Photo of Lauri Aaltonen
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • PL 63 (Haartmaninkatu 8), B514b2

    HELSINGIN YLIOPISTO

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1992 …2019
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Publications 1992 2019

1997

MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis

Wu, Y., Nyström-Lahti, M., Osinga, J., Looman, M. W. G., Peltomäki, P., Aaltonen, L. A., de la Chapelle, A., Hofstra, R. M. W. & Buys, C. H. C. M., 1997, In : Genes, Chromosomes & Cancer. 18, p. 269-278 10 p.

Research output: Contribution to journalArticleScientificpeer-review

1996

No evidence of microsatellite instability in bone tumors

Tarkkanen, M., Aaltonen, L. A., Böhling, T. O., Kivioja, A. H., Karaharju, E., Elomaa, A. I. & Knuutila, Y. S., 1996, In : British Journal of Cancer. 74, p. 453-455

Research output: Contribution to journalArticleScientificpeer-review

Semiautomated assessment of loss of heterozygosity and replication error in tumors

Canzian, F., Salovaara, R., Hemminki, A., Kristo, P., Chadwick, R. B., Aaltonen, L. A. & delaChapelle, A., 1996, In : Cancer Research. 56, p. 3331-3337 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic microsatellite mutations as molecular tumor clocks

Shibata, D., Navidi, W., Salovaara, R., Li, Z. H. & Aaltonen, L. A., 1996, In : Nature Medicine. 2, p. 676-681 6 p.

Research output: Contribution to journalArticleScientificpeer-review

1995

Founding mutations and Alu-mediated recombination in hereditary colon cancer

Nyström-Lahti, M., KRISTO, P., NICOLAIDES, N. C., CHANG, S. Y., Aaltonen, L. A., MOISIO, A. L., Järvinen, H. J., MECKLIN, J. P., KINZLER, K. W., VOGELSTEIN, B., de la Chapelle, A. & Peltomäki, P., 1995, In : Nature Medicine. 1, 11, p. 1203-1206 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Periytyvä syöpä

Translated title of the contribution: Hereditary cancerMecklin, J-P., Peltomäki, P. T., Aaltonen, L. A. & Kääriäinen, H., 1995, In : Suomen lääkärilehti. 50, 18-19, p. 2057-2064

Research output: Contribution to journalReview ArticleScientificpeer-review

1994

A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancel burden

Aaltonen, L. A., SANKILA, R., MECKLIN, J. P., Järvinen, H., PUKKALA, E., Peltomäki, P. & de la Chapelle, A., 1994, In : Cancer Detection and Prevention. 18, p. 57-63 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families

Nyström-Lahti, M., Sistonen, P., Mecklin, J. P., Pylkkänen, L., Aaltonen, L. A., Järvinen, H., Weissenbach, J., de la Chapelle, A. & Peltomäki, P., 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, p. 6054-6058 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Genes involved in hereditary nonpolyposis colorectal carcinoma

Aaltonen, L. A. & Peltomäki, P. T., 1994, In : Anticancer Research. 14, p. 1657-1660

Research output: Contribution to journalReview ArticleScientificpeer-review

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

Hemminki, A., Peltomäki, P., MECKLIN, J. P., Järvinen, H., Salovaara, R., Nyström-Lahti, M., de la Chapelle, A. & Aaltonen, L. A., 1994, In : Nature Genetics. 8, p. 405-410 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage

Nyström-Lahti, M., PARSONS, R., SISTONEN, P., Pylkkänen, L., Aaltonen, L. A., LEACH, F. S., HAMILTON, S. R., WATSON, P., BRONSON, E., CAVALIERI, J., LYNCH, J., LANSPA, S., SMYRK, T., LYNCH, P., DROUHARD, T., KINZLER, K. W., VOGELSTEIN, B., LYNCH, H. T., de la Chapelle, A. & Peltomäki, P., 1994, In : American Journal of Human Genetics. 55, p. 659-665 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Replication errors in benign and malignant tumors from hederitary nonpolyposis colorectal cancer patients

Aaltonen, L. A., Peltomäki, P., MECKLIN, J. P., Järvinen, H., JASS, J. R., GREEN, J. S., LYNCH, H. T., WATSON, P., TALLQVIST, G., JUHOLA, M., SISTONEN, P., HAMILTON, S. R., KINZLER, K. W., VOGELSTEIN, B. & de la Chapelle, A., 1994, In : Cancer Research. 54, p. 1645-1648 4 p.

