Research output per year
Research output per year
Personal profile
Research interests
Maciej Maurycy Lalowski works at the Medicum, Department of Biochemistry and Developmental Biology, Meilahti Clinical Proteomics Core Facility, HiLIFE, University of Helsinki. Maciej does research in Proteomics, Neurodegeneration and Mass Spectrometry Imaging. The current research projects relate to Alzheimer's Disease, Mood Disorders, Neuronal Ceroid Lipofuscinosis and Schizophrenia.
Education information
MSc degree (1991), graduated with distinction/Faculty of Biology, University of Warsaw, Poland, scope biochemistry
1991-1992: Postgraduate studies, graduated with distinction
Faculty of Geography, Institute of Developing Countries, University of Warsaw
PhD degree (1997), graduated with distinction
Polish Academy of Sciences, Warsaw-Poland /joint research at NYU Medical Center, Dept. of Pathology, NYC, USA (1992-1996)
Docent (2011): University of Helsinki, Faculty of Medicine, scope medical biochemistry
Doctor habilitated (doktor habilitowany) (2021) Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan
Title: "Systematic studies on protein interactions and affected disease pathways underlying neuronal ceroid lipofuscinosis" (15.07.2021)
Education/Academic qualification
Biological sciences, Doctor of Science (Doctor habilitated), Systematic studies on protein interactions and affected disease pathways underlying Neuronal Ceroid Lipofuscinosis, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan
20 Nov 2020 → 15 Jul 2021
Award Date: 15 Jul 2021
Alzheimer's Disease/aging, Doctor of Philosophy, Characterization of Amyloid Beta peptides and associated factors in Alzheimer's Disease and aging brain, Medical Research Center, Polish Academy of Sciences
1 Mar 1992 → 1 Dec 1997
Award Date: 1 Dec 1997
External positions
Visiting professor, Adam Mickiewicz University, Institute of Molecular Biology and Biotechnology, Department of Gene Expression
1 Nov 2022 → …
Adjunct, Institute of Bioorganic Chemistry, Polish Academy of Science, Poznan-Poland
3 Aug 2020 → 31 Jul 2021
Fields of Science
- 3111 Biomedicine
- Neurodegeneration
- Mass spectrometry
- Network biology
- Proteomics
- Bioinformatics, Systems biology
- MALDI Imaging
- Drug delivery
- 1182 Biochemistry, cell and molecular biology
- 3112 Neurosciences
- 318 Medical biotechnology
International and National Collaboration
Publications and projects within past five years.
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CLN5 deficiency impairs glucose uptake in Batten disease.
Marchese, M., Bernardi, S., Vivarelli, R., Doccini, S., Santucci, L., Ogi, A., Licitra, R., Zang, J., Soliymani, R., Mero, S., Neuhauss, S. C., Signore, G., Lalowski, M. & Santorelli, F. M., 2 Jan 2025, In: bioRxiv : the preprint server for biology . 2025.01.02, 630719Research output: Contribution to journal › Article › Scientific
Open AccessFile -
The lipidome and proteome of high-density lipoprotein are altered in menopause.
