1993 …2019
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Publications 1993 2019

2019

In vivo Two-Photon Imaging of Anesthesia-Specific Alterations in Microglial Surveillance and Photodamage-Directed Motility in Mouse Cortex

Sun, W., Suzuki, K., Toptunov, D., Stoyanov, S., Yuzaki, M., Khiroug, L. & Dilyatev, A., 7 May 2019, In : Frontiers in Neuroscience. 13, 12 p., 421.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Emerging Role of (Endo)Cannabinoids in Migraine

Leimuranta, P., Khiroug, L. & Giniatullin, R., 24 Apr 2018, In : Frontiers in Pharmacology. 9, 7 p., 420.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Longitudinal two-photon imaging in somatosensory cortex of behaving mice reveals dendritic spine formation enhancement by subchronic administration of low-dose ketamine

Pryazhnikov, E., Mugantseva, E., Casarotto, P., Kolikova, J., Fred, S. M., Toptunov, D., Afzalov, R., Hotulainen, P., Voikar, V., Terry-Lorenzo, R., Engel, S., Kirov, S., Castren, E. & Khiroug, L., 24 Apr 2018, In : Scientific Reports. 8, 12 p., 6464.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-beta

Gureviciene, I., Gurevicius, K., Mugantseva, E., Kislin, M., Khiroug, L. & Tanila, H., 2017, In : Journal of Alzheimer's Disease. 55, 1, p. 147-157 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function

Markkanen, M., Ludwig, A., Khirug, S., Pryazhnikov, E., Soni, S., Khirug, L., Delpire, E., Rivera, J., Airaksinen, M. S. & Uvarov, P., 2017, In : Brain Research . 1675, p. 87-101 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Integrin alpha 4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection

Cui, L., Nitzsche, F., Pryazhnikov, E., Tibeykina, M., Tolppanen, L., Rytkonen, J., Huhtala, T., Mu, J., Khiroug, L., Boltze, J. & Jolkkonen, J., Oct 2017, In : Stroke. 48, 10, p. 2895-+ 20 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Antila, H., Ryazantseva, M., Popova, D., Sipilä, P., Guirado, R., Kohtala, S., Yalcin, I., Lindholm, J., Vesa, L., Sato, V., Cordeira, J., Autio, H., Kislin, M., Rios, M., Joca, S., Casarotto, P., Khiroug, L., Lauri, S., Taira, T., Castren, E. & 1 othersRantamäki, T., 10 Aug 2017, In : Scientific Reports. 7, 12 p., 7811.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Reversible disruption of neuronal mitochondria by ischemic and traumatic injury revealed by quantitative two-photon imaging in the neocortex of anesthetized mice

Kislin, M., Sword, J., Fomitcheva, I. V., Croom, D., Pryazhnikov, E., Lihavainen, E., Toptunov, D., Rauvala, H. M. E., Ribeiro, A. S., Khirug, L. & Kirov, S. A., 2017, In : Journal of Neuroscience. 37, 2, p. 333-348 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2016

HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix

Paveliev, M., Fenrich, K. K., Kislin, M., Kuja-Panula, J., Kulesskiy, E., Varjosalo, M., Kajander, T., Mugantseva, E., Ahonen-Bishopp, A., Khirug, L., Kulesskaya, N., Rougon, G. & Rauvala, H., 27 Sep 2016, In : Scientific Reports. 6, 17 p., 33916.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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In vivo Calcium Imaging of Evoked Calcium Waves in the Embryonic Cortex

Yuryev, M., Pellegrino, C., Jokinen, V., Andriichuk, L., Khirug, S., Khiroug, L. & Rivera Baeza, C., 6 Jan 2016, In : Frontiers in Cellular Neuroscience. 9, 9 p., 500.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

Automatic quantification of mitochondrial fragmentation from two-photon microscope images of mouse brain tissue

Lihavainen, E., Kislin, M., Toptunov, D., Khiroug, L. & Ribeiro, A. S., Dec 2015, In : Journal of Microscopy. 260, 3, p. 338-351 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging.

Paveliev, M., Kislin, M., Molotkov, D., Yuryev, M., Rauvala, H. & Khiroug, L., 2014, In : Journal of Visualized Experiments. 86, 8 p., e51559.