Research output: Contribution to journalArticleScientificpeer-review

1993

Clues to the pathogenesis of familial colorectal cancer

AALTONEN, L. A., Peltomäki, P., LEACH, F. S., SISTONEN, P., PYLKKANEN, L., MECKLIN, J. P., Järvinen, H., POWELL, S. M., JEN, J., HAMILTON, S. R., PETERSEN, G. M., KINZLER, K. W., VOGELSTEIN, B. & de la Chapelle, A., 1993, In : Science. 260, p. 812-816 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic mapping of a locus predisposing to human colorectal cancer

Peltomäki, P., AALTONEN, L. A., SISTONEN, P., PYLKKANEN, L., MECKLIN, J. P., JARVINEN, H., GREEN, J. S., JASS, J. R., WEBER, J. L., LEACH, F. S., PETERSEN, G. M., HAMILTON, S. R., DELACHAPELLE, A. & VOGELSTEIN, B., 1993, In : Science. 260, p. 810-812 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history

LOTHE, R. A., Peltomäki, P., MELING, G. I., AALTONEN, L. A., NYSTROMLAHTI, M., PYLKKANEN, L., HEIMDAL, K., ANDERSEN, T. I., MOLLER, P., ROGNUM, T. O., FOSSA, S. D., HALDORSEN, T., LANGMARK, F., BROGGER, A., DELACHAPELLE, A. & BORRESEN, A. L., 1993, In : Cancer Research. 53, p. 5849-5852 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Läpimurto paksusuolisyövän geneettisen taustan selvittämisessä

Translated title of the contribution: A breakthrough that elucidates the genetic basis of hereditary colon cancerPeltomäki, P. T., Aaltonen, L. A., Mecklin, JP. & de la Chapelle, A., 1993, In : Duodecim. 109, p. 1367-1369

Research output: Contribution to journalReview ArticleScientificpeer-review

Microsatellite instability is associated with tumors that characterize the hereditary nonpolyposis colorectal carcinoma syndrome

Peltomäki, P., LOTHE, R. A., AALTONEN, L. A., PYLKKANEN, L., Nyström-Lahti, M., SERUCA, R., DAVID, L., HOLM, R., RYBERG, D., HAUGEN, A., BROGGER, A., BORRESEN, A. L. & de la Chapelle, A., 1993, In : Cancer Research. 53, p. 5853-5855 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations of a MutS homolog in hereditary non-polyposis colorectal cancer

LEACH, F. S., NICOLAIDES, N. C., PAPADOPOULOS, N., LIU, B., JEN, J., PARSONS, R., Peltomäki, P., SISTONEN, P., Aaltonen, L. A., NYSTROMLAHTI, M., GUAN, X. Y., ZHANG, J., MELTZER, P. S., YU, J. W., KAO, F. T., CHEN, D. J., CEROSALETTI, K. M., FOURNIER, R. E. K., TODD, S., LEWIS, T. & 15 othersLEACH, R. J., NAYLOR, S. L., WEISSENBACH, J., MECKLIN, J. P., Järvinen, H., PETERSEN, G. M., HAMILTON, S. R., GREEN, J., JASS, J., WATSON, P., LYNCH, H. T., TRENT, J. M., de la Chapelle, A., KINZLER, K. W. & VOGELSTEIN, B., 1993, In : Cell. 75, p. 1215-1225 11 p.

Research output: Contribution to journalArticleScientificpeer-review

1992

EVIDENCE THAT THE MCC-APC GENE REGION IN 5Q21 IS NOT THE SITE FOR SUSCEPTIBILITY TO HEREDITARY NONPOLYPOSIS COLORECTAL-CARCINOMA

PELTOMAKI, P., SISTONEN, P., MECKLIN, J. P., PYLKKANEN, L., AALTONEN, L., NORDLING, S., KERE, J., JARVINEN, H., HAMILTON, S. R., PETERSEN, G., KINZLER, K. W., VOGELSTEIN, B. & DELACHAPELLE, A., 1992, In : Cancer Research. 1992, 52, p. 4530-4533 4 p.

Research output: Contribution to journalArticleScientificpeer-review