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Leena Peltonen

  • PL 56 (Viikinkaari 5)

    00014

    Finland

1997 …2023
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Publications 1997 2019

2019

Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering

Saarinen, J. K. S., Gütter, F., Lindman, M. M., Agopov, M., Fraser-Miller, S. J., Scherließ, R., Jokitalo, E., Almeida Santos, H., Peltonen, L., Isomäki, A. & Strachan, C. J., Apr 2019, In : Biotechnology Journal. 14, 4, 10 p., 1800413.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Centrifugal fractionation of softwood extracts improves biorefinery workflow and yields functional emulsifiers

Valoppi, F., Lahtinen, M., Bhattarai, M., Kirjoranta, S., Juntti, V., Peltonen, L., Kilpeläinen, P. O. & Mikkonen, K. S., 1 Aug 2019, In : Green Chemistry.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Environmentally-compatible alkyd paints stabilized by wood hemicelluloses

Mikkonen, K. S., Kirjoranta, S., Xu, C., Hemming, J., Pranovich, A., Bhattarai, M., Peltonen, L., Kilpeläinen, P., Maina, N., Tenkanen, M., Lehtonen, M. & Willför, S., 16 Mar 2019, In : Industrial Crops and Products. 133, p. 212-220

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes

Khan, D. H., Bashir, S., Figueiredo, P., Santos, H. A., Khan, M. I. & Peltonen, L., Apr 2019, In : Journal of Drug Delivery Science and Technology. 50, p. 27-33 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Submission of Rifaximin to Different Techniques: Characterization, Solubility Study, and Microbiological Evaluation

Kogawa, A. C., Peltonen, L., Antonio, S. G. & Nunes Salgado, H. R., Apr 2019, In : AAPS PharmSciTech. 20, 3, 13 p., 125.

Research output: Contribution to journalArticleScientificpeer-review

2018

Analytical tools for reliable in vitro and in vivo performance testing of drug nanocrystals

Tuomela, A., Saarinen, J., Hirvonen, J. & Peltonen, L., 2018, Nanoscale fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. Grumezescu, A. M. (ed.). San Diego: Elsevier, p. 441-477 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Design Space and QbD Approach for Production of Drug Nanocrystals by Wet Media Milling Techniques

Peltonen, L., 25 Jul 2018, In : Pharmaceutics. 10, 3, 17 p., 104.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Drug nanocrystals - versatile option for formulation of poorly soluble materials

Peltonen, L. & Hirvonen, J., 15 Feb 2018, In : International Journal of Pharmaceutics. 537, 1-2, p. 73-83 11 p.

Research output: Contribution to journalArticleScientificpeer-review

High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions

Selin, M., Nummelin, S., Deleu, J., Ropponen, J., Viitala, T., Lahtinen, M., Koivisto, J., Hirvonen, J., Peltonen, L., Kostiainen, M. A. & Bimbo, L. M., Oct 2018, In : Biomacromolecules. 19, 10, p. 3983-3993 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Practical guidelines for the characterization and quality control of pure drug nanoparticles and nano-cocrystals in the pharmaceutical industry

Peltonen, L., 18 Jun 2018, In : Advanced Drug Delivery Reviews. 131, p. 101-115 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Understanding Dissolution and Crystallization with Imaging: A Surface Point of View

Novakovic, D., Isomäki, A., Pleunis, B., Fraser-Miller, S. J., Peltonen, L. J., Laaksonen, T. & Strachan, C. J., Nov 2018, In : Molecular Pharmaceutics. 15, 11, p. 5361-5373 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Elucidation of Compression-Induced Surface Crystallization in Amorphous Tablets Using Sum Frequency Generation (SFG) Microscopy

Mah, P. T., Novakovic, D., Saarinen, J., Landeghem, S. V., Peltonen, L., Laaksonen, T., Isomäki, A. & Strachan, C. J., 2017, In : Pharmaceutical Research. 34, 5, p. 957-970 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Insights into Caco-2 cell culture structure using coherent anti-Stokes Raman scattering (CARS) microscopy

Saarinen, J., Sõzeri, E., Fraser-Miller, S., Peltonen, L., A. Santos, H., Isomäki, A. & Strachan, C. J., 15 May 2017, In : International Journal of Pharmaceutics. 523, 1, p. 270–280 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multimodal Nonlinear Optical Imaging for Sensitive Detection of Multiple Pharmaceutical Solid-State Forms and Surface Transformations