Research output: Contribution to journalArticleScientificpeer-review

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents.

Kislin, M., Mugantseva, E., Molotkov, D., Kulesskaya, N., Khirug, S., Kirilkin, I., Pryazhnikov, E., Kolikova, J., Toptunov, D., Yuryev, M., Giniatullin, R., Voikar, V., Rivera Baeza, C., Rauvala, H. & Khiroug, L., 1 Jan 2014, In : Journal of Visualized Experiments. 2014, 88, p. e51869 e51869.

Research output: Contribution to journalArticleScientificpeer-review

Opposite Reactivity of Meningeal versus Cortical Microvessels to the Nitric Oxide Donor Glyceryl Trinitrate Evaluated In Vivo with Two-Photon Imaging

Pryazhnikov, E., Kislin, M., Tibeykina, M., Toptunov, D., Ptukha, A., Shatillo, A., Gröhn, O., Giniatullin, R. & Khiroug, L., 28 Feb 2014, In : PLoS One. 9, 2, 8 p., 89699.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

Calcium-induced outgrowth of astrocytic peripheral processes requires actin binding by Profilin-1

Molotkov, D., Zobova, S., Miguel Arcas, J. & Khirug, L., 8 Apr 2013, In : Cell Calcium. 53, 5-6, p. 338-348 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparative analysis of cytosolic and mitochondrial ATP synthesis in embryonic and postnatal hippocampal neuronal cultures

Surin, A. M., Khiroug, S., Gorbacheva, L. R., Khodorov, B. I., Pinelis, V. G. & Khiroug, L., 2013, In : Frontiers in Molecular Neuroscience. 5, January, 15 p., Article 102.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Low micromolar Ba2+ potentiates glutamate transporter current in hippocampal astrocytes

Afzalov, R., Pryazhnikov, E., Shih, P-Y., Kondratskaya, E., Zobova, S., Leino, S., Salminen, O., Khirug, L. & Semyanov, A., 2013, In : Frontiers in Cellular Neuroscience. 7, p. 1-7 7 p., 135.

Research output: Contribution to journalArticleScientificpeer-review

Motility of astrocytic mitochondria is arrested by Ca2+-dependent interaction between mitochondria and actin filaments

Kremneva, E., Kislin, M., Kang, X. & Khiroug, L., Feb 2013, In : Cell Calcium. 53, 2, p. 85-93 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Transmembrane Prostatic Acid Phosphatase (TMPAP) Interacts with Snapin and Deficient Mice Develop Prostate Adenocarcinoma

Quintero, I. B., Herrala, A. M., Araujo, C. L., Pulkka, A. E., Hautaniemi, S., Ovaska, K., Pryazhnikov, E., Kulesskiy, E., Ruuth, M. K., Soini, Y., Sormunen, R. T., Khirug, L. & Vihko, P. T., 10 Sep 2013, In : PLoS One. 8, 9, 11 p., 73072.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012

Dynamic longitudinal investigation of individual nerve endings in the skin of anesthetized mice using in vivo two-photon microscopy

Yuryev, M. & Khiroug, L., 2012, In : Journal of Biomedical Optics. 17, 4, p. 046007

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Organotypic cell cultures and two-photon imaging: Tools for in vitro and in vivo assessment of percutaneous drug delivery and skin toxicity

Pappinen, S., Pryazhnikov, E., Khiroug, L., Ericson, M. B., Yliperttula, M. & Urtti, A., 20 Jul 2012, In : Journal of Controlled Release. 161, 2, p. 656-667 12 p.

Research output: Contribution to journalArticleScientificpeer-review

The Effect of MII alpha-Conotoxin and Its N-Terminal Derivatives on Ca2+- and Na+-Signals Induced by Nicotine in SH-SY5Y Neuroblastoma Cells

Surin, A. M., Kryukova, E. V., Strukov, A. S., Zhmak, M. N., Talka, R., Tuominen, R., Salminen, O., Khiroug, L. S., Kasheverov, I. E. & Tsetlin, V. I., 2012, In : Russian Journal of Bioorganic Chemistry. 38, 2, p. 184-191 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Deficient mitochondrial Ca2+ buffering in the Cln8(mnd) mouse model of neuronal ceroid lipofuscinosis

Kolikova, J., Afzalov, R., Surin, A., Lehesjoki, A-E. & Khiroug, L., 2011, In : Cell Calcium. 50, 6, p. 491-501 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of alpha-conotoxin MII and its n-terminal derivatives on Ca2+ and Na+ signalling induced by nicotine in SH-SY5Y cells

Surin, A., Kryukova, E., Strukov, A., Zhmak, A., Talka, R., Tuominen, R., Salminen, O., Khirug, L., Kasheverov, I. & Tsetlin, V., 2011, In : Bioorganicheskaya Khimiya. 28, p. 1-8 8 p.

