Photo of Lauri Aaltonen

Lauri Aaltonen, Professor

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1992 …2019
If you made any changes in Pure these will be visible here soon.

Publications 1992 2019

2010

A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants

Theodoratou, E., Campbell, H., Tenesa, A., Houlston, R., Webb, E., Lubbe, S., Broderick, P., Gallinger, S., Croitoru, E. M., Jenkins, M. A., Win, A. K., Cleary, S. P., Koessler, T., Pharoah, P. D., Kuery, S., Bezieau, S., Buecher, B., Ellis, N. A., Peterlongo, P., Offit, K. & 12 others, Aaltonen, L. A., Enholm, S., Lindblom, A., Zhou, X-L., Tomlinson, I. P., Moreno, V., Blanco, I., Capella, G., Barnetson, R., Porteous, M. E., Dunlop, M. G. & Farrington, S. M., 2010, In : British Journal of Cancer. 103, 12, p. 1875-1884 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Allelic Variation at the 8q23.3 Colorectal Cancer Risk Locus Functions as a Cis-Acting Regulator of EIF3H

Pittman, A. M., Naranjo, S., Jalava, S. E., Twiss, P., Ma, Y., Olver, B., Lloyd, A., Vijayakrishnan, J., Qureshi, M., Broderick, P., van Wezel, T., Morreau, H., Tuupanen, S., Aaltonen, L. A., Eva Alonso, M., Manzanares, M., Gavilan, A., Visakorpi, T., Luis Gomez-Skarmeta, J. & Houlston, R. S., 2010, In : PLoS Genetics. 6, 9 , p. e1001126 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Clinical Characteristics and Therapeutic Responses in Patients with Germ-Line AIP Mutations and Pituitary Adenomas: An International Collaborative Study

Daly, A. F., Tichomirowa, M. A., Petrossians, P., Heliövaara, E., Jaffrain-Rea, M-L., Barlier, A., Naves, L. A., Ebeling, T., Karhu, A., Raappana, A., Cazabat, L., De Menis, E., Fajardo Montanana, C., Raverot, G., Weil, R. J., Sane, T., Maiter, D., Neggers, S., Yaneva, M., Tabarin, A. & 43 others, Verrua, E., Eloranta, E., Murat, A., Vierimaa, O., Salmela, P. I., Emy, P., Toledo, R. A., Isabel Sabate, M., Villa, C., Popelier, M., Salvatori, R., Jennings, J., Ferrandez Longas, A., Labarta Aizpun, J. I., Georgitsi, M., Paschke, R., Ronchi, C., Välimäki, M., Saloranta, C., De Herder, W., Cozzi, R., Guitelman, M., Magri, F., Lagonigro, M. S., Halaby, G., Corman, V., Hagelstein, M-T., Vanbellinghen, J-F., Barra, G. B., Gimenez-Roqueplo, A-P., Cameron, F. J., Borson-Chazot, F., Holdaway, I., Toledo, S. P. A., Stalla, G. K., Spada, A., Zacharieva, S., Bertherat, J., Brue, T., Bours, V., Chanson, P., Aaltonen, L. A. & Beckers, A., 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 11, p. E373-E383 11 p.

