Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology

Madsen, A. L., Bonàs-Guarch, S., Gheibi, S., Prasad, R., Vangipurapu, J., Ahuja, V., Cataldo, L. R., Dwivedi, O. P., Hatem, G., Atla, G., Guindo-Martínez, M., Jørgensen, A. M., Jonsson, A. E., Miguel-Escalada, I., Hassan, S., Linneberg, A., Ahluwalia, T. S., Drivsholm, T., Pedersen, O. & Sørensen, T. I. A. & 15 others, Astrup, A., Witte, D., Damm, P., Clausen, T. D., Mathiesen, E., Pers, T. H., Loos, R. J. F., Hakaste, L., Fex, M., Grarup, N., Tuomi, T., Laakso, M., Mulder, H., Ferrer, J. & Hansen, T. F., Oct 2024, In: Nature metabolism. 6, 10, p. 1897-1912 16 p.

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

VA Million Veteran Program, Suzuki, K., Hatzikotoulas, K., Southam, L., Hakaste, L., Tuomilehto, J. & Tuomi, T., 1 Mar 2024, In: Nature. 627, 8003, p. 347-357 11 p.

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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Williamson, A., Norris, D. M., Yin, X., Broadaway, K. A., Moxley, A. H., Vadlamudi, S., Wilson, E. P., Jackson, A. U., Ahuja, V., Andersen, M. K., Arzumanyan, Z., Bonnycastle, L. L., Bornstein, S. R., Bretschneider, M. P., Buchanan, T. A., Chang, Y.-C., Chuang, L.-M., Chung, R.-H., Clausen, T. D. & Damm, P. & 95 others, Delgado, G. E., de Mello, V. D., Dupuis, J., Dwivedi, O. P., Erdos, M. R., Silva, L. F., Frayling, T. M., Gieger, C., Goodarzi, M. O., Guo, X., Gustafsson, S., Hakaste, L., Hammar, U., Hatem, G., Herrmann, S., Hojlund, K., Horn, K., Hsueh, W. A., Hung, Y.-J., Hwu, C.-M., Jonsson, A., Karhus, L. L., Kleber, M. E., Kovacs, P., Lakka, T. A., Lauzon, M., Lee, I.-T., Lindgren, C. M., Lindström, J., Linneberg, A., Liu, C.-T., Luan, J., Aly, D. M., Mathiesen, E., Moissl, A. P., Morris, A. P., Narisu, N., Perakakis, N., Peters, A., Prasad, R. B., Rodionov, R. N., Roll, K., Rundsten, C. F., Sarnowski, C., Savonen, K., Scholz, M., Sharma, S., Stinson, S. E., Suleman, S., Tan, J., Taylor, K. D., Uusitupa, M., Vistisen, D., Witte, D. R., Walther, R., Wu, P., Xiang, A. H., Zethelius, B., Ahlqvist, E., Bergman, R. N., Chen, Y.-D. I., Collins, F. S., Fall, T., Florez, J. C., Fritsche, A., Grallert, H., Groop, L., Hansen, T., Koistinen, H. A., Komulainen, P., Laakso, M., Lind, L., Loeffler, M., Marz, W., Meigs, J. B., Raffel, L. J., Rauramaa, R., Rotter, J. I., Schwarz, P. E. H., Stumvoll, M., Sundstrom, J., Toenjes, A., Tuomi, T., Tuomilehto, J., Wagner, R., Barroso, I., Walker, M., Grarup, N., Boehnke, M., Wareham, N. J., Mohlke, K. L., Wheeler, E., O'Rahilly, S., Fazakerley, D. J. & Langenberg, C., Jun 2023, In: Nature Genetics. 55, p. 973–983 32 p.

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Loci for insulin processing and secretion provide insight into type 2 diabetes risk

Broadaway, K. A., Yin, X., Williamson, A., Parsons, V. A., Wilson, E. P., Moxley, A. H., Vadlamudi, S., Varshney, A., Jackson, A. U., Ahuja, V., Bornstein, S. R., Corbin, L. J., Delgado, G. E., Dwivedi, O. P., Silva, L. F., Frayling, T. M., Grallert, H., Gustafsson, S., Hakaste, L. & Hammar, U. & 51 others, Herder, C., Herrmann, S., Højlund, K., Hughes, D. A., Kleber, M. E., Lindgren, C. M., Liu, C. T., Luan, J., Malmberg, A., Moissl, A. P., Morris, A. P., Perakakis, N., Peters, A., Petrie, J. R., Roden, M., Schwarz, P. E. H., Sharma, S., Silveira, A., Strawbridge, R. J., Tuomi, T., Wood, A. R., Wu, P., Zethelius, B., Baldassarre, D., Eriksson, J. G., Fall, T., Florez, J. C., Fritsche, A., Gigante, B., Hamsten, A., Kajantie, E., Laakso, M., Lahti, J., Lawlor, D. A., Lind, L., März, W., Meigs, J. B., Sundström, J., Timpson, N. J., Wagner, R., Walker, M., Wareham, N. J., Watkins, H., Barroso, I., O'Rahilly, S., Grarup, N., Parker, S. C., Boehnke, M., Langenberg, C., Wheeler, E. & Mohlke, K. L., 2 Feb 2023, In: American Journal of Human Genetics. 110, 2, p. 284-299 16 p.

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A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY

Kettunen, J. L. T., Rantala, E., Dwivedi, O. P., Isomaa, B., Sarelin, L., Kokko, P., Hakaste, L., Miettinen, P. J., Groop, L. C. & Tuomi, T., Apr 2022, In: Diabetologia. 65, 4, p. 632-643 12 p.

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