Novakovic, D., Saarinen, J., Rojalin, T., Antikainen, O., Fraser-Miller, S., Laaksonen, T., Peltonen, L., Isomäki, A. & Strachan, C. J., 2017, In : Analytical Chemistry. 89, 21, p. 11460-11467 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Ultrasonic Processing Technique as a Green Preparation Approach for Diacerein-Loaded Niosomes

Khan, M. I., Madni, A., Hirvonen, J. & Peltonen, L., Jul 2017, In : AAPS PharmSciTech. 18, 5, p. 1554-1563 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Dendrimers and their supramolecular nanostructures for biomedical applications

Selin, M., Peltonen, L., Hirvonen, J. & Bimbo, L. M., Aug 2016, In : Journal of Drug Delivery Science and Technology. 34, p. 10-20 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Development and in-vitro characterization of sorbitan monolaurate and poloxamer 184 based niosomes for oral delivery of diacerein

Khan, M. I., Madni, A. & Peltonen, L., 1 Dec 2016, In : European Journal of Pharmaceutical Sciences. 95, p. 88-95 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Editorial, Special issue BBBB

Sandler, N. & Peltonen, L. J., 2016, In : European Journal of Pharmaceutical Sciences. 95, p. 1 1 p.

Research output: Contribution to journalArticleScientific

Editorial for the Special Issue "Scandinavia"

Peltonen, L. J., 2016, In : Journal of Drug Delivery Science and Technology. 34, p. A1 1 p.

Research output: Contribution to journalArticleScientific

Polymeric Stabilizers for Drug Nanocrystals

Peltonen, L. J., Tuomela, A. L. & Hirvonen, J. T., 2016, Handbook of Polymers for Pharmaceutical Technologies: Volume 4: Bioactive and Compatible Synthetic Hybrid Polymers. Vijay Kumar, T. & Manju Kumari, T. (eds.). New Jersey: Wiley, p. 67-87 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Production, applications and in vivo fate of drug nanocrystals

Tuomela, A. L., Saarinen, J. K. S., Strachan, C. J., Hirvonen, J. T. & Peltonen, L. J., 2016, In : Journal of Drug Delivery Science and Technology. 34, p. 21-31 11 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Stabilizing agents for drug nanocrystals: effect on bioavailability

Tuomela, A., Hirvonen, J. & Peltonen, L., 2016, In : Pharmaceutics. 8, 2, 18 p., 16.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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The effect of surfactants on the dissolution behavior of amorphous formulations

Mah, P. T., Peltonen, L., Novakovic, D., Rades, T., Strachan, C. J. & Laaksonen, T., Jun 2016, In : European Journal of Pharmaceutics and Biopharmaceutics. 103, p. 13-22 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Chapter 18: Inorganic Nanoparticles in Targeted Drug Delivery and Imaging (Book Chapter)

Santos, H. A., Bimbo, L. M., Peltonen, L. & Hirvonen, J., 2015, Targeted Drug Delivery – Concepts and Design. Sanyog, J. & Devarajan, P. (eds.). Cham: Springer International Publishing AG, p. 571-613 43 p. (Advances in Delivery Science and Technology).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Differential scanning calorimetry predicts the critical quality attributes of amorphous glibenclamide

Mah, P. T., Laaksonen, T., Rades, T., Peltonen, L. & Strachan, C. J., 1 Dec 2015, In : European Journal of Pharmaceutical Sciences. 80, p. 74-81 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Interaction Studies Between Indomethacin Nanocrystals and PEO/PPO Copolymer Stabilizers

Liu, P., Viitala, T., Kartal-Hodzic, A., Liang, H., Laaksonen, T., Hirvonen, J. & Peltonen, L., 2015, In : Pharmaceutical Research. 32, 2, p. 628-639 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Multimodal Non-Linear Optical Imaging for the Investigation of Drug Nano-/Microcrystal-Cell Interactions

Darville, N., Saarinen, J., Isomäki, A., Khriachtchev, L., Sterkens, P., van Heerden, M., Annaert, P., Peltonen, L., Almeida Santos, H., Strachan, C. J. & Van den Mooter, G., 2 Oct 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 96, p. 338–348 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Polymer incorporation method affects the physical stability of amorphous indomethacin in aqueous suspension