Research output: Contribution to journalArticleScientificpeer-review

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

Tomlinson, I. P. M., Dunlop, M., Campbell, H., Zanke, B., Gallinger, S., Hudson, T., Koessler, T., Pharoah, P. D., Niittymäki, I., Tuupanen, S., Aaltonen, L. A., Hemminki, K., Lindblom, A., Forsti, A., Sieber, O., Lipton, L., van Wezel, T., Morreau, H., Wijnen, J. T., Devilee, P. & 31 others, Matsuda, K., Nakamura, Y., Castellvi-Bel, S., Ruiz-Ponte, C., Castells, A., Carracedo, A., Ho, J. W. C., Sham, P., Hofstra, R. M. W., Vodicka, P., Brenner, H., Hampe, J., Schafmayer, C., Tepel, J., Schreiber, S., Volzke, H., Lerch, M. M., Schmidt, C. A., Buch, S., Moreno, V., Villanueva, C. M., Peterlongo, P., Radice, P., Echeverry, M. M., Velez, A., Carvajal-Carmona, L., Scott, R., Penegar, S., Broderick, P., Tenesa, A. & Houlston, R. S., 2010, In : British Journal of Cancer. 102, 2, p. 447-454 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Ashrafian, H., O'Flaherty, L., Adam, J., Steeples, V., Chung, Y-L., East, P., Vanharanta, S., Lehtonen, H., Nye, E., Hatipoglu, E., Miranda, M., Howarth, K., Shukla, D., Troy, H., Griffiths, J., Spencer-Dene, B., Yusuf, M., Volpi, E., Maxwell, P. H., Stamp, G. & 11 others, Poulsom, R., Pugh, C. W., Costa, B., Bardella, C., Di Renzo, M. F., Kotlikoff, M. I., Launonen, V., Aaltonen, L., El-Bahrawy, M., Tomlinson, I. & Pollard, P. J., 2010, In : Cancer Research. 70, 22, p. 9153-9165 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Low-Penetrance Susceptibility Variants in Familial Colorectal Cancer

Niittymaki, I., Kaasinen, E., Tuupanen, S., Karhu, A., Jarvinen, H., Mecklin, J-P., Tomlinson, I. P. M., Di Bernardo, M. C., Houlston, R. S. & Aaltonen, L. A., 2010, In : Cancer Epidemiology, Biomarkers & Prevention. 19, 6, p. 1478-1483 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

Houlston, R. S., Cheadle, J., Dobbins, S. E., Tenesa, A., Jones, A. M., Howarth, K., Spain, S. L., Broderick, P., Domingo, E., Farrington, S., Prendergast, J. G. D., Pittman, A. M., Theodoratou, E., Smith, C. G., Olver, B., Walther, A., Barnetson, R. A., Churchman, M., Jaeger, E. E. M., Penegar, S. & 26 others, Barclay, E., Martin, L., Gorman, M., Mager, R., Johnstone, E., Midgley, R., Niittymäki, I., Tuupanen, S., Colley, J., Idziaszczyk, S., Thomas, H. J. W., Lucassen, A. M., Evans, D. G. R., Maher, E. R., Maughan, T., Dimas, A., Dermitzakis, E., Cazier, J-B., Aaltonen, L. A., Pharoah, P., Kerr, D. J., Carvajal-Carmona, L. G., Campbell, H., Dunlop, M. G., Tomlinson, I. P. M. & CORGI Consortium, COGENT Consortium, COINB Collaborative Grp, COIN Collaborative Grp, 2010, In : Nature Genetics. 42, 11, p. 973-U89 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Mice with Inactivation of Aryl Hydrocarbon Receptor-Interacting Protein (Aip) Display Complete Penetrance of Pituitary Adenomas with Aberrant ARNT Expression

Raitila, A., Lehtonen, H. J., Arola, J., Heliovaara, E., Ahlsten, M., Georgitsi, M., Jalanko, A., Paetau, A., Aaltonen, L. A. & Karhu, A., 2010, In : The American Journal of Pathology. 177, 4, p. 1969-1976 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours

Velho, S., Oliveira, C., Paredes, J., Sousa, S., Leite, M., Matos, P., Milanezi, F., Ribeiro, A. S., Mendes, N., Licastro, D., Karhu, A., Oliveira, M. J., Ligtenberg, M., Hamelin, R., Carneiro, F., Lindblom, A., Peltomaki, P., Castedo, S., Schwartz, S., Jordan, P. & 6 others, Aaltonen, L. A., Hofstra, R. M. W., Suriano, G., Stupka, E., Fialho, A. M. & Seruca, R., 2010, In : Human Molecular Genetics. 19, 4, p. 697-706 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations in the Circadian Gene CLOCK in Colorectal Cancer

