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Personal profile

Description of research and teaching

My research interests include different advanced drug delivery systems, especially nanoscale systems enabling intracellular delivery of drugs. I am currently working in a project on stimuli-responsive drug delivery vehicles. These lipid nanoparticle carriers, liposomes, can be induced to release the drug with exposition to light and change in pH after cell uptake. These light triggerable and pH-sensitive liposomes would enable time- and site-controlled drug delivery, thus allowing refined treatment regimens and reducing drug exposition of non-target cells. Drug delivery via these stimuli-responsive liposomes would provide improved delivery methods for the treatment of, for instance, diseases of the posterior eye (such as age-related macular degeneration and diabetic retinopathy) that currently need to be treated with frequent, invasive intravitreal injections.

Fields of Science

  • 317 Pharmacy

International and National Collaboration Publications and projects within past five years.

Publications 2010 2019

Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy

Galli, E., Lindholm, P., Kontturi, L-S., Saarma, M., Urtti, A. & Yliperttula, M., Apr 2019, In : Cell Transplantation. 28, 4, p. 413-424 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Light-Triggered Cellular Delivery of Oligonucleotides

Kontturi, L-S., van den Dikkenberg, J., Urtti, A., Hennink, W. E. & Mastrobattista, E., Feb 2019, In : Pharmaceutics. 11, 2, 16 p., 90.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Indocyanine Green-Loaded Liposomes for Light-Triggered Drug Release

Lajunen, T., Kontturi, L-S., Viitala, L., Manna, M., Cramariuc, O., Rog, T., Bunker, A., Laaksonen, T., Viitala, T., Murtomäki, L. & Urtti, A., Jun 2016, In : Molecular Pharmaceutics. 13, 6, p. 2095-2107 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Light activated liposomes: Functionality and prospects in ocular drug delivery

Lajunen, T., Nurmi, R., Kontturi, L., Viitala, L., Yliperttula, M., Murtomaki, L. & Urtti, A., 28 Dec 2016, In : Journal of Controlled Release. 244, p. 157-166 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Photothermally Triggered Lipid Bilayer Phase Transition and Drug Release from Gold Nanorod and Indocyanine Green Encapsulated Liposomes

Viitala, L., Pajari, S., Lajunen, T., Kontturi, L-S., Laaksonen, T., Kuosmanen, P., Viitala, T., Urtti, A. & Murtomaki, L., 10 May 2016, In : Langmuir. 32, 18, p. 4554-4563 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Activities 2013 2015

  • 1 Member of doctoral thesis committee / follow-up group
  • 1 Academic visit to other institution

Utrecht University, Department of Pharmaceutical Sciences

Leena Kontturi (Visiting researcher)
1 Nov 201531 Dec 2016

Activity: Visiting an external institution typesAcademic visit to other institution

Member of doctoral thesis committee

Yan-Ru Lou (Member of thesis committee / follow-up group)
22 May 2013

Activity: Examination typesMember of doctoral thesis committee / follow-up group