Surwase, S. A., Itkonen, L., Aaltonen, J., Saville, D., Rades, T., Peltonen, L. & Strachan, C. J., Oct 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 96, p. 32-43 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Solid formulations by a nanocrystal approach: Critical process parameters regarding scale-ability of nanocrystals for tableting applications

Tuomela, A., Laaksonen, T., Laru, J., Antikainen, O., Kiesvaara, J., Ilkka, J., Oksala, O., Rönkkö, S., Järvinen, K., Hirvonen, J. & Peltonen, L., 15 May 2015, In : International Journal of Pharmaceutics. 485, 1-2, p. 77-86 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Understanding critical quality attributes for nanocrystals from preparation to delivery

Peltonen, L. & Strachan, C., 2015, In : Molecules. 20, 12, p. 22286-22300

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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2014

Brinzolamide nanocrystal formulations for ophthalmic delivery: Reduction of elevated intraocular pressure in vivo

Tuomela, A., Liu, P., Puranen, J., Rönkkö, S., Laaksonen, T., Kalesnykas, G., Oksala, O., Ilkka, J., Laru, J., Järvinen, K., Hirvonen, J. & Peltonen, L., 5 Jun 2014, In : International Journal of Pharmaceutics. 467, 1-2, p. 34-41 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug Nanocrystals and nanosuspensions in medicine

Peltonen, L., Hirvonen, J. & Laaksonen, T., 2014, Handbook of nanobiomedical research - Fundamentals, applications and recent developments : 1. Materials for nanomedicine . Torchilin, V. (ed.). Hackensack, N. J.: World Scientific, Vol. 1. p. 169-197 29 p. (Frontiers in nanobiomedical research ; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Nanocrystal-based per-oral itraconazole delivery: Superior in vitro dissolution enhancement versus Sporanox(R) is not realized in in vivo drug absorption

Sarnes, A., Kovalainen, M., Häkkinen, M. R., Laaksonen, T., Laru, J., Kiesvaara, J., Ilkka, J., Oksala, O., Rönkkö, S., Järvinen, K., Hirvonen, J. & Peltonen, L., 28 Apr 2014, In : Journal of Controlled Release. 180, p. 109-116 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Unravelling the Relationship between Degree of Disorder and the Dissolution Behavior of Milled Glibenclamide

Mah, P. T., Laaksonen, T., Rades, T., Aaltonen, J., Peltonen, L. & Strachan, C. J., Jan 2014, In : Molecular Pharmaceutics. 11, 1, p. 234-242 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Coated particle assemblies for the concomitant pulmonary administration of budesonide and salbutamol sulphate

Raula, J., Rahikkala, A., Halkola, T., Pessi, J., Peltonen, L., Hirvonen, J., Jarvinen, K., Laaksonen, T. & Kauppinen, E. I., 2013, In : International Journal of Pharmaceutics. 441, 1-2, p. 248-254 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Dissolution Studies of Poorly Soluble Drug Nanosuspensions in Non-sink Conditions

Liu, P., De Wulf, O., Laru, J., Heikkilä, T., van Veen, B., Kiesvaara, J., Hirvonen, J., Peltonen, L. & Laaksonen, T., Jun 2013, In : AAPS PharmSciTech. 14, 2, p. 748-756 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods

Sarnes, A., Ostergaard, J., Jensen, S. S., Aaltonen, J., Rantanen, J., Hirvonen, J. & Peltonen, L., 2013, In : European Journal of Pharmaceutical Sciences. 50, 3-4, p. 511-519 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug nanocrystals

Peltonen, L., 2013, Fundamentals of Pharmaceutical Nanoscience. Schätzlein, A. G., Uchegbu, I. F., Cheng, W. P. & Lalatsa, A. (eds.). New York: Springer Science+Business Media, p. 277-297 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels

Valo, H., Arola, S., Laaksonen, P., Torkkeli, M., Peltonen, L., Linder, M. B., Serimaa, R., Kuga, S., Hirvonen, J. & Laaksonen, T., 27 Sep 2013, In : European Journal of Pharmaceutical Sciences. 50, 1, p. 69-77 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Evaluation of drug interactions with nanofibrillar cellulose