Research output: Contribution to journalArticleScientificpeer-review

GLIA-SPECIFIC MGFAP PROMOTER DIRECTS EXPRESSION PREFERENTIALLY TO NEURONS IN RAT VISUAL CORTEX IN VIVO

Molotkov, D., Zobova, S. & Khiroug, L., 2011, In : Glia. 59, Supplement 1, p. P1-53 1 p.

Research output: Contribution to journalConference articleProfessional

Unusually strong temperature dependence of P2X3 receptor traffic to the plasma membrane

Pryazhnikov, E., Fayuk, D., Niittykoski, M. J., Giniatullin, R. & Khiroug, L., 20 Dec 2011, In : Frontiers in Cellular Neuroscience. 5, Article 27, p. 1-9 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Gene delivery to postnatal rat brain by non-ventricular plasmid injection and electroporation.

Molotkov, D., Yukin, A., Afzalov, R. & Khirug, L., 2010, In : Journal of Visualized Experiments. 43

Research output: Contribution to journalArticleScientificpeer-review

K(v)4.2 channels tagged in the S1-S2 loop for alpha-bungarotoxin binding provide a new tool for studies of channel expression and localization

Moise, L., Liu, J., Pryazhnikov, E., Khiroug, L., Jeromin, A. & Hawrot, E., 2010, In : Channels (Austin, Tex.). 4, p. 115-123 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Activity dependent plasma membrane insertion and internalization of Kv4.2 potassium channels in cultured hippocampal neurons

Pryazhnikov, E., Khiroug, S., Coleman, S. K., Keinänen, K., Jeromin, A. & Khirug, L., Oct 2009, Abstract book of 39th SfN annual meeting.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientific

Dynamic visualization of membrane-inserted fraction of pHluorin-tagged channels using repetitive acidification technique

Khiroug, S., Pryazhnikov, E., Coleman, S. K., Jeromin, A., Keinänen, K. & Khirug, L., 2009, In : BMC Neuroscience. 10, p. 141-151 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

Van Ryssen, M. P., Avlonitis, N., Giniatullin, R., McDougall, C., Carr, J. L., Stanton-Humphreys, M. N., Borgström, E. L. A., Brown, C. T. A., Fayuk, D., Surin, A., Niittykoski, M. J., Khirug, L. & Conway, S. J., 2009, In : Organic & Biomolecular Chemistry. 7, p. 4695-4707 13 p.

Research output: Contribution to journalArticleScientificpeer-review

The role of cytoskeleton in Ca2+-dependent and Ca2+-independent motility of mitochondria in rat astrocytes

Kremneva, E. & Khiroug, L., 2009, 9th European Meeting on Glial Cells in Health and Disease. Bologna: Medimond Srl, p. 113-117 5 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionProfessional

2008

GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1

Khirug, S., Yamada, J., Afzalov, R., Voipio, J., Khirug, L. & Kaila, K., 2008, In : Journal of Neuroscience. 28, 18, p. 4635-4639 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Sub-micromolar increase in [Ca2+](i) Triggers delayed exocytosis of ATP in cultured Astrocytes

Pryazhnikov, E. & Khirug, L., 2008, In : Glia. 56, 1, p. 38-49 12 p.