Alhopuro, P., Björklund, M., Sammalkorpi, H. P., Turunen, M., Tuupanen, S. J., Bistrom, M., Niittymäki, I., Lehtonen, H., Kivioja, T., Launonen, V., Saharinen, J. M. N., Nousiainen, K. J., Hautaniemi, S., Nuorva, K., Mecklin, J-P., Järvinen, H., Orntoft, T., Arango, D., Lehtonen, R. J., Karhu, A. I. & 2 others, Taipale, J. & Aaltonen, L. A., 2010, In : Molecular Cancer Research. 8, 7, p. 952-960 9 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome

Vahteristo, P., Koski, T. A., Naatsaari, L., Kiuru, M., Karhu, A., Herva, R., Sallinen, S-L., Vierimaa, O., Bjorck, E., Richard, S., Gardie, B., Bessis, D., Van Glabeke, E., Blanco, I., Houlston, R., Senter, L., Hietala, M., Aittomaki, K., Aaltonen, L. A., Launonen, V. & 1 others, Lehtonen, R., 2010, In : Familial Cancer. 9, p. 245-251 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1)

Kaasinen, E., Aittomaki, K., Eronen, M., Vahteristo, P., Karhu, A., Mecklin, J-P., Kajantie, E., Aaltonen, L. A. & Lehtonen, R., 2010, In : Human Molecular Genetics. 19, p. 2747-2753 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic mutations and germline sequence variants in patients with familial colorectal cancer

Gylfe, A. E., Sirkiä, J., Ahlsten, M., Järvinen, H., Mecklin, J-P., Karhu, A. & Aaltonen, L. A., 2010, In : International Journal of Cancer. 127, 12, p. 2974-2980 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Aggressive pituitary adenomas occurring in young patients in a large Polynesian kindred with a germline R271W mutation in the AIP gene

Jennings, J. E., Georgitsi, M., Holdaway, I., Daly, A. F., Tichomirowa, M., Beckers, A., Aaltonen, L. A., Karhu, A. & Cameron, F. J., 2009, In : European Journal of Endocrinology. 161, 5, p. 799-804 6 p.

Research output: Contribution to journalArticleScientificpeer-review

An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression

Yuan, Z., Shin, J., Wilson, A., Goel, S., Ling, Y-H., Ahmed, N., Dopeso, H., Jhawer, M., Nasser, S., Montagna, C., Fordyce, K., Augenlicht, L. H., Aaltonen, L. A., Arango, D., Weber, T. K. & Mariadason, J. M., 2009, In : Cancer Research. 69, 29, p. 7811-7818 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer

Koski, T. A., Lehtonen, H. J., Jee, K. J., Ninomiya, S., Joosse, S. A., Vahteristo, P., Kiuru, M., Karhu, A., Sammalkorpi, H., Vanharanta, S., Lehtonen, R., Edgren, S. H. T., Nederlof, P. M., Hietala, M., Aittomäki, K., Herva, R., Knuutila, S., Aaltonen, L. A. & Launonen, V., 2009, In : Genes, Chromosomes & Cancer. 48, 7, p. 544-551 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Aryl hydrocarbon receptor interacting protein mutations seem not to associate with familial non-medullary thyroid cancer

Raitila, A., Georgitsi, M., Bonora, E., Vargiolu, M., Tuppurainen, K., Mäkinen, M. J., Vierimaa, O., Salmela, P. I., Launonen, V., Vahteristo, P., Aaltonen, L. A., Romeo, G. & Karhu, A., 2009, In : Journal of Endocrinological Investigation. 32, 5, p. 426-429 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas

Raimundo, N., Vanharanta, S., Aaltonen, L. A., Hovatta, I. & Suomalainen, A., 2009, In : Oncogene. 28, 9, p. 1261-1273 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer

Andersen, C. L., Christensen, L. L., Thorsen, K., Schepeler, T., Sorensen, F. B., Verspaget, H. W., Simon, R., Kruhoffer, M., Aaltonen, L. A., Laurberg, S. & Ørntoft, T. F., 2009, In : British Journal of Cancer. 100, 3, p. 511-523 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

