Photo of Lauri Aaltonen
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • Finland

  • PL 63 (Haartmaninkatu 8), B514b2

    HELSINGIN YLIOPISTO

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1992 …2019
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Publications 1992 2019

2007

Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia

Georgitsi, M., Raitila, A., Karhu, A., van der Luijt, R. B., Aalfs, C. M., Sane, T., Vierimaa, O., Mäkinen, M. J., Tuppurainen, K., Paschke, R., Gimm, O., Koch, C. A., Gundogdu, S., Lucassen, A., Tischkowitz, M., Izatt, L., Aylwin, S., Bano, G., Hodgson, S., De Menis, E. & 3 othersLaunonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Journal of Clinical Endocrinology and Metabolism. 92, 8, p. 3321-3325 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability

Lehtonen, H. J., Mäkinen, M. J., Kiuru, M., Laiho, P., Herva, R., van Minderhout, I., Hogendoorn, P. C. W., Cornelisse, C., Devilee, P., Launonen, V. & Aaltonen, L. A., 2007, In : International Journal of Cancer. 121, 6, p. 1386-1389 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations

Georgitsi, M., Raitila, A., Karhu, A., Tuppurainen, K., Mäkinen, M. J., Vierimaa, O., Paschke, R., Saeger, W., van der Luijt, R. B., Sane, T., Robledo, M., de Menis, E., Weil, R. J., Wasik, A., Zielinski, G., Lucewicz, O., Lubinski, J., Launonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, p. 4101-4105 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers

Georgitsi, M., Karhu, A., Winqvist, R., Visakorpi, T., Waltering, K., Vahteristo, P., Launonen, V. & Aaltonen, L. A., 2007, In : British Journal of Cancer. 96, 2, p. 352-356 5 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence for association of NOD2 R702W and G908R with colorectal cancer

Tuupanen, S., Alhopuro, P., Mecklin, J-P., Järvinen, H. J. & Aaltonen, L. A., 2007, In : International Journal of Cancer. 121, 1, p. 76-79 4 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer

Tuupanen, S., Karhu, A., Järvinen, H. J., Mecklin, J-P., Launonen, V. & Aaltonen, L. A., 2007, In : Oncogene. 26, 17, p. 2513-2517 5 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia

Raitila, A., Georgitsi, M., Karhu, A., Tuppurainen, K., Mäkinen, M. J., Birkenkamp-Demtröder, K., Salmenkivi, K., Ørntoft, T. F., Arola, J., Launonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Endocrine - Related Cancer. 14, 3, p. 901-906 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Paksusuolisyövälle altistavat geenivirheet ja niiden diagnostiikka

Aaltonen, L. A. & Järvinen, H. J., 2007, Gastroenterologia ja hepatologia. Helsinki: Duodecim, p. 544-549 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro

Birkenkamp-Demtroder, K., Mansilla, F., Sorensen, F. B., Kruhoffer, M., Cabezon, T., Christensen, L. L., Aaltonen, L. A., Verspaget, H. W. & Orntoft, T. F., 2007, In : Molecular oncology. 1, p. 181-195 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis

Laiho, P., Kokko, A., Vanharanta, S., Salovaara, R. K., Sammalkorpi, H., Järvinen, H. J., Mecklin, J-P., Karttunen, T. J., Tuppurainen, K., Davalos, V., Schwartz, S., Arango, D., Mäkinen, M. J. & Aaltonen, L. A., 2007, In : Oncogene. 26, 2, p. 312-320 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Stress-induced expression of a novel variant of human fumarate hydratase (FH)

Lehtonen, H. J., Ylisaukko-oja, S. K., Kiuru, M., Karhu, A., Lehtonen, R., Vanharanta, S., Jalanko, A., Aaltonen, L. A. & Launonen, V., 2007, In : Gene Expression. 14, p. 59-69 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Susceptibility to pituitary neoplasia related to MEN-1, CDKN1B and AIP mutations: an update

Karhu, A. & Aaltonen, L. A., 2007, In : Human Molecular Genetics. 16, Rev.is, p. 1, s. R73-R79

Research output: Contribution to journalReview ArticleScientificpeer-review

Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells

Alazzouzi, H., Suriano, G., Guerra, A., Plaja, A., Espin, E., Armengol, M., Alhopuro, P., Velho, S., Shinomura, Y., Gonzales-Aguilera, J. J., Yamamoto, H., Aaltonen, L. A., Moreno, V., Capella, G., Peinado, M. A., Seruca, R., Arango, D. & Schwartz, S., 2007, In : Journal of Medical Genetics. 44, 1, p. 75-80 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

AIP-mutaatiot altistavat aivolisäkkeen adenomalle: [referaatti Science lehden artikkelista]

Vierimaa, O., Georgitsi, M., Lehtonen, R., Vahteristo, P., Kokko, A., Raitila, A., Tuppurainen, K., Ebeling, T., Salmela, P. I., Paschke, R., Gundogdu, S., de Menis, E., Mäkinen, M. J., Launonen, V., Aaltonen, L. A. & Karhu, A., 2006, In : Duodecim. 122, 12, p. 1419-1420 2 p.

