Photo of Lauri Aaltonen

Lauri Aaltonen, Professor

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1992 …2020
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Publications 1992 2020

2006

LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome: [electronic letter]

Volikos, E., Robinson, J., Aittomäki, K., Mecklin, J-P., Järvinen, H., Westerman, A. M., de Rooij, F. W. M., Vogel, T., Moeslein, G., Launonen, V., Tomlinson, I. P. M., Silver, A. R. J. & Aaltonen, L. A., 2006, In : Journal of Medical Genetics. 43, 5, p. e18 3 p.

Research output: Contribution to journalArticleScientificpeer-review

MDM2 SNP309 accelerates colorectal tumour formation in women

Bond, G. L., Menin, C., Bertorelle, R., Alhopuro, P., Aaltonen, L. A. & Levine, A. J., 2006, In : Journal of Medical Genetics. 43, 12, p. 950-952 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Modeling tumor predisposing FH mutations in yeast: effects on fumarase activity, growth phenotype and gene expression profile

Kokko, A., Ylisaukko-oja, S., Kiuru, M., Takatalo, M., Salmikangas, P., Tuimala, J., Arango, D., Karhu, A., Aaltonen, L. A. & Jäntti, J., 2006, In : International Journal of Cancer. 118, 6, p. 1340-1345 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies

Karppinen, S-M., Barkardottir, R. B., Backenhorn, K., Sydenham, T., Syrjäkoski, K., Schleutker, J., Ikonen, T., Pylkäs, K., Rapakko, K., Erkko, H., Johannesdottir, G., Gerdes, A-M., Thomassen, M., Agnarsson, B. A., Grip, M., Kallioniemi, A., Kere, J., Aaltonen, L. A., Arason, A., Møller, P. & 3 others, Kruse, T. A., Borg, Å. & Winqvist, R., 2006, In : Journal of Medical Genetics. 43, 11, p. 856-862 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Periytyvän kasvainalttiuden molekyylitausta: Äyräpään luento

Aaltonen, L. A., 2006, In : Duodecim. 122, 18, p. 2221-2230

Research output: Contribution to journalArticleScientific

Pituitary adenoma predisposition caused by germline mutations in the AIP gene

Vierimaa, O., Georgitsi, M., Lehtonen, R., Vahteristo, P., Kokko, A., Raitila, A., Tuppurainen, K., Ebeling, T., Salmela, P. I., Paschke, R., Gundogdu, S., De Menis, E., Mäkinen, M. J., Launonen, V., Karhu, A. & Aaltonen, L. A., 2006, In : Science. 312, 5777, p. 1228-1230 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers

Hienonen, T., Salovaara, R., Mecklin, J-P., Järvinen, H. J., Karhu, A. & Aaltonen, L. A., 2006, In : International Journal of Cancer. 118, 2, p. 505-508 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

A recurrent mutation in PALB2 in Finnish cancer families

Erkko, H., Xia, B., Nikkilä, J., Schleutker, J., Syrjäkoski, K., Mannermaa, A., Kallioniemi, A., Pylkäs, K., Karppinen, S-M., Rapakko, K., Miron, A., Sheng, Q., Li, G., Mattila, H., Bell, D. W., Haber, D. A., Grip, M., Reiman, M., Jukkola-Vuorinen, A., Mustonen, A. & 8 others, Kere, J., Aaltonen, L. A., Kosma, V-M., Kataja, V., Soini, Y., Drapkin, R. I., Livingston, D. M. & Winqvist, R., 2007, In : Nature. 446, 7133, p. 316-319 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Background mutation frequency in microsatellite-unstable colorectal cancer

Sammalkorpi, H., Alhopuro, P., Lehtonen, R., Tuimala, J., Mecklin, J-P., Järvinen, H. J., Jiricny, J., Karhu, A. & Aaltonen, L. A., 2007, In : Cancer Research. 67, 12, p. 5691-5698 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Blood-derived gene-expression profiling in unravelling susceptibility to recessive disease

Vahteristo, P., Kokko, A., Saksela, O., Aittomäki, K. & Aaltonen, L. A., 2007, In : Journal of Medical Genetics. 44, 11, p. 718-720 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer

Niemela, A. M., Hynninen, P., Mecklin, J-P., Kuopio, T., Kokko, A., Aaltonen, L. A., Parkkila, A-K., Pastorekova, S., Pastorek, J., Waheed, A., Sly, W. S., Ørntoft, T. F., Kruhøffer, M., Haapasalo, H., Parkkila, S. & Kivelä, A., 2007, In : Cancer Epidemiology, Biomarkers & Prevention. 16, 9, p. 1760-1766 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Clusterin expression in normal mucosa and colorectal cancer

