Jarvinen, H., Aaltonen, L. A. & Joensuu, H., 2000, In : Gastroenterology. 119, p. 921-928 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Microsatellite instability is associated with tumors that characterize the hereditary nonpolyposis colorectal carcinoma syndrome

Peltomäki, P., LOTHE, R. A., AALTONEN, L. A., PYLKKANEN, L., Nyström-Lahti, M., SERUCA, R., DAVID, L., HOLM, R., RYBERG, D., HAUGEN, A., BROGGER, A., BORRESEN, A. L. & de la Chapelle, A., 1993, In : Cancer Research. 53, p. 5853-5855 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC)

Loukola, A., Eklin, K., Laiho, P., Salovaara, R., Kristo, P., Jarvinen, H., Mecklin, JP., Launonen, T. & Aaltonen, LA., 1 Jun 2001, In : Cancer Research. 61, 11, p. 4545-4549 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Mismatch repair genes and mononucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instability

Percesepe, A., Kristo, P., Aaltonen, L. A., de Leon, M. P., de la Chapelle, A. & Peltomäki, P., 1998, In : Oncogene. 17, p. 157-163 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage

Nyström-Lahti, M., PARSONS, R., SISTONEN, P., Pylkkänen, L., Aaltonen, L. A., LEACH, F. S., HAMILTON, S. R., WATSON, P., BRONSON, E., CAVALIERI, J., LYNCH, J., LANSPA, S., SMYRK, T., LYNCH, P., DROUHARD, T., KINZLER, K. W., VOGELSTEIN, B., LYNCH, H. T., de la Chapelle, A. & Peltomäki, P., 1994, In : American Journal of Human Genetics. 55, p. 659-665 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours

Velho, S., Oliveira, C., Paredes, J., Sousa, S., Leite, M., Matos, P., Milanezi, F., Ribeiro, A. S., Mendes, N., Licastro, D., Karhu, A., Oliveira, M. J., Ligtenberg, M., Hamelin, R., Carneiro, F., Lindblom, A., Peltomaki, P., Castedo, S., Schwartz, S., Jordan, P. & 6 others, Aaltonen, L. A., Hofstra, R. M. W., Suriano, G., Stupka, E., Fialho, A. M. & Seruca, R., 2010, In : Human Molecular Genetics. 19, 4, p. 697-706 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Modeling tumor predisposing FH mutations in yeast: effects on fumarase activity, growth phenotype and gene expression profile

Kokko, A., Ylisaukko-oja, S., Kiuru, M., Takatalo, M., Salmikangas, P., Tuimala, J., Arango, D., Karhu, A., Aaltonen, L. A. & Jäntti, J., 2006, In : International Journal of Cancer. 118, 6, p. 1340-1345 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis

Cornish, A. J., Law, P. J., Timofeeva, M., Palin, K., Farrington, S. M., Palles, C., Jenkins, M. A., Casey, G., Brenner, H., Chang-Claude, J., Hoffmeister, M., Kirac, I., Maughan, T., Brezina, S., Gsur, A., Cheadle, J. P., Aaltonen, L. A., Tomlinson, I., Dunlop, M. G. & Houlston, R. S., Jan 2020, In : The Lancet gastroenterology & hepatology. 5, 1, p. 55-62 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis

Sweet, K., Willis, J., Zhou, X-P., Gallione, C., Sawada, T., Alhopuro, P., Khoo, S. K., Patocs, A., Martin, C., Bridgeman, S., Heinz, J., Pilarski, R., Lehtonen, R., Prior, T. W., Frebourg, T., Teh, B. T., Marchuk, D. A., Aaltonen, L. A. & Eng, C., 2005, In : JAMA : The Journal of the American Medical Association. 294, 19, p. 2465-2473 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations

Georgitsi, M., Raitila, A., Karhu, A., Tuppurainen, K., Mäkinen, M. J., Vierimaa, O., Paschke, R., Saeger, W., van der Luijt, R. B., Sane, T., Robledo, M., de Menis, E., Weil, R. J., Wasik, A., Zielinski, G., Lucewicz, O., Lubinski, J., Launonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, p. 4101-4105 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular staging for survival prediction of colorectal cancer patients

Eschrich, S., Yang, I., Bloom, G., Kwong, K. Y., Boulware, D., Cantor, A., Coppola, D., Kruhøffer, M., Ørntoft, T. F., Quackenbush, J., Yeatman, T. J. & Aaltonen, L. A., 2005, In : Journal of Clinical Oncology. 23, 15, p. 3526-3535 10 p.