Research output: Contribution to journalArticleScientific

Analysis of fumarate hydratase mutations in a population-based series of early onset uterine leiomyosarcoma patients

Ylisaukko-oja, S., Kiuru, M., Lehtonen, H. J., Lehtonen, R., Pukkala, E., Arola, J., Launonen, V. & Aaltonen, L. A., 2006, In : International Journal of Cancer. 119, 2, p. 283-287 5 p.

Research output: Contribution to journalArticleScientificpeer-review

A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

Ropero, S., Fraga, M. F., Ballestar, E., Hamelin, R., Yamamoto, H., Boix-Chornet, M., Caballero, R., Alaminos, M., Setien, F., Paz, M. F., Herranz, M., Palacios, J., Arango, D., Ørntoft, T. F., Aaltonen, L. A., Schwartz, S. & Esteller, M., 2006, In : Nature Genetics. 38, 5, p. 566-569 4 p.

Research output: Contribution to journalArticleScientificpeer-review

CHEK2 I157T associates with familial and sporadic colorectal cancer: [electronic letter]

Kilpivaara, O., Alhopuro, P., Vahteristo, P., Aaltonen, L. A. & Nevanlinna, H., 2006, In : Journal of Medical Genetics. 43, p. e34

Research output: Contribution to journalArticleScientificpeer-review

Distinct expression profile in fumarate-hydratase-deficient uterine fibroids

Vanharanta, S., Pollard, P. J., Lehtonen, H. J., Laiho, P., Sjöberg, J., Leminen, A., Aittomäki, K., Arola, J., Kruhøffer, M., Ørntoft, T. F., Tomlinson, I. P., Kiuru, M., Arango, D. & Aaltonen, L. A., 2006, In : Human Molecular Genetics. 15, 1, p. 97-103 7 p.

Research output: Contribution to journalArticleScientificpeer-review

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis

Kokko, A., Laiho, P., Lehtonen, R., Korja, S., Carvajal-Carmona, L., Järvinen, H. J., Mecklin, J-P., Eng, C., Schleutker, J., Tomlinson, I. P. M., Vahteristo, P. & Aaltonen, L. A., 2006, In : BMC Cancer. 6, 145, 6 p.

Research output: Contribution to journalArticleScientificpeer-review

EPHB4 and survival of colorectal cancer patients

Davalos, V., Dopeso, H., Castano, J., Wilson, A. J., Vilardell, F., Romero-Gimenez, J., Espin, E., Armengol, M., Capella, G., Mariadason, J. M., Aaltonen, L. A., Schwartz, S. & Arango, D., 2006, In : Cancer Research. 66, 18, p. 8943-8948 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma

Ylisaukko-oja, S. K., Cybulski, C., Lehtonen, R., Kiuru, M., Matyjasik, J., Szymanska, A., Szymanska-Pasternak, J., Dyrskjot, L., Butzow, R., Orntoft, T. F., Launonen, V., Lubinski, J. & Aaltonen, L. A., 2006, In : European Journal of Human Genetics. 14, 7, p. 880-883 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased risk of cancer in patients with fumarate hydratase germline mutation

Lehtonen, H., Kiuru, M., Ylisaukko-oja, S., Salovaara, R., Herva, R., Koivisto, P., Vierimaa, O., Aittomäki, K., Pukkala, E., Launonen, V., Aaltonen, L. A. & Lehtonen, H., 2006, In : Journal of Medical Genetics. 43, 6, p. 523-526 4 p.

Research output: Contribution to journalArticleScientificpeer-review

In response: SMAD4 levels and allelic imbalance in 18q21 in colorectal cancer

Arango, D., Alhopuro, P. & Aaltonen, L. A., 2006, In : Clinical Cancer Research. 12, 5, p. 1654-1655 2 p.

Research output: Contribution to journalArticleScientific

LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome: [electronic letter]

Volikos, E., Robinson, J., Aittomäki, K., Mecklin, J-P., Järvinen, H., Westerman, A. M., de Rooij, F. W. M., Vogel, T., Moeslein, G., Launonen, V., Tomlinson, I. P. M., Silver, A. R. J. & Aaltonen, L. A., 2006, In : Journal of Medical Genetics. 43, 5, p. e18 3 p.