Andersen, C. L., Schepeler, T., Thornsen, K., Birkenkamp-Demtröder, K., Mansilla, F., Aaltonen, L. A., Laurberg, S. & Ørntoft, T. F., 2007, In : Molecular & Cellular Proteomics. 6, 6, p. 1039-1048 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Computational identification of candidate loci for recessively inherited mutation using high-throughput SNP arrays: genetics and population analysis

Laakso, M., Tuupanen, S., Karhu, A., Lehtonen, R., Aaltonen, L. A. & Hautaniemi, S., 2007, In : Bioinformatics. 23, 15, p. 1952-1961 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Conventional renal cancer in a patient with fumarate hydratase mutation

Lehtonen, H. J., Blanco, I., Piulats, J. M., Herva, R., Launonen, V. & Aaltonen, L. A., 2007, In : Human Pathology. 38, 5, p. 793-796 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region

Vanharanta, S., Wortham, N. C., Langford, C., El-Bahrawy, M., van der Spuy, Z., Sjöberg, J., Lehtonen, R., Karhu, A., Tomlinson, I. P. M. & Aaltonen, L. A., 2007, In : Genes, Chromosomes & Cancer. 46, 5, p. 451-458 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome

Mecklin, J-P., Aarnio, M., Läärä, E., Kairaluoma, M., Pylvänäinen, K., Peltomäki, P., Aaltonen, L. A. & Järvinen, H. J., 2007, In : Gastroenterology. 133, 4, p. 1093-1098 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups

Mansilla, F., Birkenkamp-Demtröder, K., Kruhøffer, M., Sørensen, F. B., Andersen, C. L., Laiho, P., Aaltonen, L. A., Verspaget, H. W. & Ørntoft, T. F., 2007, In : British Journal of Cancer. 96, 12, p. 1896-1903 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing

Aktan-Collan, K., Haukkala, A., Pylvänäinen, K., Järvinen, H. J., Aaltonen, L. A., Peltomäki, P., Rantanen, E., Kääriäinen, H. & Mecklin, J-P., 2007, In : Journal of Medical Genetics. 44, 11, p. 732-738 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors

Aaltonen, L. A., Johns, L., Järvinen, H. J., Mecklin, J-P. & Houlston, R. S., 2007, In : Clinical Cancer Research. 13, 1, p. 356-361 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence

Yang, Q., Zhang, R., Horikawa, I., Fujita, K., Afshar, Y., Kokko, A., Laiho, P., Aaltonen, L. A. & Harris, C. C., 2007, In : Cancer Research. 67, 24, p. 11677-11686 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Gastroenterologia ja hepatologia

Höckerstedt, K. (ed.), Aaltonen, L. A. (ed.), Kivilaakso, E. (ed.) & Färkkilä, M. (ed.), 2007, 1. [i.e. 3 täyd. uus.] p ed. Helsinki: Duodecim. 910 p.

Research output: Book/ReportAnthology or special issue

Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia

Georgitsi, M., Raitila, A., Karhu, A., van der Luijt, R. B., Aalfs, C. M., Sane, T., Vierimaa, O., Mäkinen, M. J., Tuppurainen, K., Paschke, R., Gimm, O., Koch, C. A., Gundogdu, S., Lucassen, A., Tischkowitz, M., Izatt, L., Aylwin, S., Bano, G., Hodgson, S., De Menis, E. & 3 others, Launonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Journal of Clinical Endocrinology and Metabolism. 92, 8, p. 3321-3325 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability

Lehtonen, H. J., Mäkinen, M. J., Kiuru, M., Laiho, P., Herva, R., van Minderhout, I., Hogendoorn, P. C. W., Cornelisse, C., Devilee, P., Launonen, V. & Aaltonen, L. A., 2007, In : International Journal of Cancer. 121, 6, p. 1386-1389 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations

Georgitsi, M., Raitila, A., Karhu, A., Tuppurainen, K., Mäkinen, M. J., Vierimaa, O., Paschke, R., Saeger, W., van der Luijt, R. B., Sane, T., Robledo, M., de Menis, E., Weil, R. J., Wasik, A., Zielinski, G., Lucewicz, O., Lubinski, J., Launonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, p. 4101-4105 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers

Georgitsi, M., Karhu, A., Winqvist, R., Visakorpi, T., Waltering, K., Vahteristo, P., Launonen, V. & Aaltonen, L. A., 2007, In : British Journal of Cancer. 96, 2, p. 352-356 5 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence for association of NOD2 R702W and G908R with colorectal cancer

Tuupanen, S., Alhopuro, P., Mecklin, J-P., Järvinen, H. J. & Aaltonen, L. A., 2007, In : International Journal of Cancer. 121, 1, p. 76-79 4 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer

Tuupanen, S., Karhu, A., Järvinen, H. J., Mecklin, J-P., Launonen, V. & Aaltonen, L. A., 2007, In : Oncogene. 26, 17, p. 2513-2517 5 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia

Raitila, A., Georgitsi, M., Karhu, A., Tuppurainen, K., Mäkinen, M. J., Birkenkamp-Demtröder, K., Salmenkivi, K., Ørntoft, T. F., Arola, J., Launonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Endocrine - Related Cancer. 14, 3, p. 901-906 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Paksusuolisyövälle altistavat geenivirheet ja niiden diagnostiikka

Aaltonen, L. A. & Järvinen, H. J., 2007, Gastroenterologia ja hepatologia. Helsinki: Duodecim, p. 544-549 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro

Birkenkamp-Demtroder, K., Mansilla, F., Sorensen, F. B., Kruhoffer, M., Cabezon, T., Christensen, L. L., Aaltonen, L. A., Verspaget, H. W. & Orntoft, T. F., 2007, In : Molecular oncology. 1, p. 181-195 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis

Laiho, P., Kokko, A., Vanharanta, S., Salovaara, R. K., Sammalkorpi, H., Järvinen, H. J., Mecklin, J-P., Karttunen, T. J., Tuppurainen, K., Davalos, V., Schwartz, S., Arango, D., Mäkinen, M. J. & Aaltonen, L. A., 2007, In : Oncogene. 26, 2, p. 312-320 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Stress-induced expression of a novel variant of human fumarate hydratase (FH)

Lehtonen, H. J., Ylisaukko-oja, S. K., Kiuru, M., Karhu, A., Lehtonen, R., Vanharanta, S., Jalanko, A., Aaltonen, L. A. & Launonen, V., 2007, In : Gene Expression. 14, p. 59-69 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Susceptibility to pituitary neoplasia related to MEN-1, CDKN1B and AIP mutations: an update

Karhu, A. & Aaltonen, L. A., 2007, In : Human Molecular Genetics. 16, Rev.is, p. 1, s. R73-R79

Research output: Contribution to journalReview ArticleScientificpeer-review

Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells

Alazzouzi, H., Suriano, G., Guerra, A., Plaja, A., Espin, E., Armengol, M., Alhopuro, P., Velho, S., Shinomura, Y., Gonzales-Aguilera, J. J., Yamamoto, H., Aaltonen, L. A., Moreno, V., Capella, G., Peinado, M. A., Seruca, R., Arango, D. & Schwartz, S., 2007, In : Journal of Medical Genetics. 44, 1, p. 75-80 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

Tomlinson, I. P. M., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A. & CORGI Consortium and EPICOLON Consortium, 2008, In : Nature Genetics. 40, 5, p. 623-630 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution

Tuupanen, S., Niittymäki, I., Nousiainen, K. J., Vanharanta, S., Mecklin, J-P., Nuorva, K., Järvinen, H., Hautaniemi, S., Karhu, A. & Aaltonen, L. A., 2008, In : Cancer Research. 68, 1, p. 14-17 4 p.

Research output: Contribution to journalArticleScientificpeer-review

ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer

Siltanen, S., Syrjäkoski, K., Fagerholm, R., Ikonen, T., Lipman, P., Mallot, J., Holli, K., Tammela, T. L. J., Järvinen, H. J., Mecklin, J-P., Aittomäki, K., Blomqvist, C., Bailey-Wilson, J. E., Nevanlinna, H., Aaltonen, L. A., Schleutker, J. & Vahteristo, P., 2008, In : European Journal of Human Genetics. 16, 8, p. 983-991 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children and adolescents with sporadic pituitary adenomas

Georgitsi, M., De Menis, E., Cannavo, S., Mäkinen, M. J., Tuppurainen, K., Pauletto, P., Curto, L., Weil, R. J., Paschke, R., Zielinski, G., Wasik, A., Lubinski, J., Vahteristo, P., Karhu, A. & Aaltonen, L. A., 2008, In : Clinical Endocrinology. 69, 4, p. 621-627 7 p.