Research output: Contribution to journalArticleScientificpeer-review

MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis

Wu, Y., Nyström-Lahti, M., Osinga, J., Looman, M. W. G., Peltomäki, P., Aaltonen, L. A., de la Chapelle, A., Hofstra, R. M. W. & Buys, C. H. C. M., 1997, In : Genes, Chromosomes & Cancer. 18, p. 269-278 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas

Heinonen, H-R., Pasanen, A., Heikinheimo, O., Tanskanen, T., Palin, K., Tolvanen, J., Vahteristo, P., Sjoberg, J., Pitkänen, E., Butzow, R., Makinen, N. & Aaltonen, L. A., 21 Apr 2017, In : Scientific Reports. 7, 7 p., 1015.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer

Tomlinson, I. P. M., Carvajal-Carmona, L. G., Dobbins, S. E., Tenesa, A., Jones, A. M., Howarth, K., Palles, C., Broderick, P., Jaeger, E. E. M., Farrington, S., Lewis, A., Prendergast, J. G. D., Pittman, A. M., Theodoratou, E., Olver, B., Walker, M., Penegar, S., Barclay, E., Whiffin, N., Martin, L. & 31 others, Ballereau, S., Lloyd, A., Gorman, M., Lubbe, S., Howie, B., Marchini, J., Ruiz-Ponte, C., Fernandez-Rozadilla, C., Castells, A., Carracedo, A., Castellvi-Bel, S., Duggan, D., Conti, D., Cazier, J-B., Campbell, H., Sieber, O., Lipton, L., Gibbs, P., Martin, N. G., Montgomery, G. W., Young, J., Baird, P. N., Gallinger, S., Newcomb, P., Hopper, J., Jenkins, M. A., Aaltonen, L. A., Kerr, D. J., Cheadle, J., Pharoah, P. & CORGI Collaborators, COGENT Consortium, EPICOLON Consortium, 2011, In : PLoS Genetics. 7, 6, p. e1002105 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multiple components of PKA and TGF-beta pathways are mutated in pseudomyxoma peritonei

Saarinen, L., Nummela, P., Thiel, A., Lehtonen, R., Järvinen, P., Järvinen, H., Aaltonen, L. A., Lepisto, A., Hautaniemi, S. & Ristimaki, A., 20 Apr 2017, In : PLoS One. 12, 4, 16 p., 0174898.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer

Fang, H., Barbour, J. A., Poulos, R. C., Katainen, R., Aaltonen, L. A. & Wong, J. W. H., 3 Feb 2020, In : PLoS Genetics. 16, 2, e1008572.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers

Georgitsi, M., Karhu, A., Winqvist, R., Visakorpi, T., Waltering, K., Vahteristo, P., Launonen, V. & Aaltonen, L. A., 2007, In : British Journal of Cancer. 96, 2, p. 352-356 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas

Mäkinen, N., Heinonen, H-R., Sjoberg, J., Taipale, J., Vahteristo, P. & Aaltonen, L. A., 29 Apr 2014, In : British Journal of Cancer. 110, 9, p. 2246-2249 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of MEN1, HRPT2, CASR, CDKN1B, and AIP genes in primary hyperparathyroidism patients with features of genetic predisposition

Vierimaa, O., Villablanca, A., Alimov, A., Georgitsi, M., Raitila, A., Vahteristo, P., Larsson, C., Ruokonen, A., Eloranta, E., Ebeling, T. M. L., Ignatius, J., Aaltonen, L. A., Leisti, J. & Salmela, P. I., 2009, In : Journal of Endocrinological Investigation. 32, 6, p. 512-518 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of MYH11 in acute myeloid leukemia

Sammalkorpi, H., Alhopuro, P., Niittymäki, I., Ørntoft, T. F., Hokland, P., Karhu, A. & Aaltonen, L. A., 2008, In : Leukemia & lymphoma. 49, 9, p. 1829-1831 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal cancer

Roth, S., Johansson, M., Loukola, A., Peltomäki, P., Järvinen, H., Mecklin, J. P. & Aaltonen, L. A., 2000, In : Journal of Medical Genetics. 37, 4, p. 298-300 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

Alhopuro, P., Katajisto, P., Lehtonen, R. J., Ylisaukko-oja, S., Näätäsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P. M., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, 6, p. 1126-1129 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRAD alpha, and MO25 alpha, in Peutz-Jeghers syndrome

Alhopuro, P., Katajisto, P., Lehtonen, R., Ylisaukko-oja, S. K., Näätsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, p. 1126-1129 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer

Ylikorkala, A., Avizienyte, E., Tomlinson, I. P. M., Tiainen, M., Roth, S., Loukola, A., Hemminki, A., Johansson, M., Sistonen, P., Markie, D., Neale, K., Phillips, R., Zauber, P., Twama, T., Sampson, J., Järvinen, H., Makela, T. P. & Aaltonen, L. A., 1999, In : Human Molecular Genetics. 8, p. 45-51 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer

Koski (Ahvenainen), T. A., Lehtonen, H. J., Lehtonen, R., Vahteristo, P., Aittomäki, K., Baynam, G., Dommering, C., Eng, C., Gruber, S. B., Grönberg, H., Harvima, R., Herva, R., Hietala, M., Kujala, M., Kääriäinen, H., Sunde, L., Vierimaa, O., Pollard, P. J., Tomlinson, I. P., Björck, E. & 2 others, Aaltonen, L. A. & Launonen, V., 2008, In : Cancer Genetics and Cytogenetics. 183, 2, p. 83-88 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations in BRIP1 confer high risk of ovarian cancer

Rafnar, T., Gudbjartsson, D. F., Sulem, P., Jonasdottir, A., Sigurdsson, A., Jonasdottir, A., Besenbacher, S., Lundin, P., Stacey, S. N., Gudmundsson, J., Magnusson, O. T., le Roux, L., Orlygsdottir, G., Helgadottir, H. T., Johannsdottir, H., Gylfason, A., Tryggvadottir, L., Jonasson, J. G., de Juan, A., Ortega, E. & 25 others, Ramon-Cajal, J. M., Garcia-Prats, M. D., Mayordomo, C., Panadero, A., Rivera, F., Aben, K. K. H., van Altena, A. M., Massuger, L. F. A. G., Aavikko, M., Kujala, P. M., Staff, S., Aaltonen, L. A., Olafsdottir, K., Bjornsson, J., Kong, A., Salvarsdottir, A., Saemundsson, H., Olafsson, K., Benediktsdottir, K. R., Gulcher, J., Masson, G., Kiemeney, L. A., Mayordomo, J. I., Thorsteinsdottir, U. & Stefansson, K., 2011, In : Nature Genetics. 43, 11, p. 1104-U91 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations in the Circadian Gene CLOCK in Colorectal Cancer

Alhopuro, P., Björklund, M., Sammalkorpi, H. P., Turunen, M., Tuupanen, S. J., Bistrom, M., Niittymäki, I., Lehtonen, H., Kivioja, T., Launonen, V., Saharinen, J. M. N., Nousiainen, K. J., Hautaniemi, S., Nuorva, K., Mecklin, J-P., Järvinen, H., Orntoft, T., Arango, D., Lehtonen, R. J., Karhu, A. I. & 2 others, Taipale, J. & Aaltonen, L. A., 2010, In : Molecular Cancer Research. 8, 7, p. 952-960 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Jarvinen, H. J., Sistonen, P., Tomlinson, I. P. M., Houlston, R. S., Bevan, S., Mitros, F. A., Stone, E. M. & Aaltonen, L. A., 1998, In : Informing Science. 280, p. 1086-1088 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers

Hienonen, T., Sammalkorpi, H., Enholm, S., Alhopuro, P., Barber, T. D., Lehtonen, R., Nupponen, N. N., Lehtonen, H., Salovaara, R., Mecklin, J-P., Järvinen, H. J., Koistinen, R., Arango, D., Launonen, V., Vogelstein, B., Karhu, A. & Aaltonen, L. A., 2005, In : Cancer Research. 65, 11, p. 4607-4613 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations of a MutS homolog in hereditary non-polyposis colorectal cancer

LEACH, F. S., NICOLAIDES, N. C., PAPADOPOULOS, N., LIU, B., JEN, J., PARSONS, R., Peltomäki, P., SISTONEN, P., Aaltonen, L. A., NYSTROMLAHTI, M., GUAN, X. Y., ZHANG, J., MELTZER, P. S., YU, J. W., KAO, F. T., CHEN, D. J., CEROSALETTI, K. M., FOURNIER, R. E. K., TODD, S., LEWIS, T. & 15 others, LEACH, R. J., NAYLOR, S. L., WEISSENBACH, J., MECKLIN, J. P., Järvinen, H., PETERSEN, G. M., HAMILTON, S. R., GREEN, J., JASS, J., WATSON, P., LYNCH, H. T., TRENT, J. M., de la Chapelle, A., KINZLER, K. W. & VOGELSTEIN, B., 1993, In : Cell. 75, p. 1215-1225 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Nationwide Registry-Based Analysis of Cancer Clustering Detects Strong Familial Occurrence of Kaposi Sarcoma

Kaasinen, E., Aavikko, M., Vahteristo, P., Patama, T., Li, Y., Saarinen, S., Kilpivaara, O., Pitkänen, E., Knekt, P., Laaksonen, M., Lehtonen, R., Artama, M., Aaltonen, L. A. & Pukkala, E., 24 Jan 2013, In : PLoS One. 8, 1, p. Article Number: e55209 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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New Target Genes in Endometrial Tumors Show a Role for the Estrogen-Receptor Pathway in Microsatellite-Unstable Cancers