Jorissen, R. N., Gibbs, P., Christie, M., Prakash, S., Lipton, L., Desai, J., Kerr, D., Aaltonen, L. A., Arango, D., Kruhoffer, M., Orntoft, T. F., Andersen, C. L., Gruidl, M., Kamath, V. P., Eschrich, S., Yeatman, T. J. & Sieber, O. M., 2009, In : Clinical Cancer Research. 15, p. 7642-7651 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of MEN1, HRPT2, CASR, CDKN1B, and AIP genes in primary hyperparathyroidism patients with features of genetic predisposition

Vierimaa, O., Villablanca, A., Alimov, A., Georgitsi, M., Raitila, A., Vahteristo, P., Larsson, C., Ruokonen, A., Eloranta, E., Ebeling, T. M. L., Ignatius, J., Aaltonen, L. A., Leisti, J. & Salmela, P. I., 2009, In : Journal of Endocrinological Investigation. 32, 6, p. 512-518 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members

Järvinen, H. J., Renkonen-Sinisalo, L., Aktan-Collan, K., Peltomäki, P., Aaltonen, L. A. & Mecklin, J-P., 2009, In : Journal of Clinical Oncology. 27, 28, p. 4793-4797 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

Tuupanen, S., Turunen, M., Lehtonen, R., Hallikas, O., Vanharanta, S., Kivioja, T., Björklund, M., Wei, G., Yan, J., Niittymäki, I., Mecklin, J-P., Järvinen, H., Ristimäki, A., Di-Bernardo, M., East, P., Carvajal-Carmona, L., Houlston, R. S., Tomlinson, I., Palin, K., Ukkonen, E. & 3 others, Karhu, A., Taipale, J. & Aaltonen, L. A., 2009, In : Nature Genetics. 41, 8, p. 885-890 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas

Heliövaara, E., Raitila, A., Launonen, V., Paetau, A., Arola, J., Lehtonen, H., Sane, T., Weil, R. J., Vierimaa, O., Salmela, P., Tuppurainen, K., Mäkinen, M., Aaltonen, L. A. & Karhu, A., 2009, In : The American Journal of Pathology. 175, 6, p. 2501-2507 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

Tomlinson, I. P. M., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A. & CORGI Consortium and EPICOLON Consortium, 2008, In : Nature Genetics. 40, 5, p. 623-630 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution

Tuupanen, S., Niittymäki, I., Nousiainen, K. J., Vanharanta, S., Mecklin, J-P., Nuorva, K., Järvinen, H., Hautaniemi, S., Karhu, A. & Aaltonen, L. A., 2008, In : Cancer Research. 68, 1, p. 14-17 4 p.

Research output: Contribution to journalArticleScientificpeer-review

ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer

Siltanen, S., Syrjäkoski, K., Fagerholm, R., Ikonen, T., Lipman, P., Mallot, J., Holli, K., Tammela, T. L. J., Järvinen, H. J., Mecklin, J-P., Aittomäki, K., Blomqvist, C., Bailey-Wilson, J. E., Nevanlinna, H., Aaltonen, L. A., Schleutker, J. & Vahteristo, P., 2008, In : European Journal of Human Genetics. 16, 8, p. 983-991 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children and adolescents with sporadic pituitary adenomas

Georgitsi, M., De Menis, E., Cannavo, S., Mäkinen, M. J., Tuppurainen, K., Pauletto, P., Curto, L., Weil, R. J., Paschke, R., Zielinski, G., Wasik, A., Lubinski, J., Vahteristo, P., Karhu, A. & Aaltonen, L. A., 2008, In : Clinical Endocrinology. 69, 4, p. 621-627 7 p.