Kolakovic, R., Peltonen, L., Laukkanen, A., Hellman, M., Laaksonen, P., Linder, M. B., Hirvonen, J. & Laaksonen, T., 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, p. 1238-1244 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Indomethacin: New Polymorphs of an Old Drug

Surwase, S. A., Boetker, J. P., Saville, D., Boyd, B. J., Gordon, K. C., Peltonen, L. & Strachan, C. J., Dec 2013, In : Molecular Pharmaceutics. 10, 12, p. 4472-4480 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mesoporous materials and nanocrystals for enhancing the dissolution behavior of poorly water-soluble drugs

Santos, H. A., Peltonen, L., Limnell, T. & Hirvonen, J., Nov 2013, In : Current Pharmaceutical Biotechnology. 14, 10, p. 926-938 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Nanofibrillar cellulose films for controlled drug delivery

Kolakovic, R., Peltonen, L., Laukkanen, A., Hirvonen, J. & Laaksonen, T., Oct 2012, In : European Journal of Pharmaceutics and Biopharmaceutics. 82, 2, p. 308-315 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Spray-dried nanofibrillar cellulose microparticles for sustained drug release

Kolakovic, R., Laaksonen, T., Peltonen, L., Laukkanen, A. & Hirvonen, J., 2012, In : International Journal of Pharmaceutics. 430, 1-2, p. 47-55 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Tablet preformulations of indomethacin-loaded mesoporous silicon microparticles

Tahvanainen, M., Rotko, T., Makila, E., Santos, H. A., Neves, D., Laaksonen, T., Kallonen, A., Hämäläinen, K., Peura, M., Serimaa, R., Salonen, J., Hirvonen, J. & Peltonen, L., 2012, In : International Journal of Pharmaceutics. 422, 1-2, p. 125-131 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Toxicological Profile of Therapeutic Nanodelivery Systems

Bimbo, L. M., Peltonen, L., Hirvonen, J. & A. Santos, H., 2012, In : Current Drug Metabolism. 13, 8, p. 1068-1086 19 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2011

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

Skytthe, A., Valensis, S., Jeune, B., Cevenini, E., Balard, F., Beekman, M., Bezrukov, V., Blanche, H., Bolund, L., Broczek, K., Carru, C., Christensen, K., Christiansen, L., Collerton, J. C., Cotichini, R., de Craen, A. J. M., Dato, S., Davies, K., De Benedictis, G., Deiana, L. & 38 othersFlachsbart, F., Gampe, J., Gilbault, C., Gonos, E. S., Haimes, E., Hervonen, A., Hurme, M. A., Janiszewska, D., Jylhä, M., Kirkwood, T. B. L., Kristensen, P., Laiho, P., Leon, A., Marchisio, A., Masciulli, R., Nebel, A., Passarino, G., Pelicci, G., Peltonen, L., Perola, M., Poulain, M., Rea, I. M., Remacle, J., Robine, J. M., Schreiber, S., Scurti, M., Sevini, F., Sikora, E., Skouteri, A., Slagboom, P. E., Spazzafumo, L., Stazi, M. A., Toccaceli, V., Toussaint, O., Törnwall, O., Vaupel, J. W., Voutetakis, K. & Franceshi, C., 2011, In : Experimental Gerontology. 2011, 11, p. 934-945 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug delivery formulations of ordered and nonordered mesoporous silica: Comparison of three drug loading methods

Limnell, T., Santos, H. A., Mäkilä, E., Heikkilä, T., Salonen, J., Yu. Murzin, D., Kumar, N., Laaksonen, T., Peltonen, L. & Hirvonen, J., 2011, In : Journal of Pharmaceutical Sciences. 100, 8, p. 3294–3306 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid

Heikkilä, T., Karjalainen, M., Ojala, K., Partola, K., Lammert, F., Augustijns, P., Urtti, A., Yliperttula, M., Peltonen, L. & Hirvonen, J., 2011, In : International Journal of Pharmaceutics. 405, 1-2, p. 132-136 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices—Enhanced stability and release

Valo, H. K., Kovalainen, M., Laaksonen, P., Häkkinen, M., Auriola, S., Peltonen, L., Linder, M., Järvinen, K., Hirvonen, J. & Laaksonen, T., 20 Dec 2011, In : Journal of Controlled Release. 156, 3, p. 390-397 8 p.

Research output: Contribution to journalArticleScientificpeer-review