Research output: Contribution to journalArticleScientificpeer-review

DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

Jorissen, R. N., Lipton, L., Gibbs, P., Chapman, M., Desai, J., Jones, I. T., Yeatman, T. J., East, P., Tomlinson, I. P. M., erspaget, H. W., Aaltonen, L. A., Kruhøffer, M., Ørntoft, T. F., Andersen, C. L. & Sieber, O. M., 2008, In : Clinical Cancer Research. 14, 24, p. 8061-8069 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Dna-tieto liian tulkinnanvaraista jokamiehen huvitukseksi

Translated title of the contribution: DNA data too ambiguous for layman interpretationsAaltonen, L. A., 3 Jan 2008, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

Large genomic deletions in AIP in pituitary adenoma predisposition

Georgitsi, M., Heliövaara, E., Paschke, R., Kumar, A. V. K., Tischkowitz, M., Vierimaa, O., Salmela, P., Sane, T., De Menis, E., Cannavo, S., Gundogdu, S., Lucassen, A., Izatt, L., Aylwin, S., Bano, G., Hodgson, S., Koch, C. A., Karhu, A. & Aaltonen, L. A., 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 4146-4151 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

Houlston, R. S., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A. & CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium, 2008, In : Nature Genetics. 40, 12, p. 1426-1435 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of MYH11 in acute myeloid leukemia

Sammalkorpi, H., Alhopuro, P., Niittymäki, I., Ørntoft, T. F., Hokland, P., Karhu, A. & Aaltonen, L. A., 2008, In : Leukemia & lymphoma. 49, 9, p. 1829-1831 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer

Koski (Ahvenainen), T. A., Lehtonen, H. J., Lehtonen, R., Vahteristo, P., Aittomäki, K., Baynam, G., Dommering, C., Eng, C., Gruber, S. B., Grönberg, H., Harvima, R., Herva, R., Hietala, M., Kujala, M., Kääriäinen, H., Sunde, L., Vierimaa, O., Pollard, P. J., Tomlinson, I. P., Björck, E. & 2 others, Aaltonen, L. A. & Launonen, V., 2008, In : Cancer Genetics and Cytogenetics. 183, 2, p. 83-88 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer

Pittman, A. M., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A. & CORGI Consortium and EPICOLON Consortium, 2008, In : Human Molecular Genetics. 17, 23, p. 3720-3727 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Smad4 haploinsufficiency: a matter of dosage

Alberici, P., Gaspar, C., Franken, P., Gorski, M. M., de Vries, I., Scott, R. J., Ristimäki, A., Aaltonen, L. A. & Fodde, R., 2008, In : PathoGenetics. 1, 2, 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic mutation analysis of MYH11 in breast and prostate cancer

Alhopuro, P., Karhu, A., Winqvist, R., Waltering, K., Visakorpi, T. & Aaltonen, L., 2008, In : BMC Cancer. 8, p. 263 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype

Petrova, T., Nykänen, A., Norrmen, C., Ivanov, K. I., Andersson, L. C., Haglund, C., Puolakkainen, P., Wempe, F., von Melchner, H., Gradwohl, G., Vanharanta, S., Aaltonen, L. A., Saharinen, J. M. N., Gentile, M., Clarke, A., Taipale, J., Oliver, G. & Alitalo, K., 2008, In : Cancer Cell. 13, 5, p. 407-419 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Unregulated smooth-muscle myosin in human intestinal neoplasia

Alhopuro, P., Phichith, D., Tuupanen, S., Sammalkorpi, H., Nybondas, M., Saharinen, J., Robinson, J. P., Yang, Z., Chen, L-Q., Ørntoft, T. F., Mecklin, J-P., Järvinen, H., Eng, C., Moeslein, G., Shibata, D., Houlston, R. S., Lucassen, A., Tomlinson, I. P. M., Launonen, V., Ristimäki, A. & 4 others, Arango, D., Karhu, A., Sweeney, H. L. & Aaltonen, L. A., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5513-5518 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Aggressive pituitary adenomas occurring in young patients in a large Polynesian kindred with a germline R271W mutation in the AIP gene

Jennings, J. E., Georgitsi, M., Holdaway, I., Daly, A. F., Tichomirowa, M., Beckers, A., Aaltonen, L. A., Karhu, A. & Cameron, F. J., 2009, In : European Journal of Endocrinology. 161, 5, p. 799-804 6 p.

Research output: Contribution to journalArticleScientificpeer-review