Research output: Contribution to journalArticleScientificpeer-review

TIRF study of P2X3 receptors trafficking in cultured neurons

Pryazhnikov, E., Giniatullin, R. & Khirug, L., Aug 2008, Abstract book of Annual Meeting of Scandinavian Physiological Society. Oulu

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientific

2007

Ca2+ requirements for cerebellar long-term synaptic depression: Role for a postsynaptic leaky integrator

Tanaka, K., Khiroug, L., Santamaria, F., Doi, T., Ogasawara, H., Ellis-Davies, G. C. R., Kawato, M. & Augustine, G. J., 2007, In : Neuron. 54, p. 787-800 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain

Sokka, A-L., Putkonen, N. J. E., Mudo, G., Pryazhnikov, E., Reijonen, S., Khirug, L., Belluardo, N., Lindholm, D. & Korhonen, L., 2007, In : Journal of Neuroscience. 27, 4, p. 901-908 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Exocytotic release of ATP from cultured Astrocytes

Pangrsic, T., Potokar, M., Stenovec, M., Kreft, M., Fabretti, E., Nistri, A., Pryazhnikov, E., Khirug, L., Giniatullin, R. & Zorec, R., 2007, In : Journal of Biological Chemistry. 282, 39, p. 28749-28758 10 p.

Research output: Contribution to journalArticleScientificpeer-review

KCC2 interacts with the dendritic cytoskeleton to promote spine development

Li, H., Khirug, S., Cai, C., Ludwig, A., Blaesse, P., Kolikova, J., Afzalov, R., Coleman, S. K., Lauri, S., Airaksinen, M. S., Keinanen, K., Khiroug, L., Saarma, M., Kaila, K. & Rivera, C., 2007, In : Neuron. 56, 6, p. 1019-1033 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction

Ahtiainen, L., Kolikova, J., Mutka, A-L., Luiro, K., Gentile, M., Ikonen, E., Khiroug, L., Jalanko, A. & Kopra, O., 2007, In : Neurobiology of Disease. 28, p. 52-64 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Calcium-dependent trapping of mitochondria near plasma membrane in stimulated astrocytes

Kolikova, J., Afzalov, R., Giniatullina, A., Surin, A., Giniatullin, R. & Khiroug, L., 2006, In : Brain Cell Biology. 35, p. 75-86 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Oligomerization of KCC2 correlates with development of inhibitory neurotransmission

Blaesse, P., Guillemin, I., Schindler, J., Schweizer, M., Delpire, E., Khiroug, L., Friauf, E. & Nothwang, H. G., 2006, In : Journal of Neuroscience. 26, 41, p. 10407-10419 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Reactive oxygen species mediate the potentiating effects of ATP on GABAergic synaptic transmission in the immature hippocampus

Safiulina, V. F., Afzalov, R., Khiroug, L., Cherubini, E. & Giniatullin, R., 2006, In : Journal of Biological Chemistry. 281, 33, p. 23464-23470 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices

Khirug, S., Huttu, K., Ludwig, A., Smirnov, S., Voipio, J., Rivera, C., Kaila, K. & Khiroug, L., 2005, In : European Journal of Neuroscience. 21, p. 899-904 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcranial in vivo optical imaging using confocal microscopy

Tsytsarev, V., Kirilkin, I. & Khiroug, L., 2005, In : Journal of Cognitive Neuroscience. p. 31-32 2 p.

Research output: Contribution to journalConference articleProfessional

2004

Rat nicotinic acetylcholine receptor alpha 2 beta 2 channels: Comparison of functional properties with alpha 4 beta 2 channels in Xenopus oocytes

Khiroug, S. S., Khiroug, L. & Yakel, J. L., 2004, In : Neuroscience. 124, p. 817-822 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Rat nicotinic ACh receptor α2β2 channels: Comparison of functional properties with α4β2 channels in Xenopus oocytes

Khiroug, S. S., Khirug, L. & Yakel, J. L., 2004, In : Neuroscience. 124, 4, p. 817-822

Research output: Contribution to journalArticleScientificpeer-review

2003

Functional mapping and Ca2+ regulation of nicotinic acetylcholine receptor channels in rat hippocampal CA1 neurons

Khiroug, L., Giniatullin, R., Klein, R. C., Fayuk, D. & Yakel, J. L., 2003, In : European Journal of Neuroscience. 23, p. 9024-9031 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

Nicotinic acetylcholine receptor α7 and β2 subunits co-assemble to form functional heteromeric nicotinic receptor channels

Khiroug, S. S., Harkness, P. C., Lamb, P. W., Sudweeks, S. N., Khirug, L., Millar, N. S. & Yakel, J. L., 2002, In : Journal of Physiology. 540, 2, p. 425-434

Research output: Contribution to journalArticleScientificpeer-review