Research output: Contribution to journalArticleScientificpeer-review

DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

Jorissen, R. N., Lipton, L., Gibbs, P., Chapman, M., Desai, J., Jones, I. T., Yeatman, T. J., East, P., Tomlinson, I. P. M., erspaget, H. W., Aaltonen, L. A., Kruhøffer, M., Ørntoft, T. F., Andersen, C. L. & Sieber, O. M., 2008, In : Clinical Cancer Research. 14, 24, p. 8061-8069 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Dna-tieto liian tulkinnanvaraista jokamiehen huvitukseksi

Translated title of the contribution: DNA data too ambiguous for layman interpretationsAaltonen, L. A., 3 Jan 2008, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

Large genomic deletions in AIP in pituitary adenoma predisposition

Georgitsi, M., Heliövaara, E., Paschke, R., Kumar, A. V. K., Tischkowitz, M., Vierimaa, O., Salmela, P., Sane, T., De Menis, E., Cannavo, S., Gundogdu, S., Lucassen, A., Izatt, L., Aylwin, S., Bano, G., Hodgson, S., Koch, C. A., Karhu, A. & Aaltonen, L. A., 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 4146-4151 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

Houlston, R. S., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A. & CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium, 2008, In : Nature Genetics. 40, 12, p. 1426-1435 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of MYH11 in acute myeloid leukemia

Sammalkorpi, H., Alhopuro, P., Niittymäki, I., Ørntoft, T. F., Hokland, P., Karhu, A. & Aaltonen, L. A., 2008, In : Leukemia & lymphoma. 49, 9, p. 1829-1831 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer

Koski (Ahvenainen), T. A., Lehtonen, H. J., Lehtonen, R., Vahteristo, P., Aittomäki, K., Baynam, G., Dommering, C., Eng, C., Gruber, S. B., Grönberg, H., Harvima, R., Herva, R., Hietala, M., Kujala, M., Kääriäinen, H., Sunde, L., Vierimaa, O., Pollard, P. J., Tomlinson, I. P., Björck, E. & 2 others, Aaltonen, L. A. & Launonen, V., 2008, In : Cancer Genetics and Cytogenetics. 183, 2, p. 83-88 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer

Pittman, A. M., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A. & CORGI Consortium and EPICOLON Consortium, 2008, In : Human Molecular Genetics. 17, 23, p. 3720-3727 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Smad4 haploinsufficiency: a matter of dosage

Alberici, P., Gaspar, C., Franken, P., Gorski, M. M., de Vries, I., Scott, R. J., Ristimäki, A., Aaltonen, L. A. & Fodde, R., 2008, In : PathoGenetics. 1, 2, 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic mutation analysis of MYH11 in breast and prostate cancer

Alhopuro, P., Karhu, A., Winqvist, R., Waltering, K., Visakorpi, T. & Aaltonen, L., 2008, In : BMC Cancer. 8, p. 263 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype

Petrova, T., Nykänen, A., Norrmen, C., Ivanov, K. I., Andersson, L. C., Haglund, C., Puolakkainen, P., Wempe, F., von Melchner, H., Gradwohl, G., Vanharanta, S., Aaltonen, L. A., Saharinen, J. M. N., Gentile, M., Clarke, A., Taipale, J., Oliver, G. & Alitalo, K., 2008, In : Cancer Cell. 13, 5, p. 407-419 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Unregulated smooth-muscle myosin in human intestinal neoplasia

Alhopuro, P., Phichith, D., Tuupanen, S., Sammalkorpi, H., Nybondas, M., Saharinen, J., Robinson, J. P., Yang, Z., Chen, L-Q., Ørntoft, T. F., Mecklin, J-P., Järvinen, H., Eng, C., Moeslein, G., Shibata, D., Houlston, R. S., Lucassen, A., Tomlinson, I. P. M., Launonen, V., Ristimäki, A. & 4 others, Arango, D., Karhu, A., Sweeney, H. L. & Aaltonen, L. A., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5513-5518 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