Research output: Contribution to journalArticleScientificpeer-review

MDM2 SNP309 accelerates colorectal tumour formation in women

Bond, G. L., Menin, C., Bertorelle, R., Alhopuro, P., Aaltonen, L. A. & Levine, A. J., 2006, In : Journal of Medical Genetics. 43, 12, p. 950-952 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Modeling tumor predisposing FH mutations in yeast: effects on fumarase activity, growth phenotype and gene expression profile

Kokko, A., Ylisaukko-oja, S., Kiuru, M., Takatalo, M., Salmikangas, P., Tuimala, J., Arango, D., Karhu, A., Aaltonen, L. A. & Jäntti, J., 2006, In : International Journal of Cancer. 118, 6, p. 1340-1345 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies

Karppinen, S-M., Barkardottir, R. B., Backenhorn, K., Sydenham, T., Syrjäkoski, K., Schleutker, J., Ikonen, T., Pylkäs, K., Rapakko, K., Erkko, H., Johannesdottir, G., Gerdes, A-M., Thomassen, M., Agnarsson, B. A., Grip, M., Kallioniemi, A., Kere, J., Aaltonen, L. A., Arason, A., Møller, P. & 3 othersKruse, T. A., Borg, Å. & Winqvist, R., 2006, In : Journal of Medical Genetics. 43, 11, p. 856-862 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Periytyvän kasvainalttiuden molekyylitausta: Äyräpään luento

Aaltonen, L. A., 2006, In : Duodecim. 122, 18, p. 2221-2230

Research output: Contribution to journalArticleScientific

Pituitary adenoma predisposition caused by germline mutations in the AIP gene

Vierimaa, O., Georgitsi, M., Lehtonen, R., Vahteristo, P., Kokko, A., Raitila, A., Tuppurainen, K., Ebeling, T., Salmela, P. I., Paschke, R., Gundogdu, S., De Menis, E., Mäkinen, M. J., Launonen, V., Karhu, A. & Aaltonen, L. A., 2006, In : Science. 312, 5777, p. 1228-1230 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers

Hienonen, T., Salovaara, R., Mecklin, J-P., Järvinen, H. J., Karhu, A. & Aaltonen, L. A., 2006, In : International Journal of Cancer. 118, 2, p. 505-508 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

7q deletion mapping and expression profiling in uterine fibroids

Vanharanta, S., Wortham, N. C., Laiho, P., Sjöberg, J., Aittomäki, K., Arola, J., Tomlinson, I. P. M., Karhu, A., Arango, D. & Aaltonen, L. A., 2005, In : Oncogene. 24, 43, p. 6545-6554 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A 17p11.2 germline deletion in a patient with Smith-Magenis syndrome and neuroblastoma

Hienonen, T., Sammalkorpi, H., Isohanni, P., Versteeg, R., Karikoski, R. & Aaltonen, L. A., 2005, In : Journal of Medical Genetics. 42, 1, p. e3 6 p.

Research output: Contribution to journalArticleScientificpeer-review

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis

Alhopuro, P., Parker, A. R., Lehtonen, R., Enholm, S., Järvinen, H. J., Mecklin, J-P., Karhu, A., Eshleman, J. R. & Aaltonen, L. A., 2005, In : Human Mutation. 26, 4, p. 393 9 p.

Research output: Contribution to journalArticleScientificpeer-review

BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes

Domingo, E., Niessen, R., Oliveira, C., Alhopuro, P., Moutinho, C., Espin, E., Armengol, M., Sijmons, R. H., Kleibeuker, J. H., Seruca, R., Aaltonen, L. A., Imai, K., Yamamoto, H., Schwartz, S. & Hofstra, R. M. W., 2005, In : Oncogene. 24, 24, p. 3995-3998 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset

Hampel, H., Stephens, J. A., Pukkala, E., Sankila, R., Aaltonen, L. A., Mecklin, J-P. & Chapelle, A. D. L., 2005, In : Gastroenterology. 129, 2, p. 415-421 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid

Birkenkamp-Demtröder, K., Olesen, S. H., Sørensen, F. B., Laurberg, S., Laiho, P., Aaltonen, L. A. & Ørntoft, T. F., 2005, In : Gut. 54, 3, p. 374-384 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer

Arango, D., Laiho, P., Kokko, A., Alhopuro, P., Sammalkorpi, H., Salovaara, R., Nicorici, D., Hautaniemi, S., Alazzouzi, H., Mecklin, J-P., Järvinen, H. J., Hemminki, A. E., Astola, J., Schwartz, S. & Aaltonen, L. A., 2005, In : Gastroenterology. 129, 3, p. 874-884 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Gene expression signatures for colorectal cancer microsatellite status and HNPCC

Kruhøffer, M., Jensen, J. L., Laiho, P., Dyrskjot, L., Salovaara, R., Arango, D., Birkenkamp-Demtröder, K., Sørensen, F. B., Christensen, L. L., Buhl, L., Mecklin, J-P., Järvinen, H. J., Thykjaer, T., Wikman, F., Bech-Knudsen, F., Juhola, M., Nupponen, N., Laurberg, S., Andersen, C. L., Aaltonen, L. A. & 1 othersØrntoft, T. F., 2005, In : British Journal of Cancer. 92, 12, p. 2240-2248 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors

Alazzouzi, H., Davalos, V., Kokko, A., Domingo, E., Woerner, S. M., Wilson, A. J., Konrad, L., Laiho, P., Espin, E., Armengol, M., Imai, K., Yamamoto, H., Mariadason, J. M., Gebert, J. F., Aaltonen, L. A., Schwartz, S. & Arango, D., 2005, In : Cancer Research. 65, 22, p. 10170-10173 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis

Sweet, K., Willis, J., Zhou, X-P., Gallione, C., Sawada, T., Alhopuro, P., Khoo, S. K., Patocs, A., Martin, C., Bridgeman, S., Heinz, J., Pilarski, R., Lehtonen, R., Prior, T. W., Frebourg, T., Teh, B. T., Marchuk, D. A., Aaltonen, L. A. & Eng, C., 2005, In : JAMA : The Journal of the American Medical Association. 294, 19, p. 2465-2473 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular staging for survival prediction of colorectal cancer patients

Eschrich, S., Yang, I., Bloom, G., Kwong, K. Y., Boulware, D., Cantor, A., Coppola, D., Kruhøffer, M., Ørntoft, T. F., Quackenbush, J., Yeatman, T. J. & Aaltonen, L. A., 2005, In : Journal of Clinical Oncology. 23, 15, p. 3526-3535 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

Alhopuro, P., Katajisto, P., Lehtonen, R. J., Ylisaukko-oja, S., Näätäsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P. M., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, 6, p. 1126-1129 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRAD alpha, and MO25 alpha, in Peutz-Jeghers syndrome

Alhopuro, P., Katajisto, P., Lehtonen, R., Ylisaukko-oja, S. K., Näätsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, p. 1126-1129 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers

Hienonen, T., Sammalkorpi, H., Enholm, S., Alhopuro, P., Barber, T. D., Lehtonen, R., Nupponen, N. N., Lehtonen, H., Salovaara, R., Mecklin, J-P., Järvinen, H. J., Koistinen, R., Arango, D., Launonen, V., Vogelstein, B., Karhu, A. & Aaltonen, L. A., 2005, In : Cancer Research. 65, 11, p. 4607-4613 7 p.

Research output: Contribution to journalArticleScientificpeer-review

No germline FH mutations in familial breast cancer patients

Kiuru, M. H. T., Lehtonen, R., Eerola, H., Aittomäki, K., Blomqvist, C., Nevanlinna, H., Aaltonen, L. A. & Launonen, V., 2005, In : European Journal of Human Genetics. 13, 4, p. 506-509 4 p.

Research output: Contribution to journalArticleScientificpeer-review

No MSH6 germline mutations in breast cancer families with colorectal and/or endometrial cancer

Vahteristo, P., Ojala, S., Tamminen, A., Tommiska, J., Sammalkorpi, H., Kiuru-Kuhlefelt, S., Eerola, H., Aaltonen, L. A., Aittomäki, K. & Nevanlinna, H., 2005, In : Journal of Medical Genetics. 42, 4, p. e22 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Numbers of mutations to different types of colorectal cancer

Calabrese, P., Mecklin, J-P., Järvinen, H. J., Aaltonen, L. A., Tavare, S. & Shibata, D., 2005, In : BMC Cancer. 5, 126, 7 p.

Research output: Contribution to journalArticleScientificpeer-review

p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome

Sotamaa, K., Liyanarachchi, S., Mecklin, J-P., Järvinen, H. J., Aaltonen, L. A., Peltomäki, P. & Chapelle, A. D. L., 2005, In : Clinical Cancer Research. 11, 19, p. 6840-6844 5 p.

Research output: Contribution to journalArticleScientificpeer-review

SMAD4 as a prognostic marker in colorectal cancer

Alazzouzi, H., Alhopuro, P., Salovaara, R., Sammalkorpi, H., Järvinen, H. J., Mecklin, J-P., Hemminki, A., Schwartz, S., Aaltonen, L. A. & Arango, D., 2005, In : Clinical Cancer Research. 11, 7, p. 2606-2611 6 p.

Research output: Contribution to journalArticleScientificpeer-review

SMAD4 levels and response to 5-fluorouracil in colorectal cancer

Alhopuro, P., Alazzouzi, H., Sammalkorpi, H., Davalos, V., Salovaara, R., Hemminki, A., Järvinen, H. J., Mecklin, J-P., Schwartz, S., Aaltonen, L. A. & Arango, D., 2005, In : Clinical Cancer Research. 11, 17, p. 6311-6316 6 p.

Research output: Contribution to journalArticleScientificpeer-review