Ferreira, A. M., Tuominen, I., Sousa, S., Gerbens, F., van Dijk-Bos, K., Osinga, J., Kooi, K. A., Sanjabi, B., Esendam, C., Oliveira, C., Terpstra, P., Hardonk, M., van der Sluis, T., Zazula, M., Stachura, J., van der Zee, A. G., Hollema, H., Sijmons, R. H., Aaltonen, L. A., Seruca, R. & 2 others, Hofstra, R. M. W. & Westers, H., Dec 2014, In : Human Mutation. 35, 12, p. 1514-1523 10 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome

Vahteristo, P., Koski, T. A., Naatsaari, L., Kiuru, M., Karhu, A., Herva, R., Sallinen, S-L., Vierimaa, O., Bjorck, E., Richard, S., Gardie, B., Bessis, D., Van Glabeke, E., Blanco, I., Houlston, R., Senter, L., Hietala, M., Aittomaki, K., Aaltonen, L. A., Launonen, V. & 1 others, Lehtonen, R., 2010, In : Familial Cancer. 9, p. 245-251 7 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence for association of NOD2 R702W and G908R with colorectal cancer

Tuupanen, S., Alhopuro, P., Mecklin, J-P., Järvinen, H. J. & Aaltonen, L. A., 2007, In : International Journal of Cancer. 121, 1, p. 76-79 4 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer

Tuupanen, S., Karhu, A., Järvinen, H. J., Mecklin, J-P., Launonen, V. & Aaltonen, L. A., 2007, In : Oncogene. 26, 17, p. 2513-2517 5 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence of microsatellite instability in bone tumors

Tarkkanen, M., Aaltonen, L. A., Böhling, T. O., Kivioja, A. H., Karaharju, E., Elomaa, A. I. & Knuutila, Y. S., 1996, In : British Journal of Cancer. 74, p. 453-455

Research output: Contribution to journalArticleScientificpeer-review

No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas

Launonen, T., Avizienyte, E., Loukola, A., Laiho, P., Salovaara, R., Jarvinen, H., Mecklin, JP., Oku, A., Shimane, M., Kim, HC., Kim, JC., Nezu, J. & Aaltonen, LA., 1 Feb 2000, In : Cancer Research. 60, 3, p. 546-548 3 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence of RET germline mutations in familial pituitary adenoma

Heliovaara, E., Tuupanen, S., Ahlsten, M., Hodgson, S., de Menis, E., Kuismin, O., Izatt, L., Gardner, R. J. M., Gundogdu, S., Lucassen, A., Arola, J., Tuomisto, A., Makinen, M., Karhu, A. & Aaltonen, L. A., 2011, In : Journal of Molecular Endocrinology. 46, 1, p. 1-8 8 p.

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No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia

Raitila, A., Georgitsi, M., Karhu, A., Tuppurainen, K., Mäkinen, M. J., Birkenkamp-Demtröder, K., Salmenkivi, K., Ørntoft, T. F., Arola, J., Launonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Endocrine - Related Cancer. 14, 3, p. 901-906 6 p.

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No germline FH mutations in familial breast cancer patients

Kiuru, M. H. T., Lehtonen, R., Eerola, H., Aittomäki, K., Blomqvist, C., Nevanlinna, H., Aaltonen, L. A. & Launonen, V., 2005, In : European Journal of Human Genetics. 13, 4, p. 506-509 4 p.

Research output: Contribution to journalArticleScientificpeer-review

No MSH6 germline mutations in breast cancer families with colorectal and/or endometrial cancer

Vahteristo, P., Ojala, S., Tamminen, A., Tommiska, J., Sammalkorpi, H., Kiuru-Kuhlefelt, S., Eerola, H., Aaltonen, L. A., Aittomäki, K. & Nevanlinna, H., 2005, In : Journal of Medical Genetics. 42, 4, p. e22 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies

Karppinen, S-M., Barkardottir, R. B., Backenhorn, K., Sydenham, T., Syrjäkoski, K., Schleutker, J., Ikonen, T., Pylkäs, K., Rapakko, K., Erkko, H., Johannesdottir, G., Gerdes, A-M., Thomassen, M., Agnarsson, B. A., Grip, M., Kallioniemi, A., Kere, J., Aaltonen, L. A., Arason, A., Møller, P. & 3 others, Kruse, T. A., Borg, Å. & Winqvist, R., 2006, In : Journal of Medical Genetics. 43, 11, p. 856-862 7 p.

Research output: Contribution to journalArticleScientificpeer-review