Lehti, S., Korhonen, T.-M., Soliymani, R., Ruhanen, H., Lähteenmäki, E., Palviainen, M., Siljander, P., Lalowski, M., Käkelä, R., Lehti, M. & Laakkonen, E. K., 11 Jan 2025, In: BioRxiv beta : the preprint server for biology.Research output: Contribution to journal › Article › Scientific
Open AccessFile -
USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cells
Srinivasan, V., Soliymani, R., Ivanova, L., Eriksson-Rosenberg, O., Peitsaro, N., Lalowski, M., Karelson, M. & Lindholm, D. B., 22 Jan 2025, (Accepted/In press) In: Heliyon. e42031Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease
Scordino, M., Stepanova, P., Srinivasan, V., Pham Duc, D., Eriksson, O., Lalowski, M., Mudo, G., Di Liberto, V., Korhonen, L. & Lindholm, D., 18 Sept 2024, In: Frontiers in Molecular Neuroscience. 17, 14 p., 1473058.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
CX3CR1 modulates migration of resident microglia towards brain injury
Wagner, J., Hoyer, C., Antony, H., Lundgren, A. K., Soliymani, R., Crux, S., Justus, L., Keppler, K., Steffen, J., Kurts, C., Engel, D. R., Herms, J., Lalowski, M. & Fuhrmann, M., 23 Sept 2024, In: bioRxiv : the preprint server for biology .Research output: Contribution to journal › Article › Scientific
Open Access
Projects
- 4 Finished
-
MicroSynDep: Microglial control of synaptic function in stress response and vulnerability to depression
Lalowski, M. (Project manager)
01/10/2018 → 31/10/2022
Project: Research project
-
SZ_TEST: Towards Early Molecular Diagnostics of Schizophrenia
Lalowski, M. (Participant)
01/01/2017 → 31/12/2020
Project: Research project
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H2020 RISE project SZ_TEST
Lindholm, D. B. (Project manager), Lalowski, M. (Principal Investigator), Vaheri, A. (Project manager), Tienari, P. (Project manager) & Korhonen, L. (Principal Investigator)
01/01/2017 → 31/12/2020
Project: Research project
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Prop-AD: PROP-AD: Propagation behaviour of peripheral amyloid-β towards brain structures: effects of the blood-brain barrier.
Lalowski, M. (Project manager)
01/10/2016 → 31/08/2019
Project: Research project
Activities
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Diagnostic and prognostic role of expressed KRAS and BRAF mutations in MAPK/ERK-driven cancers
Lalowski, M. (Other role (describe in more detail in "Relation description, notes" field)), Stenman, J. (Supervisor), Orpana, A. (Co-supervisor), Ho, T. H. (Supervisor), Gunarsson, U. (Opponent), Elenius, K. (Pre-examiner) & Mäkinen, M. (Pre-examiner)
21 Jun 2021Activity: Examination types › Pre-examiner of doctoral thesis
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Platelet-derived extracellular vesicle subpopulations in health and disease
Lalowski, M. (Member of thesis committee / follow-up group)
1 Jan 2021 → 31 Dec 2025Activity: Examination types › Member of doctoral thesis committee / follow-up group
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Regression plane concept for analysing continuous cellular processes with machine learning
Lalowski, M. (Member of thesis committee / follow-up group)
1 Apr 2021 → 31 Dec 2025Activity: Examination types › Member of doctoral thesis committee / follow-up group
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Spring Proteomics Highlights
Lalowski, M. (Speaker: Chair)
14 Apr 2021Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
File -
Regulation of Pol II polymerase transcriptional reponse to DNA-damage by RBM7 and P-TEFb
Fisher, R. (Opponent), Lalowski, M. (Other role (describe in more detail in "Relation description, notes" field)), Barboric, M. (Supervisor), Lindholm, D. B. (Supervisor), Sistonen, L. (Pre-examiner) & Kaikkonen-Määttä, M. (Pre-examiner)
22 Jan 2020Activity: Examination types › Pre-examiner of doctoral thesis
Press/Media
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A potential treatment for cardiac regeneration
30/06/2020
3 items of Media coverage
Press/Media: Press / Media
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Researchers have found a promising therapy for cardiac regeneration
30/06/2020
5 items of Media coverage
Press/Media: Press / Media
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'Multiomics' and the newborn mouse heart
01/06/2018 → 04/06/2018
3 items of Media coverage
Press/Media: Press / Media
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Researchers use 'multiomics' approach to study newborn mouse heart
04/06/2018
1 item of Media coverage
Press/Media: Press / Media
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'Multiomics' and the newborn mouse heart - New insights into the development of heart disease therapeutics
Lalowski, M., Lakkisto, P., Kankuri, E. & Baumann, M.
01/06/2018
1 item of Media coverage
Press/Media: Press / Media