A recurrent mutation in PALB2 in Finnish cancer families

Erkko, H., Xia, B., Nikkilä, J., Schleutker, J., Syrjäkoski, K., Mannermaa, A., Kallioniemi, A., Pylkäs, K., Karppinen, S-M., Rapakko, K., Miron, A., Sheng, Q., Li, G., Mattila, H., Bell, D. W., Haber, D. A., Grip, M., Reiman, M., Jukkola-Vuorinen, A., Mustonen, A. & 8 others, Kere, J., Aaltonen, L. A., Kosma, V-M., Kataja, V., Soini, Y., Drapkin, R. I., Livingston, D. M. & Winqvist, R., 2007, In : Nature. 446, 7133, p. 316-319 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Background mutation frequency in microsatellite-unstable colorectal cancer

Sammalkorpi, H., Alhopuro, P., Lehtonen, R., Tuimala, J., Mecklin, J-P., Järvinen, H. J., Jiricny, J., Karhu, A. & Aaltonen, L. A., 2007, In : Cancer Research. 67, 12, p. 5691-5698 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Blood-derived gene-expression profiling in unravelling susceptibility to recessive disease

Vahteristo, P., Kokko, A., Saksela, O., Aittomäki, K. & Aaltonen, L. A., 2007, In : Journal of Medical Genetics. 44, 11, p. 718-720 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer

Niemela, A. M., Hynninen, P., Mecklin, J-P., Kuopio, T., Kokko, A., Aaltonen, L. A., Parkkila, A-K., Pastorekova, S., Pastorek, J., Waheed, A., Sly, W. S., Ørntoft, T. F., Kruhøffer, M., Haapasalo, H., Parkkila, S. & Kivelä, A., 2007, In : Cancer Epidemiology, Biomarkers & Prevention. 16, 9, p. 1760-1766 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Clusterin expression in normal mucosa and colorectal cancer

Andersen, C. L., Schepeler, T., Thornsen, K., Birkenkamp-Demtröder, K., Mansilla, F., Aaltonen, L. A., Laurberg, S. & Ørntoft, T. F., 2007, In : Molecular & Cellular Proteomics. 6, 6, p. 1039-1048 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Computational identification of candidate loci for recessively inherited mutation using high-throughput SNP arrays: genetics and population analysis

Laakso, M., Tuupanen, S., Karhu, A., Lehtonen, R., Aaltonen, L. A. & Hautaniemi, S., 2007, In : Bioinformatics. 23, 15, p. 1952-1961 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Conventional renal cancer in a patient with fumarate hydratase mutation

Lehtonen, H. J., Blanco, I., Piulats, J. M., Herva, R., Launonen, V. & Aaltonen, L. A., 2007, In : Human Pathology. 38, 5, p. 793-796 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region

Vanharanta, S., Wortham, N. C., Langford, C., El-Bahrawy, M., van der Spuy, Z., Sjöberg, J., Lehtonen, R., Karhu, A., Tomlinson, I. P. M. & Aaltonen, L. A., 2007, In : Genes, Chromosomes & Cancer. 46, 5, p. 451-458 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome

Mecklin, J-P., Aarnio, M., Läärä, E., Kairaluoma, M., Pylvänäinen, K., Peltomäki, P., Aaltonen, L. A. & Järvinen, H. J., 2007, In : Gastroenterology. 133, 4, p. 1093-1098 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups

Mansilla, F., Birkenkamp-Demtröder, K., Kruhøffer, M., Sørensen, F. B., Andersen, C. L., Laiho, P., Aaltonen, L. A., Verspaget, H. W. & Ørntoft, T. F., 2007, In : British Journal of Cancer. 96, 12, p. 1896-1903 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing

Aktan-Collan, K., Haukkala, A., Pylvänäinen, K., Järvinen, H. J., Aaltonen, L. A., Peltomäki, P., Rantanen, E., Kääriäinen, H. & Mecklin, J-P., 2007, In : Journal of Medical Genetics. 44, 11, p. 732-738 7 p.

Research output: Contribution to journalArticleScientificpeer-review